Clinical trials: Ruptured Aneurysm
Intracranial Aneurysm
Endovascular Treatment of Wide Neck Intracranial Aneurysms With the LEO + Stent : The LEO + II Cohort Study
This is a prospective, multicenter, single-arm observational study to evaluate the efficacy and the morbi-mortality of LEO + in patients with wide neck intracranial aneurysms (fusiform, saccular or dissecting), ruptured or not…
- Trial name
- NCT03504436
- Testing
- LEO +
- Volunteers
- 176 people
- Sponsor
- Balt Extrusion
Ruptured Cerebral Aneurysm
Effect of Propofol Midazolam on Cerebral Oxygenation and Metabolism During Clipping of Ruptured Cerebral Aneurysm
Despite the theoretical benefits of i.v. agents, volatile agents remain popular. In a study comparing desflurane, isoflurane, and sevoflurane in a porcine model of intracranial hypertension, at equipotent doses and normocapnia…
- Trial name
- NCT03778723
- Testing
- Total intravenous anesthesia (TIVA), Inhalation Anesthesia, Rescue fentanyl
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Transradial Access
Transradial Access for Ruptured Intracranial Aneurysms Embolization
The goal of this clinical trail is to compare the difference between transradial access (TRA) and transfemoral access(TFA) for ruptured intracranial aneurysms embolization.
- Trial name
- TRA-RIA (NCT05851274)
- Testing
- transradial access, Transfemoral access
- Where
- China
- Volunteers
- 242 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Intracranial Aneurysms, Wide Neck Intracranial Aneurysms
Kaneka iED Coil System for the Treatment of Wide Necked Ruptured and Unruptured Intracranial Aneurysms
This is a multi-center, prospective, propensity matched twin armed study conducted on 50 patients in the experimental arm followed for 18 months after intervention evaluating cost effectiveness, safety and efficacy of therapy.
- Trial name
- CLASS (NCT05636124)
- Testing
- Kaneka i-ED coil
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ruptured and Unruptured Intracranial Aneurysms
Safety and EffecTiveness of the Silk Vista Flow DiverteR in the TrEatment of Unruptured IntracrAnial AneurysMs
Intracranial aneurysms (IA) are abnormal outpouchings of cerebral arteries' walls that occur mostly in arteries found in the Circle of Willis and the middle cerebral artery bifurcation with a risk of rupture leading to…
- Trial name
- STREAM (NCT07073118)
- Testing
- Endovascular treatment with placement of a flow-diverting stent
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Ruptured Aneurysm
European, Multi-center, Exploratory Trial to Assess WEB Versus Other Endovascular Treatment in Ruptured Aneurysms.
Comparison of efficacy and safety between WEB and other endovascular techniques
- Trial name
- WAVE (NCT06511245)
- Testing
- Randomisation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Microvention-Terumo, Inc.
Submacular Hemorrhage, Ruptured Retinal Arterial Macro Aneurysms
Submacular Hemorrhage Associated With Retinal Arterial Macro Aneurysm
Evaluation of surgical outcome of vitrectomy with subretinal injection of recombinant tissue-plasminogen activator for submacular hemorrhage associated with retinal arterial macroanuerysms.
- Trial name
- NCT02120066
- Testing
- Vitrectomy for submacular hemorrhage, subretinal injection of tissue-plasminogen activator
- Where
- Japan
- Volunteers
- 22 people
- Sponsor
- Kyorin University
Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation
Treatment of Brain AVMs (TOBAS) Study
The objectives of this study and registry are to offer the best management possible for patients with brain arteriovenous malformations (AVMs) (ruptured or unruptured) in terms of long-term outcomes, despite the presence of…
- Conditions
- Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation, Arteriovenous Malformations, AVM
- Trial name
- TOBAS (NCT02098252)
- Testing
- Neurosurgery, Radiation therapy, Embolization
- Where
- 30 sites in United States, Brazil and 4 more
- Volunteers
- 1,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Subarachnoid Hemorrhage
Is the Measured Diameter of the Optic Nerve Sheath by Cerebral Scan in Patients With Early-phase Meningeal Hemorrhage, Due to a Ruptured Aneurysm, a Prognostic 6-month Mortality Factor ?
Sub Arachnoid Hemorrhage (SAH) is a public health concern because of its high incidence (7/100 000 inhab.), its mortality rate (25%), and its morbidity rate (50%).
