Clinical trials: Roux-en-Y
Morbid Obesity, Metabolic Disease
Study Evaluating Metabolic Syndrome in Subjects Undergoing Gastric Bypass Bariatric Syndrome
Metabolic syndrome is rapidly emerging as an epidemic of global proportions and its definition is still evolving. Patients with this syndrome are at increased risk for cardiovascular disease, and at increased risk of mortality…
- Trial name
- NCT00283374
- Testing
- Laparoscopic Roux-en-Y Gastric Bypass
- Where
- 17 sites in United States, Italy and 1 more
- Volunteers
- 120 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Obesity
StomaphyX Versus Sham for Revisional Surgery in Post-Roux-en-Y Patients to Reduce Regained Weight
The Roux-en-Y gastric bypass (RNYGB) is a weight loss surgery that involves the creation of a small gastric pouch and rearrangement of the small intestine.
- Trial name
- NCT00939055
- Testing
- StomaphyX
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- EndoGastric Solutions
Roux-en Y Gastric Bypass
Feasibility and Health-economic Evaluation of Remote Clinical Monitoring Enabling Same-day Discharge After Bariatric Surgery
The ultimate goal of this research is to optimize care for patients undergoing laparoscopic bariatric surgery while alleviating pressure on hospital resources and staff.
- Trial name
- REMABS (NCT07483775)
- Testing
- remote clinical monitoring, Control group
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Jessa Hospital
Obesity, Weight Loss
Changes in Gut Hormones, Body Composition and Energy Expenditure After Roux-en-Y
The purpose of this study is to gain a better understanding of the mechanism of weight regain through gut hormone (substances in the gut that control various functions of the digestive organs) and energy expenditure (the amount…
- Trial name
- NCT02048501
- Testing
- Resting Metabolic Rate (RMR), Duel-energy x-ray absorptiometry (DEXA), Visual Analog Scale (VAS)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Metabolic and Nutritional Complications, Protein Malnutrition
Laparoscopic Revision From Biliopancreatic Diversion to Gastric Bypass
The aim of this study is to describe the clinical presentation, indications, and operative treatment as well as assess the morbidity, mortality, and overall performance of revisional GBP after either failed and/or complicated…
- Conditions
- Metabolic and Nutritional Complications, Protein Malnutrition, Intestinal Malabsorptive Syndrome, Metabolic Bone Disease
- Trial name
- BPD-to-RYGB (NCT01041456)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Bariatric Surgery
Novel Technique in Closure of Mesenteric Defects After Laparoscopic Roux-en-Y Gastric Bypass and Its Effect on Internal Hernia: a Case-control Study
This study is to investigate the rate of internal hernia after laparoscopic Rox-en-Y gastric bypass when the defects are closed using cyano-acrylate glue.
- Trial name
- NCT04788199
- Testing
- Closure of mesenteric defects using glue
- Where
- United Kingdom
- Volunteers
- 928 people
- Sponsor
- Mansoura University
Morbid Obesity
Gut Hormones After Roux-en-Y Gastric Bypass (RYGBP) Plus Gastric Fundus Resection
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is considered a combination of restriction-malabsorption procedure and one of the most common operative procedures implemented.
- Trial name
- NCT01341028
- Testing
- Roux-en-Y gastric bypass (LRYGBP), LRYGBP+gastric fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Obesity, Vitamin D Deficiency
Efficacy of Vitamin D Supplementation in Bariatric Surgery Patients
As the use of bariatric surgery for treatment of extreme obesity adults continues to rise, clinicians must be aware of pre-existing nutritional deficiencies in overweight and obese patients.
- Trial name
- NCT01385098
- Testing
- Vitamin D3 and Calcium
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Vadim Sherman, MD
Pain, Postoperative
Laparoscopic-guided TAP Block in Patients Undergoing Gastric Bypass
A prospective randomized trial will be performed. Patients undergoing gastric bypass will be randomized into 2 groups: patients undergoing laparoscopic-guided transversus abdominis plane (TAP) block as part of multimodal…
- Trial name
- NCT03203070
- Testing
- Metamizol iv, TAP block
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Elche
Obesity
Brain Activation in Response to Appetitive Cues Pre- and Post- Bariatric Surgery
Utilizing fMRI, this study will examine changes in BOLD signal as a proxy measure of brain activation in response to highly palatable (high energy density [kcal/g]), less palatable and non-food stimuli in severely obese women…
- Trial name
- NCT01590914
- Testing
- Fed Condition, Fasted Condition
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- New York Obesity and Nutrition Research Center
Type 2 Diabetes Mellitus
Medically Reproducing Bariatric Surgery
Type 2 diabetes (DM2) is a chronic disease affecting 29 million Americans and a leading cause of blindness, kidney failure, and limb loss (Engelgau et al 2004).
- Trial name
- MRB (NCT03225209)
- Testing
- OPTIFAST
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Moahad S Dar
Morbid Obesity
The Influence of Aerobic Endurance Training After Roux-en-Y-Gastric Bypass
The aim of this study was to assess the efficiency of aerobic physical exercise (APE) on weight loss, body composition and co-morbidities in patients after laparoscopic Roux-en-Y Gastric bypass (RYGBP).
- Trial name
- AET (NCT00875186)
- Testing
- aerobic endurance training
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Hyperinsulinemic Hypoglycemia, Postprandial Hypoglycemia
Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass
The aim of this study is investigating the effect of a novel glucagon analogue administration in gastric bypass operated individuals, who are reactive hypoglycemic.
- Trial name
- NCT03984370
- Testing
- ZP4207
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Weight Loss
Long-term Follow up After SG vs RYGB vs OAGB
A prospective randomized clinical study of all morbidly obese patients undergoing SG, RYGB and OAGB, as primary bariatric procedures, was performed.
- Trial name
- NCT03467646
- Testing
- Sleeve Gastrectomy, Roux-en-Y gastric bypass, One-Anastomosis Gastric Bypass
- Volunteers
- 600 people
- Sponsor
- Hospital General Universitario Elche
Obesity
Randomized Trial Comparing Laparoscopic Roux-en-y Gastric Bypass to Micro-laparoscopic Roux-en-y Gastric Bypass
Background Laparoscopy is the preferred surgical approach for a number of different diseases as it allows for diagnosis and treatment in the setting of a safe and feasible method offering enhanced cosmesis.
- Trial name
- NCT01183273
- Testing
- Microlaparoscopic gastric bypass, Laparoscopic Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Suzanne J. Rose
Obesity, Morbid, Postmenopause
Serum Estradiol and Endometrial Thickness After Bariatric Surgery in Postmenopausal Women With Obesity
Obesity changes how the body produces and processes estrogen. After menopause, higher estrogen exposure is linked to thickening of the lining of the womb (endometrium) and a higher risk of endometrial cancer.
- Conditions
- Obesity, Morbid, Postmenopause, Endometrial Thickening
- Trial name
- NCT07919054
- Testing
- Bariatric surgery, Conventional non-surgical obesity management
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Kasr El Aini Hospital
Gastrostomy
Predictive Factors for Roux Stasis Syndrome
Patients who were pathologically diagnosed with gastric cancer and underwent distal gastrectomy with R-Y reconstruction between March 2014 and March 2021 were retrospectively analyzed.
- Trial name
- PFRSS (NCT04919577)
- Testing
- X-ray
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Peking University Third Hospital
Obesity, Morbid, Bariatric Surgery
Physiological Effects of Gastric Sleeve Operation
After gastric sleeve patients undergo a substantial weight loss, but the physiological mechanisms behind the weight loss is not fully elucidated.
- Trial name
- NCT03046186
- Testing
- Mixed meal test with double tracer technique
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Bypass Complications
Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects
The purpose of this study is to determine whether sustained release morphine pharmacokinetics parameters in patients undergone roux-en-y gastric bypass (RYGB) differ from subjects who did not.
- Trial name
- OBEMO2 (NCT02641301)
- Testing
- Sustained release morphine sulfate, 30 mg
- Where
- 2 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hopital Lariboisière
Postoperative Complications
Sleeve Gastrectomy as a Standard Bariatric Procedure
This study compared differences in weight loss, comorbidity resolution and complications and reoperations between a recently established sleeve gastrectomy (SG) and prior laparoscopic Rox-en-Y gastric bypass (RYGB).
- Trial name
- NCT05336331
- Testing
- SG or a RYGB
- Where
- Sweden
- Volunteers
- 1,015 people
- Sponsor
- Umeå University