Clinical trials: Risk Stratification
Renal Injury, Acute
Acute Kidney Injury : Long-term Renal and Cardiovascular Prognosis and Biomarker-based Risk Assessment
Patients who develop severe acute kidney injury (AKI) in intensive care remain at increased long-term risk of mortality, major cardiovascular events, and chronic renal complications, including prolonged dependence on renal…
- Trial name
- AKIRA (NCT07596407)
- Where
- France
- Volunteers
- 412 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Disease
Evaluation of Non-invasive Measurements of Atherosclerosis in Cardiovascular Risk Stratification
Multiple risk factors contribute to atherosclerosis, which ultimately results in clinical manifestation of cardiovascular disease.
- Trial name
- NIMA (NCT01555294)
- Where
- Netherlands
- Volunteers
- 1,960 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Acute Coronary Syndrome
TnThs for Identification Myocardial Infarction
OBJECTIVES/BACKGROUND: We sought to determine the early diagnostic value of the new high sensitive cardiac troponin T assay (TnThs) in suspected acute coronary syndrome (ACS) and to compare it with the 4th generation cTnT assay…
- Trial name
- NCT00950469
- Where
- Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Osteoporosis
Changes in Bone Mineral Density and Fracture Risk in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer
The aim of this study is to determine the long term effects of two types of hormonal treatment for advanced prostate cancer (LHRH agonists and the antiandrogen bicalutamide)on the bone mineral density of patients.
- Trial name
- NCT00536653
- Testing
- Bicalutamide and Calcium/ Vitamin D supplementation, LHRH agonists (Goserelin acetate) and Calcium/ Vitamin D supplementation, LHRH agonists (Goserelin acetate)
- Where
- United Kingdom
- Volunteers
- 618 people
- Sponsor
- Wirral University Teaching Hospital NHS Trust
Prostate Cancer (Diagnosis), Clinically Significant Prostate Cancer
Multimodal Imaging and Digital Pathology for Prostate Cancer Prediction
This is a multicenter observational study. A deep learning model integrated with multimodal imaging and digital pathology spatial registration is built based on preoperative multiparametric magnetic resonance imaging, transrectal…
- Trial name
- NCT07614256
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangxi Medical University
Penicillin Allergy
Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting
Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic.
- Trial name
- NCT03702283
- Testing
- Penicillin Allergic Risk Stratification Best Practice Alert
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Acute Heart Failure (AHF), Congestive Heart Failure(CHF)
Evaluating Residual Congestion at Discharge in Acute Heart Failure Patients
Treatment of congestion is one of the main goals in patients hospitalized for acute heart failure. Nevertheless, current evidence shows that decongestion is often not achieved and that residual congestion at discharge is strongly…
- Trial name
- NCT06993220
- Testing
- Evaluation of residual congestion at discharge
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Consorci Sanitari Integral
Ventricular Tachycardia, Ventricular Arrythmia
Better Mechanistic Understanding of and Risk Stratification for Ventricular Tachyarrhythmias Through ECGI
This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with (increased risk of) ventricular tachyarrhythmias (VTA) and sudden cardiac arrest, and in a control cohort.
- Conditions
- Ventricular Tachycardia, Ventricular Arrythmia, Ventricular Fibrillation, Polymorphic Ventricular Tachycardia
- Trial name
- BREACH-ECGI (NCT04548804)
- Testing
- ECG-Imaging
- Where
- 2 sites in Netherlands
- Volunteers
- 270 people
- Sponsor
- Maastricht University Medical Center
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Metabolic Syndrome, Diabetes
Biomarkers of Metabolic Syndrome and Prediabetes
The purpose of this study is to investigate the feasibility of using salivary biomarkers to screen for complications of metabolic syndrome including prediabetes.
- Conditions
- Metabolic Syndrome, Diabetes, Prediabetes, Hypertension
- Trial name
- NCT01086137
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- West Virginia School of Osteopathic Medicine
Triage Risk Stratification
Triage - Symptoms and Other Predictors in an All-comer Emergency Department Population; (EKBB 236/13)
This study is to develop a tool capable of improved risk prediction regarding the 30-day mortality. Based on vital signs, impaired mobility on presentation (IMOP), Clinical Frailty Scale (CFS) and patients' symptomatology three…
- Trial name
- EMERGE IV (NCT03892551)
- Testing
- Assessment of symptoms patients presenting when admitted to ED, Reason for patient presentation at ED, physicians rating of severity of illness
- Where
- Switzerland
- Volunteers
- 7,309 people
- Sponsor
- University Hospital, Basel, Switzerland
Copd Exacerbation Acute, Readmission
Identification of Patients Admitted With COPD Exacerbations and Predicting Readmission Risk Using Machine Learning
Patients with Chronic Obstructive Pulmonary Disease (COPD) who are admitted to hospital are at high risk of readmission. While therapies have improved and there are evidence-based guidelines to reduce readmissions, there are…
- Conditions
- Copd Exacerbation Acute, Readmission, Machine Learning, Natural Language Processing
- Trial name
- NCT04192175
- Where
- Canada
- Volunteers
- 65,000 people
- Sponsor
- University Health Network, Toronto
Endometrial Cancer
Preoperative Risk Stratification in Endometrial Cancer for Tailoring Lymph Node Staging
The goal of this observational study is to evaluaty the accuracy of current risk stratification of patients with endometrial cancer and to redefine lymph node staging recommendations based on real-world clinical data.
