Clinical trials: SARS-COV-2 Infections
SARS-CoV-2 Pneumonia, COVID-19
Hydroxychloroquine in SARS-CoV-2 (COVID-19) Pneumonia Trial
Novel coronavirus SARS(Severe Acute Respiratory Syndrome)-CoV-2 was first identified during the outbreak in Wuhan, China in December 2019 with the now resulting pandemic.
- Trial name
- NCT04382625
- Testing
- Hydroxychloroquine
- Where
- United States
- Sponsor
- Kootenai Health
COVID-19
Bank of Human Leukocytes From COVID-19 Convalescent Donors With an Anti-SARS-CoV-2 Cellular Immunity
The SARS-CoV-2 identified in China in January 2020 is the cause of an unprecedented pandemic. The SARS-CoV-2 and each viral variant are responsible of a respiratory infectious disease, which can be asymptomatic.
- Trial name
- COVIBank (NCT05458440)
- Testing
- Generation of a biobank allowing the cryopreservation of leucocytes from COVID19 convalescent donors
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Central Hospital, Nancy, France
COVID-19
Calcifediol in the Treatment of COVID 19
Patients hospitalized with COVID-19 treated with calcifediol during the first outbreaks of the pandemic (until the first vaccinations) are compared with the aim of determining the therapeutic, clinical, functional, and…
- Trial name
- NCT05819918
- Testing
- Calcifediol, Best available therapy
- Where
- Spain
- Volunteers
- 728 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Covid19
Charité Trial of Cenicriviroc (CVC) Treatment for COVID-19 Patients
The aim of this study is to test Cenicriviroc (CVC) as a means to reduce the severity of the lung disease COVID-19 caused by an infection with SARS-CoV-2.
- Trial name
- NCT04500418
- Testing
- Cenicriviroc (CVC)
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Charite University, Berlin, Germany
Covid19
Treatment of Respiratory Complications Associated With COVID-19 Using Umbilical Cord Mesenchymal Stromal Cells
This is a randomized phase II placebo controlled clinical trial. Active arm: Allogeneic Wharton's jelly derived MSCs (WJ-MSCs). Both groups will receive standard of care treatment for COVID (e.g. dexamethasone)
- Trial name
- ProTrans19+ (NCT04869397)
- Testing
- Allogeneic Wharton's jelly-MSCs (WJ-MSC)
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Covid19
PCR Cycle Threshold Values and COVID-19 Outcomes
This is a retrospective observational study. The study will use high quality, reliable data that has already been collected for the ISARIC 4C COVID-19 study in order to analyse the relation between predictor variables (laboratory…
- Trial name
- NCT04651413
- Testing
- PCR Value
- Where
- United Kingdom
- Volunteers
- 934 people, healthy volunteers welcome
- Sponsor
- University Hospitals of North Midlands NHS Trust
SARS-CoV2 Infection
Fatigue a Long COVID-19 Symptom Substudy of FSC19-KN Trial
Prospective, controlled follow-up observation of SARS-CoV-2 positive patients with regard to the aspect of fatigue (cognitive / motor) and psychological disorders in the areas of anxiety, depression and somatization.
- Trial name
- SubFSC19-KN (NCT04883190)
- Testing
- Fulfilling Questionaires
- Where
- Germany
- Volunteers
- 353 people
- Sponsor
- Hegau-Bodensee-Klinikum Singen
Covid19, Femur Fracture
Femoral frACturEs and COVID-19.
Retrospective cohort study comparing the early prognosis after surgically-treated proximal femur fragility fractures in patients affected and not affected by COVID-19.
- Conditions
- Covid19, Femur Fracture, Fragility Fracture
- Trial name
- FACE COVID-19 (NCT04657510)
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
COVID-19 Pneumonia, Diaphragm Disease
Diaphragm Ultrasound Evaluation During Weaning From Mechanical Ventilation in the Positive COVID-19 Patient
Hypoxemic acute respiratory failure is one of the main COVID-19 patients complication that lead to in intensive care hospitalization. This complication determines a variable mortality from 25 to 30%.
