Clinical trials: Rhythm
Shift-Work Sleep Disorder
Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)
1. To determine the effects of tDCS on subjective measures of sleepiness in night-shift workers with shift work disorder. 2. To determine the effects of transcranial direct current stimulation (tDCS) on vigilance in night-shift…
- Trial name
- tDCS-SWORD (NCT03879044)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
EEG Brain Oscillations, Alzheimer's Disease (AD)
Effects of Endogenous Gamma Light Stimulation on Brain Oscillations in Cognitively-normal Older Adults
This study aims to evaluate the effects of endogenous gamma non-flickering light stimulation on resting-state EEG rhythms and cognitive function in cognitively healthy older adults.
- Conditions
- EEG Brain Oscillations, Alzheimer's Disease (AD), Cognitively Normal Older Adults
- Trial name
- NCT06715995
- Testing
- Gamma Wave Stimulation Table Lamp (Aleddra, Inc., USA)
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cardiovascular Diseases, Atrial Fibrillation
A Digital Flu Intervention for People With Cardiovascular Conditions
A 6-month prospective, digital randomized controlled trial targeting approximately 49,000 individuals to evaluate the effectiveness of an influenza vaccination intervention during influenza season for people with cardiovascular…
- Conditions
- Cardiovascular Diseases, Atrial Fibrillation, Abnormal Heart Rhythms, Cardiac Arrest
- Trial name
- CardioFlu (NCT04584645)
- Testing
- Targeted digital intervention
- Where
- United States
- Volunteers
- 49,138 people
- Sponsor
- Evidation Health
Mitral Regurgitation, Atrial Fibrillation
Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR)
The aim of this project is to determine the morphological criteria of apoptosis in atrial tissues of patients with AF versus SR at transcriptome and genomic size.
- Conditions
- Mitral Regurgitation, Atrial Fibrillation, Sinus Rhythm
- Trial name
- NCT00970034
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara University
Atrial Fibrillation (AF), Obesity & Overweight
Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term…
- Trial name
- MOVE-AF (NCT07430007)
- Testing
- Tailored Exercise and Dietary Lifestyle Program, Usual Clinical Care
- Where
- 4 sites in Finland
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Breast Cancer, Circadian Rhythms
The Effects of Light Therapy to Treat Cancer-related Side Effects
Severe fatigue, depression, sleep problems and cognitive impairment are the most commonly reported side effects of cancer treatment.
- Conditions
- Breast Cancer, Circadian Rhythms, Fatigue, Sleep Disturbance
- Trial name
- NCT04418856
- Testing
- Light Glasses (Experimental), Light Glasses (Comparison)
- Where
- Iceland
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Reykjavik University
Aging, Mental Disorder
Self-Care for Dementia Caregivers
The Self-care for Dementia Caregivers Study is a behavioral health intervention that uses digital monitoring tools and motivational health coaching to help caregivers of persons with dementia engage in a regular routine of sleep…
- Conditions
- Aging, Mental Disorder, Eating, Healthy, Physical Inactivity
- Trial name
- Care2 (NCT05309577)
- Testing
- Behavioral Self-Monitoring + Motivational Interviewing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Intensive Care Unit, Ventilator
Effects of Light and Sound Modification on Sleep Quality and Circadian Rhythm in the MICU Patients
This study will investigate the effectiveness of light and sound modification in improving sleep qualit , and circadian rhythms in MICU patients with Mechanical Ventilation in Taiwan. Hypothesis: 1.
- Conditions
- Intensive Care Unit, Ventilator, Sleep Quality, Circadian Rhythm
- Trial name
- MICU (NCT04129918)
- Testing
- light and sound modification (earplugs and eye masks)
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Beta Rhythm, Tactile Perception
Beta Events and Sensory Perception
Low-frequency brain rhythms in the alpha (8-14Hz) and beta (15-29Hz) bands are strong predictors of perception and functional performance in a range of tasks, and are disrupted in several disease states.
- Trial name
- NCT04062318
- Testing
- Online Active SI-Hand TMS, Online Active Control TMS
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Brown University
Melanoma
Timing of Immunotherapy in Melanoma
The TIME-NL trial is a multicenter, randomized, open-label clinical trial in the Netherlands to assess the effect of the timing of the first administration of standard-of-care intravenous combination immunotherapy (early morning…
- Trial name
- TIME-NL (NCT07696715)
- Testing
- Timing of first administration (early morning), Timing of immunotherapy (afternoon)
- Where
- 5 sites in Netherlands
- Volunteers
- 170 people
- Sponsor
- Radboud University Medical Center
Hemodialysis, Game-Based Learning
A Story-Based Game to Reduce Anxiety and Improve Compliance in Hemodialysis Patients: RCT
This clinical study is testing whether a short, story-based digital game played during dialysis can help improve the health and well-being of patients receiving hemodialysis.
