Clinical trials: SARS-COV-2 Infections
SARS-CoV2 Infection, Proximal Tubule Dysfunction
Analysis of SARS-CoV2 Urine Viral Particles and Association With Proximal Tubular Dysfunction
The primary goal is to detect Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV2) urine viral particles in patients in intensive care units, hospitalized for coronavirus Coronavirus Disease-19 (COVID-19) infection, and…
- Trial name
- CovUrinePTD (NCT04937712)
- Testing
- RT-PCR SARS-COV2 in urine
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Central Hospital, Nancy, France
SARS-CoV-2
A Study to Evaluate the Immunogenicity and Safety of mRNA-1283 COVID-19 Vaccine Boosters
The main goal of Part A of this study is to assess the safety, reactogenicity, and immunogenicity of the study vaccine candidates.
- Trial name
- NCT05137236
- Testing
- mRNA-1283, mRNA-1283.211, mRNA-1273
- Where
- 17 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
COVID-19
Convalescent Plasma Therapy - Zurich Protocol
This is an open-label, single-center, phase I study to assess the safety and efficacy of convalescent plasma therapy (CPT) obtained from donors who were tested positive for SARS-CoV-2 and fully recovered from the infection and…
- Trial name
- CPT-ZHP (NCT04869072)
- Testing
- Convalescent plasma
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
COVID-19, Pediatric ALL
Symptom Patterns and Life With Longer Term COVID-19 in Children and Young People (SPLaT-19 Cohort & Qualitative Study)
Introduction: While there is a substantial body of knowledge about acute Covid-19 in children and young people (CYP), less is known about long-COVID, where symptoms continue beyond four weeks, particularly since the most recent…
- Trial name
- SPLaT-19 (NCT05422937)
- Where
- United Kingdom
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- Keele University
Vaccine Refusal, Covid19
Project 2VIDA! COVID-19 Vaccine Intervention Delivery for Adults in Southern California
The United States (U.S.) is the country with the largest number of infections and deaths due to COVID- 19 and racial/ethnic minorities are disproportionately affected.
- Trial name
- 2VIDA! (NCT05022472)
- Testing
- COVID-19 Individual Awareness and Education., COVID-19 Community Outreach & Health Promotion., COVID-19 Individual Health Education & Linkages to Medical and Supportive Services.
- Where
- 6 sites in United States
- Volunteers
- 1,051 people, healthy volunteers welcome
- Sponsor
- Britt Skaathun
ME/CFS, Long COVID
Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome?
Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people…
- Conditions
- ME/CFS, Long COVID, Post- COVID-19 Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
- Trial name
- ME/CFS (NCT07454395)
- Testing
- Swimming, Cycling
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
COVID-19, Telemedicine
Acceptability of Telehealth Triage Using Robotic Systems in COVID-19
The overall objective of this investigation is to understand the patient response to a robotic platform used to facilitate telehealth triage in the emergency department during the COVID-19 pandemic.
- Conditions
- COVID-19, Telemedicine, Robotics, Emergencies
- Trial name
- NCT04452695
- Testing
- Doctor Spot
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
COVID-19 Infection
ESICM UNITE COVID-19 Project (UNITE-COVID)
COVID-19 is arguably the biggest challenge critical care medicine has been confronted with since its conception. Critical care services around the world are flooded by patients presenting with severe respiratory failure who…
- Trial name
- UNITE-COVID (NCT04836065)
- Where
- Belgium
- Volunteers
- 4,995 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
COVID-19
Risk Factors for Severe Disease in Hospitalized Patients With COVID-19 and the Effect of Azvudine Treatment: a Retrospective Cohort Study
The purpose of this study is to explore the factors that can affect the development of severe cases in hospitalized patients with COVID-19, including basic diseases, laboratory parameters, and clinical manifestations; In…
- Trial name
- NCT06006611
- Testing
- Azvudine
- Where
- China
- Volunteers
- 4,201 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
COVID-19, COVID-19 (SARS-CoV-2 Infection)
Evaluation of Safety, Tolerance, and Efficacy of Allogeneic LB-DTK-COV19 in Severe Coronavirus Disease 2019 Patients
The goal of this clinical trial is to evaluate the safety, tolerability, and efficacy of allogeneic SARS-CoV-2-Specific T cells (LB-DTK-COV19) in patients with persistent clinical symptoms following a positive SARS-CoV-2 PCR test…
- Trial name
- NCT07709637
- Testing
- LB-DTK-COV19
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- LucasBio
COVID-19, Corona Virus Infection
Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care
This study will assess the efficacy of hydroxychloroquine in reducing the severity of symptoms in patients with COVID-19
- Conditions
- COVID-19, Corona Virus Infection, SARS-CoV-2, 2019-nCoV
- Trial name
- NCT04334967
- Testing
- Hydroxychloroquine, Vitamin C
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Providence Health & Services
Number of Patients During the Studying Period, Reason for Consultation
Conséquences of the COVID-19 Lockdown Measures on the CHRU Nancy Pediatric Emergency Services
The first period of COVID 19 Lockdown Measures (From 18 March to 11 may 2020) change the French people way of life and their medicine knowledges.
