Clinical trials: SARS-COV2 Infection
Covid19, Humoral Acquired Immunodeficiency
Antibody Detection of Vaccine-Induced Secretory Effects
The purpose of this research study is to conduct a prospective longitudinal surveillance research study, enrolling approximately 60 lactating mothers who receive the SARS-CoV-2 vaccine, and then following their clinical and…
- Conditions
- Covid19, Humoral Acquired Immunodeficiency, Coronavirus, SARS-CoV Infection
- Trial name
- ADVISE (NCT04895475)
- Testing
- SARS-CoV-2 vaccine
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Covid19
Ivermectin Role in Covid-19 Clinical Trial
Because ivermectin is being used to treat COVID-19 with insufficient evidence, the investigator conducted a randomized clinical trial to investigate the efficacy and safety of ivermectin in comparison to hydroxychloroquine and…
- Trial name
- IRICT (NCT04746365)
- Testing
- ivermectin, hydroxychloroquine
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Elaraby Hospital
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Functional Disorders, Post Covid-19
AIR-program and HUS Internet Therapy Compared to Treatment as Usual in Functional Disorders and Post Covid-19 Condition
This study will compare an Amygdala and insula retraining (AIR) program to an internet therapy developed at Helsinki University Hospital. The study will be a multi-center randomized controlled trial.
- Trial name
- NCT05212467
- Testing
- AIR-program, HUS Internet therapy, Treatment as usual
- Where
- 2 sites in Finland
- Volunteers
- 360 people
- Sponsor
- Helsinki University Central Hospital
Coronavirus, Covid19
Place of Circulating Biomarkers and Respiratory Eicosanoids in the Prognosis of Severe Forms of Covid-19 Pneumonia
The research is a prospective, multicentric (Groupe hospitalier Paris Saint-Joseph, Centre Hospitalier de Versailles André Mignot and Centre Hospitalier Victor Dupouy), non-interventional, prospective study.
- Trial name
- BIOCOVID (NCT04485364)
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Fondation Hôpital Saint-Joseph
COVID-19
Elimination or Prolongation of ACE Inhibitors and ARB in Coronavirus Disease 2019
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with a high incidence of acute respiratory distress syndrome (ARDS) and death.
- Trial name
- REPLACECOVID (NCT04338009)
- Testing
- Discontinuation of ARB/ACEI, Continuation of ARB/ACEI
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Pennsylvania
Long COVID, Long COVID-19 Syndrome
Quality of Life After Hyperbaric Oxygen Therapy in Post-COVID Patients
Post-Covid syndrome, also known as long Covid, is a clinical condition in which patients experience long term symptoms after Covid-19 infection. Treatment options for post-Covid are not effective.
- Conditions
- Long COVID, Long COVID-19 Syndrome, Long Covid19, Long Covid 19
- Trial name
- QoL COVID HBOT (NCT06159309)
- Testing
- Hyperbaric oxygen therapy
- Where
- 6 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Rutger Lalieu
Long COVID, Long Covid19
Narrative Intervention for Long COVID-19 (NICO)
This T1 proof of concept trial is designed to test the Narrative Intervention for Long COVID-19 intervention.
- Trial name
- NICO (NCT06091293)
- Testing
- Narrative Intervention for Long COVID-19 (NICO)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Coronavirus
Covid-19 and Vitamin D in Nursing-home
First epidemiological data about COVID-19 pandemic confirm that older adults are likely to experience severe and lethal forms of SARS-CoV-2 infection, in particular frail elderly living in nursing-homes.
- Trial name
- COVIT-EHPAD (NCT04435119)
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Angers
COVID, Corona Virus Infection
Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation
The purpose of this study is to examine the impact of ascorbic acid (vitamin c) and zinc gluconate in reducing duration of symptoms in patients diagnosed with coronavirus disease 2019 (COVID-19).
- Trial name
- COVIDAtoZ (NCT04342728)
- Testing
- Ascorbic Acid, Zinc Gluconate, Ascorbic Acid and Zinc Gluconate
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- The Cleveland Clinic
COVID-19
Efficacy and Safety of MTX-loaded Nanoparticles to Treat Severe COVID-19 Patients
The aim of this study is to evaluate the efficacy and safety of MTX-loaded nanoparticles in three different doses to treat severe COVID-19 patients.
- Trial name
- NCT04352465
- Testing
- Methotrexate
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Azidus Brasil
Covid19
Colchicine for the Treatment of Cardiac Injury in Hospitalized Patients With COVID-19 (COLHEART-19)
This is an open-label unblinded, randomized study to treat hospitalized covid-19 patients with colchicine plus current care (per institution treating physicians) vs.
- Trial name
- Colheart-19 (NCT04762771)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baptist Health South Florida
Acute Respiratory Distress Syndrome (ARDS), COVID-19
Impact of Intravenous Lidocaine on Clinical Outcomes of Patients With ARDS During COVID-19 Pandemia
The purpose of our prospective monocentric, randomized, controlled trial is to evaluate the effects of intravenous lidocaine on gas exchange and inflammation in acute respiratory distress syndrome (ARDS) due or not to Covid-19…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), COVID-19, Corona Virus Infection
- Trial name
- LidoCovid (NCT04609865)
- Testing
- Lidocaine 2%, Control
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Autoimmune Diseases, Inflammatory Disorder
Immunological Response to COVID-19 Vaccine in Patients With Autoimmune and Inflammatory Diseases Treated With Immunosuppressants and/or Biologics
Vaccination against the new coronavirus (SARS-CoV-2) was extended to patients at risk of severe forms of Covid-19, including in particular patients with autoimmune and inflammatory diseases treated by immunosuppressants and/or…
- Trial name
- COVADIS (NCT04870411)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
The Effect of Covid-19 on the Disease Course of Multiple Sclerosis :Belgian Lessons Learned From Rocky I to Rocky IV
Retrospective observational cohort study. ToFCoMS: two years of follow-up of COVID-19 in MS.
- Trial name
- TofCoMS (NCT05403463)
- Where
- Belgium
- Volunteers
- 230 people
- Sponsor
- Marie D'hooghe
COVID-19, Organ Transplant
Immune Registry for Organ Transplantation From COVID Positive Donors.
The purpose of this study is to collect data generated by standard clinical practice to determine the short term and long term clinical outcomes of recipients of solid organ transplantation from COVID-19 infected donors and…
- Trial name
- NCT05595837
- Testing
- Standard organ transplant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Complication of Medical Care, Pneumonia, Viral
Antiviral Drugs on the Treatment of SARS-CoV-2
Retrospective Non-Randomized Analytical Cohort Study of Completed SARS-CoV2 COVID19 Cases
- Trial name
- FavRem (NCT04727775)
- Testing
- Favipiravir, Remdesivir
- Where
- 2 sites in Kazakhstan
- Volunteers
- 150 people
- Sponsor
- Astana Medical University
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
Characteristics and Outcome of Patients With COVID-19 in ICUs in South Tyrol
The investigators retrospectively investigate the epidemiology, clinical characteristics and therapeutic interventions of patients with COVID-19 associated respiratory failure admitted to the intensive care units in South Tyrol…
- Trial name
- NCT05077319
- Where
- Italy
- Volunteers
- 550 people
- Sponsor
- Institute of Mountain Emergency Medicine
Mental Disorder, General Population
Death Number Perception in Depression, Anxiety, and Schizoypal Personnality in General Population (Covid-19 Pandemic)
France has been put on a lockdown for 8 weeks to prevent the spread of the COVID-19 virus between 17/03/2020 and 11/05/2020. During this lockdown, which is likely to have psychopathological repercussions on the population, the…
- Trial name
- DeathPercep (NCT04384419)
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Coronavirus
Viral Excretion in Contact Subjects at High/Moderate Risk of Coronavirus 2019-nCoV Infection. COVID-19.
In December 2019, a pneumonia due to a novel coronavirus (SARS-CoV-2) emerged in the city of Wuhan, in China. In a few weeks, the number of confirmed cases of SARS-CoV-2 infection has dramatically increased, with almost 150'000…
- Trial name
- Cov-CONTACT (NCT04259892)
- Testing
- 2019-nCoV PCR
- Where
- 16 sites in France, French Guiana
- Volunteers
- 324 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
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