Clinical trials: SARS-COV2 Infection
SARS-CoV-2 Infection, Hematological Malignancies
COVID19-hematological Malignancies: the Italian Hematology Alliance
This is a retrospective/prospective, cohort, non-interventional observational study. This means that all patients with documented COVID and HM diagnosed between February 2020 and study initiation will compose the retrospective…
- Trial name
- NCT04352556
- Where
- 81 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Covid-19, Risk Factor, Mortality
Possible Predictors of Mortality Based on COVID-19 for Patients Under 50 Years Old: A Multi-Center Experience of Istanbul
COVID-19, which emerged in China in December 2019, has become a pandemic with its spread to many countries of the world. Mortality rates of COVID-19 pandemics vary between countries.
- Trial name
- NCT04479137
- Testing
- PCR for COVID-19
- Where
- Turkey (Türkiye)
- Volunteers
- 5,000 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
COVID -19, Influenza A
Clinical Validation of the Aptitude Medical Systems Metrix Respiratory Panel Test in At-Home/Non-Laboratory Settings
The Metrix Respiratory Panel Test will be evaluated for use in Non-Laboratory settings in a home testing environment utilizing the clinical study design described herein.
- Conditions
- COVID -19, Influenza A, Influenza B, Respiratory Synctial Virus
- Trial name
- NCT07217639
- Testing
- Aptitude Medical Systems Respiratory Panel Test
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Aptitude Medical Systems
Blood Plasma Therapy, COVID
Convalescent Plasma for COVID-19
The purpose of this proof of concept study is to provide COVID-19 convalescent plasma to patients with moderate to severe COVID-19 and assess: the titer of anti-COVID-19 antibodies in the donors and in the patients before and…
- Trial name
- NCT04365439
- Testing
- Blood plasma
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Enos Bernasconi
SARS-CoV Infection
Do Angiotensin Receptor Blockers Mitigate Progression to Acute Respiratory Distress Syndrome With SARS-CoV-2 Infection
The purpose of this research is to identify whether or not Angiotensin Receptor Blockers (ARB) can halt the progression to respiratory failure requiring transfer into the intensive care unit (ICU), as well as halt mechanical…
- Trial name
- NCT04340557
- Testing
- Losartan
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Sharp HealthCare
Intraoperative Hypertension, Pain Threshold
Post SARS-Cov-2 Disease Anesthesia Events
Estimating and recording the rate of occurrence of pulmonary and cardiovascular complications during the perioperative period in patients with past covid infection
- Conditions
- Intraoperative Hypertension, Pain Threshold, Postoperative Pain, Postoperative Hypoxemia
- Trial name
- NCT05252234
- Testing
- Observation of hemodynamic status and post operative pain
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Virus Diseases
Post-COVID-19 Monitoring in Routine Health Insurance Data With Focus on Autoimmune Diseases (POINTED-AD)
The SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) infection was in 2020 responsible for new disease related chronic conditions which have been referred to as Post-COVID.
- Trial name
- POINTED-AD (NCT05606198)
- Testing
- Exposed to a SARS-CoV-2 infection
- Where
- Germany
- Volunteers
- 641,407 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
SARS-CoV-2, Prevention
The Safety and Tolerability of A8G6 COVID-19 Neutralization Antibody Combined With Nasal Spray
This is a randomized, double-blind, placebo-parallel intervention clinical study that will include approximately 108 healthy subjects based on inclusion and exclusion criteria.
- Trial name
- NCT06127498
- Testing
- A8G6 SARS-CoV-2 Neutralization Antibody combination nasal spray, A8G6 SARS-CoV-2 Neutralization Antibody nasal excipient
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
SARS Virus
Immune Cells in Inflammatory Arthritis With Coronaviruses, Including COVID-19
A team at the University of Manchester are developing a test that tcould be helpful in detecting immunity to the Coronavirus (which causes the COVID-19 disease) in participants with inflammatory arthritis.
- Trial name
- NCT04363047
- Testing
- 40ml blood sample
- Where
- United Kingdom
- Volunteers
- 125 people
- Sponsor
- University of Manchester
Acute Respiratory Distress Syndrome, Viral or Bacterial Infections
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
A Phase 2a, randomized, double-blind, placebo-controlled, multiple ascending dose study in patients who are hospitalized with presumed pneumonia requiring supplemental oxygen therapy.
- Conditions
- Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral
- Trial name
- NCT05123755
- Testing
- AV-001 Injection
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Vasomune Therapeutics, Inc.
