Clinical trials: Risk for Colorectal Cancer
Anastomotic Leak, Colorectal Cancer
Anastomotic Leakage After Colorectal Surgery.
Anastomotic leakage (AL) is a severe complication after colorectal surgery, with incidence rates of 2-30%. This prospective, single-center observational cohort study aims to identify and quantify independent risk factors for AL…
- Conditions
- Anastomotic Leak, Colorectal Cancer, Diverticulitis
- Trial name
- AL (NCT07144683)
- Testing
- Patients Undergoing Colorectal Resection with Anastomosis
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Breast Cancer Risk, Ovarian Cancer Risk
Population Based Germline Testing for Early Detection and Prevention of Cancer
PROTECT-C is a research study offering genetic testing to people to see whether they have a genetic change that increases their risk of breast, ovary, bowel, and/or womb cancer.
- Conditions
- Breast Cancer Risk, Ovarian Cancer Risk, Cancer Gene Mutation
- Trial name
- PROTECT-C (NCT07498829)
- Testing
- Genetic testing for Cancer Susceptibility Genes (CSGs) (BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2, MLH1, MSH2, MSH6) and personalised breast and ovarian cancer risk
- Where
- United Kingdom
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Colorectal Cancer
A Patient Portal Tool, E-assist, for Supporting CRC Screening
To compare patient perceptions, intent to screen, and screening use among those using a patient portal with and without a colorectal cancer (CRC) screening decision support tool, e-assist.
- Trial name
- NCT02798224
- Testing
- e-assist: Colon Health, Healthwise Educational Program
- Where
- United States
- Volunteers
- 1,826 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Rectal Cancer, Colorectal Cancer
Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer
The purpose of this study is to demonstrate the functionality of a novel endorectal photoacoustic ultrasound imaging modality in humans with rectal cancer.
- Trial name
- NCT04339374
- Testing
- Photoacoustic imaging, photoacoustic microscopy, Endorectal photoacoustic imaging probe, Reader Performance
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
Rectal Cancer, Neoadjuvant Chemotherapy
Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer
To compare the pathological effect between 2 cycles and 4 cycles of Capox regimen as neoadjuvant chemotherapy for low/ intermediate risk stage II/III rectal cancer.
- Trial name
- COPEC (NCT04922853)
- Testing
- Capox chemotherapy
- Where
- 4 sites in China
- Volunteers
- 554 people
- Sponsor
- West China Hospital
Colorectal Polyp, Colorectal Cancer Recurrent
Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy
The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated.
- Conditions
- Colorectal Polyp, Colorectal Cancer Recurrent, Colorectal Adenoma
- Trial name
- NCT06957626
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer, Anaesthesia
Cardiopulmonary Exercise Testing and Preoperative Risk Stratification
The investigators would like to evaluate the use of cardiopulmonary exercise tests (CPX) in guiding the care pathway of patients undergoing colorectal operations.
- Conditions
- Colorectal Cancer, Anaesthesia, Critical Illness
- Trial name
- NCT00737828
- Testing
- Perioperative care pathway guided by CPX results
- Where
- 3 sites in United Kingdom
- Volunteers
- 228 people
- Sponsor
- University College London Hospitals
Rectal Cancer
ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer
The goal of this clinical trial is to investigate whether adjuvant chemotherapy can prevent disease recurrence in patients with high-risk rectal cancer who have detectable ctDNA after surgery.
- Trial name
- REACT (NCT07188025)
- Testing
- Adjuvant chemotherapy
- Where
- 25 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Colorectal Cancer
Folate-Depleted Diet Compared With Folate-Supplemented Diet in Preventing Colorectal Cancer in Patients at High Risk for Colorectal Cancer
RATIONALE: Chemoprevention therapy is the use of certain agents to try to prevent the development of cancer. The use of folic acid may be effective in preventing colorectal cancer.
- Trial name
- NCT00096330
- Testing
- dietary intervention, folic acid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Colon Cancer
A Prospective Study for the Assessment of Recurrence Risk in Stage II Colon Cancer Patients Using ColoPrint
The aim of this study is to enroll 785 eligible stage II colon cancer patients in order to validate the performance of ColoPrint in estimating 3-year relapse rate.
- Trial name
- PARSC (NCT00903565)
- Where
- 35 sites in United States, Austria and 10 more
- Volunteers
- 1,200 people
- Sponsor
- Agendia
Colorectal Cancer, Wound Infection
Comparing PP and PVDF Meshes in Midline Laparotomy Closure for High-risk Colorectal Surgery. Impact on Incisional Hernia and Surgical Wound Infection.
