Clinical trials: Risk Factor, Cardiovascular
Tricuspid Regurgitation
Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study)
This study is a multicenter cohort study including patients diagnosed with tricuspid regurgitation during hospitalization. The primary outcome of the study is all-cause death, and the secondary outcome is cardiovascular events.
- Trial name
- NCT06926959
- Where
- 7 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Health Behavior, Genetic Information
The DNA-Based Lifestyle Enhancement Trial
Despite the known cardiovascular benefits of regular physical activity and having a balanced diet, it has proven challenging to change health behaviours towards favourable lifestyles.
- Conditions
- Health Behavior, Genetic Information, Cardiovascular Risk Factor
- Trial name
- DNAble (NCT03583983)
- Testing
- Personalized Health Recommendations, Generic Health Recommendations
- Where
- Canada
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Cardiovascular Risk Factor, Menopause Related Conditions
The Clinical Utility of Resistance Training for Improving Cardiovascular Disease Risk in Post-Menopausal Women
Given the heightened cardiovascular disease (CVD) risk in post-menopausal women, studies are needed to explore novel, feasible methods for reducing risk in this population.
- Conditions
- Cardiovascular Risk Factor, Menopause Related Conditions, Neuromuscular Function, Aerobic Capacity
- Trial name
- NCT03752060
- Testing
- Resistance Exercise, Aerobic Exercise
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Spinal Cord Injury
Cardiovascular Disease Study
Coronary heart disease (CHD) is a leading cause of death in the spinal cord injured (SCI) population, occurring at younger ages than in the able-bodied population.
- Trial name
- NCT00857194
- Testing
- 2 hour Oral Glucose Tolerance Test, Fat Meal Test
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes, Cardiovascular Risk Factor
Therapeutic Approach of Cardiovascular Risk Factors in T2DM by Gender
Background: Patients with type 2 diabetes mellitus (T2DM) are at 2- to 4-fold higher risk of cardiovascular mortality compared with non-diabetic subjects.
- Conditions
- Type 2 Diabetes, Cardiovascular Risk Factor, Gender
- Trial name
- NCT04653805
- Testing
- Current clinical practice in primary care of patients with type 2 diabetes mellitus
- Where
- Spain
- Volunteers
- 300,000 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
COVID-19
Effectiveness of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19
The purpose of this pragmatic randomized trial is to evaluate the vaccine effectiveness of the COVID-19 vaccine, mRNA-1273, in adults aged 50-64 years without known risk factors for severe COVID-19 infection.
- Trial name
- DAN-COVID (NCT07279766)
- Testing
- mRNA-1273 (Moderna COVID-19 vaccine)
- Where
- 2 sites in Denmark
- Volunteers
- 41,060 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Coronary Artery Disease
Cardiovascular Health and Texting Messaging (CHAT) Study
The study is a two-arm, parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness of automated mobile phone text message-based intervention for secondary prevention, including lifestyles…
- Trial name
- NCT02888769
- Testing
- Text Messaging
- Where
- China
- Volunteers
- 822 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiovascular Disease
Impact of Text Messages to Promote Secondary Prevention After Acute Coronary Syndrome
The study is a two-arm, parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness of automated mobile phone text message-based intervention for secondary prevention after acute coronary…
- Trial name
- IMPACS (NCT03414190)
- Testing
- Mobile phone text message
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Federal University of Minas Gerais
Cardiovascular Diseases
Modulation of Cardiovascular Risk Factors by the Diet
The interventional study will evaluate effectiveness and potential of a 'cardioprotective diet' for adults with increased risk for cardiovascular diseases (CVD).
- Trial name
- MoKaRi-Diet (NCT02637778)
- Testing
- Cardioprotective diet, Cardioprotective diet + 3 g EPA + DHA/d
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Jena
Hypertension, Metabolic Syndrome
WB-EMS Effects on Cardiometabolic Risk Factors
From the age of 50 onwards, there is a disproportionate decline in muscle strength, mass and function, which can be prevented or at least delayed by physical training.
- Conditions
- Hypertension, Metabolic Syndrome, Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT07406191
- Testing
- WB-EMS, Control
- Where
- 2 sites in Germany
- Volunteers
- 28 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Diabetes Mellitus, Type 2, Adverse Event
Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes
Lowering of blood pressure (BP) in high-risk hypertensive individuals reduces major adverse cardiovascular and cerebrovascular events. Diabetic patients with hypertension benefit from BP lowering treatment.
- Conditions
- Diabetes Mellitus, Type 2, Adverse Event, Blood Pressure, Prehypertension
- Trial name
- IPAD (NCT03264352)
- Testing
- Allisartan Isoproxil, Amlodipine 5mg, Standard treatment by current guideline
- Where
- China
- Volunteers
- 11,414 people
- Sponsor
- XueQing Yu
Cardiovascular Risk Factor, Burnout
Impact of Burnout on Cardiovascular and Immune Biomarkers in Healthcare Professionals - Covid-19 Pandemic in Abu Dhabi
The main objective of our project is to investigate the evolution of psychosocial, cardiovascular and immune markers in healthcare with different levels of exposure to the COVID-19 pandemic.
- Conditions
- Cardiovascular Risk Factor, Burnout, Immune Deficiency
- Trial name
- NCT04422418
- Where
- 4 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Khalifa University for Science and Technology
Obesity, Cardiovascular Risk Factor
Visualizing Vascular Mechanisms of Salt Sensitivity
This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.
- Conditions
- Obesity, Cardiovascular Risk Factor, Salt; Excess
- Trial name
- NCT03696433
- Testing
- Low-salt diet, High-salt diet
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Non-seminomatous Testicular Cancer
Cardiovascular Morbidity in Testicular Cancer Survivors: Study of Risk Factors and Assessment of Pharmacogenomic Determinants of Toxicity
BACKGROUND: Evidence has emerged that patients cured with cisplatin-bleomycin chemotherapy from disseminated testicular cancer (TC) develop a large number of cardiovascular risk factors (CRF) several years later.
- Trial name
- NCT00161174
- Where
- Netherlands
- Volunteers
- 173 people
- Sponsor
- University Medical Center Groningen
Obesity
Effect of Vitamin D3 Supplementation on Insulin Resistance and Cardiovascular Risk Factors in Obese Adolescents
The prevalence of obesity has reached epidemic proportions nationally as well as internationally. Currently, 16 % of American adolescents are obese.
- Trial name
- NCT00858247
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Adrenal Gland Hyperfunction, Cardiovascular Disease
Heart Disease Risk Factors in Major Depression
A series of studies in patients with major depression have consistently demonstrated a doubling of the mortality rate at any age, independent of suicide.
- Conditions
- Adrenal Gland Hyperfunction, Cardiovascular Disease, Involutional Depression
- Trial name
- NCT00001969
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obesity, Cardiovascular Risk Factor
Healthy Nordic Foods to Prevent Cardiometabolic Risk in Obese Subjects
This project will examine whether long-term consumption of healthy Nordic foods can maintain a healthy weight also after weight loss, and decrease abdominal fat accumulation and cardiometabolic risk.
- Conditions
- Obesity, Cardiovascular Risk Factor, Diet Modification
- Trial name
- NCT03102853
- Testing
- Nordic diet, Control diet
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lund University
Diabetes Mellitus, Cardiovascular Diseases
The Risk Factors of Cardiovascular Disease in Elderly Diabetic Patients: A Prospective Cohort Study
In the previous cohort studies focused on diabetes in China, there were few studies on elderly patients with diabetes. The aim of this prospective cohort study was to investigate the prevalence, management and nutritional status…
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases, Complication Diabetic
- Trial name
- NCT04544527
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiovascular Risk Factor, Circadian Dysregulation
Body Weight, Sleep, and Heart Health
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity.
- Conditions
- Cardiovascular Risk Factor, Circadian Dysregulation, Obesity
- Trial name
- NCT03388788
- Testing
- Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obstetric Labor Complications, Cardiovascular Diseases in Pregnancy
Transthoracic Echocardiography of Ventricular Function of Parturients in Labor
This echocardiography study will characterize heart structure and function during labor. Imaging of the heart during the stress of labor could increase detection of subclinical cardiovascular disease using advanced imaging…
- Conditions
- Obstetric Labor Complications, Cardiovascular Diseases in Pregnancy, Cardiovascular Risk Factor
- Trial name
- NCT04481503
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center