Clinical trials: Rhythm
Rheumatoid Arthritis
Circadian RA Study in Rheumatoid Arthritis Subjects
Primary objective: To determine the changes in circadian activity rhythms and disease activity in rheumatoid arthritis (RA) patients from pre-treatment to one month after Enbrel initiation.
- Trial name
- NCT03178955
- Testing
- Etanercept
- Where
- United States
- Sponsor
- University of California, Davis
Breast Neoplasms
Chemotherapy-induced Circadian Rhythm Disruption
The purpose of this study is to investigate chemotherapy-induced circadian rhythm disruption through biomarkers, and the relationship between chemotherapy-induced circadian rhythm disruptions and side effects of chemotherapy.
- Trial name
- NCT04364347
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Seoul National University Hospital
Electrical Alternation of Heart, Blood Pressure
Impact of Energy Drinks and Panax Ginseng on Heart Rhythm
To assess the cardiac effects of an energy drink and Panax Ginseng in healthy volunteers.
- Trial name
- NCT02572102
- Testing
- Energy Drink, Panax Ginseng
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of the Pacific
Sleep Apnea, Cardiovascular Diseases
Platelet Activation and Circadian Rhythms of Clotting-Fibrinolysis Factors in Patients With Sleep Apnea Syndrome
The objective of the study is to define and compare clotting- fibrinolysis patterns, platelet function markers and endothelial dysfunction in patients with SAHS before and after treatment and normal controls age and weight…
- Trial name
- NCT00456287
- Testing
- CPAP (Continuous Positive Airway Pressure)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Healthy Volunteers
Language and Brain Rhythms
For humans and other animals, predicting the timing of sensory events is essential for their daily behavior. Importantly, natural sensory stimulation (such as movements, music, or speech) can present temporal regularities…
- Trial name
- LaBRhythms (NCT04457622)
- Testing
- Auditory perception tasks in healthy participants
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder
Recovery and Early Sleep Tracking Using the SuperPatch REM Patch
A Phase 1 Feasibility Study of the SuperPatch REM Patch for Post-Night-Shift Sleep Recovery in NHS Doctors
- Conditions
- Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Shift Work Sleep Disorders
- Trial name
- REST (NCT07785960)
- Testing
- SuperPatch REM Patch
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SuperPatch Limited LLC
Cardiac Arrhythmias, Sudden Cardiac Death
The Circadian Rhythm of Potassium and Cystatin C
The potassium value is important to prevent cardiac arrhythmias and sudden cardiac death. In patients with renal failure, the potassium value is not stable and tends to raise.
- Trial name
- Potassium (NCT01318746)
- Testing
- Blood withdrawal
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Peri-dialytic Cardiac Rhythms, Intradialytic Hypotension
Trial of Variable Dialysate Bicarbonate
QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death.
- Conditions
- Peri-dialytic Cardiac Rhythms, Intradialytic Hypotension, Electrolyte Changes, pH Changes
- Trial name
- NCT05814146
- Testing
- Dialysate bicarbonate concentration, Dialysate bicarbonate concentration - telemetry monitoring
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Brigham and Women's Hospital
Ovarian Hyperstimulation
Progesterone Diurnal Rhythm During Ovarian Stimulation for IVF
To evaluate the influence of circadian rhythm on progesterone levels during follicular phase of natural cycle and during follicular phase of controlled ovarian stimulation during IVF.
- Trial name
- NCT02975713
- Where
- United Arab Emirates
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Atrial Fibrillation, Stroke
Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control
A prospective, non-blinded, multi-center study to assess the impact of early Catheter Ablation (CA) in patients with a new diagnosis of Atrial Fibrillation(AF) at the time of stroke. 100 patients will be enrolled.
- Trial name
- SAVE STROKE II (NCT06783868)
- Testing
- Catheter Ablation, Market-approved AVNB, OAC and AAD
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Epilepsy
Mobile Phone Radiation and Brain Rhythm in Epileptic Patients
This work is intended to assess the effect of -30 minutes- exposure to mobile-phone on the functions of the central nervous system (CNS) in epileptic patients.
- Trial name
- NCT02854384
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Premature Atrial Contractions, Premature Ventricular Contractions
The MARY-JANE Cannabis and Heart Rhythm Trial
Despite recreational cannabis now being legal in 23 states, where more than 100 million Americans reside, studies on the actual health effects are limited.
- Trial name
- NCT06021613
- Testing
- Randomized instructions
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Musculoskeletal Diseases
Strength Training Effects on Musculoskeletal Health
The objective here is to assess the efficacy of variable resistance muscle training on bone, sleep parameters and quality of life in healthy populations of men and women age 30 or older.
- Trial name
- Muscle:Time (NCT04810975)
- Testing
- Muscle Strength Training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Shift-Work Sleep Disorder, Shift-Work Related Sleep Disturbance
Sleep and Circadian Treatments for Shift Workers
There are three components to this study: a Field Trial, a Shift Worker Survey, and Focus Groups. The Investigators will study the effectiveness, feasibility, and acceptability of an 8-h sleep intervention in older night workers…
- Trial name
- NCT03813654
- Testing
- 8-h Afternoon-Evening Sleep, 8-h Free Sleep
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression, Sleep Disorders, Circadian Rhythm
Longitudinal Ecological Study on Sleep-Wake Patterns in MDD Using Actigraphy
The proposed study will include a longitudinal ecological study (Study 1) and a randomised controlled trial (Study 2). The aims will be to (1) identify the sleep-wake profiles in individuals with Major Depressive Disorder (MDD)…
- Trial name
- NCT06233422
- Testing
- No intervention involved
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Maternal; Malnutrition, Infant Malnutrition
Impact of Maternal Stress on Infant Stunting
This study takes place in rural Mam-Mayan communities of Guatemala characterized by high rates of childhood stunting. It aims to characterize women's exposure to nutrition, infection and psychosocial stressors vs.
- Conditions
- Maternal; Malnutrition, Infant Malnutrition, Physiological Stress, Emotional Stress
- Trial name
- NCT02755012
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- McGill University
Atrial Fibrillation, Atrial Flutter
Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 mg OD With Amiodarone as Calibrator for the Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/Flutter
Double blind study to evaluate the efficacy and tolerability of SSR149744C and select a dose to be further investigated in the maintenance of sinus rhythm after electrical, pharmacological or spontaneous conversion of AF/AFL.
- Trial name
- MAIA (NCT00233441)
- Testing
- CELIVARONE (SSR149744C)
- Where
- 17 sites in United States, Argentina and 15 more
- Volunteers
- 673 people
- Sponsor
- Sanofi
Cardiac Rhythm Disorder, Heart Failure
Post-market Surveillance of Micorport CRM Cardiac Implantable Electronic Devices
The primary objective of the study is to assess the chronic safety of MicroPort CRM market-released systems.
- Conditions
- Cardiac Rhythm Disorder, Heart Failure, Sudden Cardiac Death
- Trial name
- PIANO (NCT05694572)
- Testing
- Implantation of a CIED
- Where
- Portugal
- Volunteers
- 2,500 people
- Sponsor
- MicroPort CRM
Cancer-related Problem/Condition, Fatigue
Systematic Light Exposure for Fatigue in Breast Cancer Patients
Cancer related fatigue (CRF) is a stressful and constant tiredness related to cancer and/or its treatment. CRF is the most intense during treatment and can severely interfere with activities of daily living, such as tasks that…
- Conditions
- Cancer-related Problem/Condition, Fatigue, Circadian Rhythm Disorders
- Trial name
- NCT03217201
- Testing
- Light Glasses (Experimental), Light Glasses (Comparison)
- Where
- 3 sites in United States
- Volunteers
- 194 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atrial Fibrillation, Atrial Flutter
Detection of Atrial Fibrillation After Cardiac Surgery
The aim of the SEARCH-AF trial is to evaluate a novel diagnostic tool for detecting post-operative atrial fibrillation or flutter (POAF/AFL) in cardiac surgical subjects during the early, sub-acute post-operative period.
- Conditions
- Atrial Fibrillation, Atrial Flutter, C.Surgical Procedure; Cardiac, Arrhythmias, Cardiac
- Trial name
- SEARCH-AF (NCT02793895)
- Testing
- Medtronic SEEQ™ mobile cardiac telemetry system, Usual Care, CardioSTAT (Icentia Inc.) cardiac rhythm monitoring device
- Where
- 10 sites in Canada
- Volunteers
- 336 people
- Sponsor
- Unity Health Toronto
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