Clinical trials: Ruptured Cerebral Aneurysm
Arteriovenous Malformations, Cerebral, Unruptured Brain Arteriovenous Malformation
Transvenous Approach for the Treatment of Cerebral Arteriovenous Malformations
A new endovascular route for the treatment of brain AVMs may be possible in some cases: Trans-Venous Embolization (TVE). The technique uses microcatheters to navigate to the draining veins of AVM, to reach and then fill the AVM…
- Conditions
- Arteriovenous Malformations, Cerebral, Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation
- Trial name
- TATAM (NCT03691870)
- Testing
- Standard Trans-Arterial Embolization (TAE), Trans-Venous Embolization (TVE)
- Where
- 9 sites in Canada, France
- Volunteers
- 77 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Subarachnoid Hemorrhage, Aneurysmal
Efficacy and Safety of Bivalirudin Versus Heparin During Coil Embolization in Patients With Ruptured Intracranial Aneurysms
This is a randomized, open label, multi-center, positive-controlled study, in which a total of 236 patients will be enrolled and randomly assigned to receive bivalirudin or heparin in a 1:1 ratio during coil embolization in…
- Trial name
- BUILD (NCT04532333)
- Testing
- Bivalirudin 250 MG Injection, Heparin
- Volunteers
- 236 people
- Sponsor
- Changhai Hospital
Brain Aneurysm
CLARYS: CLinical Assessment of WEB® Device in Ruptured aneurYSms
An observational non-randomized, multi-center, prospective assessment of the clinical utility of the WEB Aneurysm Embolization System in subjects with ruptured intracranial aneurysms deemed appropriate for endovascular treatment.
- Trial name
- CLARYS (NCT02687607)
- Testing
- WEB Aneurysm Embolization System
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Microvention-Terumo, Inc.
Intracranial Aneurysm
Endovascular Treatment of Wide Neck Intracranial Aneurysms With the LEO + Stent : The LEO + II Cohort Study
This is a prospective, multicenter, single-arm observational study to evaluate the efficacy and the morbi-mortality of LEO + in patients with wide neck intracranial aneurysms (fusiform, saccular or dissecting), ruptured or not…
- Trial name
- NCT03504436
- Testing
- LEO +
- Volunteers
- 176 people
- Sponsor
- Balt Extrusion
Subarachnoid Hemorrhage, Intracranial Aneurysm
Swiss Study on Subarachnoid Hemorrhage
This registry was created to assess management parameters of patients treated for aneurysmal subarachnoid hemorrhage in Switzerland.
- Trial name
- Swiss-SOS (NCT03245866)
- Testing
- Observational/ no intervention
- Where
- 9 sites in Switzerland
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Geneva
Social Determinant of Health, Intracranial Aneurysms
Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health
Intracranial aneurysms (IA) are arterial malformations affecting about 3% of the overall population. Rupture is the most severe complication, as it is associated with nearly 30% of death or severe disability.
- Conditions
- Social Determinant of Health, Intracranial Aneurysms, Subarachnoid Hemorrhage, Treatment Outcomes
- Trial name
- ARAMISS (NCT06866210)
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Nantes University Hospital
Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured
The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in…
- Conditions
- Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured, Aneurysmatic Subarachnoid Haemorrhage, Aneurysm Cerebral
- Trial name
- pAVM-rFA (NCT07050381)
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Randomized Controlled Trial, Intracranial Aneurysm
Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms
Endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. However, there has few prospective randomized controlled studies on the comparison of therapeutic effect between…
- Conditions
- Randomized Controlled Trial, Intracranial Aneurysm, Microsurgery, Endovascular Procedures
- Trial name
- NCT05049564
- Testing
- keyhole microneurosurgery, conventional microneurosurgery, endovascular coiling
- Volunteers
- 150 people
- Sponsor
- ZhuQing
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm
The purpose of this study is to evaluate the safety and performance of the Delta system in the treatment of cerebral vasospasm post aneurysmal subarachnoid hemorrhage (aSAH) patients.
- Trial name
- NCT02129413
- Testing
- Delta system
- Where
- 7 sites in Czechia, Germany and 1 more
- Volunteers
- 23 people
- Sponsor
- Samson NeuroSciences
Printing, Three-Dimensional, Simulation Training
Preoperative Assessment and Individualized Operation Optimization of Acute Ruptured Cerebral Aneurysms
Cerebral aneurysm is one of the main diseases that seriously affect human health. The most important treatment method is surgical clipping and endovascular embolization.
- Trial name
- PAOCA (NCT02977520)
- Testing
- Printing, Three-Dimensional
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Luhe Hospital
Aneurysm, Ruptured, Vasospasm, Intracranial
Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)
Previous work has demonstrated patients presenting with ruptured aneurysms that develop radiographic and clinical vasospasm have a higher permeability of the blood brain membrane.
- Conditions
- Aneurysm, Ruptured, Vasospasm, Intracranial, Delayed Cerebral Ischemia, Blood Brain Barrier Defect
- Trial name
- NCT04876638
- Testing
- Minocyclin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
Metabolomic Profile and Proteasic Activity as Biomarkers for Early Detection of Arterial Vasospas in Arterial Vasospasm After Aneurysmal Subarachnoid Hemorrhage
The subarachnoid hemorrhage (SAH) from ruptured aneurysm is a situation that is life-threatening, which is largely dependent on the occurrence of vasospasm from the 4th day after the bleeding.
- Trial name
- NCT02397759
- Testing
- Blood draw and cerebrospinal fluid draw
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cerebral Aneurysm
Multidimensional Evaluation of Patients With Ruptured or Unruptured Cerebral Aneurysm Undergoing Endovascular or Surgical Treatment
Cerebral aneurysms are common changes in intracranial angioarchitecture. Unruptured aneurysms are increasingly identified thanks to the imaging techniques used in daily clinical practice.
- Trial name
- NCT05713825
- Testing
- Endovascular embolization or surgery
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Supratentorial Neoplasms, Aneurysms
Scalp Nerve Blocks for Post-Craniotomy Pain
The objective of this study is to demonstrate that scalp nerve blocks ("scalp freezing"), performed at the end of supratentorial brain surgery, will reduce post-operative pain, opioids side effects, and the time required for…
- Conditions
- Supratentorial Neoplasms, Aneurysms, Arteriovenous Malformation, Epilepsy
- Trial name
- NCT00972790
- Testing
- Bilateral Scalp Nerve Blocks
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Unity Health Toronto
Intracranial Aneurysms, Ruptured Aneurysm
Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN
Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location.
- Trial name
- PLAQRAN (NCT03408379)
- Testing
- Collection of blood sample in aneurysm
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Subarachnoid Hemorrhage, Ruptured Intracranial Aneurysm
Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of Ruptured Aneurysms
This is a randomized, double-blind, placebo-controlled, single-dose study investigating the safety and efficacy of NA-1 in patients with subarachnoid hemorrhage (SAH) undergoing endovascular repair of ruptured intracranial…
- Trial name
- ENACT-2 (NCT02056574)
- Testing
- NA-1
- Where
- 12 sites in United States, Canada
- Sponsor
- NoNO Inc.
Ruptured Cerebral Aneurysm
A Medical Device to Treat Wide-Neck Brain Aneurysms
The study aims to evaluate the safety and probable benefit of a medical device to treat wide-neck ruptured brain aneurysms.
- Trial name
- TORNADO-US (NCT05550571)
- Testing
- Nautilus Intrasaccular Bridging System
- Where
- 5 sites in United States, Bulgaria
- Volunteers
- 45 people
- Sponsor
- EndoStream Medical
Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage
The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage
The purpose of the study is to see that in addition to existing therapy, how well an additional procedure named spinal cord stimulation might reduce blood vessel spasm from aneurysm rupture.
- Trial name
- NCT06443177
- Testing
- Vectris trial leads and stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Aneurysm Abdominal, Cerebral Aneurysm Ruptured
Occurrence of Abdominal Aortic Aneurysms in Patients With Aneurysmal Subarachnoid Hemorrhage
Rationale: Aneurysms of different types are known to be associated. In literature, concurrence of intracranial- and aortic aneurysms is described.
- Trial name
- TRACE-aSAH (NCT07312565)
- Where
- Netherlands
- Volunteers
- 233 people
- Sponsor
- Leiden University Medical Center
Brain Aneurysm, Aneurysm, Ruptured
Superior Cervical Ganglion Block, Transcranial Doppler
The aim of this study is to assess blood flow velocity in middle cerebral artery measured by transcranial doppler to determine the efficacy of SCG block in decreasing incidence or severity of vasospasm after MCA aneurysm surgery.
- Trial name
- NCT04439760
- Testing
- Superior Cervical Ganglion Block
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Fatma Ibrahim El Sayed Salman