Clinical trials: Risk-Taking, open to volunteers
Risk Behavior, Alcohol Use Disorder
TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk
Ecological momentary interventions (EMI), which use phones to deliver messages to reduce alcohol use and related risk behaviors during or prior to drinking events, can help to address triggers in real-time.
- Conditions
- Risk Behavior, Alcohol Use Disorder, HIV Infections
- Trial name
- TRAC-ER (NCT05576350)
- Testing
- Smartphone Based Alcohol Monitoring (SAM), Tracking and Reducing Alcohol Consumption (TRAC), TRAC-ER
- Where
- 2 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Mild Traumatic Brain Injury, Suicidal Ideation
Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury
The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicidal Ideation, Impulsivity
- Trial name
- NCT05647044
- Testing
- intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Suicidal Ideas, Suicidal Ideation
Exploratory Analysis of Interpersonal and Intrapersonal Psychological Processes Implied in Risk-taking and Suicidal Behaviors, in Adult and Adolescent At-risk
In a recent report, Santé Publique France (2023), reported that 4.2% of 18-85 year-olds had thought about suicide in the last 12 months, and 6.8% had attempted suicide in their lifetime and 0.5% in the last year.
- Conditions
- Suicidal Ideas, Suicidal Ideation, Risk-taking
- Trial name
- RISKY (NCT06921226)
- Testing
- Psychological Processes, Risk-taking variables, Suicidal ideation and behavior
- Where
- 3 sites in France
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Insomnia, Impulsivity
Effects of CBT-I on Impulsivity and Risk Taking in Youths With Insomnia
Insomnia is prevalent in adolescents. Impulsive behaviours and excessive risk-taking have been linked to the manifestation of psychopathology in youths.
- Conditions
- Insomnia, Impulsivity, Risk-Taking
- Trial name
- NCT07399964
- Testing
- Cognitive Behavioural Therapy for Insomnia, Health-related Psychoeducation
- Where
- Hong Kong
- Volunteers
- 124 people
- Sponsor
- The University of Hong Kong
Young-onset Dementia
YOD-RiSoCo: Social Cognition and Risk-taking Behaviour in Patients with Young-onset Dementia
The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD).
- Trial name
- YOD-RiSoCo (NCT06286293)
- Testing
- Neuropsychological assessment, driving simulator task
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Communication, Message Perception
Messages That Motivate: Communicating Alcohol-Related Breast Cancer Risk to Young Adult Women
This is an online cross-sectional experimental survey study examining two cancer communication questions: 1) What features of social media messages communicating the breast cancer risks from alcohol consumption will motivate…
- Conditions
- Communication, Message Perception, Alcohol, Cancer Prevention
- Trial name
- MEMO (NCT07802054)
- Testing
- Risk Message, Efficacy Message, Industry Deception
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Depression - Major Depressive Disorder
Understanding the Neural Underpinnings of Risk-Taking Behavior in Psychiatric Disease
The purpose of this study is to understand how the orbitofrontal cortex (OFC), a region at the front of the brain, guides decisions about whether to pursue a possible reward when doing so also carries a risk of loss, and how this…
- Trial name
- NCT07896343
- Testing
- Approach-Avoidance Decision-Making Task
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Gambling Disorder
Contingency Management as an Adjunct Treatment for Rural and Remote Disordered Gamblers
The purpose of this project is to pilot contingency management as an adjunct treatment to counselling as usual using internet delivered video-conferencing applications for remote disordered gamblers.
- Trial name
- NCT02953899
- Testing
- Contingency Management, Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Lethbridge
Gambling Disorder
Virtual Reality Exposure Therapy for Gambling Disorder
Gambling disorder (GD) is recognized as an addictive disorder in the DSM-5. Craving is a core phenomenon in addiction that can lead to relapse in problem gambling for pathological gamblers.
- Trial name
- VIRET-GAD (NCT04467502)
- Testing
- cognitive-behavioral therapy for gambling disorder, imaginal exposure therapy focus on gambling cues, virtual reality exposure therapy focus on gambling cues
- Where
- 10 sites in France
- Volunteers
- 124 people
- Sponsor
- University Hospital, Lille
HIV, Risk Behavior
Project SPACE: Testing Daily Text Messages to Reduce Alcohol Use and HIV Risk Behavior
Project SPACE is a micro-randomized trial evaluating the proximal effects theory-based text messages on alcohol use and sexual HIV risk behaviors among HIV-negative young adult men at the day-level.
- Conditions
- HIV, Risk Behavior, Alcohol Abuse
- Trial name
- NCT07769580
- Testing
- CLT- Concrete text messages, CLT- Abstract text messages, Control messages
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Emory University
Behavior, Risk
Human Laboratory Study of the Effects of Nicotine Product Claims on Appeal, Perceptions, and Use Behavior
This study evaluates knowledge, feelings and thoughts regarding nicotine products among young adults who are susceptible to but do not use tobacco/nicotine and adults who use tobacco/nicotine.
- Trial name
- NCT06192316
- Testing
- 3x3 between-subjects experimental exposure
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Blood Loss, Surgical, Coagulation Disorder
Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.
The goal of this clinical trial is to learn if reltodecacog alfa (VMX-C001) works to to allow blood clotting control in participants who take FXa Direct Oral Anticoagulants (DOACs) during surgery or other invasive procedures that…
- Trial name
- EQUILIBRIX-S (NCT07288489)
- Testing
- Reltodecacog alfa, Usual Pharmacological Care
- Where
- 77 sites in United States, Australia and 16 more
- Volunteers
- 800 people
- Sponsor
- VarmX B.V.
Endometrial Cancer, Genetic Predisposition
Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors
Endometrial cancer (EC) is one of the most prevalent cancers in women worldwide with a significantly increasing incidence, especially in developed countries.
- Conditions
- Endometrial Cancer, Genetic Predisposition, Risk Behavior
- Trial name
- MPEC (NCT06680791)
- Where
- Czechia
- Volunteers
- 280 people
- Sponsor
- Lukas Vanek
Gambling Disorder
Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation
In this project the investigators propose a randomized double-blind placebo-controlled design in which 40 patients with GD will receive active or sham cTBS to the pre-SMA for 2 weeks.
- Trial name
- TMS-GD (NCT03669315)
- Testing
- Transcranial Magnetic stimulation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- CNS Onlus
Gambling Disorder, Gambling
Digital Cognitive Behavioral Therapy for Gambling Disorder
This pilot randomized controlled trial evaluates the feasibility, acceptability, and preliminary clinical effects of digital cognitive behavioral therapy (CBT) for adults with gambling disorder involving online gambling in…
- Trial name
- Indo CHIP (NCT07863440)
- Testing
- Digital Cognitive Behavioral Therapy for Gambling Disorder, Digital Family Intervention for Gambling-Related Harms, Face-to-Face Cognitive Behavioral Therapy for Gambling Disorder
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Gambling Addiction
Testing the Interplay of Gambling, Emotion and Reward
Background The nature and direction of dysfunctional reward processing in gambling disorder remains unclear. We aim to test a novel neurobiological model of gambling addiction, that takes into account inter-individual…
- Trial name
- TIGER (NCT06122298)
- Testing
- fMRI, Ecological Momentary Assessment
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Gambling Disorder
COMpulsive Gambling: Efficacy of DEEP Transcranial Magnetic Stimulation With H7 COIL
This study aims to investigate whether a treatment called high-frequency repetitive transcranial magnetic stimulation (rTMS) can help reduce the symptoms of gambling disorder and whether it is safe and well tolerated.
- Trial name
- COMET-7 (NCT07828782)
- Testing
- active r-TMS
- Volunteers
- 60 people
- Sponsor
- Sveti Ivan Psychiatric Hospital
Gambling Disorder
Effect of High-Intensity Transcranial Alternating Current Stimulation on Gambling Disorder: A Randomized Controlled Trial
The investigators assume that High-intensity transcranial Alternating Current Stimulation (HI-tACS) could improve gambling disorder patients' executive-control function by modulating abnormal neural activity, particularly…
- Trial name
- HITACSRCT-GD (NCT07228182)
- Testing
- HI-tACS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Fat Mass, Risk Factors Cardiovascular Disease
Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging
A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is…
- Conditions
- Fat Mass, Risk Factors Cardiovascular Disease, Epigenetic Aging, Metabolism Changes
- Trial name
- NCT07255300
- Testing
- fasting mimicking diet
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Fondazione Valter Longo