Clinical trials: SARS-COV2 Virus
Severe Acute Respiratory Syndrome, Coronavirus
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults for COVID-19
This study aims to evaluate the safety and reactogenicity profile after 1 and 2 dose administrations of CVnCoV at different dose levels.
- Conditions
- Severe Acute Respiratory Syndrome, Coronavirus, SARS-CoV-2, COVID-19
- Trial name
- NCT04449276
- Testing
- CVnCoV Vaccine
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- CureVac
COVID-19 Pandemic, Transplantation, Kidney
Seroprevalence of the Anti-SARS-CoV-2 Antibodies (Causing COVID-19) in Kidney Transplant Recipients in Severely Affected Region
Goal of this study is to evaluate the seroprevalence of anti-SARS-CoV-2 antibodies in patients after kidney transplantation who are one of the risk groups for the severe course of the infection and map the progression of the…
- Trial name
- SECOVtx (NCT04874740)
- Testing
- No intervention
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- University Hospital Ostrava
SARS-CoV2
Clinical Features of Severe Patients With COVID-19
As coronavirus disease 2019 (COVID-19) spreads across the world, the intensive care unit (ICU) community must prepare for the challenges associated with this pandemic.
- Trial name
- NCT04450017
- Testing
- The demographic, clinical, laboratory, and instrumental data
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
SARS-CoV-2 Acute Respiratory Disease, COVID-19 Respiratory Infection
The CircumVent Project: A CPAP/O2 Helmet Solution for Non-Invasive Ventilation Among Patients With COVID-19
The purpose of the CircumVent Project is to evaluate the feasibility, adaptability and acceptability of a CPAP/O2 helmet solution for non-invasive ventilation among patients with COVID-19 and health workers in eight COVID-19…
- Trial name
- CircumVent (NCT04929691)
- Testing
- CPAP helmet, Standard of care non-helmet based CPAP ventilation
- Where
- 9 sites in Nigeria
- Volunteers
- 370 people
- Sponsor
- New York University
COVID-19, SARS-CoV 2
Convalescent Plasma for the Treatment of Patients With COVID-19
This expanded access program will provide access to COVID-19 convalescent plasma 150 or more individuals with moderate to severe or life-threatening manifestations of COVID-19, or documented to be at high risk of developing such…
- Trial name
- NCT04372368
- Testing
- COVID-19 Convalescent Plasma
- Where
- 6 sites in United States
- Sponsor
- University of Colorado, Denver
COVID-19, SARS CoV 2 Virus
Passive Detection- SARS-CoV-2 (COVID-19) A&M Breathalyzer (PROTECT Kiosk) for Operational Medicine
The primary objective of this effort will be to optimize and operationalize innovative passive surveillance systems and in parallel, the effort will identify, evaluate, and transition groundbreaking new technologies in…
- Conditions
- COVID-19, SARS CoV 2 Virus, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- COVID-19 (NCT06402318)
- Testing
- A&M Breathalyzer PROTECT Kiosk
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
Long Covid, Chronic Inflammation
Periodic Fasting for Treatment of Long Covid in Adults: a Pilot Study
Background: Long COVID, characterized by persistent symptoms following acute COVID-19 infection, has emerged as a significant public health concern.
- Trial name
- FASTCOV-P (NCT06522750)
- Testing
- 7-day ambulatory caloric restriction intervention using the Buchinger-Wilhelmi method
- Where
- Luxembourg
- Volunteers
- 20 people
- Sponsor
- University of Luxembourg
COVID-19, SARS CoV-2 Infection
COVID-19 Vaccination Status and The Clinical Outcomes of Long COVID-19 Patients
Long COVID is defined by the persistence or emergence of symptoms for more than 4 weeks beyond the acute phase of Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) infection.
- Trial name
- SURVIVOR (NCT05587868)
- Testing
- COVID-19 Vaccine
- Where
- Indonesia
- Volunteers
- 250 people
- Sponsor
- Universitas Indonesia
Post COVID-19 Condition, Long COVID
Study to Evaluate the Efficacy and Safety of Ampligen in Patients With Post-COVID Conditions
The purpose of this study is to assess the efficacy and safety of Ampligen® administered twice weekly by intravenous (IV) infusions in subjects experiencing the Post-COVID Condition of fatigue.
- Trial name
- NCT05592418
- Testing
- Rintatolimod
- Where
- 5 sites in United States
- Volunteers
- 80 people
- Sponsor
- AIM ImmunoTech Inc.
Covid-19, Pneumonia, Viral
Inhalation of Ciclesonide for Patients With COVID-19: A Randomised Open Treatment Study (HALT COVID-19)
Randomized open label clinical trial carried out at study centers in Sweden, including Karolinska University Hospital, S:t Göran Hospital, Danderyd Hospital and Västmanlands Hospital.
