Clinical trials: Roux-en-Y
Gastric Cancer
Oncometabolic Surgery
Recently, the concept of "Onco-metabolic surgery" has emerged, and it is a theory that if anastomosis bypassing the duodenum and upper jejunum is performed after gastrectomy in gastric cancer patients with type 2 diabetes…
- Trial name
- KLASS-09 (NCT07437573)
- Testing
- long-limb Roux-en-Y gastrojejunostomy
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Korea University Guro Hospital
Diabetes Mellitus, Non-Insulin-Dependent
Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Non-severe Obesity With Type 2 Diabetes Mellitus
The effect of roux-en-Y gastric bypass(RYGB) on patients with type 2 diabetes mellitus(T2DM) and a body mass index(BMI)>35kg/m2 is clear.
- Trial name
- NCT02091323
- Testing
- gastric bypass surgery
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Iron Deficiency Anemia
Trial of IV vs Oral Iron Treatment of Iron Deficiency Anemia in the Post-Operative Bariatric Surgical Patient
Given the limited long-term effectiveness of traditional weight loss methods, bariatric surgery is increasingly becoming the preferred option for sustained weight loss.
- Trial name
- NCT04268849
- Testing
- Ferumoxytol, Saline, Ferrous sulfate tablets
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Auerbach Hematology Oncology Associates P C
Morbid Obesity
Semaglutide Given Before and After Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass for Recurrent Weight Gain
Recurrent weight gain affects 15% to 40% of patients after metabolic and bariatric surgery (MBS). SG is the most performed operation worldwide, and long-term regain after SG is well documented.
- Trial name
- NCT07859163
- Testing
- Semaglutide weekly injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Obesity (Disorder)
Three M Study (Malabsorption, Microbiota, Mini-Gastric Bypass)
Bariatric surgery represents the best therapeutic option to induce sustainable weight loss and to solve serious comorbidities improving the life-expectancy and the quality of life.
- Trial name
- NCT03412149
- Testing
- Mini Gastric Bypass, Roux en Y Gastric Bypass
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Healthy Volunteers, Enteric Hyperoxaluria
Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects
The first stage of this study is a prospective, adaptive, Phase 1, first-in-human, randomized, controlled study evaluating safety, tolerability, and pharmacodynamics of NOV-001 in adult healthy volunteers.
- Trial name
- NCT04909723
- Testing
- NOV-001, NB1000S, NB2000P
- Where
- 20 sites in United States, Canada
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Novome Biotechnologies Inc
Obesity
Use of Radiofrequency Ablation for RGB Salvage
The present study will assess the feasibility of using endoscopic radiofrequency ablation (RFA) to treat the gastric pouch and stoma with the intent to cause tissue contraction and decreased compliance after a failed Roux-en-Y…
- Trial name
- NCT01910688
- Testing
- RFA treatment
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastric Cancer, Roux-en-y Anastomosis Site
Roux-en-Y vs. Roux-en-Y+ Pouch for D2 Total Gastrectomy
Gastric is one of the most prevalence digestive malignance tumors in China. Radical resection of primary tumors and combine with dissection of regional lymph-nodes is acknowledged by surgeons all over the world.
- Conditions
- Gastric Cancer, Roux-en-y Anastomosis Site, Gastric Anastomosis (Site), Quality of Life
- Trial name
- WCGCC-1202 (NCT02110628)
- Testing
- Roux-en-Y anastomosis, Roux-en-Y+Pouch anastomosis
- Where
- 9 sites in China
- Volunteers
- 588 people
- Sponsor
- West China Hospital
Pancreatic Neoplasms; Periampullary Neoplasms
Enhanced Recovery After Minimally Invasive Pancreaticoduodenectomy
This prospective observational cohort study aims to improve the postoperative course after minimally invasive pancreaticoduodenectomy (MIP) with stented pancreaticogastrostomy (sPG) for pancreatic head or peri-ampullary…
- Trial name
- ERAMIP (NCT02671357)
- Testing
- ERAMIP
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- University Hospital, Gasthuisberg
Morbid Obesity
Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass
Prospective randomized clinical trial aiming to compare laparoscopic Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) with primary outcome on excess weight loss, and secondary outcomes on nutritional status, glycolipid…
- Trial name
- NCT02475590
- Testing
- Laparoscopic sleeve gastrectomy, Laparoscopic Roux-en-Y gastric bypass
- Where
- France
- Volunteers
- 100 people
- Sponsor
- IHU Strasbourg
Dumping Syndrome, Post-bariatric Hypoglycemia
Continuous Glucose Monitoring With iCan i3 in Post-Bariatric Patients With Late Dumping Syndrome
Late dumping syndrome is a common complication following Roux-en-Y gastric bypass, characterized by postprandial hypoglycemia with significant impact on patient safety and quality of life.
- Trial name
- iCan3 Dumping (NCT07440706)
- Testing
- Can i3 Continuous Glucose Monitoring System
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Kaiser Clinic and Hospital
Severe Obesity
Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass
The purpose of this study is to examine the effects of bile acid and bile acids sequestrants on GLP-1 Secretion, during a meal, in patients after Roux-en-Y gastric bypass.
- Trial name
- NCT02876484
- Testing
- Colesevelam, Chenodeoxycholic Acid, Water
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Obesity
Omega Loop Versus Roux-en-Y Gastric Bypass
Several prospective trials and metaanalysis have demonstrated the superiority of bariatric surgery on the medical treatment of obesity.
- Trial name
- YOMEGA (NCT02139813)
- Testing
- Laparoscopic Mini-gastric bypass, Procedure of reference in bariatric surgery
- Where
- 9 sites in France
- Volunteers
- 256 people
- Sponsor
- Hospices Civils de Lyon
Type 2 Diabetes
Surgery Or Lifestyle Intervention for Type 2 Diabetes (SOLID)
This research study will investigate the safety and effectiveness of weight loss surgery for overweight persons with type 2 diabetes.
- Trial name
- SOLID (NCT01040468)
- Testing
- Roux-en-Y Gastric Bypass surgery, Laparoscopic Adjustable Gastric Banding surgery, Intensive Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Bariatric Surgery Candidate, Gastric Bypass
Assessment of Pouch Emptying With MRI After Roux-en-Y Gastric Bypass
A cross-sectional observational study in which pouch emptying rate is measured with MRI in good (TWL>35%) and bad responders (TWL<25%) two years after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB).
- Conditions
- Bariatric Surgery Candidate, Gastric Bypass, Obesity, Morbid, Pouch Emptying
- Trial name
- MRI pouch (NCT06298162)
- Testing
- 2 years after RYGB, no intervention. MRI measurement. Observational.
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Rijnstate Hospital
Type II Diabetes in Subjects BMI 27 to 32
Roux-en-Y Gastric Bypass for BMI 27-32 Type 2 Diabetes Versus Best Medical Treatment
Investigators aim to show that Roux-en-Y Gastric Bypass (RYGB) is superior to best medical treatment in reaching well-defined treatment end points in Asian subjects of BMI 27-32 with type 2 Diabetes (DM2).
- Trial name
- NCT02041234
- Testing
- Roux-en-Y Gastric Bypass (RYGB), Incretin analogues, Xenical
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Khoo Teck Puat Hospital
Obesity, Morbid Obesity
DIT After RYGB - A Prospective Study
Bariatric surgery is the only satisfactory treatment for loss and weight maintenance in obese patients. This loss is a result of several factors that go beyond the simple anatomical abnormality of the gastrointestinal tract and…
- Conditions
- Obesity, Morbid Obesity, Bariatric Surgery
- Trial name
- DIT RYGB (NCT01759667)
- Testing
- A standard mixed Meal
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Silvia Leite Faria
Obesity, Bariatric Surgery Candidate
Evaluation of Hormonal Contraceptive Treatments in Obese Women
The aim of our study is to assess the concentrations of different oral contraceptive agents in morbid obese women before and after two types of bariatric surgeries (RYGB and sleeve gastrectomy) in order to study the role of the…
- Conditions
- Obesity, Bariatric Surgery Candidate, Oral Contraceptive
- Trial name
- OBECO (NCT02398903)
- Testing
- Blood samples for measurement of drug Css, DXA and impedancemetry
- Where
- 2 sites in France
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 2, Obesity
Effect of Roux-en-Y Gastric Bypass or Gastric Sleeve Surgery on Type 2 Diabetes
Roux-en-Y Gastric Bypass surgery (RYGB) ameliorates type 2 diabetes within days after surgery. Studies indicate that the gastric sleeve procedure has comparable effect on type 2 diabetes, but to what extent and how is not fully…
- Trial name
- NCT02713555
- Testing
- Roux-en-Y Gastric Bypass, Gastric Sleeve
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Roux-en-Y Gastric Bypass
A Post-market Observational Study With the easyEndoTM Universal Linear Cutting Stapler in Standard Laparoscopic and Robot-assisted Laparoscopic Roux-en-Y Gastric Bypass (RYGB) Surgery
The primary purpose of this observational registry is to evaluate the safety of the easyEndoTM Universal Linear Cutting Stapler and reloads from Ezisurg Medical when used to create anastomoses during standard and robot-assisted…
- Trial name
- SIRIUS (NCT04543526)
- Testing
- easyEndoTM Universal Linear Cutting Stapler and reloads (Ezisurg Medical)
- Where
- 2 sites in Belgium
- Sponsor
- Duomed