Clinical trials: Right Side
Right Ventricular Dysfunction
Right Ventricular Echocardiography in caRdiac SurgEry
Postoperative right ventricular (RV) dysfunction increases mortality and risk of cardiac failure after cardiac surgery substantially.
- Trial name
- ReVERSE (NCT03301571)
- Testing
- Change in preload and afterload, Inspired oxygen, Pacemaker mode
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pulmonary Hypertension, Pulmonary Embolism (Diagnosis)
China Pulmonary Vascular Disease Intervention Diagnosis and Management Study-right Heart Catheterization
Right heart catheterization(RHC) plays a crucial role in the diagnosis and treatment of pulmonary vascular diseases(PVD). In China, the lack of equipment and technical expertise has historically limited the implementation of RHC…
- Conditions
- Pulmonary Hypertension, Pulmonary Embolism (Diagnosis), Pulmonary Arterial Hypertension, Right Heart Catheterization
- Trial name
- CHA-RHC (NCT06954727)
- Testing
- No intervention; Observational study
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- China-Japan Friendship Hospital
CTEPH
Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)
1. To identify biological sex differences in baseline RV function in CTEPH 2. To identify biological sex differences in recovery of RV function after PTE surgery in CTEPH 3.
- Trial name
- NCT06105242
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Intermountain Health Care, Inc.
Pulmonary Embolism, Acute Pulmonary Embolism
FlowTriever Pulmonary Embolectomy Clinical Study
Evaluate the safety and effectiveness of the FlowTriever System for use in the removal of emboli from the pulmonary arteries in the treatment of acute pulmonary embolism.
- Conditions
- Pulmonary Embolism, Acute Pulmonary Embolism, Submassive Pulmonary Embolism, Massive Pulmonary Embolism
- Trial name
- FLARE (NCT02692586)
- Testing
- FlowTriever System
- Where
- 18 sites in United States
- Volunteers
- 106 people
- Sponsor
- Inari Medical
Pulmonary Hypertension, Right Ventricular Dysfunction
Feasibility Trial for a Right Ventricular Failure Platform Trial
The primary objective of the CRAVE feasibility trial is to assess the feasibility of conducting a larger CRAVE platform trial by performing a randomized trial of 30 participants with pulmonary hypertension and right ventricular…
- Conditions
- Pulmonary Hypertension, Right Ventricular Dysfunction, Right Heart Failure
- Trial name
- CRAVE (NCT06570473)
- Testing
- Empagliflozin, Ranolazine
- Where
- 5 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Coronary Artery Disease, Congestive Heart Failure
Cardiac Stem Cell Infusion in Patients With Ischemic CardiOmyopathy (SCIPIO)
The purpose of this study is to investigate the safety of intracoronary cardiac stem cells (CSCs) therapy in humans. Currently, there is no effective intervention to regenerate (regrow) dead heart muscle after a heart attack.
- Trial name
- SCIPIO (NCT00474461)
- Testing
- Treatment group
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Louisville
Asthma Control
OptimAIR: Towards Right Care in Asthma Through Point-of-care Phenotyping, Guideline-based Assessment and Management Optimalisation Using the AsthmaOptimiser in Primary Care
Asthma is mainly managed in primary care, yet disease control remains suboptimal. Many patients experience ongoing symptoms, exacerbations, and frequent short-acting β₂-agonist use, while underestimating the severity of their…
- Trial name
- OptimAIR (NCT07390669)
- Testing
- AsthmaOptimiser-supported structured asthma review
- Where
- 3 sites in Argentina, Chile and 1 more
- Volunteers
- 746 people
- Sponsor
- General Practitioners Research Institute
Autism Spectrum Disorder
Cerebellar Transcranial Direct Current Stimulation (tDCS) in Children With Autism Spectrum Disorder: Raynor Cerebellum Project
The purpose of this research study is to investigate the effects of transcranial direct current stimulation (tDCS) on some of the challenges faced by children with Autism Spectrum Disorder (ASD).
- Trial name
- NCT05691283
- Testing
- trans cranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Dupuytren's Disease, Dupuytren Contracture
Post-contracture Release Radiation for Dupuytren's Disease
To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.
