Clinical trials: Rupture of Fetal Membranes
Preterm Premature Rupture of Membrane
The Value of Amniopatch in Preterm Premature Rupture of Membranes
A randomized controlled trial that involved 100 women diagnosed with PPROM between 24 and 34 weeks of gestational age. Participants were randomized equally into 2 groups.
- Trial name
- NCT03473210
- Testing
- Antibiotics, Corticosteroid, Amniopatch
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Preterm Rupture of Membranes, Threatened Preterm Labor
Premature Rupture Membranes and tPTL: a Personalised Approach (PROMPT)
Preterm birth (less than 37 weeks) affect approximately 8% of babies in the UK and is the worldwide leading cause of death in children under the age of 5.
- Trial name
- PROMPT (NCT04878978)
- Testing
- Amniocentesis, Routine care without amniocentesis
- Volunteers
- 276 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Human Immunodeficiency Virus, HIV
Fetal HIV Transmission Risk and Duration of Membrane Rupture
In optimally managed HIV+ women with undetectable viral loads, who are on HAART and also receiving intrapartum IV ZDV, the risk of vertical transmission of HIV is independent of the length of time of rupture of membranes.
- Trial name
- NCT01616823
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- Unity Health Toronto
Bacterial Vaginosis, Fetal Membranes, Premature Rupture
Perinatal Infections in Pakistan
There are large differences in health outcomes related to pregnancy and birth between developed and developing countries. This study will investigate how infections, medical history, health care behavior and psychosocial issues…
- Conditions
- Bacterial Vaginosis, Fetal Membranes, Premature Rupture, Chorioamnionitis, Pregnancy
- Trial name
- NCT00070746
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Induction of Labor, Cervical Ripening
Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)
Premature rupture of membranes (PROM) at term complicates 6 to 22% of singleton pregnancies. Spontaneous labour occurs in 60-67% of these patients within 24h.
- Conditions
- Induction of Labor, Cervical Ripening, Premature Rupture of Fetal Membranes, Nulliparous
- Trial name
- RUBAPRO2 (NCT05568745)
- Testing
- Balloon for cervical ripening (Teleflex French Dufour catheter CH20 reference 174000), Oxytocin, Misoprostol Oral Tablet
- Where
- 5 sites in France
- Volunteers
- 152 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preeclampsia, Fetal Death
Comparing the Effect of Vaginal Misoprostol With Dinoprostone in Term Pregnancies
Hypothesis (H0): Labor duration and obstetric complications are not significantly different in the three groups (misoprostol-dinoprostone-oxytocin).
- Conditions
- Preeclampsia, Fetal Death, Fetal Membranes, Premature Rupture
- Trial name
- NCT00432588
- Testing
- misoprostol, dinoprostone
- Where
- Iran
- Sponsor
- Hormozgan University of Medical Sciences
Premature Rupture of Fetal Membranes, Group B Streptococcal Infection
Group B Streptococcus Infection and PROM Incidince
To investigate incidince of prom with GBS infection and role of prophylaxis against it
- Trial name
- NCT06735703
- Testing
- To provide ampicillin sulbactam to pregnant women with premature rupture of membrane
- Volunteers
- 150 people
- Sponsor
- Assiut University
Fetal Membranes, Premature Rupture
Perinatal Outcome After Premature Rupture of Membranes
Premature rupture of membranes is an important cause of neonatal morbidity and mortality, mainly because of the complications associated with this pathology (oligohydramnios, cord compression or prolapse, infection).
- Trial name
- NCT01538030
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
Fetal Membranes, Premature Rupture
Early Detection of Chorioamnionitis in Preterm Premature Rupture of Membranes
All included patients will have their fetal heart rate recording performed with an EDAN F3 fetal monitor that allowed the back up recording of the fetal heart rate beat to beat detection.