COVID-19 Pneumonia
The Effect of Special Discharge Training in the COVID-19
This study aimed to evaluate the impact of specialized discharge education on the daily life activities and quality of life of geriatric patients hospitalized in COVID-19 wards.
- Trial name
- NCT05867485
- Testing
- COVID-19 Discharge Education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kilis 7 Aralik University
COVID-19
COVID-19 Coagulopathy Extension Study
At the University of Iowa, the investigators led a multicenter randomized clinical trial comparing standard prophylactic dose to intermediate dose enoxaparin in hospitalized patients with COVID-19 (NCT04360824).
- Trial name
- NCT05334615
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Iowa
Dyspepsia
The Impact of COVID-19 Infection on the Symptoms of Functional Dyspepsia
Although respiratory symptoms were predominant in patients infected with COVID-19, gastrointestinal symptoms were always reported in about 10% patients.
- Trial name
- NCT05749692
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Air Force Military Medical University, China
Covid19, Stress
Stress and Recovery in Frontline COVID-19 Workers
The novel coronavirus (COVID-19) pandemic has caused an unprecedented stress on healthcare systems in affected countries, and in particular, on the healthcare workers at the frontline working directly with COVID-19 positive…
- Conditions
- Covid19, Stress, Wearables
- Trial name
- NCT04713111
- Testing
- Lifestyle (Meditation), Lifestyle (Exercise)
- Where
- United States
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- 4YouandMe
COVID-19, SARS-CoV-2 Infection
rSIFN-co Among Healthy Subjects and Subjects With Mild or Asymptomatic COVID-19
This is a phase II pilot, international, multicenter, randomized, double-blind, placebo-controlled study that aims to evaluate the safety and preliminary efficacy of rSIFN-co nasal spray in healthy subjects in close contact with…
- Trial name
- NCT05485584
- Testing
- rSIFN-co Nasal Spray
- Where
- 2 sites in Philippines
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Sichuan Huiyang Life Science and Technology Corporation
Covid19
Methylation Effects of COV-19 Infection and Vaccinations
This is a retrospective non-randomized clinical study of 60 patients total to assess the effects of SARS-CoV-2 infection and the SARS-CoV-2 vaccination.
- Trial name
- NCT04939155
- Testing
- SARS-CoV-2 mRNA vaccine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- TruDiagnostic
Sars-CoV2, Covid-19
COPE - COVID-19 in Pregnancy and Early Childhood
Purpose: The emergence of a new coronavirus SARS-CoV-2 causing a novel infection in the human race resulting in a world-spanning pandemic came as a surprise and at a tremendous cost both for individual human lives as well as for…
- Conditions
- Sars-CoV2, Covid-19, Pregnancy Complications, Pregnancy Preterm
- Trial name
- COPE (NCT04433364)
- Testing
- biological samples, questionnaires and interviews
- Where
- 27 sites in Sweden
- Volunteers
- 3,834 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
COVID-19
Phase I/II Clinical Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in Canada
This study is a phase I /II adaptive clinical trial to evaluate the safety, tolerability and the Immunogenicity of Ad5-nCoV in healthy adults from 18 to <55 and 65 to <85 years of age，with the randomized, observer-blind…
- Trial name
- NCT04398147
- Testing
- Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
- Where
- Canada
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Covid19
A Immuno-bridging and Immunization Schedules Study of COVID-19 Vaccine (Vero Cell), Inactivated
This trial is a randomized study to evaluate the immunogenicity of COVID-19 Vaccine (Vero Cell), Inactivated and in population aged 60 years old and 3-17 years old with different schedules compared to that in population aged…
- Trial name
- COVID-19 (NCT04863638)
- Testing
- 3-doses schedule 1 of COVID-19 Vaccine (Vero Cell), Inactivated, 3-doses schedule 2 of COVID-19 Vaccine (Vero Cell), Inactivated, 3-doses schedule 3 of COVID-19 Vaccine (Vero Cell), Inactivated
- Where
- China
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
COVID-19 Infection, COVID-19 VACCINE
Third Dose Vaccination With AstraZeneca or Pfizer COVID-19 Vaccine Among Adults Received Sinovac COVID-19 Vaccine
This prospective, multi-center, randomized, observer-blind Phase 2 study. A total of 1320 participants will be divided into 2 groups (660 each) receiving either full dose or half dose of either AZ or PF.
- Trial name
- NCT05049226
- Testing
- AstraZeneca ChAdOx1 AZD1222 vaccine (AZ) full dose, Pfizer/BioNTech BNT162b2 vaccine (PF) full dose, AstraZeneca ChAdOx1 AZD1222 vaccine (AZ) half dose
- Where
- 7 sites in Thailand
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Mahidol University
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