Clinical trials: Rhythm
Circadian Rhythm, Sleep Quality
Circadian Rhythm and Delirium in ICU
The study aims to investigate the status of circadian rhythm and sleep quality in ICU patients and their influence factors. And explore the pathway of circadian rhythm on ICU delirium.
- Conditions
- Circadian Rhythm, Sleep Quality, Intensive Care Unit Delirium
- Trial name
- NCT05342987
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Shanghai Zhongshan Hospital
Preterm Infants
Light/Dark Cycle Promotes Weight Gain in Preterm Infants
The study focuses on the use of light/dark alternation as chronotherapy to prevent deterioration and reduce morbidity and mortality in premature patients, as well as favoring circadian alteration after birth, which should lead…
- Trial name
- NCT05230706
- Testing
- Cephalic helmet
- Volunteers
- 300 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Atrial Fibrillation
A Fib Clinic of the Future Using KardiaPro Platform for Chronic Care of Patients With AF After Ablation Procedure
Pulmonary vein isolation is a widely used strategy for the treatment of patients with symptomatic atrial fibrillation. After successful pulmonary vein isolation (no atrial fibrillation on transtelephonic rhythm recordings for 3…
- Trial name
- AliveCor (NCT03557034)
- Testing
- Kardia Monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Cleveland Clinic
Cardiac Arrest
Vfib by ECG or Echo During Cardiac Arrest
The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm.
- Trial name
- REASON3-2021 (NCT04906252)
- Testing
- Echocardiography, Electrocardiogram (ECG)
- Where
- 6 sites in United States
- Volunteers
- 813 people
- Sponsor
- Romolo Gaspari
Diabetic Retinopathy, Melatonin
Diabetic Retinopathy: Effects of Melatonin Treatment on Visual Functions and Circadian Rhythm
This study evaluates the effect of melatonin 4 mg on circadian rhythm and visual function of patients with diabetes mellitus. Half of the patients will receive melatonin (arm-1) and the other half will receive placebo (arm-2)…
- Conditions
- Diabetic Retinopathy, Melatonin, Circadian Dysrhythmia, Circadian Rhythm Sleep Disorder, Unspecified Type
- Trial name
- NCT03478306
- Testing
- Melatonin 4 mg Tablet
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Heart Disease, Implantable Cardioverter Defibrillator (ICD)
Optimal Settings for Anti Tachycardia Pacing (ATP) on ICD
This is a pragmatic, two-group, cluster randomized trial designed to compare strategies for the Anti Tachycardia Pacing (ATP)-setting in the ventricular tachyarrhythmias (VT) zone when implanting a new implantable cardioverter…
- Conditions
- Heart Disease, Implantable Cardioverter Defibrillator (ICD), Heart Rhythm Disorders, Ventricular Tachyarrhythmias
- Trial name
- DAN-ATP (NCT07354347)
- Testing
- Burst, Ramp
- Where
- Denmark
- Volunteers
- 3,980 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-24-Hour Sleep-Wake Disorder
Tasimelteon for the Treatment of Non-24-hour Sleep-Wake Disorder (N24HSWD) in Blind Individuals With no Light Perception
The purpose of this study is to evaluate the safety of tasimelteon in male and female patients who suffer from Non-24-Hour Sleep-Wake Disorder.
- Trial name
- NCT01429116
- Testing
- tasimelteon
- Where
- 22 sites in United States
- Volunteers
- 200 people
- Sponsor
- Vanda Pharmaceuticals
Heart Failure
Resynchronization for Ambulatory Heart Failure Trial in Patients With Preserved LV Function
This trial will compare two management strategies for HF patients with preserved LV function in sinus rhythm and LBBB. The control group will be treated with practice guideline optimal medical therapy for HF.
- Trial name
- NCT04582578
- Testing
- CRT
- Where
- Canada
- Sponsor
- Anthony Tang
Sleep Disorders
Sleep Length and Circadian Regulation in Humans
This research will examine why sleep restriction reduces the body clock's response to bright light. The results will enable the optimization of the bright light treatment of people who suffer from circadian rhythm sleep…
- Trial name
- HAM (NCT00843843)
- Testing
- Bright light box
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Atrial Fibrillation, Stroke
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial
EAST prospectively tests the hypothesis that an early, structured rhythm control therapy based on antiarrhythmic drugs and catheter ablation can prevent atrial fibrillation (AF) related complications in patients with AF when…
- Trial name
- EAST (NCT01288352)
- Testing
- early standardised rhythm control
- Where
- 11 sites in Belgium, Czechia and 9 more
- Volunteers
- 2,789 people
- Sponsor
- Atrial Fibrillation Network
Pulmonary Arterial Hypertension
Pulmonary Hypertension: Intensification and Personalisation of Combination Rx
The goal of this clinical trial is to evaluate the capacity of implantable/remote technology for early evaluation of drug therapies in patients with pulmonary arterial hypertension (PAH).