- Trial name
- NCT04668937
- Where
- France
- Volunteers
- 11,000 people
- Sponsor
- Central Hospital, Nancy, France
Sleepiness, SARS-CoV2 Infection
Obstructive Sleep Apnoea Post Covid 19: Role of the Upper Airway Microbiome
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing coronavirus disease, Covid-19, has spread rapidly across the globe since its emergence in January 2020.
- Conditions
- Sleepiness, SARS-CoV2 Infection, Fatigue Syndrome, Chronic, Snoring
- Trial name
- NCT05116657
- Testing
- Nasal Lavage and Oral Wash
- Volunteers
- 50 people
- Sponsor
- Royal College of Surgeons, Ireland
Severe COVID-19
Comparative Analysis of Clinical Parameters and Radiographic Changes of Severe COVID-19
Novel Coronavirus Pneumonia (COVID-19) is the pneumonia caused by the 2019 novel coronavirus infection. Critically ill patients with this disease develop dyspnea and hypoxemia, and even further aggravate acute respiratory…
- Trial name
- NCT04918901
- Testing
- NO Severe COVID-19
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Covid19
Changes in Physical Activity Status: Comparison of Older Adults With Versus Without a History of Covid-19 Infection
The negative impact of the Covid-19 pandemic on the physical activity behavior of overall adults has been reported. But much less is known in older adults.
- Trial name
- NCT04958681
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Gulhane Training and Research Hospital
STEMI - ST Elevation Myocardial Infarction
Thrombolysis in STEMI Patients Compared With pPCI on Recanalization Time in the Context of the COVID-19 Outbreak.
During the outbreak of COVID-19, for patients with acute ST-segment elevation myocardial infarction with unclear infection, the time of primary PCI is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes.
- Trial name
- RESCUE-STEMI (NCT05354128)
- Testing
- Thrombolytic, percutaneous coronary stenting
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ya-Wei Xu
COVID-19, Elderly Patients
Outcomes and Prognostic Factors in COVID-19
The primary aim is to study the short-term outcome of elderly ICU patients (≥ 70 years) suffering from COVID-19 using a multicenter and multi-national approach.
- Conditions
- COVID-19, Elderly Patients, Critical Illness, Survival
- Trial name
- COVIP (NCT04321265)
- Where
- 7 sites in Denmark, France and 2 more
- Volunteers
- 1,500 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
COVID-19
Accelerated Prone Position Ventilation of Patients With COVID-19
Prone position ventilation is frequently used in the ICU to treat severe hypoxemia in patients with COVID-19 associated acute respiratory distress syndrome (ARDS).
- Trial name
- PROVENT-COVID (NCT04384900)
- Testing
- Prone position ventilation
- Where
- Denmark
- Sponsor
- Nordsjaellands Hospital
Telemedicine, Pharynx
Telemedically Assisted Sampling of COVID-19 Patients - Is the Sampling Quality Sufficient
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) pandemic has resulted in more than 3.8 billion registered tests, 275 million positive cases, and 5 million deaths worldwide.
- Conditions
- Telemedicine, Pharynx, COVID-19
- Trial name
- NCT05386407
- Testing
- telemedically guided oropharyngeal + nasal (OP+N) self-sampling (GSS) and nasopharyngeal (NP) or OP+N sampling performed by health care professionals (HCP)
- Where
- Switzerland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Teststation Praxis Dr. med Bielecki
Covid19
Convalescent Plasma for the Treatment of COVID-19 (Coronavirus Disease 2019)
This pilot, prospective study will assess the safety and efficacy of COVID-19 convalescent plasma versus standard care as treatment for severe and/or critical COVID-19 (as defined in the inclusion criteria) in adults 18 years of…
- Trial name
- NCT04554992
- Testing
- COVID 19 Convalescent Plasma
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The Methodist Hospital Research Institute
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