- Conditions
- Dupuytren's Disease, Dupuytren Contracture, Dupuytren Disease of Palm and Finger, Dupuytren Disease of Finger
- Trial name
- NCT04122313
- Testing
- Evaluation of Dupuytren's Disease Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Healthy
Prevention of Potentially Inappropriate Prescribing in Late Life Using Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) Criteria
Potentially inappropriate prescribing is common in older patients and encompasses overuse, misuse and underuse of medications. Potentially inappropriate prescribing is associated with negative outcomes including adverse drug…
- Trial name
- NCT00915824
- Testing
- STOPP/START criteria
- Where
- Ireland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cork University Hospital
Pulmonary Hypertension, Arrhythmias, Cardiac
Arrhythmias in Pulmonary Hypertension Assessed by Continuous Long-term Cardiac Monitoring
Arrhythmias are considered a prominent phenomenon in pulmonary hypertension (PH) as the disease progresses. According primarily to retrospective studies with up to 24 hours of monitoring, supraventricular tachycardias (SVT) can…
- Conditions
- Pulmonary Hypertension, Arrhythmias, Cardiac, Heart Rate Variability, Risk Assessment
- Trial name
- ASPIRE (NCT04554160)
- Testing
- Loop recorder implantation, A smartwatch
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pulmonary Arterial Hypertension
Assessmet of Patients With PAH Right Ventricular Volume
The primary endpoint of this study is the percent difference between the VentriPoint Medical System (VMS) and cMRI for estimating the end diastolic and end systolic right ventricular volumes (RVEDV and RVESV) in subjects with…
- Trial name
- NCT01557582
- Testing
- Ventripoint Medical System
- Where
- 7 sites in United States, Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VentriPoint Diagnostics Ltd.
Liver Diseases, Hepatectomy
Liver Regeneration After Liver Resection
The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy.
- Trial name
- NCT01220986
- Testing
- Liver biopsy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Pulmonary Arterial Hypertension
Assessment of Right Ventricular Function by Cardiac MRI in Patients With Pulmonary Arterial Hypertension (IRMA)
Pulmonary hypertension (PH) is a pathophysiological condition defined by an increase in pulmonary arterial pressure above 20mmHg, which encompasses many very dissimilar conditions.
- Trial name
- IRMA (NCT05624242)
- Testing
- cardiac magnetic resonance imaging
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may…
- Conditions
- Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction
- Trial name
- PREFER-HF (NCT03480633)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Liver Regeneration, Ursodeoxycholic Acid
Effect of Ursodeoxycholic Acid Supplementation on Liver Regeneration on Right Lobe Donor Hepatectomy
The goal of this open label randomized trial is to understand the role of oral ursodeoxycholic acid(UDCA) supplementation in the liver regeneration (in terms of liver function and anatomical growth) following right lobe donor…
- Conditions
- Liver Regeneration, Ursodeoxycholic Acid, Partial Liver Resection
- Trial name
- NCT06091787
- Testing
- Ursodeoxycholic acid, Standard Medical Treatment
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Right Colectomy
Evaluation of an Arterial Calcification Score as a Predictive Factor of Anastomotic Leakage in Right Colectomy
Anastomotic leakage is the major postoperative complication in right colectomy. Evaluation of calcification on coeliac trunk and mesenteric arteries on the preoperative CT scan could allow the identification of patient at-risk of…
- Trial name
- RIGHTCOLOCALCI (NCT04002921)
- Where
- 12 sites in France
- Volunteers
- 615 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Liver Regeneration
To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery
Posthepatectomy liver failure (PHLF) remains a significant life-threatening problem after major hepatectomies. Pentoxifylline is shown to have potent vasodilating properties for peripheral blood vessels, along with the hepatic…
- Trial name
- NCT07085806
- Testing
- Pentoxifylline (also known as oxpentifylline), Plasmalyte
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acne Vulgaris
Explorative Trial Evaluating the Efficacy and Tolerability of LEO43204 in Moderate to Severe Acne
An exploratory Phase 2, single, centre, prospective, randomized, placebo-controlled, double-blinded, split-pace (left/right) design trial to evaluate the efficacy and tolerability of LEO 43204 in adults with moderate to severe…
- Trial name
- NCT02575950
- Testing
- LEO43204
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- LEO Pharma
Right Ventricular Dysfunction
Hemodynamic Assessment of the Right Ventricle Using Pressure-volume Loop Catheter and Pulmonary Artery Catheter in Patients Undergoing Left Ventricular Assist Device Placement
This study will include the placement of a pressure volume (PV) loop catheter in the right atrium of patients undergoing left ventricular assist device (LVAD) placement and measure relevant PV loop data.
- Trial name
- NCT04478890
- Testing
- Hemodynamic assessment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
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