Clinical trials: Rhythm
Aging, Memory Loss
Couples Health Aging, Rhythms and Sleep Study
Alzheimer's disease and related dementias (ADRD), including mild cognitive impairment (MCI), are becoming among the most prevalent causes of disability, death and healthcare costs worldwide.
- Trial name
- CHARMS (NCT05952284)
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy
A Study in Healthy People to Test Whether Different Doses of BI 1015550 Have Potential to Induce Heart Rhythm Abnormalities
The main objective of this trial is to evaluate the effects of a single therapeutic and a single supra-therapeutic dose of BI 1015550 following oral administration on cardiac safety parameters in healthy male and female…
- Trial name
- NCT06107036
- Testing
- BI 1015550, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Human Sleep and Chronobiology
Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms
The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.
- Trial name
- LumEnColor (NCT05232383)
- Testing
- polychromatic light, red light, green light
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Anxiety
Measurement of the Hippocampal Theta Rhythm From the Outer Ear Canal
New technologies are needed to help diagnose anxiety disorders. EVestG has facilitated the identification of numerous possible biomarkers of several psychiatric disorders.
- Trial name
- NCT03954483
- Testing
- Buspirone 10 Mg Oral Tablet, Triazolam 0.25 MG Oral Tablet
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Depression in Adolescence, Delayed Sleep Phase
Better Sleep Study
The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable…
- Trial name
- NCT06139861
- Testing
- TranS-C, Psychoeducation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Los Angeles
Shift-Work Sleep Disorder, Shift-Work Related Sleep Disturbance
Sleep and Circadian Treatments for Shift Workers
There are three components to this study: a Field Trial, a Shift Worker Survey, and Focus Groups. The Investigators will study the effectiveness, feasibility, and acceptability of an 8-h sleep intervention in older night workers…
- Trial name
- NCT03813654
- Testing
- 8-h Afternoon-Evening Sleep, 8-h Free Sleep
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep, Sleep Disturbance
WEsleep Trial: Improving Sleep in Hospitalized Patients
In the WEsleep study, the investigators will perform a cluster randomized controlled trial. 3 surgical and 3 medical departments will be randomized to implement low-cost and simple interventions aimed at improving sleep in…
- Conditions
- Sleep, Sleep Disturbance, Sleep Hygiene, Circadian Dysrhythmia
- Trial name
- WEsleep (NCT05683483)
- Testing
- WEsleep Interventions
- Where
- Netherlands
- Volunteers
- 396 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Non-valvular Atrial Fibrillation
Safety and Effectiveness of Apixaban Compared to Warfarin in Patients With Non-valvular Atrial Fibrillation (a Type of Irregular Heart Rhythm) at Higher Chance of Bleeding
The purpose of this study is to compare effectiveness and safety of warfarin and apixaban among non-valvular atrial fibrillation (NVAF) patients at higher chance of bleeding using a Japanese nation-wide administrative claims…
- Trial name
- NCT05471505
- Where
- Japan
- Volunteers
- 120,722 people
- Sponsor
- Pfizer
Heart Rate and Rhythm Disorders, Blood Pressures
Hemodynamic Responses of Different Laryngoscopes
During laryngoscopy and endotracheal intubation, stimulation of supraglottic regions leads to an increase in the plasma catecholamine concentrations due to the activation of the sympatho-adrenal system.
- Conditions
- Heart Rate and Rhythm Disorders, Blood Pressures, Oxygen Disorders
- Trial name
- NCT02469363
- Testing
- Macintosh laryngoscope, Mc-Coy laryngoscope, C-Mac videolaryngoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Dietary Supplements, Caffeine
Effect of Acute Caffeine and Beetroot Juice Intake on Strength, Power, and Muscular Endurance
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine and beetroot juice intake on sports performance.
- Conditions
- Dietary Supplements, Caffeine, Nitrates, Sports Performance
- Trial name
- CAF+BJ (NCT06596395)
- Testing
- Acute caffeine and beetroot juice, Acute caffeine, Acute beetroot juice
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Sleep, HIV Infections
Ai Youmian (Love Better Sleep) for People Living With HIV
People living with HIV (PLWH) frequently report sleep disturbances. The social rhythm theory, which proposes that stressful life events can interfere with sleep by disrupting the stability of daily routines, provides new insights…
- Trial name
- NCT05576844
- Testing
- 8-week interpersonal and social rhythm intervention, Usual care
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Central South University
Alteration of Cognitive Function, Ageing
Health Behaviors and Time-of-Day: Older Adult Cognitive Function
This is a single-center, observational study design. Enrolled participants will be typically, healthy older adults. Participants will complete daily computerized measures, in addition to continuously wearing an Actiwatch device.
- Trial name
- OA-TIME (NCT02300272)
- Testing
- Polysomnograph, Actiwatch
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mitral Regurgitation, Atrial Fibrillation
Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR)
The aim of this project is to determine the morphological criteria of apoptosis in atrial tissues of patients with AF versus SR at transcriptome and genomic size.
- Conditions
- Mitral Regurgitation, Atrial Fibrillation, Sinus Rhythm
- Trial name
- NCT00970034
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara University
Healthy
Rhythm Perception and Generation
This study will examine how different brain areas are involved in the perception of rhythmic patterns and the performance of rhythmic movements.
- Trial name
- NCT00080067
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Persistent Atrial Fibrillation
Comparison of Brain Perfusion in Rhythm Control and Rate Control of Persistent Atrial Fibrillation
Atrial fibrillation (AF) is associated with impaired cognitive function (CogF) and/or dementia, but it is unclear whether rhythm control of AF improves CogF or brain perfusion.
- Trial name
- NCT02633774
- Testing
- Propafenone, Apixaban
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Primary Nocturnal Enuresis
A Cohort Study on Treating Primary Nocturnal Enuresis by Regulating Central-Peripheral Circadian Rhythm
Primary nocturnal enuresis (PNE), a prevalent pediatric disorder, suffers from therapeutic limitations characterized by low efficacy and high relapse rates.
- Trial name
- NCT07003126
- Testing
- Circadian Rhythm Intervention Combined with Bladder Training, Bladder Training (basic treatment for enuresis)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Children's Medical Center
Sleep Problem, Neurobehavioral Manifestations
NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood
The gut-brain axis plays a crucial role in the regulation and development of psychological and physical processes. The first year of life is a critical period for the development of the gut microbiome, which parallels important…
- Trial name
- NapBiome (NCT06396689)
- Testing
- Synbiotic
- Where
- 2 sites in Switzerland
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Petra Zimmermann
Mood Disorders, Major Depressive Diorder
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
This single-site prospective observational study aims to validate wearable-derived circadian and behavioral rhythm biomarkers using continuous core body temperature and raw accelerometry measurements and to explore longitudinal…
- Conditions
- Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder
- Trial name
- Calera (NCT07905378)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Wisdom Teeth
Evaluation of the Effect of Circadian Rhythm of Adrenal Glucocorticoids After Third Molar Extraction
This study aimed to investigate the effects of wisdom tooth surgery performed at different times of the day on pain, swelling and trismus based on changes in the circadian rhythm in the adrenal glands in patients aged between…
- Trial name
- NCT06610383
- Testing
- Surgical extraction of wisdom teeth in the morning, Surgical extraction of wisdom teeth in the afternoon
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Heart Rhythm Disorders
PANORAMA 2 Observational Study
Understanding the clinical practice of treatment of cardiac rhythm disorders all over the world and understanding the clinical outcomes of the treatment with its cardiac rhythm products in real world patient population is…
- Trial name
- NCT01723566
- Where
- Egypt
- Volunteers
- 4,706 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
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