- Conditions
- Hemodialysis, Game-Based Learning, Adherence, Anxiety
- Trial name
- NCT07156942
- Testing
- Story-Based Digital Game
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Afra ÇALIK
Delayed Sleep Phase Syndrome
Synchronization and Desynchronization Between Circadian Rhythms in Patients With Delayed Sleep Phase Syndrome (DSPS)
This study's first aim is to widen the knowledge of the characteristics of delayed sleep phase disorder (DSPS) by focusing on the circadian rhythms of appetite regulation factors and their phase relations to the cycles of…
- Trial name
- NCT00282061
- Testing
- Melatonin
- Where
- Israel
- Sponsor
- Sheba Medical Center
Congenital Hydronephrosis, Congenital Choledochal Cyst
Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal cortical inhibition by etomidate has received much attention.
- Conditions
- Congenital Hydronephrosis, Congenital Choledochal Cyst, Fracture
- Trial name
- NCT02013986
- Testing
- etomidate, midazolam, propofol
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Du yi
Metabolic Syndrome, Overweight or Obesity
Impact of Time-Restricted Eating on Metabolic Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome
The main purpose of the clinical trial is to determine the health impact of a dietary intervention known as time-restricted eating (TRE) in patients with metabolic syndrome (defined as the presence of elevated fasting plasma…
- Conditions
- Metabolic Syndrome, Overweight or Obesity, PreDiabetes, Weight Loss
- Trial name
- TREMNIOS (NCT04328233)
- Testing
- Time-Restricted Eating
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- Nicolaus Copernicus University
Developmental Dyslexia
Telerehabilitation vs. in Presence Rehabilitation of Reading Disorders Using the Rhythmic Reading Training (RRT)
The aim of the study is to compare the effectiveness of telerehabilitation vs. in presence rehabilitation of reading disorders, using a rhythm-based intervention for reading (i.e., Rhythmic Reading Training)
- Trial name
- NCT04995471
- Testing
- In presence RRT - prototype software, In presence RRT - online platform, Tele-RRT - prototype software
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Persistent Atrial Fibrillation
WATCHMAN for Concomitant Left Atrial Appendage Electrical Isolation and Occlusion to Treat Persistent Atrial Fibrillation Rhythm
WATCH-Rhythm is a prospective, randomized, multi-center, investigation to collect safety and effectiveness data on combining conventional AF ablation with LAA electric isolation and closure within a single procedure.
- Trial name
- WATCH-Rhythm (NCT03835338)
- Testing
- Pulmonary Vein Isolation, LAA Isolation, LAA Occlusion
- Sponsor
- Boston Scientific Corporation
Radiology, Interventional, Heart Rhythm Disorders
Dosimetric Reference Levels for Radioguided Interventional Procedures in Rhythmology.
Interventional radiology has become a widespread technique used in various fields of medicine to diagnose or treat numerous pathologies. However, the risk of X-rays must be taken into account.
- Trial name
- NR-Rythmo (NCT06507085)
- Testing
- Radio-guided interventions to correct heart rhythm disorders
- Where
- France
- Volunteers
- 4,219 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronobiology, Light
Teen Sleep and Light Study
Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents.
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- NCT04921215
- Testing
- Morning bright light
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Essential Arterial Hypertension, Circadian Disruption
Circadian Disruption And Cardiovascular Risk In Young Adults With Hypertension
This prospective observational study will investigate whether circadian disruption is associated with higher blood pressure and a less favorable cardiovascular profile in young adults aged 18 to 45 years with essential arterial…
- Trial name
- CIRCA-HT (NCT07770958)
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Medical University of Sofia
Posttraumatic Stress Disorder, Depression
A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD)
The purpose of this study is to test the effectiveness of group psychotherapy designed specifically for male veterans and active-duty personnel with Post-traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD) and with…
- Conditions
- Posttraumatic Stress Disorder, Depression, Insomnia Disorder
- Trial name
- NCT00984698
- Testing
- Cognitive Behavioral Social Rhythm Group Therapy, Present Centered Group Therapy
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- University of Arizona
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