In the latest guidelines for abdominal wall closure in emergency surgery published in the World Journal of Emergency Surgery (WJES) in 2023, no specific recommendations are made in this regard.
- Conditions
- Colorectal Cancer, Wound Infection, Hernia Incisional
- Trial name
- PROFIMESH (NCT06220045)
- Testing
- Polyvinylidene fluoride mesh, Prophylactic polypropylene mesh
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Breast Cancer, Lung Cancer
Predicting Cancer Risk With Digital and Molecular Markers
The goal of this study is to identify new markers to predict the risk of developing cancer, primarily breast cancer. For this purpose, researchers will compare data obtained from cancer patients and healthy individuals.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Gynecologic Cancer
- Trial name
- PräDigt (NCT06962670)
- Testing
- Biomaterial collection, BayPass mobile application
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Colorectal Cancer
Risk Factors for Residual Neoplasia After Endoscopic Mucosal Resection
Laterally Spreading Tumors (LST) are important precursosrs of invasive colorectal cancer. Endoscopic treatment has replaced surgery in most of the cases.
- Trial name
- NCT01478919
- Where
- Czechia
- Volunteers
- 127 people
- Sponsor
- Vitkovice Hospital
Rectal Cancer, Rectal Adenocarcinoma
SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer
The purpose of this prospective, observational, multicenter study is to evaluate the impact of adjuvant radiotherapy or chemoradiotherapy on disease-free survival (DFS) in patients with pathological T1 (pT1) rectal cancer…
- Conditions
- Rectal Cancer, Rectal Adenocarcinoma, Rectal Cancer Patients, Rectal Cancer, Radiotherapy
- Trial name
- SCARLET (NCT07695519)
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer Screening
Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure
This study is designed to determine the optimal bowel preparation regimen for PillCam® COLON 2 Capsule Endoscopy System (CCE) procedures in average risk patients.
- Trial name
- NCT02481219
- Testing
- PillCam® COLON 2 procedure-CONTROL, Senna tablets, PEG
- Where
- 6 sites in United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Colorectal Cancer, Adenomatous Polyps
Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China
The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed multitarget FIT-DNA Colorectal Cancer (CRC) screening test (ColoClear) for detecting advanced neoplasia (including colorectal…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- CLEAR-C (NCT04287335)
- Testing
- Multitarget stool FIT-DNA test - ColoClear, FIT, Colonoscopy
- Where
- 8 sites in China
- Volunteers
- 4,758 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Inflammation, Prevention and Control
Effect of High-Legume Diet on Colorectal Cancer Risk
This study, sponsored by the National Cancer Institute and Penn State University, will examine how a diet high in legumes (dried beans) influences risk factors for colon cancer and polyps.
- Conditions
- Inflammation, Prevention and Control, Colonic Neoplasms, Diet
- Trial name
- NCT00339469
- Testing
- LIFE
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer (CRC), Microbiome
CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths globally, with increasing incidence rates. While predominantly affecting older adults, CRC cases among individuals under 50 (early-onset CRC, or EoCRC)…
- Conditions
- Colorectal Cancer (CRC), Microbiome, Early Onset Colorectal Cancer
- Trial name
- CARE-CRC (NCT06734156)
- Testing
- No intervention: observational study
- Where
- 2 sites in Portugal
- Volunteers
- 400 people
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Coronary Heart Disease, Stroke
Evaluating Tools for Health Promotion and Disease Prevention
The study will evaluate the effect of familial risk assessment and prevention prompts tailored to familial risk on health behaviors and use of preventive services among adults who are members of primary care practices in the U.S.
- Conditions
- Coronary Heart Disease, Stroke, Diabetes, Breast Cancer
- Trial name
- NCT00164658
- Testing
- Familial risk assessment and personalized prevention messages
- Where
- 3 sites in United States
- Volunteers
- 8,400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Colo-rectal Cancer
Iconographies for Risk Communication and Reduction of Patient's Anxiety in a Colorectal Cancer Screening Program
Background: Participants in the colon and rectal cancer (CRC) screening program that have a positive result in the Fecal Immunological Test (FIT) are visited by the screening nurse who explains the meaning of the positive test…
- Trial name
- NCT03884868
- Testing
- Iconographies to communicate risks
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Corporacion Parc Tauli