Clinical trials: Rupture
Tear Film Thickness
Pilot Study Evaluation of 2 Artificial Tears. Evaluation of TBUT, Tear Meniscus Height and Tear Thickness
To determine baseline tear thickness and improvement immediately post installation of two artificial tear solutions:(9582X) and Allergan Refresh Tears.
- Trial name
- NCT00469521
- Testing
- Refresh Tears, 9582X
- Where
- United States
- Sponsor
- Innovative Medical
Preterm Premature Rupture of Membranes
PPROM Erythromycin Versus Azithromycin
Preterm Premature Rupture of Membranes (PPROM) is treated with an antibiotic, erythromycin or azithromycin, to prolong pregnancy.
- Trial name
- PEACE (NCT01431248)
- Volunteers
- 7 people
- Sponsor
- University of Oklahoma
Dry Eye, Dry Eye Syndromes
Efficacy and Safety of Ikervis Under Controlled Environmental Conditions Environment
The proposed study is a prospective, open-label, unicentric, phase IV clinical trial. This study is design to find new efficacy biomarkers for IKERVIS® (1mg/mL ciclosporin) eye drops after 1 and 3 month after initiation of…
- Conditions
- Dry Eye, Dry Eye Syndromes, Severe Keratitis
- Trial name
- NCT04492878
- Testing
- IKERVIS®1mg/mL
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Rotator Cuff Tears
Effect of Telerehabilitation on Quality of Life, Pain, and Function After Rotator Cuff Surgery
he purpose of this study was to find out whether telerehabilitation after rotator cuff surgery can help reduce pain, improve shoulder movement, increase muscle strength, enhance functional ability, and improve quality of life…
- Trial name
- TELERO-ROT (NCT07205094)
- Testing
- Telerehabilitation exercise program, Conventional physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aysan Yaghoubi
ACL - Anterior Cruciate Ligament Rupture
SharkScrew ACL RCT
This prospective, randomized controlled trial will compare three tibial interference screw types used for graft fixation during primary anterior cruciate ligament (ACL) reconstruction: a polyetheretherketone (PEEK) screw, a…
- Trial name
- NCT07830953
- Testing
- ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Austrian Workers Compensation Board Styria
Partial Tear of Rotator Cuff, Rotator Cuff Tears
Comparison of Hyaluronic Acid, PRP and Steroid Injections in Partial Rotator Cuff Tears: A Prospective Randomized Study
There are many conservative treatment options available for partial rotator cuff tears. However, the superiority of a certain type of injection could not be demonstrated with the available data.
- Trial name
- NCT04681937
- Testing
- Subacromial Injection (hyaluronic acid) + Physical Therapy., Subacromial Injection (Platelet-Rich-Plasma) + Physical Therapy., Subacromial Injection (methylprednisolone acetate) + Physical Therapy.
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bezmialem Vakif University
Parturition, Delivery, Obstetric
Randomized Controlled Trial of the Effectiveness of Perineal Pain and Security of the Suture Led by the Result of Hemostasis Versus Manual Compression Routine Suture Perineal Tears of First Degree During Childbirth
During childbirth, the recommendations have evolved to a restriction of episiotomy. This reduction results in an increase of superficial vaginal and perineal tears.
- Trial name
- ImSOLENCE (NCT02870712)
- Testing
- Suture of perineum, hemostatis by digital compression
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Rotator Cuff Impingement Syndrome, Rotator Cuff Injury
The Influence of a Cognitive Behavioral Approach on Changing Patient Expectations in Shoulder Pain
Background: Despite similar treatment outcomes for surgery or conservative care, the number of surgeries for the care of rotator cuff (RTC) related shoulder pain has increased.
- Conditions
- Rotator Cuff Impingement Syndrome, Rotator Cuff Injury, Shoulder Pain
- Trial name
- NCT03353272
- Testing
- Patient Engagement Education and Restructuring of Cognitions
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Duke University
PCL TEAR
Posterior Cruciate Ligament Reconstruction Using Knot/Press-fit Technique
This study presents an arthroscopic-assisted PCL reconstruction using femoral knot/press-fit technique with a periosteum-enveloping graft in tibial tunnel.
- Trial name
- NCT01200095
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
ACL Injury, Meniscus Tear
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of…
- Conditions
- ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
- Trial name
- MOCHA (NCT04572256)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Austin V Stone
Post-Infarction Heart Rupture, Gene Polymorphism
PCSK9 Polymorphism and Risk of Cardiac Rupture
Protein convertase subtilisin/kexin type 9 (PCSK9) plays a regulatory role in cholesterol homeostasis by promoting low-density lipoprotein receptor (LDLr) degradation.
- Trial name
- NCT05503095
- Testing
- Genetic analysis for PCSK9 polymorphisms
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
Partial-Thickness Rotator Cuff Tear
Injection Therapies for Partial Rotator Cuff Tears
This completed study compared four injection treatments in patients with painful partial tears of the rotator cuff, the tendons that help move and stabilize the shoulder.
- Trial name
- NCT07871695
- Testing
- Autologous Platelet-Rich Plasma (PRP), Dextrose 15%, Betamethasone Sodium Phosphate and Betamethasone Acetate
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Knee Ligament Injury
Performance and Safety of the Composite Interference Screw Used in Anterior Cruciate Ligament Reconstructions
The evaluation of the clinical data has demonstrated the conformity of the Composite Interference Screw (CIS), with the relevant essential requirements for its use in orthopaedic applications.
- Trial name
- NCT04076956
- Testing
- Anterior Cruciate Ligament Reconstruction
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Biomatlante
ACL Tear
Readiness Outcomes Affecting Return to Sport 2.0: An Intervention Feasibility & Pilot Study
This study aims to determine the feasibility of implementing a mental skills training intervention for adolescent athletes who tear their ACL and undergo ACL reconstruction surgery alongside receiving standard-of-care clinical…
- Trial name
- ROAR 2:Pilot (NCT05338385)
- Testing
- Mental Skills Coaching
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Muscle Weakness, Anterior Cruciate Ligament Rupture
Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction?
Anterior cruciate ligament (ACL) injury is a common sport injury in both professional and recreational athletes. Furthermore, persistent quadriceps weakness and wasting are frequently observed after anterior cruciate ligament…
- Trial name
- NCT03496389
- Testing
- Gabapentin, Tramadol, Panadol
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
Dry Eye
Tear Osmolarity Clinical Utility in Dry Eye Disease
Millions of people suffer from dry eye disease, causing symptoms such as redness, burning, feeling of sand or grit in the eye and light sensitivity.
- Trial name
- NCT02417116
- Testing
- Tear supplement, Tear supplement 2, Omega 3 nutrition supplement
- Where
- 6 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Aston University
Achilles Tendon Rupture
Whether Patients With Achilles Tendon Tears Have Different Lipid Levels Than Healthy People: a Retrospective Study
To explore the difference of blood lipid levels between patients with Achilles tendon rupture and healthy people without Achilles tendon rupture, and to provide clues for further exploration of its mechanism.
- Trial name
- NCT04962243
- Testing
- Repair surgery for Achilles tendon rupture
- Where
- China
- Volunteers
- 10,662 people
- Sponsor
- Peking University Third Hospital
Photobiomodulation Therapy, Low Level Laser Therapy
Photobiomodulation Therapy on Pain and Range of Motion Following Flexor Tendon Repair
The purpose of the study was to evaluate the therapeutic effect of low-level laser in improving pain and ROM following flexor tendon repair surgery.
- Conditions
- Photobiomodulation Therapy, Low Level Laser Therapy, Flexor Tendon Rupture, Flexor Tendon Repair
- Trial name
- NCT06761950
- Testing
- Low Level laser therapy, medical treatment, physical therapy program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Dry Eye
Tear Osmolarity Over Time With Artificial Tears
The effect of artificial tears on tear osmolarity
- Trial name
- NCT01227226
- Testing
- Artificial tears
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hom, Milton M., OD, FAAO
Knee Surgeries, Total Ankle Arthroplasty
Adductor Canal Block With IPACK Versus 4-in-1 Block for Postoperative Analgesia in Knee Surgery
This randomized interventional study compares the analgesic efficacy of Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) versus the 4-in-1 block technique in patients undergoing knee…
- Conditions
- Knee Surgeries, Total Ankle Arthroplasty, Anterior Cruciate Ligament (ACL) Tear, Posterior Cruciate Ligament Tear
- Trial name
- NCT07700797
- Testing
- Adductor canal block with IPACK, 4 in 1 block
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zagazig University