- Trial name
- PHoenix (NCT05825417)
- Testing
- Selexipag, Riociguat, CardioMEMS pulmonary artery pressure monitor
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Diabetes Mellitus, Type 2, Insulin Resistance
Day-Night Rhythm in Human Skeletal Muscle
This study evaluates the existence of a day-night rhythm in skeletal muscle energy metabolism in healthy lean subjects. Subjects will stay at the research facility for 44 hours with a standardized living protocol during which…
- Trial name
- NCT02261168
- Testing
- Standardized living protocol
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Delayed Sleep Phase Syndrome
Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P2 (NCT04792697)
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep Scheduling
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Dental Anxiety, Pain
Effectiveness of Hand/Eyes/Mouth Behavior Management Technique During Local Anesthesia in Preschool Children
This will be a randomized, controlled, parallel-group clinical trial. The aim of this studio will be to evaluate the effectiveness of "Hands/Eyes/mouth" behavior management technique versus a conventional technique (covering the…
- Conditions
- Dental Anxiety, Pain, Infant Behavior, Heart Rate and Rhythm Disorders
- Trial name
- NCT02591797
- Testing
- inferior alveolar and lingual nerve block procedure
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Cardenal Herrera University
Cystic Fibrosis
Circadian Rhythm Disorders in Children With Cystic Fibrosis Under CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Modulators
Cystic fibrosis (CF) is a rare disease affecting one out of 4,500 newborns in France (INSERM 2021). Despite major advances in patient care over the past two decades, with significant improvements in life expectancy, cystic…
- Trial name
- CHRONO-MUCO (NCT06370962)
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction
Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication
This study is testing two different ways of treating atrial fibrillation (AF) in people who also have heart failure with mildly reduced or preserved heart function.
- Conditions
- Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction (HFPEF), Rate Control
- Trial name
- NCT07272902
- Testing
- Catheter Ablation for Atrial Fibrillation, Rate Control Medications (beta-blockers, calcium channel blockers, digoxin)
- Where
- 4 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Nova Scotia Health Authority
Heart Failure, CPX
Pilot Study to Investigate the Creation of Physiological Rhythm by Closed Loop Stimulation in hEart Failure pAtients With chronoTropic incompEtence
The study assesses the effect of Closed Loop Stimulation (CLS) on the ventilatory efficiency slope and estimates the patient responder rate to CLS in patients with severe chronotropic incompetence treated with a cardiac…
- Trial name
- BIO|CREATE (NCT03157076)
- Testing
- Cardiac Resynchronization therapy device with Closed Loop Stimulation (CLS)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Biotronik SE & Co. KG
Metabolic Syndrome, Pre-Diabetes
The Influence of Time-Restricted Eating in Patients With Metabolic Syndrome
In a randomized controlled trial, the investigators intend to measure the health impact of TRE in patients with metabolic syndrome (with three or more of the following criteria: increased waist circumference, abnormal cholesterol…
- Trial name
- TIMET (NCT04057339)
- Testing
- Time Restricted Eating + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, San Diego
Healthy Diet, Sleep
The Role of Walnut Consumption on Sleep Quality
Walnuts have a unique nutritional profile, including the sleep-regulating hormone melatonin, tryptophan, and omega-3 fatty acids, the two latest nutrients involved in melatonin and serotonin synthesis.
- Trial name
- NCT04799821
- Testing
- Control, Walnut intake
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Ventricular Asynchrony in Cardiac Surgery Patients
Ventricular Asynchrony in Cardiac Surgery Patients
The purpose of this study is to: 1. assess the existence of inter-ventricular and intra-ventricular asynchrony in cardiac surgery patients before (PRE) and after cardiopulmonary bypass surgery (POST) 2.
- Trial name
- NCT00654199
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
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