Clinical trials: Right Heart Catheterisation
Pulmonary Hypertension, Sickle Cell Anemia
A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Study
This study will assess the safety and efficacy of bosentan therapy (in a study known as ASSET) for patients who have high blood pressure in the lungs associated with sickle cell disease.
- Trial name
- ASSET-3 (NCT00360087)
- Testing
- Bosentan
- Volunteers
- 236 people
- Sponsor
- Actelion
Scleroderma, Systemic, Hypertension, Pulmonary
Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients
The purpose of this study is to assess the value in terms of sensitivity, specificity and likelihood ratio of the stress echocardiography in the screening of pulmonary arterial hypertension in patients with systemic sclerosis and…
- Trial name
- NCT01202045
- Where
- Canada
- Sponsor
- Paul Farand
Pulmonary Hypertension
Evaluate Effect of Optison on Pulmonary Artery Systolic Pressure (PASP) and Pulmonary Vascular Resistance (PVR).
The design of this study is to conduct a comprehensive safety evaluation of the pulmonary hemodynamic effects of Optison. The study is being conducted in subjects referred for cardiac catheterization for clinical reasons.
- Trial name
- NCT00878878
- Testing
- Optison (Perflutren Protein-Type A Microspheres Injectable Suspension), Dextrose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- GE Healthcare
Pulmonary Hypertension, Pulmonary Vascular Disease
Pulmonary Hypertension in Left Heart Disease
The goal is to compare patients with and without varying severity of pulmonary vascular disease based upon hemodynamic signatures, echocardiographic measures, and lung ultrasound, in tandem with expired gas metabolic testing and…
- Conditions
- Pulmonary Hypertension, Pulmonary Vascular Disease, Left Heart Disease
- Trial name
- NCT05935605
- Testing
- Transthoracic Echocardiography (TTE), Lung ultrasound
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Mayo Clinic
Congestion, Heart Failure
Portal Vein Flow Variability to Quantify Right-Sided Hemodynamic Congestion (PORTAL)
This study evaluates the accuracy of a comprehensive venous Doppler echography including the portal vein pulsatility index (PVPI) to quantify invasively measured right-sided venous pressures.
- Conditions
- Congestion, Heart Failure, Right Heart Catheterisation, Central Venous Pressure
- Trial name
- PORTAL (NCT05411263)
- Testing
- Comprehensive transthoracic echocardiography, Doppler echography & Kino-cardiograph (Kino)
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Vrije Universiteit Brussel
Right-heart Hemodynamics, Respiratory Muscle Training
Inspiratory Muscle Training During Right-heart Catheterization
The purpose of this study is to assess hemodynamic effects of inspiratory muscle training during routinely performed right-heart catheterization.
- Conditions
- Right-heart Hemodynamics, Respiratory Muscle Training, Inspiratory Resistance
- Trial name
- NCT02054728
- Testing
- RHC and IMT
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Pulmonary Hypertension, Heart Failure
Respiratory Monitoring During Right Heart
Respiratory monitoring during right heart catheterization to differentiate between various types of pulmonary hypertension; The effects of the cardiovascular system on the lung mechanical properties.
- Trial name
- NCT03061669
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Pulmonary Hypertension
Comparison of Different Cardiac Output Measurement Methods in Patients Undergoing Right Heart Catheterization
The objective of this observational study is to compare cardiac output evaluation by the Direct Fick method, Indirect Fick method and Thermodiluition in pulmonary hypertension (PH) patients undergoing right heart catheterization…
- Trial name
- NCT05665218
- Testing
- right heart catheterization
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- UOSD Emodinamica Diagnostica e Interventistica
Pulmonary Arterial Hypertension
Effects of Pulmonary Hypertension Therapy in Atypical Pulmonary Arterial Hypertension
The purpose of this study is to characterize the clinical and hemodynamic response of Pulmonary Arterial Hypertension (PAH) therapy in patients with atypical PAH and risk factors for left heart disease.
- Trial name
- NCT04787445
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Endomyocardial Fibrosis, Aortic Valve Stenosis
Assessment of Myocardial Fibrosis in Aortic STenosis
This observational cohort study studies the impact myocardial fibrosis has on patients with severe aortic stenosis undergoing aortic valve replacement.
- Trial name
- AMFAST (NCT02316587)
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Odense University Hospital
Systemic Sclerosis, Scleroderma
Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients
The purpose of this study is to determine the timeline of progression from pre-pulmonary hypertension to diagnosable pulmonary hypertension based on right heart catheterization.
