Clinical trials: Risk of Disability
Down Syndrome, Physical Inactivity
Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome
The investigators are assessing acceptability, appropriateness, and feasibility of an remote choreographed exercise intervention using validated scales alongside qualitative data among young adults with Down Syndrome.
- Trial name
- DANCE-DS (NCT06537648)
- Testing
- Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Microcephaly, Mental Retardation
Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
This prospective cohort study will determine the natural history of fetal exposure to Zika virus (ZIKV) and its effects on the fetus and newborn with emphasis on neurodevelopment outcome.
- Trial name
- ZENI (NCT02943304)
- Testing
- Symptomatic pregnant women with positive RT-PCR ZIKV in serum or urine, or a positive serologic test specific for ZIKV
- Where
- Colombia
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Universidad Industrial de Santander
Mental Disability, Mothers
The Effect of Home Accidents Prevention Training Given to Mothers of Mentally Disabled Children
The aim of this research is to examine the effect of education for home accidents given to mothers with mentally disabled children in the age group of 0-6.
- Conditions
- Mental Disability, Mothers, Home Injury
- Trial name
- NCT06633549
- Testing
- Home Accidents Prevention Training, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Tooth Decay, Intellectual Disability
Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial.
The goal of this randomized clinical trial is to test the effect orally administration of Probiotics based on Lactobacillus rhamnosus LR04 and Lactobacillus plantarum LP14 as adjuvant in caries prevention in subjects who can not…
- Conditions
- Tooth Decay, Intellectual Disability, Caries,Dental
- Trial name
- NCT06063239
- Testing
- Test Group, Positive Control, Negative Control
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- G. d'Annunzio University
Cerebral Palsy, Cerebral Palsy (CP)
Assessing Intellectual and Motor Outcomes in High-risk Infants
Cerebral palsy (CP) is a condition when a baby has a brain injury that affects their movement and muscle tone. Some people with CP can have other developmental issues, like learning impairments, but many do not and have isolated…
- Conditions
- Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Children, High-risk Infants
- Trial name
- AIM-High (NCT06857539)
- Where
- 4 sites in Ireland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College Cork
Intellectual and/or Physical Disabilities, Dental Treatment Under General Anesthesia
Retrospective Database Study: Survival of Direct Composite Restorations Placed Under General Anesthesia in Adult Patients With Intellectual and/or Physical Disabilities and Risk Factors for Repeated Dental Treatment in General Anesthesia
The aim of this study is to assess the survival of direct anterior and/or posterior composite restoration placed in general anesthesia in permanent teeth of adult patients with intellectual and/or physical disabilities.
- Trial name
- NCT04407520
- Testing
- No patient treatment is associated with the study
- Volunteers
- 101 people
- Sponsor
- University of Göttingen
Suicidal Ideation
Improving Caregivers' Ability to Manage Life Stress
The COVID-19 pandemic has led to increased caregiving demands for caregivers of Veterans with dementia. Dementia caregivers are particularly at-risk for depression and anxiety, known risk factors for increased suicidality.
- Trial name
- NCT05539352
- Testing
- Problem Solving Therapy (PST) plus EUC
- Where
- United States
- Sponsor
- VA Office of Research and Development
Learning Disorders
Risk and Resilience Factors in Learning Disabilities Population
The purpose of this study is to report preliminary outcomes of executive function and psychopathology symptoms of a manual-based psychological intervention for adolescents diagnosed with learning disorders- I can succeed (ICS).
- Trial name
- NCT01652651
- Testing
- I Can Succeed ICS
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
The purpose of this research is to support the clinical value of the Cionic Neural Sleeve for individuals diagnosed with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
- Trial name
- NCT05964829
- Testing
- Cionic Neural Sleeve NS-100, Walking Program
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Cionic, Inc.
Work Disability Reduction and Prevention, Improving Return-to-Work Outcomes
SMART Supervisor Training Program to Prevent Work Disability
Supervisors of injured workers play a key role in preventing prolonged work absences. Providing supervisors with tools to improve their response to musculoskeletal and other workplace injuries or illnesses may improve worker…
- Trial name
- NCT02309996
- Testing
- Supervisor Training Program
- Where
- Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Developmental Delay
Coaching in Early Development Project
Among young children, homelessness is an independent predictor of child developmental delay and disability, and children experiencing homelessness (CEH) are 2-4x more likely to demonstrate developmental delays compared to housed…
- Trial name
- NCT06347666
- Testing
- Caregiver coaching
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Illnesses, Physical Disability
Suicide Risk Scale and Distress Intervention for the Patients With Chronic Medical Illness or Physical Disabilities
The aims of this study are developments of distress intervention and a suicidal risk scale for the patients with chronic medical illness or physical disabilities.
- Trial name
- NCT04441060
- Testing
- Distress intervention (CBT & Mindfulness-based program)
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Hospital
Mucopolysaccharidosis (MPS)
Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project)
Mucopolysaccharidosis (MPS) type II (MPS II; Hunter syndrome) is a rare, X-linked disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S) and occurs almost exclusively in boys, with an incidence of…
- Trial name
- NCT02095015
- Where
- 14 sites in United States, Canada and 5 more
- Volunteers
- 159 people
- Sponsor
- Shire
Autistic Disorder
Proteomic Biomarker Tests in Blood Samples from Children with Autism Spectrum Disorder (ASD)
Behavioral testing is the gold standard for diagnosing autism spectrum disorder (ASD). These tests, including ADOS and ADI-R, are subjective, require trained staff to administer, are time-consuming, and can only be administered…
- Trial name
- NCT02168868
- Testing
- Blood draw, Stool Sample Collection, Urine Sample Collection
- Where
- Israel
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Benjamin Gesundheit
Physical Disability
On the Move: Optimizing Participation in Group Exercise
Community-dwelling older adults fear loss of independence and nursing home placement more than death. Walking difficulty often leads to loss of independence.
- Trial name
- OTM-PCORI (NCT01986647)
- Testing
- On the Move exercise - exercise leader, Standard program - exercise leader, On the Move exercise - staff activity personnel
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Typical Development, Risk of Dysgraphia
Graphomotor Intervention Program for Handwriting Difficulties Prevention in Preschool Age
12-30% of children present handwriting difficulties, which has negative repercussions on their school career. For this reason, it is fundamental to bet on their prevention.
- Conditions
- Typical Development, Risk of Dysgraphia, Dysgraphia
- Trial name
- NCT03699787
- Testing
- Graphomotor intervention program
- Where
- Portugal
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Évora
Hospitalized, Older Adults
Impact of Physical Exercise on Hospitalized Older Adults Malnourished or at Risk, With Oral Nutritional Support
The aim of this research is to analyze whether nutritional intervention combined with a multicomponent physical training program based on strength, balance, and aerobic exercises can prevent disability caused during…
- Conditions
- Hospitalized, Older Adults, Physical Exercise, Oral Nutritional Supplementation
- Trial name
- NUTPHYS (NCT07067697)
- Testing
- Physical exercise, Usual Care
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Fundacion Miguel Servet
Pediatric ALL, Infant Development
PANDA Gym: Automated Assessment of Neurodevelopment in Infants at Risk for Motor Disability
Early childhood detection of motor delays or impairments provides the opportunity for early treatment which improves health outcomes.
- Conditions
- Pediatric ALL, Infant Development, Neurodevelopmental Disorders
- Trial name
- NCT04321200
- Testing
- PANDA Gym, Mobile App
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sarcopenia, Gait Disorders in Old Age
A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT)
The main objective of the study is to evaluate the effect of two daily doses of BIO101 versus placebo on mobility function as measured by gait speed using the 400MW test.
- Conditions
- Sarcopenia, Gait Disorders in Old Age, Muscle Weakness
- Trial name
- SARA-INT (NCT03452488)
- Testing
- BIO101
- Where
- 22 sites in United States, Belgium
- Volunteers
- 233 people
- Sponsor
- Biophytis
Developmental Delay, Cerebral Palsy
Mobility Training to Improve Motor Behavior in Toddlers With or at Risk for Cerebral Palsy: A Pilot Study
Background: People who have cerebral palsy often have difficulty walking and moving their legs. Cerebral palsy is sometimes not identified until a child is almost 2 years of age, which means that early motor skill development can…
- Trial name
- NCT01253083
- Testing
- mobility training with dynamic body weight support
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)