Clinical trials: Roux-En-Y Gastric Bypass
Morbid Obesity
Clinical and Health Economic Impact of Robot-assisted Surgery vs Conventional Laparoscopy : the Case of Gastric Bypass
The purpose of this study is to gather clinical and economic evidence on the use of robotics for bariatric surgery (gastric bypass).
- Trial name
- NCT01760512
- Testing
- Gastric bypass
- Where
- France
- Volunteers
- 118 people
- Sponsor
- IHU Strasbourg
Obesity, Roux-en-y Anastomosis Site
FundoRing Roux-en-Y Gastric Bypass Versus FundoRing One Anastomosis Gastric Bypass
Metabolic and bariatric surgery (MBS) is an effective and durable treatment of severe obesity and its co-morbidities. Gastric bypass is one of the main MBS procedures and is performed using various surgical techniques.
- Conditions
- Obesity, Roux-en-y Anastomosis Site, Reflux Gastritis, Reflux Esophagitis
- Trial name
- FundoRing_RY (NCT07486765)
- Testing
- Laparoscopic FundoRing gastric bypass
- Where
- Kazakhstan
- Volunteers
- 200 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Morbid Obesity
Comparison of Mini Gastric Bypass and Roux-en-Y Gastric Bypass
This study compares Roux-en-Y gastric bypass with single anastomosis gastric bypass in a randomized prospective setting. This study also adresses the issue of bile reflux after MGB.
- Trial name
- RYSA (NCT02882685)
- Testing
- Roux-en-y gastric bypass, Single anastomosis gastric bypass
- Where
- 2 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Helsinki University Central Hospital
Obese Patients, Obese Patients With Bariatric Surgery
Bariatric Surgery and Gut Microbiota Changes Over Time
The goal of this observational study is to learn how bariatric surgery affects gut bacteria and gut-related metabolic products over time in adults with obesity.
- Conditions
- Obese Patients, Obese Patients With Bariatric Surgery, Gut Microbiota, Healthy Participants
- Trial name
- RYGB-MICROGUT (NCT07381140)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Morbid Obesity
Glucose Homeostasis Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the clinical trial.
- Trial name
- RB (NCT00981500)
- Testing
- gastric bypass, gastric banding, sleeve gastrectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Morbid Obesity
Extended Pouch Roux-en-Y Gastric Bypass Study
Morbid obesity is an increasing medical problem in the western countries. It's related to comorbidities as diabetes mellitus, hypertension, OSAS, arthrosis and hypercholesterolemia.
- Trial name
- NCT02218957
- Testing
- Extended Pouch RYGB, Standard RYGB
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Rijnstate Hospital
Obesity, Morbid, NASH
The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis
Background: Ketosis after bariatric surgery is a metabolic process that occurs when the body breaks down fat for energy because of not getting enough carbohydrates.
- Conditions
- Obesity, Morbid, NASH, Ketosis, Keto Acidosis
- Trial name
- NCT06338969
- Testing
- Carbohydrate Restriction after a Gastric Bypass
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
Acid Reflux Esophagitis, Non-acid Reflux Esophagitis
Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy
Somatostatine induces a dose-dependent reduction of postprandial plasma cholecystokinin (CCK) secretion with a concomitant inhibition of postprandial gallbladder contraction, abolishing almost completely bile salts output from…
- Trial name
- NCT02054637
- Testing
- Lanreotide
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Bypass Complications
Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects
The purpose of this study is to determine whether sustained release morphine pharmacokinetics parameters in patients undergone roux-en-y gastric bypass (RYGB) differ from subjects who did not.
- Trial name
- OBEMO2 (NCT02641301)
- Testing
- Sustained release morphine sulfate, 30 mg
- Where
- 2 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hopital Lariboisière
the Focus of the Study is to Assees Efficacy of Stapled Revision of Gastric Bypass to Sleeve Gastrectomy
Exploring the Efficacy of Single-stage Stapled Conversion of Gastric Bypass to Sleeve Gastrectomy, More Leak?
Laparoscopic gastric bypass - including both Roux-en-Y gastric bypass (RYGB) and one anastomosis gastric bypass (OAGB) - is one of the most frequently performed procedures.
- Trial name
- NCT07038148
- Testing
- Stapled reversal of gastric bypass to sleeve gastrectomy utilising stapling technique.
- Where
- Egypt
- Volunteers
- 11 people
- Sponsor
- Kasr El Aini Hospital
Pain, Obesity
The Effect of Pre-Operative Transversus Abdominis Plane (TAP) Block in the Post Operative Opioid Consumption in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study
The use of preoperative TAP block in laparoscopic bariatric surgery can improve the postoperative pain and quality of recovery in patients undergoing these procedures.
- Conditions
- Pain, Obesity, Surgery
- Trial name
- NCT01075087
- Testing
- (study group) will receive a bilateral TAP block using 20 cc of 0.5% ropivacaine on each side.
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Bariatric Surgery, Hypoglycemia
Assessing Insulin Turnover Using an In-vivo Deuterated Water Experiment.
The primary objective of this study is to observe the kinetics of pre-stored and de-novo synthesized insulin that is secreted into the circulation using an in-vivo heavy water (D2O) labelling experiment in patients with…
- Conditions
- Bariatric Surgery, Hypoglycemia, Gastric Bypass
- Trial name
- DEEP1A (NCT04332289)
- Testing
- Heavy water experiment
- Where
- Switzerland
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Lia Bally
Morbid Obesity
Efficacy of IV Acetaminophen in Acute Post-Operative Pain Control in Laparoscopic Roux-en-Y Gastric Bypass Surgery (LRYGBP) Patients
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is a common type of surgery in which length of stay and morbidity is intimately associated with post-operative nausea and vomiting (PONV) and recovery of bowel function.
- Trial name
- IV APAP (NCT01460667)
- Testing
- IV acetaminophen, IV normal saline
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- McLaren Regional Medical Center
Bariatric Surgery Candidate
The Use of Laparoscopic Transversus Abdominis Plane Block in Gastric Bypass Surgery (LapTAP)
Randomized, Double-Blinded, Placebo-Controlled Trial of Laparoscopic Transverse Abdominis Plane (Lap TAP) and Rectus Sheath Block in elective Gastric Bypass Surgery aiming to evaluate the benefit of a laparoscopically -guided…
- Trial name
- LapTAP (NCT03367728)
- Testing
- Ropivacaine, Normal saline
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- Ottawa Hospital Research Institute
Type 2 Diabetes Mellitus, Obesity
Effect of Gastric Bypass Surgery on Diabetes Status and Microvascular Complications in Obese Type 2 Diabetic Patients
This study evaluates the long-term benefits of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus, focussing on the prevalence and predictors of T2DM improvement and remission after RYGB, and subsequently relapse of type…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Diabetic Retinopathy, Diabetic Nephropathy
- Trial name
- NCT02625649
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- University of Aarhus
Benchmark, Bariatric Surgery
Defining Benchmarks in Bariatric Surgery
Aim: To define benchmark outcomes in minimally-invasive primary bariatric surgery. Design: Multicenter retrospective cohort study.
- Conditions
- Benchmark, Bariatric Surgery, Roux-en-y Gastric Bypass, Sleeve Gastrectomy
- Trial name
- BBenchmarks (NCT03440138)
- Testing
- bariatric surgery (RYGB or SG)
- Where
- Switzerland
- Volunteers
- 5,741 people
- Sponsor
- Marco Bueter
Bariatric Surgery
Effects of Gastric Bypass on Blood Levels of Duloxetine
This study aims to determine the difference, if any, in the pharmacokinetics of duloxetine between patients who are nine to fifteen months post Roux-en-Y Bariatric Surgery and control subjects matched for body mass index (BMI)…
- Trial name
- NCT00989157
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Neuropsychiatric Research Institute, Fargo, North Dakota
Type 2 Diabetes Mellitus, Bariatric Surgery
Surgical Treatment of Type 2 Diabetes Mellitus in <35 Body Mass Index (BMI)
Thirty type 2 diabetic patients will be submitted to biliopancreatic diversion and 20 to gastric bypass. Subjects will be monitored during a 5 year period to assess the effects of the operations on diabetes control.
- Conditions
- Type 2 Diabetes Mellitus, Bariatric Surgery, Biliopancreatic Diversion, Gastric Bypass
- Trial name
- NCT00996294
- Testing
- biliopancreatic diversion, gastric bypass
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Iron Absorption, Bariatric Surgery
Iron Absorption Trial
Introduction: There are indications that the absorption of oral iron supplementation is reduced after a Roux- en -Y gastric bypass.
- Conditions
- Iron Absorption, Bariatric Surgery, Roux- en -y Gastric Bypass
- Trial name
- NCT02228902
- Testing
- Ferrous fumarate, Ferrous gluconate
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital