Clinical trials: Roux-en-Y
Type 2 Diabetes
The Effects of Glycemic Optimization Before Gastric Bypass Surgery
Metabolic surgery such as gastric bypass, gastric banding or sleeve gastrectomy operations can cause rapid and uncontrolled reductions in blood glucose.
- Trial name
- GLUCOSURG2 (NCT01353118)
- Testing
- gastric bypass
- Where
- 2 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- Imperial College London
Obesity
Central Nervous Processing of Visual Food Stimuli in Severely Obese Subjects
Recent evidence has pointed to distinct alterations of brain functions in obese subjects some of which may even be causative for their obesity.
- Trial name
- NCT01493583
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- Cantonal Hospital of St. Gallen
Bariatric Surgery, Alcohol Consumption
Effect of Moderate Alcohol Consumption to Cognitive Functioning After Roux-en Y Gastric Bypass
Objectives: Alcohol metabolism is changed in gastric bypass patients, leading to faster resorption and higher alcohol peak concentrations in blood.
- Conditions
- Bariatric Surgery, Alcohol Consumption, Cognitive Function
- Trial name
- NCT02380950
- Testing
- 250 ml alcohol consumption
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- eSwiss Medical & Surgical Center
Type 2 Diabetes, Obesity
Splanchnic Blood Redistribution After Incretin Hormone Infusion and Obesity Surgery
Obesity is a worldwide problem and leads to multiple metabolic and endocrinological problems. Bariatric surgeries are a growing field as a treatment choice for morbid obesity (BMI > 35 kg/m2).
- Trial name
- GIP-PET (NCT01880827)
- Testing
- Roux-en-Y, GIP-infusion, GLP-1
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Peristaltic Direction, Roux-en-Y Gastrointestinal Anastomosis
Study on the Peristaltic Direction of GI Anastomosis in Roux-en-Y Reconstruction
The aim of this study is intending to provide the optimal procedures of the peristaltic direction of gastrointestinal anastomosis in Roux-en-Y reconstruction after distal curative gastrectomy for gastric cancer, which can provide…
- Conditions
- Peristaltic Direction, Roux-en-Y Gastrointestinal Anastomosis, Gastric Cancer
- Trial name
- NCT04801459
- Testing
- Direction procedure of gastrointestinal anastomosis in Roux-en-Y reconstruction
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Gastroesophageal Reflux, Obesity
Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is considered the weight loss procedure of choice for patients suffering of gastro-esophageal reflux (GER).
- Trial name
- NCT02618044
- Volunteers
- 86 people
- Sponsor
- University of Turin, Italy
Diabetes, Insulin Resistance
Physiologic and Functional Adaptations of Insulin Sensitive Tissues
The long-term goal is to understand the mechanisms of intestinal nutrient sensing and signal relays to insulin sensitive tissues (adipose, skeletal muscle, liver) in humans.
- Conditions
- Diabetes, Insulin Resistance, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03407833
- Testing
- Endoscopy biopsy, Surgical biopsy, Mixed-meal tolerance test
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Obesity, Morbid
Biological Sample Repository for Gastrointestinal Disorders
The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients…
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Gastro-Intestinal Disorder
- Trial name
- NCT05874726
- Testing
- Blood Collection, Urine Collection, Tissue Sample Collection
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Severe Obesity, Obesity
GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial
The goal of this pilot clinical trial is to determine the effectiveness of Tirzepatide in patients with persistent obesity (BMI \> 30) 12 months after bariatric surgery (Roux-en-Y Gastric Bypass).
- Conditions
- Severe Obesity, Obesity, BMI Greater Than 30
- Trial name
- GRABS-0 (NCT06162715)
- Testing
- Tirzepatide, Standard of Care post-gastric bypass
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Obesity
Prophylactic Enoxaparin Dosing in Roux-en-Y Gastric Bypass Surgery Patients at St. Vincent Carmel
The purpose of this study is to assess anti-factor Xa concentrations in patients given prophylactic enoxaparin after bariatric surgery.
- Trial name
- NCT01230658
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Ascension St. Vincent Carmel Hospital
Bariatric Surgery, Fat Free Mass
Protein Supplementation and Resistance Training to Prevent Fat-Free Mass Loss Following Metabolic-Bariatric Surgery
The goal of this clinical trial is to investigate the effects of daily protein supplementation and participation in a weekly supervised resistance training program on the prevention of excessive muscle mass loss following…
- Trial name
- ENRICHED (NCT07156552)
- Testing
- Resistance exercise training and protein supplementation
- Where
- 2 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- Radboud University Medical Center
Systemic Hypertension, Obesity
GAstric Bypass to Treat obEse Patients With steAdy hYpertension
Phase 3, unicentric, randomized clinical trial, with allocation concealment and intention-to-treat analysis to evaluate the efficacy of videolaparoscopic Roux-en-Y Gastroplasty to decrease the prescription of antihypertensive…
- Trial name
- GATEWAY (NCT01784848)
- Testing
- Laparoscopic Roux-en-Y gastric bypass (LRYGB), Clinical treatment
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital do Coracao
Morbid Obesity
An Evaluation of the Outcomes of Bariatric Surgery - a Cohort Study
A prospective bariatric database was carried out in the Department of Digestive and Endocrine Surgery at the University Hospital of Strasbourg, France, starting in January 1996.
- Trial name
- ChirBar (NCT02811900)
- Testing
- Roux en Y gastric bypass, Sleeve gastrectomy, Gastric banding
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- IHU Strasbourg
Obesity
Roux-en-Y Gastric Bypass and Weight Regain
This study compares eating behaviors, meal size, and the size of the gastric pouch and connection between the gastric pouch and small intestine in patients who had gastric bypass surgery two or more years ago and regained weight…
- Trial name
- NCT02302898
- Testing
- Eating Behavior Evaluation, Measurement of Functional gastric volume, Measurement of gastric pouch and GJ size
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes, Obesity
Intestinal Remodeling And Reprogramming of Glucose Metabolism Following Laparoscopic Roux-en-Y Gastric Bypass
The purpose of this study is to investigate small intestinal remodeling and reprogramming of glucose metabolism in patients with Type 2 Diabetes Mellitus (T2DM) who undergo laparoscopic Roux-en-Y Gastric Bypass (RYGB).
- Trial name
- NCT02288351
- Testing
- Mix Nutrient Meal, labs, Biopsy
- Sponsor
- Duke University
Diabetes Mellitus, Prediabetes
Long Term Diabetes Improvement After Cancer Gastrectomy and Colectomy
There is evidence that gastrointestinal operations for non weight-losing purposes are beneficial for diabetes mellitus. Aiming to analyze such hypothesis, patients submitted to gastric bypass for morbid obesity, gastrectomy for…
- Conditions
- Diabetes Mellitus, Prediabetes, Morbid Obesity, Gastric Cancer
- Trial name
- NCT01518023
- Testing
- Interview, questionnaire, updated biochemical tests
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- University of Sao Paulo
Gastroesophageal Reflux Disease, Morbid Obesity
Effect of Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass on Gastroesophageal Reflux Disease: An 8-Year Prospective Cohort Study
This study represents a long-term observational follow-up of patients who had previously undergone bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) in the context of an earlier interventional trial…
- Trial name
- NCT03692455
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Clinica Gastrobese
Type 2 Diabetes Mellitus, Obesity
Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes
There is substantial clinical evidence regarding the safety and efficacy of currently practiced bariatric surgical techniques to improve metabolic control and/or resolve type 2 diabetes (T2DM) in clinically severe obese patients…
- Trial name
- SLIMM-T2D (NCT01073020)
- Testing
- Allergan Adjustable Gastric Band Surgery, Intensive Medical Diabetes & Weight Management (Why WAIT) - Band Group, Roux-en-Y Gastric Bypass (RYGB) Surgery
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Joslin Diabetes Center
Hypoglycemia, Obesity, Morbid
The Effect of 'Medical Nutrition Therapy' on Post-bariatric Hypoglycemia 2-4 Years After Gastric Bypass Surgery
This is a pilot study to explore the effect of 'medical nutritional therapy' in patients diagnosed with post-bariatric hypoglycemia (PBH), 2-4 years after gastric bypass surgery.
- Trial name
- NCT05011682
- Testing
- Regular diet, 10-point nutrition plan
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Helse Nord-Trøndelag HF
Postoperative Pain
Impact of Implementation of an Enhanced Recovery After Surgery Program in Laparoscopic Roux-en-Y Gastric Bypass
A prospective randomized study of patients undergoing Roux-en-Y gastric bypass will be randomized in 2 groups: those following an ERAS program and those ones following a standard protocol.
- Trial name
- NCT03212573
- Testing
- ERAS protocol, Standard care
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Hospital General Universitario Elche