Clinical trials: SARS-COV-2 Infection
SARS-CoV-2 Virus, Severe Acute Respiratory Syndrome Coronavirus 2
A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called variant-adapted BNT162b2 RNA-based vaccine) in healthy children.
- Conditions
- SARS-CoV-2 Virus, Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
- Trial name
- NCT05543616
- Testing
- Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 3 microgram dose, Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 6 microgram dose, Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 10 microgram dose
- Where
- 96 sites in United States, Brazil and 3 more
- Volunteers
- 4,338 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
SARS-CoV-2 Infection
A Study to Learn About PAXLOVID (a Commercial Medicine) In People With COVID-19
The purpose of this post marketing observational study is to learn about the safety and effects of the commercial medicine (called PAXLOVID) for the treatment of COVID-19.
- Trial name
- NCT05263908
- Testing
- nirmatrelvir / ritonavir
- Where
- Japan
- Volunteers
- 3,346 people
- Sponsor
- Pfizer
Covid19
Nebulized PL for Post-COVID-19 Syndrome
To evaluate and compare nebulized platelet lysate to placebo control of saline administered via handheld nebulizer 1x daily for eight weeks to determine effect on lung function in patients with post-COVID-19 ARDS syndrome.
- Trial name
- NCT04487691
- Testing
- Nebulized Platelet Lysate, Nebulized Sterile Saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Regenexx, LLC
COVID-19, SARS CoV 2 Infection
To Evaluate the Safety, Efficacy,and Pharmacokinetics of Orally Administered Prolectin-M
ProLectin M is an orally administered polysaccharide. Polysaccharides competitively bind to the N-terminal tail of human galectin-3 through a proline isomerization [10].
- Trial name
- NCT05733780
- Testing
- Prolectin-M
- Volunteers
- 40 people
- Sponsor
- Bioxytran Inc.
Covid19
Study to Evaluate a Single Dose of STI-2020 (COVI-AMG™) in Hospitalized Adults With COVID-19
This is a placebo-controlled study to investigate the safety and efficacy of a single injection of COVI-AMG in inpatient adults with COVID-19.
- Trial name
- NCT04771351
- Testing
- COVI-AMG
- Where
- United States
- Sponsor
- Sorrento Therapeutics, Inc.
Coronavirus Disease 2019 (COVID-19), Pneumonia
Frespaciguat (MK-5475) in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009)
The purpose of this study is to evaluate safety, tolerability, and pharmacodynamics of frespaciguat after administration of multiple doses to participants with COVID-19 pneumonia.
- Conditions
- Coronavirus Disease 2019 (COVID-19), Pneumonia, Hypoxemia
- Trial name
- NCT04425733
- Testing
- Frespaciguat
- Sponsor
- Merck Sharp & Dohme LLC
Covid19
Efficacy and Safety of Baricitinib in Patients With Moderate and Severe COVID-19
This is multicenter clinical trial to evaluate efficacy and safety of Baricitinib in treatment for COVID-19. This trial will compare Baricitinib, a drug recommended for Rheumatoid Arthritis, against standard of care, to assess…
- Trial name
- NCT05056558
- Testing
- Baricitinib
- Where
- Bangladesh
- Sponsor
- Incepta Pharmaceuticals Ltd
Covid19
Dräger COVID-19 Antigen Test Clinical Performance Study
The study is designed to demonstrate suitability of the Dräger Antigen Test for SARS-CoV-2 detection in clinical nasal specimens.
- Trial name
- NCT04698993
- Testing
- Dräger Antigen Test SARS-CoV-2
- Where
- Germany
- Volunteers
- 388 people
- Sponsor
- Drägerwerk AG & Co. KGaA
COVID-19
Phase 1&2 Study to Evaluate the Safety & Efficacy of Inhaled IBIO123 in Severe COVID-19 Illness
This is a Phase 1 and phase 2, adaptive, placebo-controlled, double-blind, randomized single-dose study in participants with Severe COVID-19 illness.
- Trial name
- NCT05303376
- Testing
- IBIO123
- Where
- 5 sites in South Africa, Ukraine
- Volunteers
- 123 people
- Sponsor
- Immune Biosolutions Inc
COVID-19 Pneumonia
Phase 2b/3 Trial of NuSepin® in COVID-19 Pneumonia Patients
A Randomized, Double-blinded, Placebo-controlled, Parallel-treatment Group, Adaptive Design, Multi-center, Phase 2b/3 Trial to Evaluate Efficacy and Safety of NuSepin® Intravenous Infusion in COVID-19 Pneumonia Patients
- Trial name
- NCT05352347
- Testing
- NuSepin® 0.2 mg/kg, NuSepin® 0.4 mg/kg
- Where
- South Korea
- Volunteers
- 1,134 people
- Sponsor
- Shaperon
COVID-19
A Study to Evaluate the Safety and Pharmacokinetics of HH-120 Nasal Spray in Healthy Volunteers
This is a clinical study evaluating the safety, tolerability, pharmacokinetic (PK) characteristics and immunogenicity of HH-120 nasal spray in healthy subjects.
- Trial name
- NCT05753878
- Testing
- HH-120 nasal spray, PartA cohort 1, HH-120 nasal spray, Part A cohort 2-7, HH-120 nasal spray, Part A cohort 8-9
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Huahui Health
COVID-19 Drug Treatment
A Study to Learn About the Patients With COVID-19 Prescribed Paxlovid in Morocco
The purpose of this study is to collect information on the: general information of a group of people such as their age, sex, and other facts. clinical information of the patients such as any other illness before having COVID 19.
- Trial name
- NCT05997485
- Testing
- Nirmatrelvir/Ritonavir
- Sponsor
- Pfizer
Efficacy and Safety
Proxalutamide (GT0918) Treatment for Outpatients With Mild or Moderate COVID-19 Illness
The purpose of this study is to assess the efficacy and safety of Proxalutamide (GT0918) as a treatment for outpatients COVID-19 subjects.
- Trial name
- NCT04870606
- Testing
- Proxalutamide (GT0918)
- Where
- 8 sites in United States
- Volunteers
- 733 people
- Sponsor
- Suzhou Kintor Pharmaceutical Inc,
COVID-19
A Drug-drug Interaction Study of S-892216 Coadministered With Carbamazepime to Healthy Adult Participants
The primary objective of this study is to investigate the effect of multiple-dose administration of carbamazepine on the pharmacokinetics of S-892216 in healthy adults.
- Trial name
- NCT06751017
- Testing
- S-892216, Carbamazepine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shionogi
Healthy
A Study to Learn About How Itraconazole Affects the Blood Level of Study Medicine (PF-07817883) in Healthy Adults.
The purpose of this study is to learn how Itraconazole affects the blood level of PF-07817883 in Healthy Adults. This study is seeking participants who are: male and female aged 18 to 65 years old, overtly healthy.
- Trial name
- NCT05822440
- Testing
- PF-07817883, Itraconazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
COVID-19
Efficacy and Safety of SA58 Nasal Spray in Close Contact With COVID-19 People
This is a randomized, single-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of SA58 nasal spray in close contact with COVID-19 people.
- Trial name
- NCT05667714
- Testing
- SA58 Nasal Spray
- Where
- China
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
COVID-19, Coronavirus Disease 2019
LB1148 for Pulmonary Dysfunction Associated With COVID-19 Pneumonia
This is a Phase 2, proof of concept, randomized, placebo-controlled, multicenter study to evaluate the ability of LB1148 to attenuate pulmonary dysfunction associated with COVID-19 pneumonia.
- Conditions
- COVID-19, Coronavirus Disease 2019, Covid19, COVID-19 Pneumonia
- Trial name
- NCT04390217
- Testing
- LB1148
- Sponsor
- Leading BioSciences, Inc
COVID-19
Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19
This randomized study evaluates the antiviral activity, safety, efficacy and pharmacokinetics of AT-527 versus a placebo in participants with mild or moderate coronavirus disease (COVID-19) who are not hospitalized.
- Trial name
- NCT04709835
- Testing
- AT-527
- Where
- 12 sites in Canada, Greece and 4 more
- Volunteers
- 104 people
- Sponsor
- Hoffmann-La Roche
Covid19, SARS-CoV Infection
A Virtual Prospective Study Exploring Activity Trackers and COVID-19 Infections
Prospective, observational, exploratory study exploring the relationship between passively-collected data from wearable activity devices and SARS-CoV-2 infection
- Trial name
- NCT04623138
- Where
- United States
- Volunteers
- 847 people, healthy volunteers welcome
- Sponsor
- Evidation Health
Convalescence, Corona Virus Infection
Convalescent Plasma Therapy in Patients With COVID-19
Scientists and medical workers all around the world were running out of time to manage COVID-19. Several studies have been done to understand the disease and ultimately to find possible treatment.
- Conditions
- Convalescence, Corona Virus Infection, Plaque
- Trial name
- NCT04407208
- Testing
- Convalescent plasma
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Biofarma
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