- Trial name
- AiRPM (NCT02901795)
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
Chorioamnionitis
Treatment of Chorioamnionitis After Delivery
Chorioamnionitis occurs in 1% to 5% of term pregnancies and may complicate up to 25% of cases of preterm labor. The traditional regimen used to treat intra-amniotic infection is intravenous ampicillin 2g every 6 hours and…
- Trial name
- NCT00814905
- Testing
- saline, ampicillin gentamicin, Ampicillin gentamicin clindamycin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome
Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes
The purpose of this study is to examine whether the value of vaginal fluid cytokine levels as well as computerized fetal ECG analysis are suitable clinical parameters to detect an imminent intra-amniotic inflammation with a high…
- Conditions
- Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome, Early Onset Neonatal Sepsis, Infection of Amniotic Cavity
- Trial name
- MuMFI-PPROM (NCT02702297)
- Testing
- single arm
- Where
- 4 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Chorioamnionitis
Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical Chorioamnionitis
This study will try to determine whether fetuses to mothers having clinical chorioamnionitis have changes in blood flow in middle cerebral artery.
- Trial name
- NCT00299637
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Hadassah Medical Organization
PPROM, Preterm
Preterm Rupture of Membranes Optimising Antibiotics Trial
The goal of this clinical trial is to learn which antibiotic regimen works best to prevent infection in pregnant women whose waters break early (preterm, pre-labour rupture of membranes, or PPROM) and assess the health outcomes…
- Trial name
- PROMOAT (NCT06906757)
- Testing
- Erythromycin 250mg and Amoxicillin 500mg
- Volunteers
- 3,900 people
- Sponsor
- University of Melbourne
Previous; Cesarean Section, Cicatricial, Complicating Pregnancy or Childbirth, Affecting Fetus or Newborn, Prelabor Rupture of Membranes
Balloon Induction of Labor in PROM for TOLAC
A prospective randomized controlled trial to evaluate the safety and efficacy of labor induction with a double balloon catheter (Atad Ripener Device) in women desiring TOLAC (trial of labor after cesarean) with PROM (pre labor…
- Trial name
- BILROM-TOLAC (NCT03399266)
- Testing
- Double Balloon catheter for induction of labor
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Chorioamnionitis, Intrapartum Fever
Intrapartum Fever: Antibiotics Versus no Treatment
The purpose of this study is to determine whether antibiotics can be safely avoided in women who develop a fever during labor. Because investigators have no accurate tests to determine whether women who develop fever during labor…
- Conditions
- Chorioamnionitis, Intrapartum Fever, Intra-amniotic Infection
- Trial name
- NCT03168178
- Testing
- Standard Antibiotic Treatment, No Antibiotic Treatment
- Where
- United States
- Sponsor
- University of Utah
PROM, Preterm (Pregnancy)
Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City Hospitals
Prospective observational study
- Trial name
- NCT06271863
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Chorioamnionitis
Intrapartum Study of Sterile and Clean Gloves
The purpose of this study is to determine whether the use of sterile or clean gloves during labor exams affects the rate of chorioamnionitis. Chorioamnionitis is an infection of the membranes around the baby.
- Trial name
- NCT01852188
- Testing
- Type of glove used for intrapartum vaginal exams
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Maternal; Chorioamnionitis, Affecting Fetus, Early-Onset Sepses, Neonatal
A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator
This study will review practices in relation to chorioamnionitis (CAM) before and after to the implementation of the Neonatal Early-Onset Sepsis (EOS) Risk Calculator to determine the effect in the nursery at Banner - University…
- Trial name
- NCT04513691
- Testing
- EOS Calculator
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Pediatrix
Prelabor Rupture of Membranes
Induction of Labor in Pregnant Women With Prelabor Rupture of Membranes - Oxytocin or Misoprostol
The aim of study is to compare the efficacy and safety of oral misoprostol versus oxytocin in induction of labor in pregnant women with prelabor rupture of membranes at term.
- Trial name
- NCT05215873
- Testing
- Misoprostol, Syntocinon
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams Maternity Hospital