Clinical trials: SARS-COV2 Infection
Olfaction Disorders
COVID-19: Post-covid Olfactory Disorders Assessment
Covid 19 cause an olfactory loss in more than 80% of cases. This loss most often regresses but leaves 20% of patients with an olfactory complaint, particularly with regard to the quality of daily life.
- Trial name
- NCT04799977
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Corona Virus Infection, COVID-19
Clinical Efficacy of Nafamostat Mesylate for COVID-19 Pneumonia
In-vitro studies revealed that nafamostat mesylate has antiviral activity against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and anti-inflammatory and anti-coagulation effect.
- Trial name
- NCT04418128
- Testing
- Nafamostat Mesylate
- Volunteers
- 84 people
- Sponsor
- Gyeongsang National University Hospital
Sleep
A Dyadic Telehealth Program for Alzheimer's Patients/Caregivers
This study aims to refine and evaluate feasibility of a telehealth intervention for persons with Alzheimer's disease and their caregivers.
- Trial name
- NCT05102565
- Testing
- sleep education program
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
SARS-CoV2 Infection
Safety and Immunogenicity of HDT-301 Targeting a SARS-CoV-2 Variant Spike Protein
This is Phase 1 study is to assess tolerability and immunogenicity of three dose levels of the investigational HDT-301 vaccine administered intramuscularly (IM), both in immunization-naïve participants and as a booster for those…
- Trial name
- NCT05132907
- Testing
- HDT-301
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- HDT Bio
COVID-19
Safety and Efficacy Study of Allogeneic Human Dental Pulp Mesenchymal Stem Cells to Treat Severe COVID-19 Patients
This clinical trial is set out to evaluate the safety and efficacy of allogeneic human dental pulp mesenchymal stem cells in the treatment of severe pneumonia caused by COVID-19; to explore the effects of human dental pulp…
- Trial name
- NCT04336254
- Testing
- allogeneic human dental pulp stem cells (BSH BTC & Utooth BTC)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Renmin Hospital of Wuhan University
COVID-19, SARS-CoV-2
Effect of COVID-19 on Platelet Aggregation
This is a mechanistic, observational, prospective, case and control study, to compare platelet aggregation, analyzed by Multiplate-ADP, in hospitalized patients diagnosed with COVID-19 versus healthy controls.
- Trial name
- NCT04447131
- Testing
- venipuncture in peripheral vein
- Where
- 2 sites in Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Covid19, Acute Cor Pulmonale
Cardiac Performance in Mechanically Ventilated COVID-19 Patients
Although COVID-19 affects primarily the respiratory system, several studies have shown evidence of cardiovascular alterations. Increased troponin levels were observed in a significant proportion of patients and this alteration…
- Conditions
- Covid19, Acute Cor Pulmonale, Cardiac Failure
- Trial name
- NCT04628195
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Pontificia Universidad Catolica de Chile
COVID-19
The Effect of Home-based Rehabilitation Program After COVID-19 Infection
To follow up the cardiopulmonary function after coronavirus disease 2019 (CoVID-19) infection and compare the effect of a 12-week home-based cardiopulmonary with or without add-on remote rehabilitation on the cardiopulmonary…
- Trial name
- NCT05317975
- Testing
- Add-on telerehabilitation and home-based rehabilitation, Home-based rehabilitation alone
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
COVID, Embolism and Thrombosis
COVID-19, bLOod Coagulation and Thrombosis
Coronavirus 2 (SARS-CoV2) has been identified as the pathogen responsible for severe acute respiratory syndrome associated with severe inflammatory syndrome and pneumonia (COVID-19).
- Conditions
- COVID, Embolism and Thrombosis, Pneumonia, Viral
- Trial name
- CLOT (NCT04388657)
- Testing
- Echo-Doppler
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
COVID-19 Disease
Epidemiologic Register on Diabetes and COVID-19 in Tunisia
CoviDTUN is a multicenter observatory set up by a steering committee to determine the presentation and evolution of diabetes in COVID-19 and study its pathogenesis.
