Clinical trials: Rocuronium
Incomplete Reversal of Neuromuscular Block
Sugammadex ED90 Dose in the Obese Patients
The purpose of this study is to determine the minimum effective dose of sugammadex, an antagonist of neuromuscular blockade used during anesthesia practice, in obese patients, considering that sugammadex is indicated in adults…
- Trial name
- NCT02568345
- Testing
- sugammadex ED90
- Volunteers
- 31 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Incidence of Postoperative Residual Curarization
Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium
Reversal of rocuronium-induced neuromuscular block by the combination of low-doses of neostigmine plus sugammadex decreases the cost of anesthetic medications, while maintaining efficacy of reversal in obese patients.
- Trial name
- NCT03328312
- Testing
- Sugammadex, neostigmine+atropine, neostigmine+atropine+sugammadex
- Volunteers
- 90 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Nondepolarising Muscle Relaxants
Effect of Ulinastatin on the Action of NDMRs (Rocuronium / Cisatracurium)
The aim of this research was to determine the influence of ulinastatin on nondepolarising muscle relaxants Rocuronium and Cisatracurium.
- Trial name
- NCT05716256
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Anesthesia
Succinylcholine or Rocuronium for Rigid Bronchoscopy Under General Anesthesia
Myorelaxation is generally used as a part of general anesthesia for interventional rigid bronchoscopy. Succinylcholine is most often used because its short duration of action but rocuronium can be used since sugammadex permits a…
- Trial name
- Broncho-SR (NCT01579864)
- Testing
- succinylcholine, rocuronium
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Hopital Foch
Anesthetics, Inhalation, Neuromuscular Blockade
Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children
Sugammadex is the first selective relaxant binding agent approved to reverse certain non-depolarizing neuromuscular drugs in patients 2 years old and above.
- Conditions
- Anesthetics, Inhalation, Neuromuscular Blockade, Anesthesia, General
- Trial name
- NCT03795259
- Testing
- Rocuronium, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Muscle Relaxation
The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weight on Reversal of Rocuronium.
The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight.
- Trial name
- NCT03381209
- Testing
- Sugammadex
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Awareness, Mechanical Ventilation
The ED-AWARENESS-2 Trial
The investigators will screen all mechanically ventilated ED patients for study eligibility and will enroll all consecutive patients satisfying inclusion and exclusion criteria.
- Conditions
- Awareness, Mechanical Ventilation, Intubation Complication, PTSD
- Trial name
- ED-AWARENES II (NCT05534243)
- Testing
- Standard neuromuscular blocker practices, Education
- Where
- 4 sites in United States
- Volunteers
- 3,212 people
- Sponsor
- Washington University School of Medicine
Brain Cancer
Sugammadex Given for the Reversal of Rocuronium Induced Neuromuscular Blockade Under Sevoflurane Anesthesia in Infants
The objective of this study is to evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients
- Trial name
- NCT02708056
- Testing
- Sugammadex
- Volunteers
- 26 people
- Sponsor
- Baskent University
Injection Site Irritation
Effects of Cyclooxygenase (COX) 1-2 Inhibitors on Prevention of Rocuronium Injection Pain
Purpose : The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study.
- Trial name
- NCT04582032
- Testing
- Dexketoprofen (KETAVEL 50 mg/2 ml), Saline (Isotonic Saline Solution 0.9% )
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Reversing Vecuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery, Reversing Rocuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery
A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade
Background context: Amogammadex sodium has completed Phase I-III clinical studies in China for reversal of rocuronium-induced blockade. No clinical studies have yet been conducted for vecuronium-induced blockade.
- Trial name
- NCT07595393
- Testing
- Rocuronium (0.6mg/kg), vecuronium bromide (0.1mg/kg)
- Volunteers
- 64 people
- Sponsor
- Amckaus PTY LTD.
Intubation; Difficult
Intubation Time With Low Dose Rocuronium
The investigators hypothesized that increasing the cardiac output by use of atropine in children might result in a reduction of the intubation time needed to facilitate tracheal intubation.
- Trial name
- NCT01464489
- Testing
- Atropine, Normal saline
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Gachon University Gil Medical Center
Laryngoscopy
The Effect of Rocuronium on the Response of Composite Variability Index (CVI) to Laryngoscopy
Eighty subjects will be recruited from those scheduled for surgery requiring general anesthesia at St Vincent's Hospital. Subjects must have American Society of Anesthesiologists (ASA) status of 1 or 2 (be fairly healthy), a BMI…
- Trial name
- NCT00926718
- Testing
- remifentanil infusion, rocuronium dose + remifentanil infusion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- St. Vincent's Medical Center
Underdosing of Other General Anesthetics
Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex
The primary efficacy endpoint is the time from the start of administration of sugammadex to recovery of the TOF ratio to 0.9 in deep neuromuscular block (1-2 twitches post-tetanic count) induced by rocuronium during mild…
- Trial name
- NCT01965067
- Testing
- sugammadex
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- MSD Korea Ltd.
Anesthesia, General
A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part A: Japanese Participants (P05956)
The objective of this trial was to establish the dose-response of T2 (the amplitude of the first response of second twitch to train of four (TOF) stimulation, expressed as percentage of control first twitch,T1) in Japanese and…
- Trial name
- NCT00591409
- Testing
- sugammadex
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC
TOF, Sex
Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System
To explore and compare the effects of propoful, sevoflurane, and a combination of both on the pharmacokinetics and pharmacodynamics of rocuronium.
- Trial name
- NCT02364934
- Testing
- Propofol, Sevoflurane
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Neuromuscular Blockade, Anesthesia
Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular
The aim of this study is to evaluate whether the use of Sugammadex for reversing the neuromuscular blocking effects of rocuronium during neurointerventional procedures can speed recovery of neuromuscular function.
- Trial name
- NCT03322657
- Testing
- Neostigmine, Glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The Cleveland Clinic
Rapid Sequence Intubation
Rapid Sequence Intubation With Rocuronium-Sugammadex Compared With Succinylcholine
Rapid sequence intubation is used, when there is an elevated risk of aspiration to the lungs of stomach content. It is typically used in acute settings that require acute surgery or in prehospital settings, but also in specific…
- Trial name
- NCT00953550
- Testing
- Rocuronium-Sugammadex, Succinylcholine
- Where
- 2 sites in Denmark
- Volunteers
- 61 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anesthesia, General
Comparison of Recovery From Rocuronium 1.2 mg/kg Followed by Sugammadex (Org 25969) 16 mg/kg at 3 Minutes With Recovery From Succinylcholine 1.0 mg/kg (19.4.303)(P05946)(MK-8616-026)
The purpose of the trial is to demonstrate a faster recovery from neuromuscular block induced by 1.2 mg/kg rocuronium after reversal at 3 minutes by 16.0 mg/kg of sugammadex compared with recovery after a neuromuscular block…
- Trial name
- NCT00474253
- Testing
- Sugammadex, Succinylcholine, Rocuronium
- Volunteers
- 115 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Efficacy and Safety of Org 25969 Administered After Zemuron® (MK-8616-042)
The primary objective of this study is to explore the dose-response relation of MK-8616 (Org 25969) given as a reversal agent of Zemuron® at 1 to 2 post tetanic counts (PTCs); both Zemuron® and MK-8616 are administered by…
- Trial name
- NCT03519867
- Testing
- MK-8616, Zemuron®
- Volunteers
- 50 people
- Sponsor
- Merck Sharp & Dohme LLC
Emergence Delirium
Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Pediatric Emergence Delirium in Sevoflurane-rocuronium Anesthesia
The aim of this study is to investigate the effect of sugammadex vs. a conventional acetylcholinesterase inhibitor, neostigmine on emergence delirium (ED) during sevoflurane-rocuronium anesthesia in pediatric patients…
- Trial name
- NCT03229486
- Testing
- Sugammadex Injection [Bridion], Neostigmine+Glycopyrronium
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Pusan National University Yangsan Hospital