- Conditions
- Covid-19, Pneumonia, Viral, Sars-CoV2
- Trial name
- HALT (NCT04381364)
- Testing
- Ciclesonide Inhalation Aerosol
- Where
- 11 sites in Sweden
- Volunteers
- 98 people
- Sponsor
- Ola Blennow, MD, PhD
COVID-19
Evaluate the Efficacy and Safety of FB2001 in Hospitalized Patients With Moderate to Severe COVID-19 (BRIGHT Study)
This study is a double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of FB2001 in hospitalized patients with moderate to severe Coronavirus Disease 2019 (COVID-19).
- Trial name
- NCT05445934
- Testing
- FB2001
- Where
- 2 sites in China
- Volunteers
- 1,188 people
- Sponsor
- Frontier Biotechnologies Inc.
SARS-CoV-2, COVID-19 Vaccines
Effectiveness of BNT162b2 Formulations Using State Vaccine Registry and Insurance Claims Data
The primary purpose of this study is to learn about how well different versions of the Pfizer-BioNTech COVID-19 vaccine (called BNT162b2) work at preventing death, severe COVID-19 that requires a trip to the hospital, and overall…
- Trial name
- NCT06199934
- Testing
- Vaccination
- Where
- United States
- Volunteers
- 19,853,610 people
- Sponsor
- Pfizer
SARS-CoV-2 Infection (COVID-19)
PREEMPTIVE THERAPY WITH COLCHICINE IN PATIENTS OLDER THAN 60 YEARS WITH HIGH RISK OF SEVERE PNEUMONIAE DUE TO CORONAVIRUS
This is a phase 3 clinical trial, randomized, single-center, opened, controlled, to evaluate efficacy and safety of early administration of colchicines in patients older than 60 years, with high risk of pulmonary complications…
- Trial name
- COLCHI-COVID (NCT04416334)
- Testing
- Colchicine plus symptomatic treatment (paracetamol), Symptomatic treatment (paracetamol or best symptomatic treatment based on doctor recommendations)
- Where
- 4 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
SARS Cov2, Immune Response
Immune Response and Risk of Serious Infection to SARS-Cov2
To date, nearly 2 million people, including at least 100,000 in France, have been infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
- Trial name
- NCT04410432
- Testing
- Blood sample collection
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
COVID 19
CROWN CORONATION: COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION
The objective of CROWN CORONATION is the prevention of symptomatic COVID-19 by using combinations of approved and safe repurposed interventions, with complementary mechanisms of action.
- Trial name
- CROWN CORONA (NCT04333732)
- Testing
- MR or M-M-R II ® vaccine
- Where
- 17 sites in United States, Ghana and 3 more
- Volunteers
- 3,411 people
- Sponsor
- Washington University School of Medicine
Long COVID, Post-acute COVID-19 Syndrome
Home-based Exercise Program in Patients With the Post-COVID-19 Condition
The management of the sequelae of COVID-19 is described as the next great challenge of global public health. Multiple symptoms may compose the clinical picture of these patients (eg, fatigue, dyspnea, cognitive dysfunction…
- Trial name
- NCT05360563
- Testing
- Home-based physical training
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- University of Sao Paulo
COVID 19
A Simple Approach to Treat COVID-19 Patients at Home.
The newly recognised disease COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which by early December 2019 had spread from China to the rest of the world, especially Europe, the United…
- Trial name
- COVER (NCT04794998)
- Testing
- Recommended treatment schedule, Control treatment schedule
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
SARS-CoV Infection, COVID-19
CorONa Virus edoxabaN ColchicinE (CONVINCE) COVID-19
There is emerging evidence that patients with SARS-CoV-2 are affected by increased coagulopathy, including in the most advanced forms, a fully blown disseminated intravascular coagulation, leading to multi organ failure (MOF).
- Trial name
- CONVINCE (NCT04516941)
- Testing
- Edoxaban Tablets, Colchicine Tablets
- Where
- 5 sites in Belgium, Italy and 1 more
- Volunteers
- 60 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
SARS-CoV-2
Ascending Dose Study of Investigational SARS-CoV-2 Vaccine ARCT-021 in Healthy Adult Subjects
Determine safety and tolerability and immungenicity of investigational vaccine ARCT-021 in healthy adult volunteers.
- Trial name
- NCT04480957
- Testing
- ARCT-021 Dose 1, ARCT-021 Dose 2, ARCT-021 Dose 3
- Where
- Singapore
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Arcturus Therapeutics, Inc.
Covid19
ACTIV-6: COVID-19 Study of Repurposed Medications
The purpose of this study is to evaluate the effectiveness of repurposed medications (study drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19.
- Trial name
- NCT04885530
- Testing
- Ivermectin, Fluvoxamine, Fluticasone
- Where
- 110 sites in United States
- Volunteers
- 10,956 people
- Sponsor
- Susanna Naggie, MD
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