Clinical trials: SARS-COV-2 Infections
Stigma, Social, Help-Seeking Behavior
Digital Mental Health Care for COVID-19 High-Risk Populations - Phase 2
The mental health consequences of the COVID-19 (Coronavirus Disease of 2019) pandemic are likely to be vast, exceeding the capacity of mental health services and delaying treatment for people in need, with devastating…
- Trial name
- NCT05826132
- Testing
- Adjusted Content Intervention, Non-Adjusted Intervention Video
- Where
- United States
- Volunteers
- 1,402 people, healthy volunteers welcome
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
COVID-19 Respiratory Infection
An Observational, Ambispective Cohort Study of Azvudine in the Treatment of Patients With COVID-19 Pneumonia
This is a multicenter, ambispective observational cohort study. The patients with corona virus disease 2019 (COVID-19) will be included in the study.
- Trial name
- NCT05621993
- Testing
- Azvudine
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Qianfoshan Hospital
COVID-19
Povidone-Iodine Oral Rinse Study
This study is a two-arm, randomized, 2-phase study. Phase I will be double blinded clinical trial of the safety and efficacy of an antiseptic mouthwash solution on reducing SARS-CoV-2 load in COVID 19+ adult individuals.
- Trial name
- NCT05239598
- Testing
- Mouth rinse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
SARS-CoV-2, Hypoxia
Critical Care Results of SARS-CoV-2 ARDS by Dapsone and Standard COVID-19 Treatment
Abstract Background: Clinicians in pulmonary critical care medicine and critical care medicine considered dapsone administration to treat SARS-CoV-2 inflammasome.
- Conditions
- SARS-CoV-2, Hypoxia, ARDS
- Trial name
- NCT04918914
- Testing
- Dapsone 100 MG
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hunt Regional Medical Center
Biochemical Markers ,NGAL,Cystatin c, Acute Kidneyinjury, Covid 19
Role of NGAL and Cystatin C in Prediction of Acute Kidney Injury Covid-19 Infection
Recent different biomarkers of acute kidney injury (AKI) have been manufactured by pharmaceutical industry. Studies proved that Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin c are effective predictive biomarkers…
- Trial name
- NCT04603664
- Testing
- serum NGAL and cystatin c
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
COVID, Covid-19
A Study of ResCure™ to Treat COVID-19 Infection
This is a Phase I open-label interventional study which will test the efficacy of ResCure™ in the treatment of patients with COVID-19 infection.
- Conditions
- COVID, Covid-19, Corona Virus Infection, Sars-CoV2
- Trial name
- NCT04395716
- Testing
- ResCure™
- Where
- United States
- Sponsor
- ProgenaBiome
COVID-19
Impact of New Variants and Vaccines on the Course of COVID-19
Novel coronavirus disease (COVID-19), caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, was first reported in December 2019 in Wuhan, China.
- Trial name
- COVID-19 (NCT05384886)
- Testing
- Polymerase chain reaction
- Where
- Turkey (Türkiye)
- Volunteers
- 15,967 people
- Sponsor
- Izmir Katip Celebi University
Spinal Cord Injuries
Needs of Persons with Spinal Cord Injury (SCI)
Persons with spinal cord injury (PwSCI) are at a greater risk for major health conditions and poorer health outcomes than persons without spinal cord injury (SCI).
