Clinical trials: Risk Reduction Behavior, open to volunteers
Ventral Hernia, Surgery
STRONG for Surgery & Strong for Life - Intensive Prehabilitation for Risk Reduction in Ventral Hernia Repair
The five risky lifestyles Smoking, Nutrition (obesity and malnutrition), risky Alcohol intake, and Physical inactivity (SNAP) are common in surgical patients and associated with worse postoperative outcomes.
- Conditions
- Ventral Hernia, Surgery, Risk Reduction, Lifestyle
- Trial name
- STRONG-Hernia (NCT06611462)
- Testing
- Prehabilitation (the STRONG programme)
- Where
- 3 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Bispebjerg Hospital
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane
Alcohol Use
Alcohol Related Risk Reduction in Veterans
This project is designed to refine and evaluate the feasibility and preliminary effectiveness of a brief, telephone-administered alcohol risk reduction intervention for Veterans.
- Trial name
- NCT06768684
- Testing
- Brief behavioral counseling
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Dementia, Alzheimer Type
Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"
The RAATE proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group.
- Trial name
- RAATE (NCT03890861)
- Testing
- Physical activity, Successful Aging
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
PreDiabetes, Adolescent Obesity
SMART GOALS for Youth With Prediabetes
The goal of this study is to compare the impact of a SMART ((specific, measurable, attainable, realistic, or timely) Goal setting protocol on body weight, metabolic parameters (Hemoglobin A1c, lipids), diet quality and physical…
- Conditions
- PreDiabetes, Adolescent Obesity, Behavior, Health, Nutritional and Metabolic Diseases
- Trial name
- NCT06067451
- Testing
- SMART GOALS Setting Tool/ Protocol
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
Suicide, Mental Health Disorder
A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide
Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death among youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be…
- Conditions
- Suicide, Mental Health Disorder, Anhedonia
- Trial name
- NCT05920252
- Testing
- Vira, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Ksana Health
Drug Use Disorders, PrEP Uptake
Reducing Co-occurring Substance Use and HIV Risk Among Stimulant-using Men at High Risk for HIV in the United States of America.
This intervention will focus on stimulant-using men at high risk for HIV who are in need of tailored behavioral interventions to mitigate co-occurring stimulant use and HIV risk in the era of pre-exposure prophylaxis (PrEP).
- Conditions
- Drug Use Disorders, PrEP Uptake, PrEP Adherence, HIV Risk Behavior
- Trial name
- NCT07281378
- Testing
- Tailored Positive Affect Intervention, Contingency Management
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Florida
Resilience, Mental Toughness
Evaluation of a Group-based, Skills Training for Increasing Mental Toughness
The goal of the Life Force study is to (1) evaluate the efficacy of targeted, skills-based training for enhancing mental toughness and mitigating harmful and high-risk behaviors in active-duty Soldiers, and (2) to determine who…
- Trial name
- NCT07050238
- Testing
- Life Force
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
HIV Antiretroviral Therapy (ART) Adherence, Alcohol Abuse
Reducing Hazardous Alcohol Use and Optimizing Treatment as Prevention Among Men Living With HIV in Risk Environments
The investigators developed the Kisoboka ("It is possible") Intervention to address limitations of existing evidence-based interventions to optimize treatment as prevention among men living with HIV who drink alcohol at hazardous…
- Conditions
- HIV Antiretroviral Therapy (ART) Adherence, Alcohol Abuse, HIV Infection, Alcohol Use Disorder
- Trial name
- Kisoboka (NCT06771843)
- Testing
- Kisoboka, Behavioral Economics, Motivational Interviewing
- Where
- Uganda
- Volunteers
- 716 people
- Sponsor
- San Diego State University
Smoking
A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse
This study evaluates the efficacy and safety of brenipatide when compared to placebo for reducing the risk of relapse to cigarette smoking in adults who have recently quit.
- Trial name
- RENEW-Smk-1 (NCT07223840)
- Testing
- Brenipatide
- Where
- 29 sites in United States, China and 1 more
- Volunteers
- 222 people
- Sponsor
- Eli Lilly and Company
Mental Health Wellness, Family Research
Health Without Barriers/Salud Sin Barreras
The goal of this study is to address a key health inequity - lack of community access to evidence-based programs to prevent chronic health conditions (e.g., Type 2 Diabetes) - by tailoring and delivering a family-based lifestyle…
- Conditions
- Mental Health Wellness, Family Research, Lifestyle Risk Reduction
- Trial name
- NCT06052943
- Testing
- Mindfulness-Based Intervention, Parent Education, Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Hypertension (HTN)
Assessing the Feasibility of the "Heart Care Pairs" Intervention
The researchers will invite 30 patients in primary care who have high blood pressure to participate in this health program with a supportive partner of their choosing (these will be the "participant pairs").
- Trial name
- NCT07760350
- Testing
- Dyadic lifestyle intervention for CVD risk reduction
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Alabama at Birmingham
Stroke
Reduction of Recurrence of Stroke by Nurse-led Education in Bangladesh
Stroke is a major public issue that can be occurred a patient with severe and unbearable disability for a long time. Recurrence of stroke is increasing due to a lack of knowledge and compliance with treatment regarding the…
- Trial name
- NCT05520034
- Testing
- Health Education
- Where
- Bangladesh
- Volunteers
- 432 people
- Sponsor
- Hiroshima University
Osteopenia, Osteoporosis
Exercise and Fall Prevention for Fracture Reduction
According to the current guideline of the German Osteology Association (DVO), pharmacological treatment is a cornerstone of osteoporosis-related fracture prevention, effectively increasing bone mineral density and reducing…
- Conditions
- Osteopenia, Osteoporosis, High Fall Risk
- Trial name
- OsteoApp (NCT07897929)
- Testing
- Guideline-based home exercise training
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Wolfgang Kemmler, PhD
Type 2 Diabetes Risk Reduction in Young Adults
Holistic Lifestyle mHealth Intervention for Risk Reduction of Type 2 Diabetes Mellitus in Young Adults
The goal of this clinical trial (randomized controlled trial) is to examine the effectiveness of a holistic lifestyle mHealth intervention in reducing the risk of type 2 diabetes mellitus.
- Trial name
- NCT07604012
- Testing
- Holistic mHealth Intervention
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fatima Jinnah Women University
LGBTQ, Racial Disparities
Lakota Family Acceptance Project Pilot RCT
Although research documents the concerning rates of mental and behavioral health problems (e.g., substance use/initiation) among Indigenous LGBTQ2S+ youth, there is very little known about how to prevent these deleterious issues…
- Conditions
- LGBTQ, Racial Disparities, Family Relationships, Minority Stress
- Trial name
- L-FAP (NCT07865858)
- Testing
- Adapted Lakota Family Acceptance Program
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Fetal Alcohol Spectrum Disorders, Pregnancy
CARRII Native Intervention Optimization Trial
The purpose of this study is to identify the best combination of new intervention components to use with CARRII, the first automated online intervention for alcohol-exposed pregnancies (AEP).
- Conditions
- Fetal Alcohol Spectrum Disorders, Pregnancy, Alcohol-Related Disorders, Drinking, Alcohol
- Trial name
- NCT07547696
- Testing
- CARRII Native Cores
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Metabolic Syndrome, Obesity Prevention
"Improving Health and Reducing Chronic Disease Risk in Middle-Aged Adults Through Nutrition"
The goal of this clinical trial is to evaluate the effect of a multifactorial lifestyle intervention combining Mediterranean diet, energy reduction and physical activity on weight loss in middle-aged adults (men and women 30-50…
- Conditions
- Metabolic Syndrome, Obesity Prevention, Obesity and Overweight
- Trial name
- NUTRI-M-Care (NCT06857929)
- Testing
- energy reduced Mediterranean diet (25% caloric restriction) plus physical activity program, Usual Care
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- IMDEA Food
Stigma, Social, Drug Abuse Illicit
Lower Intersecting HIV-related Stigmas to Facilitate Treatment as Prevention (LIFT)
The purpose of this study is to reduce HIV transmission risk among people who inject drugs (PWID) through a multilevel intervention known as LIFT.
- Conditions
- Stigma, Social, Drug Abuse Illicit, HIV (Human Immunodeficiency Virus)
- Trial name
- LIFT (NCT07541131)
- Testing
- LIFT for People Who Use Drugs, LIFT for MMT Providers
- Where
- Kyrgyzstan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Kidney Transplant Recipients
Exercise and Diet Effects in Reducing Cardiovascular Risk in Kidney Transplant Recipients
The goal of this clinical trial is to assess whether, over an observation period of 3 years, there is a reduction in cardiovascular risk, and the extent of this reduction, in a group of adult kidney transplant patients undergoing…
- Trial name
- KT-LIFESTYLE (NCT06806670)
- Testing
- lifestyle intervention
- Where
- Italy
- Volunteers
- 275 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna