Clinical trials: SARS-COV2 Infection
Covid19, SARS-CoV Infection
Short and Medium-term Effects of Pulmonary Rehabilitation in Mild to Critical Post-acute COVID-19
As a direct consequence of the COVID-19 pandemic, it is assumed that the number of patients with COVID-19-related disabilities will increase significantly.
- Conditions
- Covid19, SARS-CoV Infection, Pulmonary Rehabilitation, Quality of Life
- Trial name
- STEPCO (NCT04649918)
- Testing
- pulmonary rehabilitation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Heart Rhythm Disorder, Covid19
Effect of Social Isolation on Physical Activity Level, and Kinesophobia in Heart Rhythm Disorders During Pandemic
The aim of our study is to examine the effect of social isolation on physical activity level, health literacy and kinesophobia in heart rhythm disorders.
- Conditions
- Heart Rhythm Disorder, Covid19, Social Isolation
- Trial name
- NCT04818697
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
COVID-19
International Validation of Wearable Sensor to Monitor COVID-19 Like Signs and Symptoms
1. Deploy wearable COVID sensor to collect high resolution physiological data (temperature, cardiac, respiratory and physical activity) from COVID positive patients. 2.
- Trial name
- NCT05334680
- Testing
- ANNE Sensor
- Where
- 3 sites in India
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Arun Jayaraman, PT, PhD
Covid19, Pneumonia
Nebulized Heparin in Severe Acute Respiratory Syndrome COVID-19
To evaluate the safety and efficacy of the use of inhalational heparin in patients with pulmonary compromise / pneumonia / SARS associated with COVID-19, laboratory with marked inflammation parameters, and prothrombotic state…
- Trial name
- NEBUHEPA (NCT04530578)
- Testing
- Heparin sodium, Enoxaparin
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Clinica San Camilo, Argentina
Covid19, Depression
Depression and Anxiety in Long Term Coronavirus Disease COVID-19
Background : Depression and Anxiety are linked to COVID (Coronavirus Disease)-19 long-term impact through several mechanisms. The possible way is the alteration of neurotransmitter regulation from the interaction of severe acute…
- Conditions
- Covid19, Depression, Anxiety
- Trial name
- DALT-COV (NCT04893668)
- Testing
- Depression, Anxiety
- Where
- Indonesia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Corona Virus Infection, Covid19
Awake Prone Position in Hypoxemic Patients With Coronavirus Disease 19 COVID-19 (COVI-PRONE)
The aim of the COVI-PRONE Trial is to determine if early awake prone positioning in COVID-19 patients with hypoxemic respiratory failure; irrespective of the mode of oxygen delivery; reduces the need for invasive mechanical…
- Conditions
- Corona Virus Infection, Covid19, COVID-19
- Trial name
- COVI-PRONE (NCT04350723)
- Testing
- Awake Proning
- Where
- 17 sites in United States, Canada and 2 more
- Volunteers
- 400 people
- Sponsor
- St. Joseph's Healthcare Hamilton
SARS-CoV-2 Infection
A Study to Assess the Efficacy and Safety of XC221 in Patients With COVID-19
The innovative drug XC221 100 mg tablet is designed for the treatment of COVID-19 (SARS-CoV-2 infection). A multicenter, adaptive, randomized, double-blind, placebo-controlled Phase III clinical study is aimed to assess the…
- Trial name
- NCT04487574
- Testing
- XC221
- Where
- 5 sites in Russia
- Volunteers
- 118 people
- Sponsor
- RSV Therapeutics LLC
COVID-19
Clinical Research of Human Mesenchymal Stem Cells in the Treatment of COVID-19 Pneumonia
The COVID-19 pneumonia has grown to be a global public health emergency since patients were first detected in Wuhan, China, in December 2019, which spread quickly to worldwide and presented a serious threat to public health.
- Trial name
- NCT04339660
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Puren Hospital Affiliated to Wuhan University of Science and Technology
Covid19 Vaccine
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of COVID-19 Vaccine, CT-COV-21 Extension Study
The purpose of this study is to assess the safety and immunogenicity of MVC-COV1901 vaccine who are generally healthy or with stable pre-existing health conditions and have received 2 doses of Placebo in the main study CT-COV-21
- Trial name
- NCT05048849
- Testing
- MVC-COV1901(S protein with adjuvant)
- Where
- 11 sites in Taiwan
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Medigen Vaccine Biologics Corp.
SARS-CoV-2 Infection, Covid19
Prospective COVID-19 Cohort Study, Dominican Republic
This project will build on an existing CDC funded cooperative agreement in the Dominican Republic with the Brigham and Women's Hospital (2018-2023) that includes (i) prospective COVID-19 and AFI surveillance at two health…
- Trial name
- NCT04898738
- Testing
- Alcohol based hand sanitizer
- Where
- Dominican Republic
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Covid-19
Treatment of Severe and Critical COVID-19 Pneumonia With Convalescent Plasma
Open label two arms, non randomized Convalescent Plasma treatment to severe and critical pneumonia COVID-19 hospitlaized patients compared to a historical cohort with matched controls.
- Trial name
- NCT04432103
- Testing
- Anti SARS-CoV 2 Convalescent Plasma in severe COVID-19 patients, Anti SARS-CoV 2 Convalescent Plasma in critical COVID-19 patients
- Where
- Mexico
- Volunteers
- 6 people
- Sponsor
- Centro Medico ABC
SARS-CoV-2 Infection, Cognitive Disorder
Investigation of the Persistence of SARS-CoV-2 in the Olfactory Mucosa of Patients With Prolonged Symptoms of COVID-19
NEUROCOVID is a prospective multicenter study comparing the proportion of patients with SARS-CoV-2 viral RNA at the level of the olfactory clefts in a group of cases compared to a group of controls as well as the correlations…
- Trial name
- NEUROCOVID (NCT05220241)
- Testing
- Nasopharyngeal swab for RT-PCR SARS-CoV-2
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hypoxemic Respiratory Failure
HFNC and Prone Positioning in Awake Patients With Severe COVID-19
The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.
- Trial name
- NCT04982341
- Testing
- prone position
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Hôpital Universitaire Fattouma Bourguiba
COVID-19, Hypercoagulability
Heparins for Thromboprophylaxis in COVID-19 Patients: HETHICO Study in Veneto
The HETHICO study aims to collect retrospectively documented clinical information on patients hospitalized in Veneto Region (Italy) for SARS-COVID-2 infection in 2 types of settings, medical environment (COORTE MED), and…
- Trial name
- HETHICO (NCT04393805)
- Testing
- Low Molecular Weight Heparin
- Where
- Italy
- Volunteers
- 744 people
- Sponsor
- Quovadis Associazione
COVID-19, Undefined
A Clinical Safety Study on AT-100 in Treating Adults With Severe COVID-19 Infection or Severed Community Acquired Pneumonia
The purpose of this study is to determine if an investigational drug, AT-100, is safe and tolerated by adults who have severe corona virus disease 2019 (COVID-19) or respiratory failure secondary to severe community acquired…
- Trial name
- NCT04659122
- Testing
- AT-100
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Airway Therapeutics, Inc.
COVID-19, SARS-CoV 2
Canakinumab in Covid-19 Cardiac Injury (The Three C Study)
TThe purpose of this prospective, Phase 2, single center, blinded, randomized controlled study is to demonstrate as a proof of concept that early treatment with canakinumab prevents progressive heart and respiratory failure in…
- Trial name
- NCT04365153
- Testing
- Canakinumab Injection 600mg, Canakinumab Injection 300mg
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Covid19, Critical Illness
REmotely Monitored, Mobile Health-Supported High Intensity Interval Training After COVID-19 Critical Illness (REMM-HIIT-COVID-19)
REmotely Monitored, Mobile Health-Supported High Intensity Interval Training after COVID-19 critical illness (REMM-HIIT-COVID-19)
- Conditions
- Covid19, Critical Illness, High Intensity Interval Training, ICU
- Trial name
- REMMHIIT-COVID (NCT04664101)
- Testing
- REmotely Monitored, Mhealth (REMM) supported High Intensity Interval Training (HIIT), Comparator
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Duke University
COVID, COVID19
International SARS-CoV-2 (COVID-19) Infection Observational Study
The general aim of this study is to estimate the rate of disease progression for adults testing positive for SARS-CoV-2. The primary endpoint for this study and the basis for sample size is hospitalization or death during the 28…
- Conditions
- COVID, COVID19, SARS-CoV 2, Dyspnea
- Trial name
- ICOS (NCT04385251)
- Testing
- Data Collection
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 11,973 people
- Sponsor
- University of Minnesota
SARS-CoV-2 Infection, COVID-19
Index Individuals in SARS-CoV-2 Prevention Research Studies (COVID-19 Index Individuals Companion Study)
Clinical trials of prevention modalities for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease (COVID-19) and pneumonia are underway under separate protocol(s) for close contacts…
- Conditions
- SARS-CoV-2 Infection, COVID-19, Coronavirus Infection, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- IICov19PRS (NCT05074719)
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- University of Washington
COVID-19 Pandemic
The Immunogenicity and Safety of V-01-351/V-01D Bivalence Vaccine
It is a Single Arm, Open Label Clinical Study to Evaluate the Immunogenicity and Safety of Sequential Immunization of V-01-351/V-01D Bivalence Vaccine in Healthy Adults Aged 18 Years and Older After the Vaccination of 2 Doses of…
- Trial name
- Omicron (NCT05273528)
- Testing
- Recombinant SARS-CoV-2 Beta Variant Fusion Protein Vaccine/Recombinant SARS-CoV-2 Delta Variant Fusion Protein Vaccine
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Livzon Pharmaceutical Group Inc.
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