Clinical trials: Risk Factors Cardiovascular Disease
Cardiovascular Diseases, Coronary Disease
Multiple Risk Factor Intervention Trial for the Prevention of Coronary Heart Disease (MRFIT)
To determine for a group of men at high risk of death from coronary heart disease whether a special intervention program to lower serum cholesterol, reduce blood pressure, and eliminate cigarette smoking would result in a…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00000487
- Testing
- antihypertensive agents, smoking cessation, diet, fat-restricted
- Sponsor
- University of Minnesota
Cardiovascular Risk Factors
Cardiovascular Patients With no Standard Modifiable Risk Factors
A growing number of patients develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of standard modifiable risk factors (SMuRF-less).
- Trial name
- SMuRF-less-ME1 (NCT06199869)
- Testing
- Evaluation of risk factors by direct interview with subjects who have atherosclerotic cardiovascular patients
- Where
- 2 sites in Jordan
- Volunteers
- 5,540 people
- Sponsor
- Jordan Collaborating Cardiology Group
Low Risk (0-10% Chance) of Developing Cardiovascular Disease Within 10 Years Based on Risk Factors, Moderate Risk (10-20% Chance) of Developing Cardiovascular (Heart) Disease Within 10 Years Based on Risk Factors
Interactive Cholesterol Advisory Tool
The purpose of this study is to show that we can effectively deliver health information and education, online, via computer regarding cholesterol. This computer program is called the Interactive Cholesterol Advisory Tool (ICAT).
- Trial name
- ICAT (NCT01890031)
- Testing
- Interactive Cholesterol Advisory Tool, Study physician visits
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Insomnia, Posttraumatic Stress Disorder
An Evaluation of Insomnia Treatment to Reduce Cardiovascular Risk in Patients With Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a chronic, debilitating psychiatric disorder that is associated with an increased risk of death due to cardiovascular disease (CVD). Most individuals with PTSD also have Insomnia Disorder.
- Conditions
- Insomnia, Posttraumatic Stress Disorder, Cardiovascular Risk Factor
- Trial name
- NCT04498754
- Testing
- Cognitive Behavior Therapy for Insomnia, Weekly phone contacts
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Duke University
Covid19, Kidney Transplant Infection
Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience From the Middle East
Methods: Out of 2000 kidney transplant recipients in our center in Kuwait, collecting data was started for all COVID-19-positive kidney transplant recipients till August 2020.
- Conditions
- Covid19, Kidney Transplant Infection, Risk Factor, Cardiovascular, Immunosuppression
- Trial name
- OMC-KTR (NCT04542954)
- Testing
- Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience from the Middle East
- Where
- Kuwait
- Volunteers
- 104 people
- Sponsor
- Hamid Al-Essa Organ Transplant Center
Thrombosis
Risk Factors of Neonatal Thrombosis
The incidence of symptomatic thrombosis is between 2.4 and 6.8 per 1000 neonatal intensive care unit admission while it is 5.1 per 100 000 live births.
- Trial name
- NCT05367466
- Volunteers
- 11 people
- Sponsor
- Kırıkkale University
Obesity, Body Composition
Study of Macronutrients and Heart Disease Risk
The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on cardiovascular disease risk factors, including blood pressure (BP), body weight and composition…
- Conditions
- Obesity, Body Composition, Blood Pressure, Cardiovascular Diseases
- Trial name
- MACRO (NCT00609271)
- Testing
- low carbohydrate diet, low fat diet
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Obesity
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
This study is open to adults who are at least 18 years old and have a body mass index (BMI) of 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease.
- Trial name
- NCT06077864
- Testing
- survodutide
- Where
- 542 sites in United States, Argentina and 33 more
- Volunteers
- 5,530 people
- Sponsor
- Boehringer Ingelheim
Coronary Artery Disease, Primary Prevention
Effect of the SCOT-HEART 2 Trial on Lifestyle.
This study will recruit 400 participants who are taking part in the Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (SCOT-HEART 2) trial.
- Trial name
- NCT04156061
- Testing
- Delivery of CT scan results
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Edinburgh
Craniopharyngioma, Apoplexy
Craniopharyngioma With Tumoral Hemorrhage
Clinical data of 185 consecutive patients receiving resective operation with a pathological diagnosis of craniopharyngioma in our hospital between January 2013 and February 2021 were collected.
