Clinical trials: SARS-COV2 Virus
Covid19 Related Anosmia and Aguesia
Cerebrolycin for Treatment of Covid-related Anosmia and Ageusia
The loss of smell and taste is a prominent symptom of COVID-19. Studies found that patterns of smell loss due to Covid-19 infection differ from that of other respiratory viruses being much more profound in the Covid-19 patents…
- Trial name
- NCT04830943
- Testing
- Cerebrolysin
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Assiut University
Covid19
Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes
The aim of this study is to analyze the efficacy of oral disinfection with 0.075% Cetylpyridinium Chloride alone and 0.075% Cetylpyridinium Chloride associated with 0.28% zinc lactate in reduction of the viral load of SARS-CoV-2…
- Trial name
- NCT04902976
- Testing
- CPC+ZN, CPC, Negative Control
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Hospital Israelita Albert Einstein
ARDS Due to Disease Caused by SARS Co-V-2, Respiratory Compliance
Altered Respiratory Compliance Under Invasive Mechanical Ventilation in SARS-CoV-2 & Development of Respiratory Sequels
The goal is to study the association between the value of the compliance of the respiratory system at the first day of the initiation of invasive mechanical ventilation and the presence of respiratory sequelae at a distance from…
- Conditions
- ARDS Due to Disease Caused by SARS Co-V-2, Respiratory Compliance, Sequels of COVID
- Trial name
- COMPLI-QUO (NCT05721768)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Covid19
Effectiveness and Safety Study of Specific Hyperimmune Equine Serum for the Treatment of Severe Hospitalized SARS-CoV-2 in Adults: Retrospective Cohort Study
An observational, retrospective, classic cohort study of adult patients hospitalized for severe pneumonia with a diagnosis of SARS-CoV-2 by RT-PCR will be carried out.
- Trial name
- NCT04954235
- Where
- Argentina
- Volunteers
- 847 people
- Sponsor
- Inmunova S.A.
COVID-19
Non Invasive Positive Pressure Ventilation to Minimize Aerosolization for COVID 19
Patients presenting to the emergency department, or needing hospitalization, for a variety of medical conditions often require non-invasive ventilation (breathing support).
- Trial name
- NCT04344925
- Testing
- Aerosol-reducing Mask, Standard Mask
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Covid19, Environmental Exposure
Study on Kidney Disease and EnviromenTal Chemical
1. Purpose: To confirm the changes in lifestyle due to differences in perceptions of infectious disease risk after the COVID-19 pandemic, decrease in exposure levels of environmentally hazardous chemicals and changes in…
- Conditions
- Covid19, Environmental Exposure, Chronic Kidney Diseases
- Trial name
- NCT04679168
- Where
- South Korea
- Volunteers
- 310 people
- Sponsor
- Seoul National University Hospital
COVID-19 (Healthy Volunteers)
Safety, Reactogenicity, and Immunogenicity Study of Heterologous Booster Vaccination of a SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine (GBP510)
This is randomized, placebo-controlled, observer-blinded, multi-center study to assess safety, reactogenicity and immunogenicity of booster vaccination of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted…
- Trial name
- NCT05175950
- Testing
- SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine (GBP510) (RBD of SARS-CoV-2 25ug / dose) Adjuvanted with AS03, Normal saline
- Where
- 9 sites in South Korea
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi
COVID-19 Drug Treatment
Ivermectin Effect on SARS-CoV-2 Replication in Patients With COVID-19
In the context of COVID-19 pandemic, a report on ivermectin suppression of SARS-CoV-2 viral replication in cell cultures has been published, and the use of this medication seems to be potentially useful for the therapy.
- Trial name
- NCT04381884
- Testing
- IVERMECTIN (IVER P®) arm will receive IVM 600 µg / kg once daily plus standard care. CONTROL arm will receive standard care.
- Where
- 3 sites in Argentina
- Volunteers
- 45 people
- Sponsor
- Laboratorio Elea Phoenix S.A.
Healthy, Immunization; Infection
BNT162b2 Vaccination With 2 Doses in COVID-19 Negative Volunteers and With a Single Dose in COVID-19 Positive Volunteers
As previously shown, individuals who experienced COVID-19 have developed some protective immunity to reinfection. The magnitude and duration of protection from reinfection conferred by the infection may be weaker after an…
- Trial name
- CoviCompareP (NCT04824638)
- Testing
- 3 doses of BNT162b2 vaccine, 2 dose of BNT162b2 vaccine
- Where
- 11 sites in France
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
COVID, ARDS
Prone Positioning and High-flow Nasal Cannula in COVID-19 Induced ARDS
Prone position (PP) has been proved to be effective in severe ARDS patients. On the other hand, High flow nasal cannula (HFNC) may prevent intubation in hypoxemic Acute respiratory failure (ARF) patients.
- Conditions
- COVID, ARDS, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- NCT04391140
- Testing
- Prone position
- Where
- Spain
- Volunteers
- 248 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Covid19, SARS (Severe Acute Respiratory Syndrome)
A Phase 3 Randomized Double Blind Efficacy and Safety Study of Oral Polio Vaccine and NA-831 for Covid-19
In this randomized double blind Phase 3 clinical trial we will study the efficacy and safety of oral polio vaccine with and without NA-831 versus placebo.
- Conditions
- Covid19, SARS (Severe Acute Respiratory Syndrome), SARS-CoV Infection, SARS-CoV-2
- Trial name
- OPV-NA831 (NCT04540185)
- Testing
- Biological: oral polio vaccine, NA-831, Combination of oral polio vaccine and NA-831
- Where
- 10 sites in United States, New Zealand
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Biomed Industries, Inc.
SARS-CoV2 Infection, Ventilator Associated Pneumonia
Ventilation Associated Pneumonia and Covid-19
In December 2019, a new pandemic emerged, the COVID-19 disease caused by a SARS-Cov-2 virus. One of the most common symptoms of COVID-19 is mainly respiratory failure and patients requires assistance by mechanical ventilation.
- Conditions
- SARS-CoV2 Infection, Ventilator Associated Pneumonia, Ards, COVID-19
- Trial name
- ECOLCOVID (NCT05089968)
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Corona Virus Infection, Pneumonia
COVID-19 Specific T Cell Derived Exosomes (CSTC-Exo)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused mass mortality in the last 3 months that necessitates urgent development of new therapeutical agents.
- Trial name
- NCT04389385
- Testing
- COVID-19 Specific T Cell derived exosomes (CSTC-Exo)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
CoV2 SARS Pneumonia
Predicting the Progression to Chronic Fibrosis of Lung Lesions Related to Covid-19 Infection From Chest CT Images
The main differences observed between SARSCoV-2 pneumonia and other epidemic viral pneumopathies (e.g., seasonal influenza) are the greater infectivity of SARSCoV-2, the clinical severity of the disease, particularly in young…
- Trial name
- PREDISCAN (NCT04483752)
- Testing
- CHEST CT SCAN
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
SARS-CoV-2
A Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021)
This trial is a phase II clinical trial of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021). The trial was randomized, blinded, placebo controlled.
- Trial name
- NCT05939648
- Testing
- SARS-CoV-2 Bivalent mRNA Vaccine, Saline
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- AIM Vaccine Co., Ltd.
Long COVID
Effect of Lithium Therapy on Long COVID Symptoms
This study will assess low-dose lithium's effects on several different symptoms experienced by long COVID patients.
- Trial name
- NCT05618587
- Testing
- Lithium
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- State University of New York at Buffalo
a Randomized Double-blind Study, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
The Effectiveness of Phytotherapy in SARS-COV2(COVID-19)
Quercetin is one of the flavonoids. Quercetin as well as rutin are recognized to be among the most active of the flavonoids. It is to quercetin that several medicinal plants, including ginkgo and St.
- Conditions
- a Randomized Double-blind Study, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), PHYTOTHERAPIE
- Trial name
- Quercetix (NCT04851821)
- Testing
- Quercetin
- Where
- Tunisia
- Volunteers
- 80 people
- Sponsor
- Hôpital Universitaire Sahloul
Covid19, SARS-CoV Infection
Initial CT Findings and CO-RADS Stage in COVID-19
This study aims to determine whether patients with different real-time reverse transcriptase-polymerase chain reaction (PCR), chest computed tomography (CT) and laboratory findings have different clinical outcomes.
- Conditions
- Covid19, SARS-CoV Infection, Pneumonia, Viral
- Trial name
- NCT04789447
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 895 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
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