- Trial name
- GAINE (NCT02894034)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Aneurysmal Subarachnoid Hemorrhage
Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2)
An exploratory, randomized, double-blinded, placebo-controlled, two-center clinical trial to determine the maximum tolerated dosage of intravenous tirofiban in patients with aneurysmal subarachnoid hemorrhage (aSAH)…
- Trial name
- iSPASM-2 (NCT07493577)
- Testing
- Tirofiban
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- Dr David Hasan, M.D.
Brain Aneurysm
Aneurysm Genetic Risk in Patients With QIB Changes
Intracranial aneurysm rupture is a leading cause of hemorrhagic strokes which carry high mortality and disability rates as well as high healthcare costs.
- Trial name
- AnGen (NCT05317169)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Shock, Septic, Hyperlactatemia
Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery
The MostCare system, thanks to the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy), provides new hemodynamic parameters of the cardiovascular system.
- Conditions
- Shock, Septic, Hyperlactatemia, Oliguria, Aortic Aneurysm, Abdominal
- Trial name
- RELASTANCE (NCT04388267)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
Abdominal Aortic Aneurysm Without Rupture
Non-invasive Aortic Aneurysm Tissue Characterization Using Wall Viscoelasticity
Abdominal aortic aneurysm (AAA) is an abnormal dilatation of the aorta in the abdomen due to a wall weakening caused by atherosclerosis.
- Trial name
- AAA multiphase (NCT04150653)
- Testing
- Multiphase scan CT, non-invasive vascular ultrasound elastography by ultrasound (NIVE)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Aortic Aneurysm, Aortic Dissection
Thoraflex™ Hybrid IDE Study
The study will assess the effectiveness, safety and clinical outcomes of the Thoraflex™ Hybrid Device in the treatment of aortic disease affecting the aortic arch and the descending thoracic aorta, with or without involvement of…
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Rupture
- Trial name
- NCT02724072
- Testing
- Thoraflex™ Hybrid Device
- Where
- 12 sites in United States
- Volunteers
- 84 people
- Sponsor
- Bolton Medical
Aneurysm, Ruptured, Hyperglycemia
Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood
The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS…
- Conditions
- Aneurysm, Ruptured, Hyperglycemia, Hydrocephalus
- Trial name
- HCP-Glc (NCT06486909)
- Testing
- Cerebrospinal Fluid (CSF) Sample, Blood Serum Sample
- Where
- 3 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Isabel Hostettler
Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm, Ruptured
Aortic Size and Height Indices in Abdominal Aortic Aneurysms
The goal of this observational study is to learn whether adjusting abdominal aortic aneurysm (AAA) size for body size helps distinguish ruptured from intact aneurysms better than maximum aneurysm diameter alone.
- Conditions
- Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm, Ruptured, Abdominal Aortic Aneurysm Without Rupture
- Trial name
- AASI (NCT07893704)
- Where
- Mexico
- Volunteers
- 2,000 people
- Sponsor
- Tecnologico de Monterrey
Circle of Willis; Aneurysm, Congenital, Ruptured
Circle of Willis Variants in Nepali Population Evaluated in TOF MR Angiography
The brain, though it constitutes only 2% of total body weight, receives 20% of the cardiac output. Blood supply to the brain comes from two major pairs of arteries: the anterior carotid arteries and the posterior vertebral…
- Trial name
- COW (NCT06751420)
- Testing
- Magnetic Resonance Imaging
- Where
- Nepal
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Grande International Hospital, Nepal
Juxtarenal Aortic Aneurysm, Aortic Rupture
Physician Modified Endovascular Grafts for the Treatment of Juxtarenal Aortic Aneurysms
The primary objective of the clinical investigation "Physician Modified Endovascular Grafts for the Treatment of Elective, Symptomatic or Ruptured Juxtarenal Aortic Aneurysms" is to assess the use of the Physician-Modified…
- Trial name
- PMEG (NCT06657794)
- Testing
- Implantation of Physician-Modified Terumo Aortic TREO abdominal stent graft system
- Sponsor
- The Cleveland Clinic
Subarachnoid Hemorrhage, Aneurysmal
Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage…
- Trial name
- STORM (NCT05103566)
- Testing
- gammaCore
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Cerebral Aneurysm
Multidimensional Evaluation of Patients With Ruptured or Unruptured Cerebral Aneurysm Undergoing Endovascular or Surgical Treatment
Cerebral aneurysms are common changes in intracranial angioarchitecture. Unruptured aneurysms are increasingly identified thanks to the imaging techniques used in daily clinical practice.
- Trial name
- NCT05713825
- Testing
- Endovascular embolization or surgery
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS