Clinical trials: Risk Factors Cardiovascular Disease
Hypertension
Effects of Doxazosin Gastrointestinal Therapeutic System on Ambulatory Blood Pressure and Cardiovascular Risk Factors in Uncontrolled Hypertensive Patients
The primary objective was to determine the effects of the Gastrointestinal Therapeutic System (GITS) formulation of Doxazosin when used in combination therapy with the 5 major classes of antihypertensive agents as measure by…
- Trial name
- NCT00646841
- Testing
- Doxazosin gastrointestinal therapeutic system (GITS)
- Where
- 7 sites in Italy, Spain and 1 more
- Volunteers
- 89 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Child, Only, Obesity
Microvascular Reactivity in Prepubertal Children
This is a cross-sectional study aimed to investigate microvascular reactivity in prepubertal children according to adiposity status.
- Conditions
- Child, Only, Obesity, Endothelial Dysfunction
- Trial name
- MicroChild (NCT03171441)
- Testing
- nailfold videocapillaroscopy, inflammatory biomarkers
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Microvascular Angina
The Impact of Cardiac Rehabilitation Participation on Cardiac Syndrome X
The study is designed to test the hypothesis that participation in a standard phase III group based cardiac rehabilitation programme will improve psychological morbidity, quality of life and cardiovascular risk factors, along…
- Trial name
- NCT00123617
- Testing
- Phase III group-based cardiac rehabilitation
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- National Heart and Lung Institute
Elevated Triglycerides, Cardiovascular Risk Factor
Effects of Omega-3 Docosapentaenoic Acid on Lipids and Other Risk Factors for Cardiovascular Disease
Elevated plasma triglycerides (TG) are due to an excess of TG-rich lipoproteins of several different types, most commonly of very-low-density lipoproteins (VLDL), but also intermediate-density lipoproteins (IDL, or VLDL…
- Trial name
- DPA (NCT04088240)
- Testing
- DPA enriched n-3, n-3 control
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Behavior Change Interventions, Cardiovascular Diseases
Primary Care - Prescribing Lifestyle Adjustments for Cardiovascular Health
Prescribing lifestyle changes to patients who are at risk of cardiovascular disease, may be an extremely cost effective mechanism of improving health for the individual themselves and the NHS.
- Conditions
- Behavior Change Interventions, Cardiovascular Diseases, Cardiovascular Risk Factor, Behavior, Health
- Trial name
- P-PLAC 2 (NCT04113213)
- Testing
- Lifestyle Prescription (LRx)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of South Wales
Cardio Vascular Disease, Metabolic Syndrome (MetS)
Norwegian Mental Illness Heart Health Study
Norwegian patients with severe mental illnesses (SMI), such as schizophrenia spectrum or bipolar disorder, lose on average 10 years of life compared to mentally healthy individuals. Much of this gap is due to heart disease.
- Conditions
- Cardio Vascular Disease, Metabolic Syndrome (MetS), Severe Mental Disorder, Schizophrenia and Schizophrenia Spectrum Psychosis
- Trial name
- NORMI-Heart (NCT07085923)
- Testing
- Lifestyle Intervention
- Where
- Norway
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Madeleine Elisabeth Angelsen
Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic organ damage due to microvascular thrombosis.
- Conditions
- Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura, Thrombotic Microangiopathies, Microangiopathy, Thromboic
- Trial name
- TWILIGHT (NCT07205861)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sub-optimal Vitamin D Status, Pre-diabetes
Effect of Vitamin D3 Supplementation on Insulin Resistance- The DIR Study
Insulin resistance is a state where the body does not respond as it should to the insulin it produces. Individuals who are insulin resistant are at increased risk of both heart disease and type 2 diabetes; importantly, diabetes…
- Conditions
- Sub-optimal Vitamin D Status, Pre-diabetes, Insulin Resistance
- Trial name
- NCT01889810
- Testing
- Vitamin D3 supplementation
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Preeclampsia, Cardiovascular Risk Factor
Blood Pressure After PREeclampsia/HELLP by SELF Monitoring Study
RATIONALE: Women with a previous history of preeclampsia (PE)/HELLP have a twofold higher risk of cardiovascular disease (CVD) and a fourfold increased risk to develop hypertension at a relative young age.
- Conditions
- Preeclampsia, Cardiovascular Risk Factor, Cardiovascular Diseases, Hypertension
- Trial name
- BP-PRESELF (NCT03228082)
- Testing
- Home Blood Pressure Monitoring (HBPM)
- Where
- 6 sites in Germany, Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypertension, Cardiovascular Risk Factors
Rosuvastatin Effect on Serial Echocardiographic Measurement of Coronary Flow Velocity Reserve
In ASCOT study, lipid lowering with a statin provided additional beneficial effects in hypertensive patients with average levels of serum total cholesterol.
- Trial name
- RESERVE (NCT01490398)
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Asan Medical Center
Coronary Disease
Bile Acids and Gut Microbiota as Potent Coronary Atheroma Risk Factors: a Prospective Study in Human
The purpose of this study is to describe the composition of bile acids and the gut microbiota comparing two populations: patients with coronary atheroma and the healthy subjects.
- Trial name
- MABAC (NCT02375893)
- Testing
- No intervention, Healthy subject
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SLE, Atherosclerosis
Premature Atherosclerosis in Systemic Lupus Erythematosus
Patients with SLE have increased rates of atherosclerosis, while the risk factors for atherosclerosis in those patients were not fully revealed.
- Trial name
- PASLE (NCT04037293)
- Testing
- CIMT and baPWV measurement
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking Union Medical College Hospital
Haemodialysis, Chronic Kidney Disease Requiring Chronic Dialysis
Lumasiran in Hyperoxalaemic Patients on Haemodialysis
This study will look at how well a drug that reduced the amount of oxalate in the body works in patients that have kidney disease and need dialysis treatment.
- Conditions
- Haemodialysis, Chronic Kidney Disease Requiring Chronic Dialysis, Cardiovascular Disease, Cardiovascular Risk Factor
- Trial name
- LHOxH (NCT06225544)
- Testing
- Lumasiran
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Hypercholesterolemia, Mixed Dyslipidemia
SurveY Followed by a Retrospective Chart Review to Describe the Key Factors Leading to Physician's Decision to Treat Patients at High and Very High Cardiovascular Risk With hyperchOlesterolemia or Mixed Dyslipidemia With NUSTENDI®
In this study, a survey of office-based cardiologists and lipid management specialists will be conducted on treatment decisions for NUSTENDI® (bempedoic acid 180 mg fixed dose combination [FDC] with ezetimibe 10 mg) followed by a…
- Trial name
- NCT05546398
- Testing
- Bempedoic Acid 180Mg/Ezetimibe 10Mg Tab, No study drug
- Where
- 63 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Obesity, Body Composition
Study of Macronutrients and Heart Disease Risk
The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on cardiovascular disease risk factors, including blood pressure (BP), body weight and composition…
- Conditions
- Obesity, Body Composition, Blood Pressure, Cardiovascular Diseases
- Trial name
- MACRO (NCT00609271)
- Testing
- low carbohydrate diet, low fat diet
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)
This is a pragmatic, risk-stratified, individually randomized controlled trial testing whether personalised WhatsApp-based digital behavioural nudges can improve completion of cardiovascular preventive actions after community…
- Trial name
- NADI-MHR (NCT07879144)
- Testing
- Personalised Digital Behavioural Nudges (NADI-MyHeartRisk Enhanced Pathway)
- Where
- 2 sites in Malaysia
- Volunteers
- 6,588 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Advancement and Research Excellence Institute
Cardiovascular Disease Risk
Impact of a Mediterranean Diet on Cardiovascular Disease Risk Factors
This approved and funded research project is part of a larger project titled "Algarve Active Ageing - Cardiac and Osteoarthritis Rehabilitation (A3-COR): personalized exercise protocol in the rehabilitation after acute myocardial…
- Trial name
- RATE (NCT06113484)
- Testing
- DIET + EXERCISE, WITHOUT DIET + EXERCISE
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Universidade Católica Portuguesa
Psychosis, Metabolic Disease
Technology-Enabled Collaborative Care for Youth
The overall objective is to develop scalable interventions to address the physical health needs of patients affected by early psychosis.
- Conditions
- Psychosis, Metabolic Disease, Cardiovascular Risk Factor
- Trial name
- TECC-Y (NCT03610087)
- Testing
- Low Intensity Intervention, High Intensity Intervention
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Centre for Addiction and Mental Health
Healthy Volunteers
The Dose-Response Effects of Lean Beef in a Mediterranean-Style Dietary Pattern on Cardiovascular Disease Risk Factors
The objective of this study is to evaluate the effects of different quantities of lean beef (0.5, 2.5, 5.5 oz/day) on lipids, lipoproteins, and vascular health endpoints in the context of a modified Mediterranean dietary pattern…
- Trial name
- NCT02723617
- Testing
- MED 0.5, MED 2.5, MED 5.5
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
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