Clinical trials: SARS-COV 2
SARS CoV 2 Infection
Study to Evaluate the Safety & Immunogenicity of IMNN-101 Administered in Healthy Adults Previously Vaccinated Against SARS-CoV-2
This is an open-label phase 1/2, dose-escalation study. Participants will receive a single intramuscular (IM) dose of IMNN-101 on Day 0 in the deltoid muscle and will be followed through 12 months post-vaccination (through Study…
- Trial name
- NCT06283459
- Testing
- IMNN-101
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Imunon
Corona Virus Infection
Clinical Characteristics and In-hospital Death of a Chilean COVID-19 Prospective Cohort
The investigators planned to examine a cohort of admitted patients at University of Chile Clinical Hospital with COVID-19 diagnosis.
- Trial name
- NCT04758039
- Where
- Chile
- Volunteers
- 395 people
- Sponsor
- University of Chile
Coronavirus Infection, Type 2 Diabetes
Effects of DPP4 Inhibition on COVID-19
The purpose of this research is to see if the DPP4 inhibitor linagliptin, an oral medication commonly used to treat type 2 diabetes,can help with diabetes control and reduce the severity of the COVID-19 infection
- Trial name
- NCT04341935
- Testing
- Linagliptin, Insulin regimen
- Where
- United States
- Sponsor
- University of Miami
COVID-19
Prognosis of Coronavirus Disease 2019 (COVID-19) Patients Receiving Receiving Antihypertensives
Coronavirus disease 2019 (COVID-19) ,caused by the newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, has shown substantial global spread affecting over 2 million people and claiming over 120,000…
- Trial name
- NCT04357535
- Testing
- Angiotensin-Converting Enzyme Inhibitors (ACE-I) and Angiotensin II Receptor Blockers (ARB)
- Where
- Saudi Arabia
- Volunteers
- 314 people
- Sponsor
- Hakeam Abdulaziz Hakeam
SARS CoV 2 Infection, COVID-19
I VACCIN Hospitalization of COVID-19 Patients
A REALLIFE evaluation of rate of hospitalized patients in Intensive Care Units and in medical Units of non -vaccinated patients vs vaccinated patients
- Trial name
- NCT05244343
- Where
- Tunisia
- Volunteers
- 1,096 people
- Sponsor
- Eshmoun Clinical Research Center
SARS-CoV 2 Infection, Covid19
Qualitative Evaluation of Tear Fluid and Blood for Auto Antibodies Produced in Response to COVID-19
This study objective is to collect tear and blood samples from individuals with positive SARS-COV2 diagnosis and test those samples for the presence of various SARS-COV2 viral antigens and autoantibodies.
- Trial name
- NCT04542980
- Testing
- SARS-CoV2 Autoantibody detection
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Namida Lab
Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS
Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection.
- Conditions
- Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), SARS CoV 2 Infection, Long COVID19
- Trial name
- NCT07189936
- Testing
- To Measure levels of circulating monocyte/ T cell doublets at Baseline, To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment, To Measure Splanchnic venous capacitance after 28 days of Treatment with 2HOBA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
SARS CoV 2 Infection, SARS-CoV-2 Acute Respiratory Disease
Efficacy and Safety of Nasal Spray Solution Containing Human IgG1 Anti-COVID-19 Antibody Cocktail
Hypromellose-based nasal spray solution containing human IgG1 anti-SARS-CoV-2 antibody cocktail is a medical device innovated to provide the dual-action physical barrier on nasal mucosa that aids the natural defence in which the…
- Trial name
- NCT05358873
- Testing
- Human IgG1 anti-SARS-CoV-2 antibody cocktail
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
COVID, SARS-CoV 2
COVID19 Clinical Predictors and Outcome
In December 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, Hubei, China, and now spreads across international borders.
- Trial name
- NCT04416347
- Testing
- SARS-CoV2 Infection
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- St George's University Hospitals NHS Foundation Trust
SARS CoV 2 Infection
Consequences in ICU of Vaccination Status of Covid-19 Patients
It is a retrospective cohort study aiming to describe the characteristics, management and prognosis of vaccinated patients hospitalized in the intensive care unit (ICU), in comparison with non-vaccinated patients.
