Clinical trials: SARS-COV2 Virus
Covid19, Morbidity
BCG to Reduce Absenteeism Among Health Care Workers During the COVID-19 Pandemic
The COVID-19 pandemic challenges available hospital capacity. Strategies to protect health care workers (HCW) are desperately needed.
- Conditions
- Covid19, Morbidity, Absenteeism
- Trial name
- EDCTP (NCT04641858)
- Testing
- BCG-Denmark, Saline
- Where
- 2 sites in Guinea-Bissau, Mozambique
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Covid19
PHRU CoV01 A Trial of Triazavirin (TZV) for the Treatment of Mild-moderate COVID-19
A) Phase II: Early viral responses to triazavirin In hospitalised patients with mild-moderate COVID-19, in addition to standard of care therapy, treatment with triazavirin 250mg three times daily for five days, the slope of…
- Trial name
- PHRUCov01 (NCT04581915)
- Testing
- Triazavirin (Riamilovir)
- Where
- South Africa
- Volunteers
- 74 people
- Sponsor
- Wits Health Consortium (Pty) Ltd
Covid19, Corona Virus Infection
Expanded Access to Zofin for Patients With COVID-19
This expanded access protocol will provide access to the investigational product Zofin for patients in outpatient facilities infected with SARS-CoV-2 who have mild to moderate COVID-19, or who are judged by a healthcare provider…
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT04657406
- Testing
- Zofin
- Sponsor
- ZEO ScientifiX, Inc.
Mortality, Intensive Care Unit
Effect of Favipiravir on Mortality in Patients With COVID-19 at a Tertiary Center Intensive Care Unit
Effect of Favipiravir and Lopinavir-Ritonavir on Mortality in a Tertiary Center Intensive Care Unit: Single Center Experience
- Trial name
- NCT04645433
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Covid19, Ophthalmopathy
Assessment of COVID-19 in Tearfilm
To assess the co-relation of COVID-19 in nasopharyngeal swabs and tears or saliva, and to determine duration of COVID-19 activity in ocular fluid and saliva by serial tests over 3 months.
- Conditions
- Covid19, Ophthalmopathy, Eye Diseases
- Trial name
- NCT04579458
- Testing
- Collection of tears and saliva.
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Coronavirus Infection
Safety, Tolerability and Immunogenicity of INO-4800 for COVID19 in Healthy Volunteers
This is an open label, phase 1 clinical trial of an intra-dermal booster dose of INO-4800 alone or in combination with INO-9112 followed by electroporation (EP) among healthy adults at least 18 years of age, who previously…
- Trial name
- NCT05430958
- Testing
- INO-4800, INO-9112, CELLECTRA® 2000
- Volunteers
- healthy volunteers welcome
- Sponsor
- Inovio Pharmaceuticals
COVID19, BETA-CELL FUNCTION
Effects of COVID-19 Infection on Beta-cell Function in Euglycemic Patients
In recent months, a new coronavirus, SARS-CoV-2, has been identified as the cause of a serious lung infection named COVID-19 by the World Health Organization.
- Trial name
- COBETOX (NCT04463849)
- Testing
- Stimulation test with arginine infusion in order to verify the possible existence of damage to the beta cell function induced by COVID-19 infection
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Milan
Covid19
Efficacy of Inhaled Therapies in the Treatment of Acute Symptoms Associated With COVID-19
Introduction: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), the new coronavirus, causes a disease called COVID-19 that can trigger aggressive inflammatory responses.
- Trial name
- TRIVID (NCT04937543)
- Testing
- inhaled beclametasone, Inahaled beclomethasone / formoterol / glycopyrronium
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
SARS-CoV2 Infection, COVID-19, Gut Microbiota, Mucosal Response, Children
COVID-19 and Intestinal Microbiota in Children
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. It appears to cause only mild to moderate upper respiratory symptoms in children, in addition to gastrointestinal symptoms resulting from its penetration into intestinal…
- Trial name
- NCT06503887
- Testing
- Stool sample collection
- Where
- Lebanon
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Cancer
Immune Responses in Oncology Patients to Novel Coronavirus Vaccines (IROC)
The goals of this study are to assess initial or booster vaccine performance (safety and efficacy) and to collect serum and peripheral blood mononuclear cells (PBMCs) pre and post-vaccination to assess immune and other response…
- Trial name
- NCT04930055
- Testing
- COVID-19 Vaccination
- Where
- 2 sites in United States
- Volunteers
- 2,206 people, healthy volunteers welcome
- Sponsor
- Indiana University
SARS-CoV2 Infection, SARS-CoV2 Antibodies
Determinants of the Level of Anti-SARS-CoV-2 IgG ANTibodiEs After Vaccination Study
Great expectations to control the pandemic are placed in vaccines against COVID-19. Currently, the four COVID-19 vaccines approved in the European Union.
- Trial name
- DANTE-SIRIO 7 (NCT05109585)
- Testing
- assessment of the anti-SARS-CoV-2 IgG antibody titer in 3-dose schedule, assessment of the anti-SARS-CoV-2 IgG antibody titer in 2-dose schedule
- Where
- Poland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Collegium Medicum w Bydgoszczy
COVID 19
Bio-reconfigurable Electronic Platform for Multiplex Detection of Viral Respiratory Pathogens
This project focuses on developing a cutting-edge electronic biosensor platform for highly sensitive and specific detection of target biomolecules, with initial applications targeting SARS-CoV-2 detection.
- Trial name
- BIOPLEX (NCT06702540)
- Testing
- Biosensor chip
- Where
- Italy
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
COVID-19, Long COVID
Long COVID-19 Syndrome in Primary Care: A Novel Protocol of Exercise Intervention "CON-VIDA Clinical Trial"
This is a randomized controlled trial of the efficacy of an individualized, progressive, exercise program (strength, cardiovascular, and breathing exercises) in recovering people from the post-COVID-19 syndrome (i.e., patients…
- Conditions
- COVID-19, Long COVID, Post-COVID-19 Syndrome
- Trial name
- CON-VIDA (NCT05543408)
- Testing
- EXERCISE
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad San Jorge
SARS-CoV 2, COVID-19
Assessment of the Psycho-social Impact of COVID-19 Outbreak
It has been shown in previous important outbreaks of infectious diseases that they have a huge impact on individuals and communities.
- Conditions
- SARS-CoV 2, COVID-19, Quality of Life, Mental Health Wellness 1
- Trial name
- COM-COVID (NCT04378452)
- Testing
- COM-COVID anonimous survey
- Where
- 4 sites in Spain
- Volunteers
- 56,656 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
COVID-19, Recombinant Human Interferon α1β
Efficacy and Safety of IFN-α2β in the Treatment of Novel Coronavirus Patients
New coronavirus infection is an important cause of public health emergencies at home and abroad, which seriously affects people's health and social stability.
- Trial name
- NCT04293887
- Testing
- Recombinant human interferon α1β
- Volunteers
- 328 people
- Sponsor
- Tongji Hospital
Covid19, SARS-CoV Infection
Can SARS-CoV-2 Viral Load and COVID-19 Disease Severity be Reduced by Resveratrol-assisted Zinc Therapy
Administration of Zinc and resveratrol or double placebo for a period of 5 days and will be monitored for a 14 day period in covid-19 positive patients in an outpatient setting
- Trial name
- Reszinate (NCT04542993)
- Testing
- Zinc Picolinate, Resveratrol
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Swedish Medical Center
COVID-19, Post COVID-19
Virtual Physical Rehabilitation for Patients Living with Long COVID
The purpose of this study is to investigate whether a timely, virtual home-based physical rehabilitation program for patients living with long COVID can improve functional mobility compared to usual care.
- Conditions
- COVID-19, Post COVID-19, Long COVID
- Trial name
- NCT05298878
- Testing
- Intervention Group: Virtual home-based rehabilitation plus usual outpatient care
- Where
- 2 sites in Canada
- Volunteers
- 132 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
COVID, Pneumonia, Viral
High Versus Low LMWH Dosages in Hospitalized Patients With Severe COVID-19 Pneumonia and Coagulopathy
Randomized, controlled study conducted in hospitalized patients with severe COViD-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation.
- Conditions
- COVID, Pneumonia, Viral, Coagulation Disorder
- Trial name
- COVID-19 HD (NCT04408235)
- Testing
- Enoxaparin
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
COVID-19
Acalabrutinib Study With Best Supportive Care in Participants Hospitalized With COVID-19
Study D822FC00005 will investigate the Phamacokinetics, Safety and tolerability of Acalabrutinib suspension when delivered via a nasogastric tube and co-administered with a Proton Pump Inhibitor, in the treatment of COVID-19.
- Trial name
- NCT04497948
- Testing
- Acalabrutinib
- Where
- 4 sites in Brazil
- Volunteers
- 9 people
- Sponsor
- Acerta Pharma BV
COVID-19
Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in COVID-19 Patients With a Systemic Inflammatory Response Syndrome
In patients infected by the SARS-Cov-2 Coronavirus a severely progressive disease requiring hospitalization in intensive care seems related to deregulation of cytokines with very high levels of IL-6, IL-2, IL-7, IL-10 and TNF-α.
- Trial name
- NCT04346017
- Testing
- Cytokines dosage, Complement dosage
- Where
- Belgium
- Volunteers
- 63 people
- Sponsor
- Francis Corazza
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