- Trial name
- NCT05603130
- Testing
- routinely collected clinical information
- Where
- Tunisia
- Volunteers
- 811 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Covid19
Evaluation of Aerosol in a Dental Clinic
The purpose of this study is to evaluate the effectiveness of external evacuation units and mouth rinses during aerosol generating procedures in a dental clinic and to determine the risk level to the dental practitioners during…
- Trial name
- NCT04659928
- Testing
- High volume evacuation (HVE), Extraoral vacuum aspirator (EVA), Hydrogen Peroxide
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
COVID-19 Pneumonia, Non-invasive Ventilation
The Difference Between Non-invasive High-frequency Oscillatory Ventilation and Non-invasive Continuous Airway Pressure Ventilation in COVID-19 With Acute Hypoxemia
High frequency oscillatory ventilation (HFOV), as an ideal lung protection ventilation method, has been gradually applied to neonatal intensive care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05706467
- Testing
- Non-invasive high-frequency oscillatory ventilation, Non-invasive continuous positive airway pressure ventilation
- Volunteers
- 20 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
SARS-CoV-2, Influenza
A Study of mRNA-1083 (SARS-CoV-2 and Influenza) Vaccine in Healthy Adult Participants, ≥50 Years of Age
The purpose of this study is to evaluate the immunogenicity, safety, and reactogenicity of mRNA-1083 as compared with active control, co-administered licensed influenza and severe acute respiratory syndrome coronavirus 2 (SARS…
- Trial name
- NCT06097273
- Testing
- mRNA-1083, Influenza Vaccine, COVID-19 Vaccine
- Where
- 146 sites in United States
- Volunteers
- 8,061 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Intubation; Difficult or Failed
Impact of Covid-19 Aerosol Box On Intubation Success Rate
The safety of novel medical device must be assessed before being implemented into clinical practice. In the case of aerosol box, one of the safety features concerned includes its impact on intubation and how it affect the…
- Trial name
- NCT06042829
- Testing
- Intubation using aerosol box, Intubation without aerosol box
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Disordered Eating, Stress
Biofeedback for CHAMPS
As a result of the COVID-19 pandemic, the degree of burnout and consequential negative psychological effects experienced by healthcare providers has been substantially exacerbated.
- Trial name
- NCT04921228
- Testing
- Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Villanova University
Coagulopathy
COVID-19 Associated Coagulopathy in Egypt
Coagulopathy is one of the most significant prognostic factors in patients with COVID-19 and is associated with increased mortality and admission to critical care.
- Trial name
- NCT04507230
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Assiut University
COVID-19 Respiratory Infection
Respiratory Muscles Electromyography in Patients With Covid-19
This research was characterized as a cross-sectional observational study, following the recommendations of the STROBE instrument.
- Trial name
- EMG-COVID (NCT05572853)
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- University of Pernambuco
Stroke
Improving Post-acute Stroke Follow-up Care by Adopting Telecare Consultations in a Nurse-led Clinic
Since 2017, Hong Kong has provided post-acute stroke services in clinics operated by stroke advanced practice nurses (APNs). Currently, the applicability of the clinics has been further limited by the emergence of the coronavirus…
- Trial name
- NCT05183672
- Testing
- Telecare consultation, Usual face-to-face consultation
- Where
- Hong Kong
- Volunteers
- 196 people
- Sponsor
- The Hong Kong Polytechnic University
COVID-19
Safety and Immunogenicity of COVID-19 Vaccine in Population Aged 18 Years and Above
This is a randomized, blinded, positive-controlled study to evaluate the safety and immnunogenicity of Recombinant SARS-CoV-2 Vaccine (CHO Cell) LYB001, in population aged 18 years old and above.
- Trial name
- NCT05552573
- Testing
- low-dose LYB001, Recombinant COVID-19 Vaccine (CHO Cell), high-dose LYB001
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guangzhou Patronus Biotech Co., Ltd.
COVID-19 (Coronavirus Disease 2019)
Physiological Finding in Management of COVID 19 Patients
This study utilizes physiological indicators of COVID-19 patients as tools for assessing, tracking, worsening, and improving the clinical symptoms of COVID-19 patients.
- Trial name
- COVID-19 (NCT07504341)
- Testing
- physiological parameters
- Where
- 2 sites in Taiwan
- Volunteers
- 15,000 people
- Sponsor
- St. Martin De Porress Hospital
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