Clinical trials: SARS-COV2 Infection
COVID-19, Chronic Lung Diseases
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs
This is study is comprised of three approaches. First, the investigators will conduct a retrospective cohort study to determine factors associated with COVID-19 severity and complications and understand COVID-19 outcomes…
- Trial name
- LAUREL (NCT04628039)
- Where
- 2 sites in United States
- Volunteers
- 622 people
- Sponsor
- VA Office of Research and Development
COVID-19
CoronaWatch - Early Detection of Cardiovascular Risks in COVID-19 Via SmartWatch
In December 2019, a new viral disease called COVID-19 emerged. It is caused by the new corona virus SARS-CoV-2. It was initially described in the chinese city of Wuhan.
- Trial name
- CoronaWatch (NCT04376853)
- Testing
- Apple Watch Series 5
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg
Tumor, COVID-19
Time to Initiated Antitumor Therapy for Tumor Patients With COVID19 Infection
The goal of this observational study is to study the safety of initiation of antitumor therapy early after nucleic acid test turn negativity in tumor patients infected with COVID-19.
- Trial name
- NCT06006845
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Seventh Affiliated Hospital of Sun Yat-sen University
SARS-CoV-2, COVID-19
The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load
Preoperative antiseptic mouth rinses have been widely used as a standard protocol before routine dental treatment reduces oral microorganism counts.
- Conditions
- SARS-CoV-2, COVID-19, Mouthwashes, Viral Load
- Trial name
- NCT04721457
- Testing
- Distilled Water, 1% Povidone Iodine (PVP-I), 1.5% Hydrogen Peroxide (H2O2)
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Femoral Neck Fractures, SARS-CoV 2
A Study of Outcomes in Patients With Fractured Neck of Femur During the COVID-19 Pandemic
In early 2020 the evolving COVID-19 Pandemic provided the world and medical community with a generational challenge. As a novel disease, countries were left with strategic decisions and many went into social lockdown.
- Trial name
- NCT04375501
- Testing
- Surgery: Dynamic Hip Screw, hemiarthroplasty, hip replacement, intramedullary nail
- Where
- United Kingdom
- Volunteers
- 442 people
- Sponsor
- Barts & The London NHS Trust
COVID-19
NGS Diagnostic in COVID-19 Hosts - Genetic Cause Relating to the Course of Disease Progression
In this study (i) the host genome to identify susceptibility regions of infection, inflammation, and host defense, (ii) host response to Severe Acute Respiratory Syndrome-Corona-Virus-2 (SARS-CoV-2) infection, and (iii) viral…
- Trial name
- COVID-19 NGS (NCT04364828)
- Testing
- Whole Genome Analysis, T-cell receptor (TCR) repertoire, SARS-CoV-2 viral composition
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital Tuebingen
Covid-19, SARS-CoV2
Efficacy and Safety of BIO101 in the Prevention of Respiratory Deterioration in Hospitalized COVID-19 Patients
The COVA clinical study is a global multicentric, double-blind, placebo-controlled, group sequential and adaptive 2 parts phase 2-3 study targeting in participants with SARS-CoV-2 pneumonia.
- Trial name
- COVA (NCT04472728)
- Testing
- BIO101
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 238 people
- Sponsor
- Biophytis
COVID-19, COVID Long
Burden of Care of Long COVID Patients After Hospital Discharge
Since March 2020, 3.5 million people have been infected with SARS-COV2 in France, and about 250 000 patients have been hospitalized and successfully discharged.
- Trial name
- BLOC (NCT05073328)
- Testing
- COVID-19 required hospitalisation
- Where
- France
- Volunteers
- 68,822 people
- Sponsor
- Mikhail Dziadzko, MD, PhD
To Assess Long-term Effects of COVID-19 in Patients Who Were Affected With COVID -19
Assessment of Long-term Effects (Complications) of COVID-19 in the Southern Part of Bangladesh - a Retrospective Observational Study.
An outbreak of the novel coronavirus nCoV-19 (SARS-CoV-2), responsible for the coronavirus disease-19 (COVID-19), was first detected in Hubei province, Wuhan, China, on December 31, 2019.
- Trial name
- NCT04987736
- Testing
- RT-PCR
- Where
- Bangladesh
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Sher-E-Bangla Medical College
Covid19, Human Milk
The Effect of Covid-19 on Breast Milk Microbiome and Its Bioactive Components
Coronavirus disease (Covid-19) is a new public health crisis threatening humanity caused by SARS-CoV-2. Although it originated in China's Hubei province in late 2019, it has spread to many countries around the world.
- Trial name
- NCT04836754
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aysu Yıldız Karaahmet
Coronavirus Infection
Mesenchymal Stromal Cell Therapy for Severe Covid-19 Infection
The overall objective of the study is to evaluate the safety and efficacy of MSC therapy combined with best supportive care in hospitalized patients with COVID-19.
- Trial name
- NCT04445454
- Testing
- Mesenchymal stromal cells
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University of Liege
Mindfulness, COVID-19
Mindfulness-based Crisis Intervention for COVID-19 Frontline Healthcare Workers During COVID-19
The COVID-19 outbreak is having an impact on the well-being of healthcare workers. Previous reports on pandemics show that such an impact may last beyond the time of the outbreak.
- Conditions
- Mindfulness, COVID-19, Healthcare Worker
- Trial name
- NCT04555005
- Testing
- Mindfulness based intervention
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
SARS-CoV Infection
Efficacy of L. Plantarum and P. Acidilactici in Adults With SARS-CoV-2 and COVID-19
Clinical research focused to evaluate the effect as coadyuvant of a combination of L. plantarum and P. acidilactici in adults positive for SARS-CoV-2 with mild clinical COVID-19 symptoms.
- Trial name
- NCT04517422
- Testing
- Probiotics
- Where
- Mexico
- Volunteers
- 300 people
- Sponsor
- AB Biotics, SA
COVID19
Efficacy of Nafamostat in Covid-19 Patients (RACONA Study)
RACONA is a prospective trial that will test the hypothesis that nafamostat can lower lung function deterioration and need for intensive care admission in COVID-19 patients.
- Trial name
- RACONA (NCT04352400)
- Testing
- Nafamostat Mesilate
- Where
- Italy
- Volunteers
- 256 people
- Sponsor
- University Hospital Padova
COVID-19
Improving COVID-19 Vaccine Uptake Among Black and Latino Youth
Black and Latino youth may be less likely to get the COVID-19 vaccine than White youth. In this study we will work with community members to come up with ways to help Black and Latino families learn more about the COVID-19…
- Trial name
- NCT05293392
- Testing
- Culturally-Tailored COVID-19 Vaccine Uptake Intervention, Standard Care
- Where
- United States
- Volunteers
- 5,792 people
- Sponsor
- Nemours Children's Health System
Coronavirus Infections, Severe Acute Respiratory Syndrome
Household Transmission Investigation Study for COVID-19 in Tropical Regions
This study is a interventional study that present minimal risks and constraints to evaluate the presence of novel coronavirus (SARS-CoV-2) or antibodies among individuals living in households where there is a confirmed…
- Conditions
- Coronavirus Infections, Severe Acute Respiratory Syndrome, SARS-CoV Infection
- Trial name
- EPI-COVID-19 (NCT04328129)
- Testing
- Human biological samples
- Where
- 4 sites in French Guiana, Guadeloupe and 1 more
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
COVID-19, Acute Respiratory Failure
Influence of Vibroacoustic Therapy Modes on the Course of Coronavirus Infection
Assessment of the dynamics of changes in physical, instrumental and laboratory parameters in patients with identified coronavirus infection complicated by acute respiratory failure included in the study in accordance with the…
- Conditions
- COVID-19, Acute Respiratory Failure, Vibration; Exposure
- Trial name
- NCT05143372
- Testing
- Vibrolung
- Where
- 3 sites in Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Astana Medical University
Vitamin C, COVID-19 Pneumonia
Efficacy of Megadose Vitamin C in Severe and Critical Ill COVID-19 Patients.
The main aim is to determine whether vitamin C can reduce 28-day all-cause mortality or persistent organ dysfunction compared with placebo in patients with severe and critical ill COVID-19 patients.
- Trial name
- NCT05694975
- Testing
- Vitamin C
- Where
- 4 sites in China
- Volunteers
- 608 people
- Sponsor
- Zhujiang Hospital
Covid19, Distress, Emotional
Video-based Psychotherapy for COVID-19 Patients in Isolation Ward in Jakarta
The COVID-19 pandemic has made severe impact worldwide for those inflicted by the disease, the caretakers, the general public, as well as the health care system.
- Trial name
- NCT04841681
- Testing
- Video-based Psychotherapy
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Stress Urinary Incontinence, Incontinence, Urinary
Comparison Between a Telerehabilitation Program for Urinary Incontinence Versus a Conventional Face-to-face Program
Urinary incontinence (UI) is defined as any involuntary loss of urine. It affects a significant percentage of the population, mainly female, with a prevalence of 21.4% in Portuguese women, having a negative impact on quality of…
- Conditions
- Stress Urinary Incontinence, Incontinence, Urinary, Covid19, Pelvic Floor Muscle Weakness
- Trial name
- NCT05114395
- Testing
- Pelvic Floor Telerehabilitation Program, Pelvic Floor Face-to-Face Program
- Where
- 2 sites in Portugal
- Volunteers
- 39 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
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