- Trial name
- CIVIC (NCT06191341)
- Where
- France
- Volunteers
- 1,058 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
COVID-19, SARS-CoV 2
Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients With Respiratory Distress Due to COVID-19
Randomized, double-blind, parallel, two-arms clinical trial to assess the efficacy and safety of 2 infusions of Wharton-Jelly mesenchymal stromal cells (day 1 and day 3, endovenously at 1E6cells/Kg per dose) in patients with…
- Conditions
- COVID-19, SARS-CoV 2, Adult Respiratory Distress Syndrome
- Trial name
- COVIDMES (NCT04390139)
- Testing
- XCEL-UMC-BETA
- Where
- 5 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Banc de Sang i Teixits
SARS-CoV 2, COVID-19
Cardiac COVID-19 Health Care Workers
The study will analyze the prevalence of cardiac involvement of health care workers from the University Hospital of Salamanca (HUSA) who have overcome SARS-CoV-2 infection.
- Conditions
- SARS-CoV 2, COVID-19, Coronavirus, Cardiac Magnetic Resonance
- Trial name
- CCC (NCT04413071)
- Testing
- Passed infection of SARS-CoV-2
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- AORTICA Group
Pre-Exposure Prophylaxis, Coronavirus
Does Hydroxychloroquine Before & During Patient Exposure Protect Healthcare Workers From Coronavirus?
On 11 March 2020, the World Health Organization declared SARS-CoV-2 (commonly called COVID-19) a global pandemic. As in any pandemic, maintaining the health and safety of the healthcare workforce is of great importance as health…
- Conditions
- Pre-Exposure Prophylaxis, Coronavirus, SARS-CoV 2
- Trial name
- HEROs (NCT04374942)
- Testing
- Hydroxychloroquine
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Megan Landes
Covid19 Vaccine
A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Adolescents
The purpose of this study is to assess the safety and immunogenicity of MVC-COV1901 vaccine compared to placebo in participants aged ≥ 12 to < 18 years.
- Trial name
- NCT04951388
- Testing
- MVC-COV1901(S protein with adjuvant), MVC-COV1901(Saline)
- Where
- 5 sites in Taiwan
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- Medigen Vaccine Biologics Corp.
Coronavirus Infection, COVID
Cytokine Adsorption in Patients With Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
In December 2019 in the city of Wuhan in China, a series of patients with unclear pneumonia was noticed, some of whom have died of it.
- Conditions
- Coronavirus Infection, COVID, SARS-CoV 2, Respiratory Failure
- Trial name
- CYCOV-II (NCT04385771)
- Testing
- vv-ECMO + cytokine adsorption (Cytosorb adsorber), vv-ECMO only (no cytokine adsorption)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Dr. Alexander Supady
SARS CoV 2 Infection, Influenza A Virus Infection
Clinical Validation of the NowFuture Digital Flu / COVID Test in Anterior Nasal Samples for Over-the-Counter (OTC) Use in Australia
Prospective clinical study conducted at three sites (with a simulated home environment) in Australia for the clinical validation of the NowFuture Digital Flu / COVID Test.
- Conditions
- SARS CoV 2 Infection, Influenza A Virus Infection, Influenza B Virus Infection
- Trial name
- NCT07743970
- Testing
- Diagnostic test for SARS-CoV-2, influenza A and influenza B
- Where
- 3 sites in Australia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Biocrucible Ltd
SARS-CoV 2
Lung Irradiation for COVID-19 Pneumonia
In this research study the investigators want to learn more about the potential benefit of radiation to the lung to improve the health of patients who are hospitalized with Coronavirus-19 (COVID-19) due to infection with a virus…
- Trial name
- NCT04393948
- Testing
- Phase 1, Phase 2
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
COVID-19 Pandemic, Immunogenicity
Safety and Immunogenicity of Omicron Variant-Matched Vaccine Booster in Adults
Under protocol versions 1.01-1.06: The five recently emerged SARS-CoV2 variants that were designated as VOCs are the Alpha variant, Beta variant, Gamma variant, Delta variant and the Omicron variant.
- Conditions
- COVID-19 Pandemic, Immunogenicity, SARS CoV 2 Infection, COVID-19
- Trial name
- SH-MO-214 (NCT05383560)
- Testing
- mRNA-1273.214 Vaccine, MRNA-1273 Vaccine, MRNA-1273.222 Vaccine
- Where
- Israel
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
SARS CoV 2 Infection, Hypoxemic Respiratory Failure
Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient
Introduction: The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure…
- Trial name
- NCT04995289
- Testing
- Prone position on ECMO patient
- Where
- Morocco
- Volunteers
- 23 people
- Sponsor
- Mohammed VI University Hospital