- Trial name
- PRSTEC_multipr (NCT07368205)
- Testing
- No Intervention: Observational Cohort
- Where
- Czechia
- Volunteers
- 350 people
- Sponsor
- University Hospital Hradec Kralove
Orbital Neoplasms
Risk Stratification of Orbital Tumors Based on MRl and Artificial Intelligence
Orbital tumors can be categorized into benign and malignant tumors, and there are significant variations in their biological behavior, treatment, and prognosis.
- Trial name
- NCT06336499
- Testing
- Multi-parametric MRI and image analysis by deep learning or machine learning algorithms
- Volunteers
- 600 people
- Sponsor
- Beijing Tongren Hospital
Heart Failure, Morality
Optimized Peak VO2 in Predicting Advanced HF
The ability and timely selection of severe heart failure (HF) patients for cardiac transplantation and advanced HF therapy is challenging. Peak VO2 by cardiopulmonary exercise test (CPET) was used for transplant listing.
- Conditions
- Heart Failure, Morality, Transplant; Failure, Heart
- Trial name
- NCT05212649
- Testing
- cardiopulmonary exercise test
- Where
- Taiwan
- Volunteers
- 377 people
- Sponsor
- Chang Gung Memorial Hospital
Myocardial Infarction, Ventricular Tachycardia
Risk Stratification of VT / VF After Myocardial Infarction Based on Cardiac MRI 2
Implantable cardioverter-defibrillators (ICD) are currently recommended (ESC guidelines 2015) for the primary prevention of sudden cardiac death (SCD) in patients with a remote myocardial infarction (MI) and a low (≤35%) left…
- Conditions
- Myocardial Infarction, Ventricular Tachycardia, Ventricular Fibrillation
- Trial name
- TVScreen-2 (NCT05226234)
- Testing
- MRI
- Where
- France
- Volunteers
- 275 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Atherosclerosis
Evaluation of Subclinical COronary Atherosclerosis for Risk Stratification Using Coronary Computed Tomography (CT) Angiography
To evaluate the prognostic value of coronary CT angiography (CCTA) for risk stratification in asymptomatic adults in comparison with conventional risk stratification (CRS) and coronary artery calcium scoring (CACS).
- Trial name
- ESCORT (NCT01416532)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Seoul National University Bundang Hospital
Prenatal Disorder, Premature Birth
Develop a Multi-disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies
Different screening modalities evaluation to develop algorithms to predict pregnancy complications in twin pregnancies, and evaluation of serologic response to BNT162b2 Pfeizer/BioNTech vaccination.
- Conditions
- Prenatal Disorder, Premature Birth, Twin Pregnancy With Antenatal Problem, Twin; Pregnancy, Affecting Fetus or Newborn
- Trial name
- PRETWINSCREN (NCT04595214)
- Testing
- TTTS cases are treated by intra-uterine laser for separation.
- Where
- 7 sites in Belgium, Canada and 4 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Covid19, Cardiovascular Risk Factor
Cardiovascular Risk Stratification in Covid-19
This retrospective double-cohort study seeks to: 1. Describe the cardiovascular manifestations and electrophysiological (EP) substrate in COVID-19 infection and their association with clinical outcomes; and 2.
- Trial name
- CaVaR-Co19 (NCT04555187)
- Where
- United States
- Volunteers
- 1,355 people
- Sponsor
- Oregon Health and Science University
Lung Neoplasm, Thoracic Surgical Procedures
Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients
This multicenter prospective clinical study focuses on elderly patients with lung cancer. The investigators will build a standardized clinical registry database, develop perioperative risk stratification and surgical…
- Conditions
- Lung Neoplasm, Thoracic Surgical Procedures, Perioperative Care, Postoperative Rehabilitation
- Trial name
- NCT07632664
- Testing
- Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling, Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling, Pulmonary Wedge Resection plus Mediastinal Lymph Node Sampling
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital