Clinical trials: Risk Factors Cardiovascular Disease
Aortic Regurgitation
Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
- Trial name
- NCT07104968
- Where
- Sweden
- Volunteers
- 35,000 people
- Sponsor
- Uppsala University
Healthy People
The Effects of Freeze-Dried Whole Grape Powder on Chronic Disease and Cardiovascular Risk Factors-a Pilot Study
Cardiovascular disease (CVD) is responsible for 1 out of every 5 deaths, is the number one killer of Americans, killing about 700K US adults per year (1).
- Trial name
- NCT06006182
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California State Polytechnic University, Pomona
Pre-diabetes, Cardiovascular Risk Factor
Effectiveness of Nurse-coordinated Follow-up Program in Primary Care for People at Risk for T2DM
Previous Icelandic studies regarding prevalence of diabetes have mostly used data from the capital area. Information on the proportion of people at risk at developing T2DM or having undiagnosed T2DM among people living in rural…
- Conditions
- Pre-diabetes, Cardiovascular Risk Factor, T2DM (Type 2 Diabetes Mellitus), Primary Health Care
- Trial name
- NCT04688359
- Testing
- Guided Self Determination
- Where
- Iceland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Akureyri
Intracerebral Hemorrhage
Etiology and Prognostic Risk Factors of Intracerebral Hemorrhage in Beijing
There were lack of data and analysis about medical management, etiology, and long-term outcome of Intracerebral Hemorrhage (ICH) in Beijing.
- Trial name
- NCT02350010
- Testing
- CT Angiography
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Neurosurgical Institute
Hyperlipidemia, Hypertension
Medication Adherence Clinical Decision Support
More than 50% of adults treated for diabetes, hypertension, or lipid disorders have suboptimal medication adherence, a prominent barrier to continued improvement in chronic disease care in the United States.
- Conditions
- Hyperlipidemia, Hypertension, Diabetes, Medication Nonadherence
- Trial name
- ADH-Wizard (NCT03748420)
- Testing
- Adherence Intervention
- Where
- United States
- Volunteers
- 5,421 people
- Sponsor
- HealthPartners Institute
Graft Failure, Death
European Transplant Registry of Senior Renal Transplant Recipients on Advagraf
SENIOR transplant Registry European transplant registry of senior renal transplant recipients (above the age of 65 years) receiving initial immunosuppression with tacrolimus once daily, mycophenolate and steroids to investigate…
- Conditions
- Graft Failure, Death, Acute Rejection of Renal Transplant, Infections
- Trial name
- SENIOR (NCT02558452)
- Testing
- Tacrolimus once daily (Advagraf)
- Volunteers
- 1,000 people
- Sponsor
- Klemens Budde
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor
Early Add-On Combination of GLP-1 Receptor Agonist and SGLT2 Inhibitor in People With Cardiovascular-Kidney-Metabolic Stage 2-3
This retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare early treatment intensification strategies in adults with obesity, type 2 diabetes…
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor, Kidney Disease, Type 2 Diabetes
- Trial name
- GLP1-SGLT2-CKM (NCT07465926)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor
- Volunteers
- 451,036 people
- Sponsor
- Chung Shan Medical University
Racial Disparities, Blood Pressure
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood…
- Conditions
- Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function
- Trial name
- MAVHS (NCT04334135)
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Auburn University
T2D
Peanut Consumption and Cardiovascular Disease Risk in a Chinese Population
This is a 2 parallel-arm randomized controlled study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of two servings of peanuts with an isocaloric matched refined…
- Trial name
- NCT03194152
- Testing
- Peanut, Control
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Harvard School of Public Health (HSPH)
Diabetes Type 1, Endothelial Dysfunction
Cardiovascular Risk Factors After Single Pancreas Transplantation
Patients accepted for the waiting list for single pancreas transplantation suffer from severe glucose instability with hyperglycemia due to diabetes type 1, but do not have significant diabetes-related complications.
- Trial name
- Diamant (NCT02066350)
- Testing
- Single pancreas transplantation
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Coronary Artery Disease
Cross-over Study of Coronary Risk Factors With a Polypill
Open-label, randomized, cross-over study conducted in a single center, applied to patients receiving a polypill with 100 mg of acetyl salicylic acid and different doses of ramipril and atorvastatin for indication of secondary…
- Trial name
- POLICROSS (NCT05030818)
- Testing
- Polypill of acetylsalicylic acid, ramipril and atorvastatin, Drugs taken separately: acetylsalicylic acid, ramipril and atorvastatin
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Fundación EPIC
Obesity and Overweight, Obese Adolescents
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3).
- Conditions
- Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
- Trial name
- MODERN (NCT06967389)
- Testing
- Ozempic®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Bauer
Cognitive Decline, Stroke
Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly
Over the past ten years, the number of endovascular procedures has increased by 5% per year in Europe with the development of interventional cardiology, such as percutaneous coronary angioplasty, aortic valve replacements (TAVR)…
- Trial name
- METHYSTROKE (NCT02972008)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Lille
Osteoarthritis, Knee, Endocrine System Diseases
Influence of Adipocytokines in Osteoarthritis
Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive.
- Conditions
- Osteoarthritis, Knee, Endocrine System Diseases, Cardiovascular Risk Factors
- Trial name
- NCT01906281
- Testing
- Blood analyse, arthrocentesis, ultrasound examination
- Where
- 2 sites in Spain
- Volunteers
- 105 people
- Sponsor
- Parc Taulí Hospital Universitari
Metabolic Syndrome, Cardiovascular Diseases
Effects of Coenzyme Q10 Supplement on Cardiovascular Risk Factors in Subjects at High Risk of Metabolic Syndrome
This study aims to evaluate the ameliorating effect of coenzyme Q10 supplementation on cardiovascular risk factors in high risk population for metabolic syndrome, including blood lipid metabolism, insulin resistance, blood…
- Trial name
- NCT06506630
- Testing
- coenzyme Q10
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tian Zezhong
Type 2 Diabetes, Insulin Resistance
The Effects of Two Days of Bedrest on Insulin Resistance in Type 2 Diabetics
The hypothesis of this study is that bed rest in diabetic patients will result in a deterioration of metabolic control (primarily glucose). Specific aims: 1.
- Trial name
- NCT00508599
- Testing
- Study 2 (48 hours of complete bed rest)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Type 2 Diabetes, Glycemic Control
Latinos Understanding the Need for Adherence in Diabetes
The Latinos Understanding the Need for Adherence in Diabetes (LUNA-D) study, is a randomized controlled trial testing the effectiveness of an integrated behavioral health and primary care chronic care disease management…
- Conditions
- Type 2 Diabetes, Glycemic Control, Cardiovascular Risk Factors, Psychological Distress
- Trial name
- LUNA-D (NCT03983499)
- Testing
- Special Intervention
- Where
- United States
- Volunteers
- 456 people
- Sponsor
- San Diego State University
Stroke
Falls in Stroke Patients After Hospital Discharge: Prevalence and Risk Factors
The purposes of this study are: (1) to investigate the incidence and causes of falls of stroke patients residing in Taipei City and Taipei county after their discharge from the National Taiwan University Hospital, (2) to…
- Trial name
- NCT00167063
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Type 2 Diabetes
Effect of Dairy Consumption on Glycemic Control, Body Weight and Cardiovascular Risk in Patients With Type 2 Diabetes
This is a randomized prospective clinical study in patients with type 2 diabetes to evaluate the effect of dairy products with full or low fat on glycemic control and cardio-metabolic risk factors in comparison to a regular diet.
- Trial name
- NCT02895867
- Testing
- Full fat dairy, Low fat dairy, Control
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Joslin Diabetes Center
Preeclampsia, Cardiovascular Risk Factor
Cardiac Dysfunction and Remodeling in Patients With Preeclampsia
Preeclampsia (PE) is a pregnancy-related hypertensive disorder drive by an anti-angiogenic environment. Women with PE have 2-4 time higher risk of developing cardiovascular disease (CVD), although the specific mechanism relating…
- Conditions
- Preeclampsia, Cardiovascular Risk Factor, Pregnancy Complications
- Trial name
- ANGIOCOR (NCT04162236)
- Testing
- Ecocardiographyc ultrasound
- Where
- Spain
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
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