Clinical trials: Rhythm
Chromosome Disorders
Melatonin Levels in Smith Magenis Syndrome (SMS)
The goal of this pilot project is to determine whether melatonin levels are disordered in patients with Smith-Magenis Syndrome (SMS) and whether melatonin treatment can correct abnormal circadian rhythms in SMS patients.
- Trial name
- NCT00691574
- Testing
- Melatonin, Enviro-light artificial light box
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Attention Deficit Hyperactivity Disorder, Delayed Sleep Phase Type Circadian Rhythm Sleep Disorder
Blue Wavelength Light-blocking Glasses in ADHD-Insomnia
Patients with ADHD often report staying up late on the computer, watching TV, or using other electronic devices, all strong emitters of blue light which may be contributing to the delayed sleep onset times seen in some of these…
- Trial name
- ADHD (NCT01557595)
- Testing
- Polarized glasses designed to filter out blue light
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Stroke, Atrial Fibrillation
Post-Embolic Rhythm Detection With Implantable Versus External Monitoring
The overall aim of this trial is to determine the most cost effective approach to diagnose paroxysmal atrial fibrillation (PAF) following transient ischemic attack (TIA) and stroke.
- Conditions
- Stroke, Atrial Fibrillation, Arrhythmias, Cardiac
- Trial name
- PERDIEM (NCT02428140)
- Testing
- Medtronic Reveal LINQ, Sorin Spiderflash-t
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Natriuretic Peptides, Obesity
The Diurnal Rhythm in Natriuretic Peptide Levels
The purpose of the study to assess the diurnal rhythm in natriuretic peptide levels and its temporal relationship with nocturnal blood pressure in obese and African-American individuals as compared with lean and white individuals.
- Conditions
- Natriuretic Peptides, Obesity, Nocturnal Blood Pressure
- Trial name
- NCT03834168
- Testing
- standardized Study Diet
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Seasonal Affective Disorder
Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder
The purpose of this study is to determine whether treating sleep difficulties in patients with seasonal affective disorder also improves their depressive symptoms.
- Trial name
- SAM-SAD (NCT00502320)
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Lehigh Valley Hospital
Sleep Disorders, Circadian Rhythm, Insomnia
Actigraphic Analysis of Treatment Response
The study examines and illustrates the utility of utilizing actigraphic measurements to assess treatment response.
- Conditions
- Sleep Disorders, Circadian Rhythm, Insomnia, Psychomotor Agitation
- Trial name
- NCT00723580
- Testing
- risperidone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Child Psychopharmacology Institute
Hyperkalemia
POtassium and Cardiac Rhythm Trends in MaintENance HemoDialysis: A Multicenter, Prospective, Observational Study
This study assesses serum potassium and cardiac rhythm trends in subjects with end stage renal disease (ESRD) who are on 3 times weekly maintenance hemodialysis for at least 60 days.
- Trial name
- PORTEND (NCT02609841)
- Testing
- Cardiac rhythm remote monitoring system
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- ZS Pharma, Inc.
Excessive Sleepiness, Shift Work Sleep Disorder
Safety/Efficacy Study With Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Chronic SWSD
The primary objective of this study is to determine whether treatment with Armodafinil (CEP-10953) is more effective than placebo treatment for patients with excessive sleepiness associated with chronic shift work sleep disorder…
- Trial name
- NCT00080288
- Testing
- Armodafinil 150 mg/day
- Volunteers
- 254 people
- Sponsor
- Cephalon
Electromagnetic Interference
Safety of Screening Procedures With Hand-held Metal Detectors Among Patients With Implanted Cardiac Rhythm Devices
Patients with implanted pacemaker (PM) or cardioverter-defibrillator (ICD) systems are restrained in daily life by possible electromagnetic interference (EMI).