- Trial name
- NCT04422769
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Washington University School of Medicine
Covid19, SARS-CoV Infection
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)
1. The purpose of this trial is to conduct a 2x3 factorial randomized trials, which efficiently allows the parallel conduct of three randomized trials to understand whether metformin, ivermectin, or fluvoxamine, is superior to…
- Trial name
- NCT04510194
- Testing
- Metformin, Fluvoxamine, Ivermectin
- Where
- 7 sites in United States
- Volunteers
- 1,323 people
- Sponsor
- University of Minnesota
Advanced Care Planning, Shared Decision Making
Advance Care Planning: Communicating With Outpatients for Vital Informed Decision
This Pre-Post, open-cohort design, pragmatic trial with 150 clinicians and will evaluate the effectiveness of the use of telehealth Advanced Care Planning (ACP) Program by comparing ACP documentation among 13,000 patients over 65
- Conditions
- Advanced Care Planning, Shared Decision Making, Video Decision Aids, Communication Skills
- Trial name
- ACP-COVID (NCT04660422)
- Testing
- VitalTalk communication skills training, ACP Decisions Video Program, Intervention training:
- Where
- United States
- Volunteers
- 42,019 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Covid19, Sars-CoV-2 Infection
Performance Study of SONA Saliva C-19 Rapid Test
The Sona Saliva C-19 Rapid Test is a bioassay intended for rapid point-of-care detection of the SARS-CoV-2 virus. Performance of the Sona Saliva C-19 Rapid Test assay will be assessed by comparison to a RT-PCR reference method
- Conditions
- Covid19, Sars-CoV-2 Infection, Corona Virus Infection
- Trial name
- NCT04877002
- Testing
- Sona Saliva C-19 Rapid Test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sona Nanotech Inc
COVID-19
A Phase 1b Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19
This is a phase 1b, randomized, double-blind, positive control trial in healthy adults, intended to evaluate the safety and immunogenicity profile of RQ3013 in healthy adults primed with a two-dose inactivated vaccine 6-9 months…
- Trial name
- NCT05396573
- Testing
- RQ3013, Comirnaty
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Walvax Biotechnology Co., Ltd.
SARS-COV2 Virus
SARS-COV2 Pandemic Serosurvey and Blood Sampling
Background: Respiratory virus outbreaks and pandemics, such as SARS, MERS, and the new SARS-COV2 virus, have major impacts worldwide.
- Trial name
- NCT04334954
- Where
- 3 sites in United States
- Volunteers
- 11,363 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post-Acute COVID-19 Syndrome, Dysautonomia
Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial
Dysautonomia in post-covid-19 condition appears to affect a significant number of patients, with reports raising the incidence up to 61%, having an overlap with myalgic encephalomyelitis/ chronic fatigue syndrome.
- Trial name
- LoCoDiRe-Dys (NCT05855356)
- Testing
- Rehabilitation, Standard of Care
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Evangelismos Hospital
Social Isolation, Physical Inactivity
Video-Based Exercises and Well-Being During Social Isolation
Both influenza and coronaviruses cause respiratory infections, which can lead to morbidity and mortality, especially in those who are immunocompromised or not immune to viruses (Zhu).
- Conditions
- Social Isolation, Physical Inactivity, Well-Being
- Trial name
- NCT04335851
- Testing
- Video based aerobic exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Biruni University
Covid19
COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
- Trial name
- NCT04476953
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
COVID-19
Portable Oxygen Concentrator (POC) Versus Standard of Care in Long-COVID: Randomized Crossover Exploratory Pilot Study.
A prospective, open label, randomized, crossover, pilot, exploratory study to describe the effect of the Inogen One® G4 POC on brain hypoxia, peripheral oxygen saturation and cognitive function in adults with longterm- COVID.
- Trial name
- RESTORE (NCT05212831)
- Testing
- Inogen One® G4
- Where
- 2 sites in Canada
- Volunteers
- 21 people
- Sponsor
- Inogen Inc.
COVID-19 Pneumonia
Low-Dose Radiation Therapy for Severe COVID-19 Pneumonia
This phase II trial studies low-dose radiation therapy as a treatment for patients with severe COVID-19 pneumonia to improve clinical status.
- Trial name
- NCT05694962
- Testing
- Low-Dose Radiation Therapy
- Volunteers
- 40 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
COVID-19
Retrospective Study of COVID-19 on Reproductive Function
This multi-center, retrospective cohort study aimed to determine which factors are associated with ongoing pregnancy rates in infertile patients received ART treatments during the current outbreak of COVID-19 infection.Couples…
- Trial name
- NCT05685966
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- Jinling Hospital, China
Covid19
Phase 3 Open-Label Controlled Trial of Convalescent Plasma in Early COVID-19 Infection
The expanded access program for investigational convalescent plasma (CP) is being utilized nationwide despite its unproven benefit and optimal timing of transfusion.
- Trial name
- NCT06084351
- Testing
- Convalescent Plasma, Standard of Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Larkin Community Hospital
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