- Trial name
- NCT05019313
- Testing
- Evaluation of diaphragmatic contractility by ultrasound
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Telemedicine
Covid-19 Predictors: Safety of Gynecological Oncology Patients Undergoing Systemic Cancer Therapy
We designed a monocenter prospective cohort study using PROM via app and remote monitoring via pho-toplethysmography (PPG). The application of these technologies enables an early detection of infections and therefore initiation…
- Trial name
- CO-SI-ONKO (NCT05043220)
- Testing
- PPG and PROM
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Mental Health
COVID19 and Physical and Emotional Wellbeing of HCP
The current COVID-19 pandemic has affected more than 3 million people worldwide across more than 200 countries. In the United Kingdom alone, at the end of April, there were almost 160,000 confirmed cases with more than 20,000…
- Trial name
- CoPE-HCP (NCT04433260)
- Testing
- Questionnaire including validated tools such as Patient Health Questionnaire (PHQ-9), the 7-item Generalised Anxiety Disorder (GAD- 7), the 7-item insomnia severity index, Questionnaire, same tools as before, with inclusion of PCL5 questionnaire too., Informed consent
- Where
- United Kingdom
- Volunteers
- 1,721 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
SARS Pneumonia
Convalescent Plasma of Covid-19 to Treat SARS-COV-2 a Randomized Doble Blind 2 Center Trial
The new SARS-CoV-2 coronavirus is an emerging virus originating in Wuhan, China that has spread rapidly throughout the world. As of March 24, 2020, China had reported 81,767 cases with 3,281 deaths, and the World Health…
- Trial name
- CPC-SARS (NCT04405310)
- Testing
- Convalescent Plasma of patients with COVID-19
- Where
- 2 sites in Mexico
- Volunteers
- 42 people
- Sponsor
- Grupo Mexicano para el Estudio de la Medicina Intensiva
COVID-19
TCM Differentiation and Treatment Protocol of COVID-19
Evaluation of the efficacy and safety of TCM differential treatment of COVID-19 in Jiangsu Province based on the historical prospective multicenter cohort study.
- Trial name
- TDATPOC (NCT04306497)
- Testing
- TCM prescriptions
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Behavior, Social, Autonomic Imbalance
Coping Strategies and Responsiveness to a Brief Online Intervention During COVID-19 Pandemic
The present study investigates the efficacy of a brief and cost-effective video-intervention that combines bottom-up elements of deep breathing and third-wave cognitive behavioral therapy techniques (i.e., mindfulness and…
- Trial name
- NCT04382560
- Testing
- Deep Breathing training, Compassion focused intervention
- Where
- Italy
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Parma
Covid19, Sars-CoV-2 Infection
Management of Cytokine Storms in Severe COVID-19 Patients With Autologous Activated Platelet-rich Plasma Therapy
The positive cases of coronavirus disease-2019 (COVID-19) in Indonesia has been increasing rapidly since the first case found in March 2020 to date.
- Conditions
- Covid19, Sars-CoV-2 Infection, ARDS, Human, Severe covid19
- Trial name
- NCT04715360
- Testing
- autologous activated platelet-rich plasma, Avigan
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Hayandra Peduli Foundation
Malnutrition, Isolation
Feasibility of Remote Home Support Coaches (SOCIAL Study)
The goal of this this study is to develop and test the feasibility of a remotely delivered brief behavioral activation intervention to decrease the negative physical and psychological consequences of being homebound among older…
- Conditions
- Malnutrition, Isolation, Depression, Anxiety
- Trial name
- NCT04772820
- Testing
- Telephone-based coaching
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
COVID-19
Working Towards Empowered Community-driven Approaches to Increase Vaccination and Preventive Care Engagement
This study will optimize, implement, and test the impact of our multicomponent health program that includes three primary implementation strategies (Cultural Weavers and co-creation, mHealth strategies using culturally meaningful…
- Trial name
- WEAVE (NCT05841810)
- Testing
- mHealth Outreach, Care Coordination
- Where
- 4 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Depressive Symptoms, Metacognitive Variables
Do Network Centrality Predict Overall Depression Symptom Reduction With Lifting of Social Distancing Protocols?
The aim of the study is to identify symptom-level intervention targets for depression related to the COVID-19 outbreak. First, we will assess centrality indices of the network of depression symptoms plus mechanism variables…
- Trial name
- NCT04444713
- Volunteers
- 10,084 people, healthy volunteers welcome
- Sponsor
- Modum Bad
Covid-19, ARDS
Prone Positioning for Patients on General Medical Wards With COVID19
COVID-PRONE is a multicenter, pragmatic, unblinded, 2-arm, parallel, randomized controlled trial seeking to compare the pre-emptive prone positioning (i.e.
- Trial name
- COVID-PRONE (NCT04383613)
- Testing
- Prone positioning
- Where
- 8 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
SARS-CoV-2 Infection Covid19
Differential Leucocyte Count and Covid-19 Diagnosis
To date, the diagnosis of SARS-CoV-2 infection is made by identifying the viral RNA in samples collected through a nasopharyngeal swab or other respiratory samples but this technique, has several limitations for its application…
- Trial name
- NCT04643860
- Testing
- Differential Leucocyte Count (CLDC) device and algorithm
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
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