Clinical trials: Rhythm
Sleep Disturbance, Circadian Rhythm Sleep Disorders
Effect of an Eye Mask-Based Blackout Protocol on Sleep Quality and Melatonin
Sleep disturbance is a common problem among patients hospitalized in intensive care units due to continuous light exposure, noise, and frequent medical interventions.
- Conditions
- Sleep Disturbance, Circadian Rhythm Sleep Disorders, Intensive Care Unit Patients
- Trial name
- NCT07385768
- Testing
- Eye Mask-Based Blackout Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Atrial Fibrillation
SmartWATCHes for Detection of Atrial Fibrillation
In this trial the Preventives Heartbeats algorithm will be tested in two wearable devices for its specificity and sensitivity to distinguish between AF and SR.
- Trial name
- WATCHAF (NCT02956343)
- Testing
- Five minutes pulse wave recording
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Major Depressive Disorder (MDD), Sleep Disorders
A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles
This proposed study will be a longitudinal follow-up study of a case-control study of 160 participants (CREC Ref: 2023.234). This study aims to follow up on the trajectory of depression and rest-activity rhythm (RAR) disruptions…
- Conditions
- Major Depressive Disorder (MDD), Sleep Disorders, Circadian Rhythm
- Trial name
- NCT07388849
- Where
- Hong Kong
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Autism Spectrum Disorder
Do Sleep and Circadian Rhythm Disturbances Impact the Cognitive and Behavioural Development of Children With Autism?
The primary objective of this study is to undertake a longitudinal investigation of the impact of sleep and circadian rhythm disturbances on cognitive and behavioural trajectories in children with autism spectrum disorder (ASD)…
- Trial name
- NCT02878499
- Testing
- polysomnography
- Where
- 5 sites in France
- Volunteers
- 105 people
- Sponsor
- University Hospital, Strasbourg, France
Obesity
Effect of Confinement on Circadian Rhythms of Patients Integrated Into a Care Pathway for Bariatric Surgery
Confinement disrupts social habits, the absence of professional activity or teleworking creates the possibility for individuals to work and/or sleep at times that are most convenient for them.
- Trial name
- CHRONO-CONF (NCT04600635)
- Testing
- Bariatric surgery
- Volunteers
- 500 people
- Sponsor
- University Hospital, Grenoble
Schizophrenia Disorders, Mental Disorder
Brain Stimulation to the Hippocampus in Schizophrenia
Schizophrenia - marked by delusions, hallucinations, and cognitive deficits - causes the most disability of any mental health condition, but existing treatments have significant side effect burden and are often ineffective.
- Conditions
- Schizophrenia Disorders, Mental Disorder, Psychotic Disorder
- Trial name
- NCT07010614
- Testing
- Intracranial electrodes, TMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Atrial Fibrillation (AF)
Clinical Phase 2 Trial of AP31969 Versus Placebo for Rhythm Control of Atrial Fibrillation
A clinical Randomized Phase 2 Trial of AP31969 versus Placebo for Rhythm Control of Atrial Fibrillation.
- Trial name
- END-AF-1 (NCT07267949)
- Testing
- AP31969
- Where
- 46 sites in Bulgaria, Denmark and 6 more
- Volunteers
- 200 people
- Sponsor
- Acesion Pharma
Sleep
Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P1 (NCT05336084)
- Testing
- Ultradian sleep/wake protocol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy, Osteopathic Manipulation
The Effect of CV4 and Sacral Technique on the Alpha Bands Power
Compression of the fourth ventricle (CV4), is the most studied cranial technique, commonly used by Osteopathy in Cranial Field practitioners.
- Trial name
- NCT04492917
- Testing
- CV4, ST
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Osteopatia di Milano
Atrioventricular Reentrant Tachycardia
Non-invasive Left-sided Cervical Vagus Nerve Stimulation for Atrioventricular Reentrant Tachycardia
The goal of this Interventional clinical trials in atrioventricular reentrant tachycardia patients. The main question it aims to answer whether non-invasive vagus nerve stimulation could be effective in restoring rhythm.
- Trial name
- NCT06219343
- Testing
- Non-invasive vagus nerve stimulation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jingye Tai
Pacemaker, ICD
Monaldi Hospital Rhythm Registry
The study is a prospective registry. Consecutive patients with indications of implant / replacement or upgrade of pacemaker (PM), implantable cardioverter defibrillator (ICD), Implanted loop recorder (ILR) will be enrolled.
- Conditions
- Pacemaker, ICD, Implanted Loop Recorder
- Trial name
- NCT05072119
- Testing
- Device implantation
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- University of Campania Luigi Vanvitelli
Chronic Neuropathic Pain
EEG Theta Band Rhythm in SCS
The investigators want to assess if reversal in EEG theta power during trial phase can serve as an objective marker for sustained clinical response, identifying true responders, and if the changes in EEG pattern during trial with…
- Trial name
- NCT07820657
- Testing
- Reversal in EEG Theta Power
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Walton Centre NHS Foundation Trust
Atrial Fibrillation (AF), Stroke
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
The aim is to investigate whether screening with long-term ECG monitoring in individuals with elevated NT-proBNP leads to a lower incidence of ischeamic stroke and death from vascular causes.
- Conditions
- Atrial Fibrillation (AF), Stroke, NT-pro-BNP, Cognitive Function and Well-Being
- Trial name
- PAFS-Tromsø (NCT07343895)
- Testing
- Long term heart rythm monitoring by ECG247
- Where
- 2 sites in Norway
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Healthy Volunteers
A Study Evaluating the Effect of a Single-dose Oral Administration of Nemonoxacin Capsule on QTc Intervals and Heart Rhythms of Healthy Subjects and the Influence of Food Intake on QTc Intervals and Pharmacokinetic Characteristics
A randomized, single-center, placebo and positive control, 4-period and 4-crossover clinical study with the following main purposes: (1) To evaluate the effect of a single-dose oral administration of nemonoxacin malate capsule on…
- Trial name
- NCT03362853
- Testing
- Nemonoxacin 500Mg Capsule, Moxifloxacin 400Mg Tablet, Nemonoxacin 750Mg Capsule
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- TaiGen Biotechnology Co., Ltd.
Other Instability of Joint, Shoulder Region, Strain of Shoulder Muscle (Disorder)
The Effects of Muscle Characteristics on the Control of Shoulder Complex During Functional Movements
The movement control of shoulder joint relies not only on the glenohumeral joint, but also the critical contributions from scapulothoracic joint.
- Conditions
- Other Instability of Joint, Shoulder Region, Strain of Shoulder Muscle (Disorder), Movement Disorders
- Trial name
- NCT04176692
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Social Jet Lag, Sleep Disturbance
Self-Acupressure and Social Jet Lag in Female Health Sciences Students
This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on social jet lag, sleep patterns, and sleep quality in female health sciences students.
- Conditions
- Social Jet Lag, Sleep Disturbance, Sleep Quality, Circadian Rhythm Disruption
- Trial name
- NCT07410936
- Testing
- Self-Acupressure Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Preterm, Chronobiology
The Effect of Oral Feeding Model With a Chronobiological Approach in Neonates
The ideal food for healthy term babies as well as preterm babies and sick term babies is breast milk. There are many studies showing that the composition of breast milk can vary from mother to mother, according to the baby's…
- Conditions
- Preterm, Chronobiology, Human Milk/Breastfeeding, Bottle Feeding
- Trial name
- NCT06821672
- Testing
- Chronobiological Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Fatigue Intensity, Sleep
MorphECOS - Evaluation of the Influence of Fatigue and Sleep on the Performance of 2nd Cycle Medical Students (OSCE)
Objective and Structured Clinical Examinations (OSCEs) has been incorporated recently in the certification process as a final national undergraduate ranking examination. This exam is a challenge for medical students.
- Conditions
- Fatigue Intensity, Sleep, Sleep Deprivation, Circadian Rhythm
- Trial name
- MorphECOS (NCT06952972)
- Where
- France
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Adverse Drug Effect, Drug Effect
Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals
Effects of switching from racemic methadone to R-methadone on serum methadone concentrations and QTc intervals
- Conditions
- Adverse Drug Effect, Drug Effect, Heart Arrhythmia
- Trial name
- MePhaCard (NCT04254731)
- Testing
- Same individuals treated with racemic methadone and switched to levomethadone (R-methadone)
- Where
- 3 sites in Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Atrial Fibrillation or Flutter
Safety and Efficacy of Vanoxerine for the Conversion of Subjects With Recent Onset Atrial Fibrillation or Flutter to Normal Sinus Rhythm
LGN-VN-003 is a prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a single oral dose of vanoxerine for the conversion of subjects with recent onset atrial…
- Trial name
- RESTORE SR (NCT02454283)
- Testing
- Vanoxerine HCl
- Where
- 16 sites in United States, Bulgaria and 3 more
- Volunteers
- 41 people
- Sponsor
- Laguna Pharmaceuticals, Inc.
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