Clinical trials: Right Heart Catheterisation
Pulmonary Hypertension Secondary
Pulmonary Artery Pressure in COVID-19 Survivors
Post COVID-19 pulmonary hypertension can develop as a result of lung parenchymal damage and altered pulmonary circulation induced by COVID-19 infection.
- Trial name
- NCT05993338
- Testing
- right heart catheterization (RHC).
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University Hospital
Systolic Chronic Heart Failure, Congestion, Venous
Ultrasound-assessed Internal Jugular Vein Distensibility in Advanced Chronic Heart Failure (US-IJVD in CHF)
Prospective validation of the ultrasound-assessed internal jugular vein distensibility (JVD) ratio to identify patients with systolic chronic heart failure and right atrial pressure (RAP) of 7 or less mmHg measured by the right…
- Conditions
- Systolic Chronic Heart Failure, Congestion, Venous, Advanced Heart Failure
- Trial name
- US-IJVD-CHF (NCT03874312)
- Testing
- Linear ultrasound (US) assessment of the internal jugular vein
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Niguarda Hospital
Heart Failure With Reduced Ejection Fraction, Chronic Heart Failure
Vericiguat and Exercise Hemodynamics in Patients With HFrEF
Heart failure with reduced ejection fraction (HFrEF) is associated with impaired exercise capacity and abnormal exercise hemodynamics despite contemporary guideline-directed medical therapy (GDMT).
- Trial name
- EVERHETT-HF (NCT07697365)
- Testing
- Vericiguat, Guideline-directed medical therapy (GDMT) for heart failure
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Argyrios Ntalianis
Heart Failure, Telemonitoring
EXPLORATORY STUDY OF THE MYHEARTSENTINEL SYSTEM, A CARDIAMETRICS MEDICAL DEVICE
Background: Chronic heart failure represents a major public health challenge, affecting approximately 64 million people worldwide and generating high costs in terms of mortality, frequent hospitalizations, and medical expenses.
- Conditions
- Heart Failure, Telemonitoring, Right Heart Catheterisation
- Trial name
- ASEMC-DR (NCT07345533)
- Testing
- MYHEARTSENTINEL SYSTEM cutaneous DEVICE
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Caen
Pulmonary Hypertension, Pulmonary Thromboembolisms
Electrical Impedance Tomography for Assessment of Pulmonary Hypertension
Pulmonary hypertension is a serious and progressive disease that is difficult to treat and diagnose, mainly because its symptoms are nonspecific and often delay recognition. Early diagnosis is a major challenge.
- Trial name
- NCT07453017
- Testing
- Electrical Impedance Tomography (EIT), Right Heart Catheterization
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Aortic Valve Stenosis, Pulmonary Hypertension
Prognostic Impact of the Evolution of PAH 3 Months After TAVI (HTP-TAVI)
Aortic stenosis (AS) is the most frequent valvulopathy in Western countries. The prevalence of AS is constantly increasing due to the aging of the population.
- Trial name
- HTP-TAVI (NCT04008550)
- Testing
- Right Heart Catheterization
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Rouen
Septic Shock
Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter.
The pulmonary artery catheter (Swan-Ganz) is a standard tool in intensive care for measuring and monitoring cardiac index by thermodilution.
- Trial name
- MICAP (NCT07628023)
- Testing
- Swan-Ganz
- Where
- 2 sites in France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tricuspid Valve Regurgitation, Nonrheumatic, Cardiac Catheterization
Evaluating Edge-to-edge Transcatheter Tricuspid Valve Repair in Patients With Severe Symptomatic Tricuspid Regurgitation
This is a national multicenter, open-label, randomized controlled trial to show superiority of edge-to-edge Transcatheter Tricuspid Valve repair (TTVr) on top of the Standard Of Care (SOC; heart failure medication) over the SOC…
- Conditions
- Tricuspid Valve Regurgitation, Nonrheumatic, Cardiac Catheterization, Heart Failure, Right Sided, Valve Regurgitation, Tricuspid
- Trial name
- TRACE-NL (NCT05628779)
- Testing
- TriClip TTVr system (Abbott Vascular), PASCAL TTVr system (Edwards Lifesciences)
- Where
- 6 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Pulmonary Hypertension, Right Heart Failure Due to Pulmonary Hypertension
Postural Changes During Right Heart Catheterization
Hemodynamic measurements obtained during pulmonary artery catheterization are essential for the diagnosis and classification of pulmonary hypertension.