- Trial name
- NCT01369706
- Testing
- Hand-held metal detector
- Where
- 2 sites in Germany, Greece
- Volunteers
- 388 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Shift-Work Sleep Disorder
Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)
1. To determine the effects of tDCS on subjective measures of sleepiness in night-shift workers with shift work disorder. 2. To determine the effects of transcranial direct current stimulation (tDCS) on vigilance in night-shift…
- Trial name
- tDCS-SWORD (NCT03879044)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Cardiovascular Diseases, Atrial Fibrillation
A Digital Flu Intervention for People With Cardiovascular Conditions
A 6-month prospective, digital randomized controlled trial targeting approximately 49,000 individuals to evaluate the effectiveness of an influenza vaccination intervention during influenza season for people with cardiovascular…
- Conditions
- Cardiovascular Diseases, Atrial Fibrillation, Abnormal Heart Rhythms, Cardiac Arrest
- Trial name
- CardioFlu (NCT04584645)
- Testing
- Targeted digital intervention
- Where
- United States
- Volunteers
- 49,138 people
- Sponsor
- Evidation Health
Aging, Mental Disorder
Self-Care for Dementia Caregivers
The Self-care for Dementia Caregivers Study is a behavioral health intervention that uses digital monitoring tools and motivational health coaching to help caregivers of persons with dementia engage in a regular routine of sleep…
- Conditions
- Aging, Mental Disorder, Eating, Healthy, Physical Inactivity
- Trial name
- Care2 (NCT05309577)
- Testing
- Behavioral Self-Monitoring + Motivational Interviewing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Beta Rhythm, Tactile Perception
Beta Events and Sensory Perception
Low-frequency brain rhythms in the alpha (8-14Hz) and beta (15-29Hz) bands are strong predictors of perception and functional performance in a range of tasks, and are disrupted in several disease states.
- Trial name
- NCT04062318
- Testing
- Online Active SI-Hand TMS, Online Active Control TMS
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Brown University
Posttraumatic Stress Disorder, Depression
A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD)
The purpose of this study is to test the effectiveness of group psychotherapy designed specifically for male veterans and active-duty personnel with Post-traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD) and with…
- Conditions
- Posttraumatic Stress Disorder, Depression, Insomnia Disorder
- Trial name
- NCT00984698
- Testing
- Cognitive Behavioral Social Rhythm Group Therapy, Present Centered Group Therapy
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- University of Arizona
Atrial Fibrillation
A Fib Clinic of the Future Using KardiaPro Platform for Chronic Care of Patients With AF After Ablation Procedure
Pulmonary vein isolation is a widely used strategy for the treatment of patients with symptomatic atrial fibrillation. After successful pulmonary vein isolation (no atrial fibrillation on transtelephonic rhythm recordings for 3…
- Trial name
- AliveCor (NCT03557034)
- Testing
- Kardia Monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Cleveland Clinic
Sleep Disorders
Sleep Length and Circadian Regulation in Humans
This research will examine why sleep restriction reduces the body clock's response to bright light. The results will enable the optimization of the bright light treatment of people who suffer from circadian rhythm sleep…
- Trial name
- HAM (NCT00843843)
- Testing
- Bright light box
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Metabolic Syndrome, Pre-Diabetes
The Influence of Time-Restricted Eating in Patients With Metabolic Syndrome
In a randomized controlled trial, the investigators intend to measure the health impact of TRE in patients with metabolic syndrome (with three or more of the following criteria: increased waist circumference, abnormal cholesterol…
- Trial name
- TIMET (NCT04057339)
- Testing
- Time Restricted Eating + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, San Diego
Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm
Fetal and Neonatal Magnetophysiology
Fetal research and clinical practice has been hampered by a lack of suitable investigational techniques. Currently, ultrasound is the only widely used method of studying fetal anatomy and physiology, but it has significant…
- Conditions
- Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm, Long QT Syndrome
- Trial name
- NCT01903564
- Testing
- magnetocardiography, postnatal ECG, fetal echocardiography
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Heart Failure, Atrial Fibrillation
Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
Atrial fibrillation and heart failure are two common heart conditions that are associated with an increase in death and suffering. When both of these two conditions occur in a patient the patient's prognosis is poor.
- Trial name
- RAFT-AF (NCT01420393)
- Testing
- Rhythm control, Rate Control
- Where
- 21 sites in Brazil, Canada and 2 more
- Volunteers
- 411 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Sleep Phase Rhythm Disturbance, Sleep Deprivation
Are Bright Lights and Regulated Sleep Effective Treatment for Depression?
Previous data suggest some depressed patients act as if their internal biological clock is out of sync with the outside world and re-aligning their clock with the timing of sunlight lessens their depressed mood and accompanying…
- Trial name
- NCT03010488
- Testing
- Morning Light Therapy, Assigned Sleep Times, Goggles
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- New York State Psychiatric Institute