- Conditions
- Systemic Sclerosis, Scleroderma, Pulmonary Hypertension, Pulmonary Arterial Hypertension
- Trial name
- NCT00377949
- Where
- 25 sites in United States
- Volunteers
- 602 people
- Sponsor
- Georgetown University
Heart Failure
Novel Wearable Device for Heart Failure Management
Heart failure (HF) is a major cardiovascular disease with high readmission and mortality rate. A wearable device that could remotely monitor and detect the worsening HF early before the symptoms appear will help reduce HF…
- Trial name
- NCT05642650
- Testing
- novel wearable device
- Volunteers
- 108 people
- Sponsor
- China-Japan Friendship Hospital
Heart Failure
Spinal Cord Stimulation in Hypotensive Heart Failure Patients: Hemodynamic Assessment
This is a prospective single-center study that aims to evaluate the effects of non-invasive transcutaneous spinal cord stimulation on systemic and pulmonary hemodynamics, assessed during right heart catheterization in patients…
- Trial name
- NCT05288387
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 6 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Sarcoidosis, Precapillary Pulmonary Hypertension
Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.
- Conditions
- Sarcoidosis, Precapillary Pulmonary Hypertension, Interstitial Lung Disease
- Trial name
- SAPPHIRE (NCT03814317)
- Testing
- Inhaled Treprostinil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Pulmonary Arterial Hypertension
Safety and Efficacy of BIA 5-1058 in PAH
This study aims to assess the safety and tolerability of the individual highest tolerated zamicastat doses, achieved in the study BIA-51058-201, during long-term treatment in Pulmonary Arterial Hypertension (PAH) disease.
- Trial name
- NCT06009185
- Testing
- Oral zamicastat
- Where
- 11 sites in Austria, Germany and 4 more
- Volunteers
- 20 people
- Sponsor
- Bial - Portela C S.A.
Right Ventricular Dysfunction
Incidence, Impact and Mechanisms of Perioperative Right VEntricular Dysfunction (IMPRoVE)
A study to see how common right heart failure (right ventricular dysfunction) after major surgery is, and to investigate if right ventricular dysfunction causes worse patient outcomes after surgery.
- Trial name
- IMPRoVE (NCT05827315)
- Testing
- Echocardiography, T1 Cardiovascular Magnetic Resonance, Right heart catheterisation and coronary sinus blood sampling
- Where
- 3 sites in United Kingdom
- Volunteers
- 175 people
- Sponsor
- NHS National Waiting Times Centre Board
Heart Failure
Acorai Machine Learning Generalization (MLG) Study
Acorai is developing a non-invasive monitoring system for the estimation of intracardiac hemodynamic parameters in patients with suspected or confirmed heart failure, and/or pulmonary hypertension, who require hemodynamic…
- Trial name
- CAPTURE-HF (NCT05835024)
- Testing
- Acorai Sensor Data Collection (ASDC) system 1.0 - Phase 1, Acorai Sensor Data Collection (ASDC) system 1.0 - Phase 2
- Where
- 18 sites in United States, Belgium and 4 more
- Volunteers
- 1,602 people, healthy volunteers welcome
- Sponsor
- Acorai AB
Pulmonary Hypertension, Precapillary Pulmonary Hypertension
Correlation Between CT Pulmonary Angiography Metrics and Right Heart Catheterization Parameters in Pre-Capillary Pulmonary Hypertension
Pulmonary hypertension (PH) is a hemodynamic and pathophysiological condition defined by a mean pulmonary artery pressure (mPAP) greater than 20 mmHg at rest, as confirmed by right heart catheterization (RHC) (1).
- Conditions
- Pulmonary Hypertension, Precapillary Pulmonary Hypertension, Right Heart Catheterisation, CT Angiography
- Trial name
- NCT07667595
- Testing
- right heart catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pulmonary Hypertension
Noninvasive Cardiac Output Measurements in Patients With Pulmonary Hypertension Undergoing Right Heart Catheterization With Acute Vasodilator Testing
Subjects in this study have been diagnosed with pulmonary hypertension (PH) and their doctors have referred them for a right heart catheterization (RHC).
- Trial name
- NCT01275690
- Sponsor
- University of Chicago
Catheterization
Bedside Ultrasound for Fluid Estimation
The study aims to standardize patient positioning during bedside ultrasound assessment of internal jugular vein (IJV) and correlate the results with invasive hemodynamics obtained immediately after.
- Trial name
- NCT05159063
- Testing
- Ultrasound imaging
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Gaurang Vaidya