- Trial name
- NCT03089164
- Testing
- Right heart catheterization
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Right Heart Failure
Predictive Value of Vasodilator Challenge for Right Heart Failure After LVAD Implantation
Prospective evaluation of the predictive value for post-LVAD right ventricular failure (RHF) of pulmonary vasodilator challenge, in addition to current laboratory, echocardiographic and haemodynamic parameters.
- Trial name
- PREVV-RHF-LVAD (NCT05836233)
- Testing
- Pulmonary Vasodilators
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- San Camillo Hospital, Rome
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Echocardiography, Transthoracic, Right-heart Hemodynamics
The Echodynamic Approach
The aim of this prospective observational study is to assess the accuracy of non-invasive hemodynamic parameter estimation via trans-thoracic echocardiography (TTE) compared to the invasive gold standard of right heart…
- Trial name
- TECH (NCT06859047)
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Ospedale San Raffaele
Group 2 Pulmonary Hypertension, CpcPH
Phosphodiesterase Type 5 Inhibitors in Patients With Group 2 Pulmonary Hypertension
The goal of this clinical trial is to test the efficacy of tadalafil in patients with group II pulmonary hypertension with CpcPH with elevated pulmonary vascular resistance (PVR equals or more than 4 WU).
- Trial name
- NCT06350773
- Testing
- tadalafil 20 mg then 40 mg if tolerated
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Beni-Suef University
Pulmonary Hypertension
Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)
If pulmonary hypertension is suspected, a right heart catheterization is usually performed to confirm or rule out the diagnosis.
- Trial name
- NCT04993612
- Testing
- Blood gas analysis
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ayham Daher
Pulmonary Hypertension, Ketonemia
Ketones for Pulmonary Hypertension - Effects on Hemodynamics
In the present study, patients with idiopathic pulmonary hypertension (IPAH) and chronic thromboembolic pulmonary hypertenion will be investigated in a randomized cross-over design with ketone infusions and placebo.
- Trial name
- KEPAH (NCT04615754)
- Testing
- Hyperketonemia - use of ketone (3-OHB) infusion
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
HIV
Sildenafil to Treat HIV-Associated Pulmonary Hypertension
This study will examine how blood pressure in the lungs is controlled in healthy people, people with HIV and people with HIV and pulmonary artery hypertension (high blood pressure in the lungs, also called PAH).
- Trial name
- NCT00327080
- Testing
- MRI, L-NMMA, Acetylcholine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Hypertension
Noninvasive Determination of Cerebral Tissue Oxygenation in Pulmonary Hypertension
To study the effect of acute pulmonary vasodilatation on cerebral tissue oxygenation (CTO) and cerebral blood flow (CBF) as indicator for cerebrovascular autoregulation in comparison to the effects of supplemental oxygen…
- Trial name
- NCT01463514
- Testing
- Right heart catheterization, Near-infrared spectroscopy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Portopulmonary Hypertension
Ambrisentan in Patients With Porto-pulmonary Hypertension A Multicenter Open Label Trial
This is an Open Label, Multicenter, pilot clinical trial to assess the efficacy and safety of an oral selective Endothelin Receptor Antagonist (ambrisentan) in patients with portopulmonary hypertension.
- Trial name
- Portopulm (NCT01224210)
- Testing
- Ambrisentan
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Pulmonary Arterial Hypertension (PAH), Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
PulmonAry hyperteNsion DiagnOsis: a National cohoRt reseArch
Understanding Delays in the Diagnosis of Pulmonary Arterial Hypertension and Rare Diseases in Brazil: A Multicenter Observational Study --- Pulmonary arterial hypertension (PAH) is a rare, progressive, and life-threatening…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH), Pulmonary Arterial Hypertension
- Trial name
- PANDORA (NCT06998329)
- Testing
- There will be no intervention
- Where
- Brazil
- Volunteers
- 139 people
- Sponsor
- University of Sao Paulo General Hospital
Pulmonary Hypertension, Magnetic Resonance Imaging
4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension
Due to radiation exposure and low but real risk of morbidity and mortality associated with right heart catheterization, non-invasive procedures to estimate mPAP are desired for the diagnosis of PH or to monitor treatment…
- Conditions
- Pulmonary Hypertension, Magnetic Resonance Imaging, Pulmonary Arterial Pressure, Right Heart Catheterization
- Trial name
- HTPFLUW (NCT05103189)
- Testing
- 4D-flow sequence
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens