Clinical trials: Risk Factors Cardiovascular Disease
Type 2 Diabetes Mellitus (T2DM)
Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin
This clinical trial is studying whether combining two commonly used diabetes medications into a single pill works better than taking them separately for people with type 2 diabetes who are already on metformin.
- Trial name
- CONTROL (NCT07057479)
- Testing
- Fixed-dose combination of SGLT2 inhibitor and thiazolidinedione, Control Group 1 Intervention - SGLT2 inhibitor monotherapy, Control Group 2 Intervention - Thiazolidinedione monotherapy
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Hypogonadism
Association Between the Prevalence of Cardiovascular Risk Factors and New Use of Testosterone
We will investigate if testosterone is preferentially given to patients at higher risk of cardiovascular events. If this is the case, then observational studies may be prone to selection bias resulting in overestimation of the…
- Trial name
- NCT03484260
- Testing
- Testosterone Product
- Where
- Germany
- Volunteers
- 27,778 people
- Sponsor
- Bayer
Type 2 Diabetes
Vitamin D Supplementation on Cardiovascular Risk Factors
The purpose of the present pilot study is to determine the effect of vitamin D supplementation (4000 IU or 6000 IU once daily for 6 months) on reducing heart disease risk and in improving blood glucose control in type 2 Diabetes…
- Trial name
- NCT01412710
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Florida International University
Cardiovascular Diseases, Heart Diseases
Age, Risk Factors for CVD and Cognitive Functioning
To relate cardiovascular disease (CHD) risk factors to cognitive performance among middle-aged and elderly men and women over a 10 year longitudinal study period.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Neurologic Manifestations
- Trial name
- NCT00007397
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Risk Factor
Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients
This is a prospective randomised trial investigating the effect of a preemptive administration of levosimendan on postoperative cardiac NT-proBNP concentrations.
- Trial name
- IMPROVE (NCT04329624)
- Testing
- Levosimendan
- Where
- Austria
- Volunteers
- 230 people
- Sponsor
- Medical University of Vienna
Aortic Dissection
Nordic Consortium for Acute Type A Aortic Dissection-2
The Nordic Consortium for Acute Type A Aortic Dissection-2 (NORCAAD-2) is a multicenter research collaboration involving up to 19 units in the Nordic countries and one in The Netherlands.
- Trial name
- NORCAAD-2 (NCT06862583)
- Testing
- surgery, endovascular intervention
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska Institutet
Cerebral Small Vessel Disease
The Impact of Excessive Dietary Sodium on Brain Health
Sporadic cerebral small vessel disease (CSVD) is not only the most common subtype of vascular dementia, in recent multi-center study showed that sporadic CSVD harbors in a third of Alzheimer's disease (AD) patients in 9 Asian…
- Trial name
- NCT05374005
- Where
- Hong Kong
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Acute Coronary Syndrome
Prediction of Cardiovascular Events in Vulnerable Patients Following Acute Coronary Syndrome
The purpose of this study is to determine if testing patients for endothelial dysfunction will help identify which patients are more likely at risk to have another heart attack in the future.
- Trial name
- NCT01500902
- Testing
- EndoPAT testing (non invasive device), WatchPAT testing (non-invasive device)
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic
Atherosclerosis of Artery
Periodontitis and Atherosclerotic-related Arterial Stenosis
This study aimed to evaluate the association between periodontitis and atherosclerosis of the cerebral vasculature in the Chinese population.
- Trial name
- NCT04303351
- Volunteers
- 1,000 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Health, Subjective, Healthy
Prevalence of Sedentary Lifestyle, Pre-hypertension, and Obesity
Hypertension has been a serious problem among people from different ages in the last few decades, so by taking this in consideration we decided to search for specific risk factors that cause hypertension in young healthy adults…
- Trial name
- NCT05629351
- Testing
- Observational Group
- Where
- Turkey (Türkiye)
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Cardiovascular Diseases, Coronary Artery Disease
Evaluation Using ClearView in Determining Association to the Cardiac Risk Factors
The objective of this study is to explore the relationship between the ClearView scan results and a variety of cardiovascular risk indicators such as the Coronary Calcium Score, Framingham Risk Factors, Reynolds Risk Score, and…
- Trial name
- Cardiac-CV (NCT01740739)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Epic Research & Diagnostics, Inc.
Type 2 Diabetes Mellitus (T2DM)
Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM: the Tai Chi Intervention for Diabetes Management During Aging (TIDA) Study
This randomized, single-blind, controlled clinical trial compares the effects of a 12-week Tai Chi program versus moderate-intensity combined exercise (MICE) training on cardiovascular health, glycemic control, and physical…
- Trial name
- TIDA (NCT07131761)
- Testing
- Tai chi, Moderate-Intensity Combined Exercise (MICE), Control ( No Exercise )
- Volunteers
- 66 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Peritoneal Dialysis
The Effects of Melatonin on Cardiovascular and Bone Metabolism Markers in Peritoneal Dialysis Patients
The aim of this double-blind randomized clinical trial is to determine the effects of Melatonin on cardiovascular disease risk factors, bone metabolism markers, serum concentrations of advanced glycated end products and quality…
- Trial name
- NCT06096558
- Testing
- Melatonin
- Volunteers
- 46 people
- Sponsor
- National Nutrition and Food Technology Institute
Obesity, Overweight
Hybridized Three Steps Intervention to Prevent Diabetes in Venezuela
The American Diabetes Association recommends implementing the Diabetes Prevention Program (DPP) in subjects with prediabetes. In the DPP, weight reduction was the main predictor of a lower incidence of type 2 diabetes (T2D), each…
- Conditions
- Obesity, Overweight, PreDiabetes, Diabetes Mellitus, Type 2
- Trial name
- HITS (NCT04927871)
- Testing
- Total Diet Replacement (TDR), Medical Nutritional Therapy (MNT), Diabetes Prevention Program 4 months
- Where
- 2 sites in Venezuela
- Volunteers
- 156 people
- Sponsor
- Foundation for Public Health and Epidemiological Research of Venezuela
Breast Cancer, Upper Extremity Deep Vein Thrombosis, Secondary
Determination of Predictive Value of Echography Doppler Abnormalities
In order to avoid to use a traumatic and iatrogenic examen (phlebography), the purpose of the study is to validate echography doppler in the diagnosis of asymptomatic related catheter related thrombosis.
- Trial name
- CAVECCAS (NCT00714909)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adrenal Incidentalomas, Cushing Syndrome
Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome
Drug interventional, controlled, randomized open-label, parallel-group, multicenter study in patients with bilateral adrenal incidentalomas associated with subclinical Cushing's syndrome
- Trial name
- NCT06801249
- Testing
- Metarapone, Standardized antihypertensive therapy
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Kidney Disease, Pediatric
The Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular (CV) morbidity and mortality. Recent studies suggest that pediatric patients with even moderately impaired kidney function may be…
- Conditions
- Chronic Kidney Disease, Pediatric, Cardiovascular Disease
- Trial name
- 4C (NCT01046448)
- Where
- 50 sites in Austria, Belgium and 13 more
- Volunteers
- 650 people
- Sponsor
- Heidelberg University
Healthy Lifestyle, Cardiovascular Risk Factors
Effectiveness of a Supervised University-Based Physical Activity and Health Education Program on Lifestyle and Psychological Well-being (Ponte en Forma)
This study evaluates the effectiveness of a structured, supervised university-based program that combines physical activity and health education to promote healthy lifestyle behaviors and psychological well-being.
- Conditions
- Healthy Lifestyle, Cardiovascular Risk Factors, Sedentary Behavior, Psychological Well-being
- Trial name
- PONTE-FORMA (NCT07268144)
- Testing
- Ponte en Forma Program
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
Venous Thromboembolism, Risk Factor, Cardiovascular
Distribution of Risk Factors for Venous Thromboembolism in Blood Donors
Venous thromboembolism occurs with an incidence of about 1 per 1000 per year in adults . The main consequences are death, recurrence, post-thrombotic syndrome and major bleeding due to anticoagulation.
- Conditions
- Venous Thromboembolism, Risk Factor, Cardiovascular, Blood Type
- Trial name
- ANEMONE (NCT03282747)
- Testing
- no intervention
- Where
- Italy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Type1diabetes, Cardiovascular Risk Factor
Increasing Heart Healthy Behaviors in Youth With Type 1 Diabetes
This study is evaluating how to encourage teens to engage in heart healthy behaviors such as being more active or eating in a healthy way.
- Trial name
- NCT03531021
- Testing
- Heart healthy intervention
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Joslin Diabetes Center
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