- Trial name
- NCT04937335
- Testing
- intratumoral hemorrhage
- Volunteers
- 185 people
- Sponsor
- Tongji Hospital
Cardiovascular Disease
Cardiovascular Prophylaxis for Postmenopausal Women
The purpose of this study was to examine the effect of 6 months moderate intensity exercise training completed three times per week upon traditional and emerging cardiovascular disease risk factors in postmenopausal women both…
- Trial name
- NCT01219725
- Testing
- Exercise training
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Hypercholesterolemia, Cardiovascular Risk Factor
Effects of 6 Weeks TOTUM-070 on Lipid Metabolism and Cardiovascular Health in Individuals at Increased Cardio-metabolic Risk
This clinical study aims to assess the efficacy of 6 weeks 2.5g dose of TOTUM-070, a mix of 5 plant extracts, on lipid metabolism and cardiovascular health in individuals at increased cardio-metabolic risk.
- Conditions
- Hypercholesterolemia, Cardiovascular Risk Factor, Dyslipidemias, Atherosclerosis
- Trial name
- OLALIP (NCT05594979)
- Testing
- TOTUM-070
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Adrenal Gland Hyperfunction, Cardiovascular Disease
Heart Disease Risk Factors in Major Depression
A series of studies in patients with major depression have consistently demonstrated a doubling of the mortality rate at any age, independent of suicide.
- Conditions
- Adrenal Gland Hyperfunction, Cardiovascular Disease, Involutional Depression
- Trial name
- NCT00001969
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer's Disease, Cardiovascular Risk Factors
Impact of Controlling Vascular Risk Factors on the Progression of Alzheimer's Disease
Three quarters of patients with Alzheimer's disease have at least one vascular risk factor (VRF). Vascular brain lesions are present in most Alzheimer's patients (especially older ones).
- Trial name
- COVARAD (NCT01423396)
- Testing
- optimal care of VRF, standard care
- Where
- 21 sites in France
- Volunteers
- 304 people
- Sponsor
- University Hospital, Lille
Obesity, Cardiovascular Risk Factor
Coordinating Pragmatic Primary Care Population Management for Obesity
The C3PO pilot and feasibility study uses a rigorous, mixed-method research design to provide information needed to refine and implement a technology-mediated primary care outreach intervention approach before conducting a larger…
- Trial name
- C3PO (NCT03998046)
- Testing
- Outreach Support for Weight Loss Goal Setting and Self-Weighing, Outreach Decision Support to Encourage Linkages to Intensive Community Lifestyle Interventions, Adaptive Tailoring of Information Delivery and Intensity of Primary Care Outreach Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Cardiovascular Diseases, Cardiovascular Abnormalities
Cardiovascular Risk Factors on Electrocardiographically and Hemodynamics Responses to Treadmill Exercise Test
The goal of this observational cross-sectional study is to analyze the effect of cardiovascular risk factors in healthy and asymptomatic populations.
- Conditions
- Cardiovascular Diseases, Cardiovascular Abnormalities, Healthy
- Trial name
- ERGO-RISC (NCT05987891)
- Testing
- Treadmill exercise stress test
- Where
- Brazil
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Psychotic Disorders
Improving Heart and Metabolic Health in People With Severe Mental Illness Through a Long-term Clinical Trial
Background Cardiometabolic conditions-including cardiovascular disease, type 2 diabetes, and obesity-are highly prevalent among individuals with psychotic disorders.
- Trial name
- LAGOM (NCT06781801)
- Testing
- Intervention
- Where
- 6 sites in Sweden
- Volunteers
- 650 people
- Sponsor
- Vastra Gotaland Region
Cardiovascular Diseases, Cardiovascular Risk Factor
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03680404
- Testing
- Control (Phenylephrine), Phenylephrine + Apocynin, Phenylephrine + Allopurinol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cardiovascular Diseases
Effects of Cocoa Products on Cardiovascular Disease Risk Factors
The purpose of this study is to evaluate the effects of optimized composition chocolates that include natural ingredients with demonstrated biological activity are observed cardioprotectores effects in the human.
- Trial name
- CoCD (NCT00511420)
- Testing
- Cocoa product type 1, Cocoa product type 2, Cocoa product type 3
- Where
- Spain
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Blood Pressure
Effect of a Probiotic-based Product on Blood Pressure
The aim of the present study was to examine the efficacy of a probiotic-based product on either reducing hypertension or preventing a high normal blood pressure from reaching hypertensive levels.
- Trial name
- NCT01989702
- Testing
- Fermented blueberry drink, Sachets with probiotic bacterial powder
- Where
- Sweden
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Probi AB
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