Clinical trials: SARS-COV2 Virus
Asymptomatic Condition, Infection Viral
ScreenNC, a Study to Determine the Number of Asymptomatic Individuals Who Have Antibodies to the Virus That Causes COVID-19
Purpose: To determine the number of asymptomatic individuals who have antibodies to SARS-CoV-2, the virus which causes COVID-19
- Conditions
- Asymptomatic Condition, Infection Viral, Coronavirus Infections, Severe Acute Respiratory Syndrome Coronavirus 2
- Trial name
- NCT04367740
- Testing
- To assess for development of IgG antibodies against SARS-CoV2
- Where
- United States
- Volunteers
- 6,313 people
- Sponsor
- University of North Carolina, Chapel Hill
Covid19
Process Evaluation of a Residence-Based SARS-CoV-2 Testing Participation Pilot
Mixed-methods process evaluation of a residence-based asymptomatic SARS-CoV-2 testing participation pilot
- Trial name
- RB-TPP (NCT05045989)
- Testing
- Residence-based testing participation pilot (SARS-CoV-2 testing with relaxed social distancing restrictions)
- Where
- United Kingdom
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Corona Virus Infection, SARS-CoV 2
Kidney in Coronavirus Disease 2019 Registry
The SARS-CoV-2 virus is a virus newly identified in January 2020. The WHO defined COVID-19 as a health emergency of international importance.
- Trial name
- KidneyCOVID19 (NCT04797091)
- Testing
- Retrospective data collection
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Cologne
COVID-19
Evaluating Safety, Tolerability, and Potential Efficacy of Intranasal AD17002 in Adults With Mild to Moderate COVID-19
AD17002 has demonstrated superior safety and efficacy as a nasal adjuvant function to an influenza vaccine in two completed clinical studies, and has innate immune modulatory and anti-inflammatory properties which could…
- Trial name
- NCT05069610
- Testing
- AD17002
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Advagene Biopharma Co. Ltd.
Adenoidectomy, Tonsillectomy
Angiotensin-converting Enzyme 2 (ACE2) Expression in Tonsils and Adenoids
The objective of the research is to study the expression of the ACE 2 receptor and the TMPRSS2 serine protease in the tonsils and adenoids of children and adults.
- Trial name
- ACE2-AVG (NCT04640610)
- Testing
- Storage of operating waste
- Where
- 9 sites in France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SARS-CoV 2
Impact of Zinc and Vitamin D3 Supplementation on the Survival of Aged Patients Infected With COVID-19
Mortality from Covid-19 increases with age, reaching 14.8% from the age of 80. The severity of the infection is linked to the acute respiratory distress syndrome (ARDS) which requires intensive care.
- Trial name
- ZnD3-CoVici (NCT04351490)
- Testing
- Zinc gluconate, 25-OH cholecalciferol
- Sponsor
- University Hospital, Lille
COVID-19, SARS-CoV-2 Infection
Study to Compare the Immunogenicity and Safety of 3 Lots of NVX-CoV2373 in Adults
This is a randomized, Phase 3 study comparing the immunogenicity and safety of 3 different lots of Novavax vaccine with Matrix-M™ adjuvant (NVX-CoV2373).The study will enroll approximately 900 previously vaccinated adults 18 to…
- Trial name
- NCT05463068
- Testing
- NVX-Cov2373
- Where
- 30 sites in United States
- Volunteers
- 911 people, healthy volunteers welcome
- Sponsor
- Novavax
SARS-CoV-2 Infections
A Study to Learn About if the Study Medicine Called Ibuzatrelvir Changes How the Body Process the Other Medicine Dabigatran Etexilate in Healthy Adults
This is a Phase 1, open-label, randomized, 2-period, 2-sequence, cross-over study to estimate the effect of ibuzatrelvir on the PK of dabigatran, a P-gp substrate, in healthy adult participants.
- Trial name
- NCT06693518
- Testing
- Treatment B, Treatment A
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Long Covid19, Fatigue Syndrome, Chronic
Effects of Cacao Flavonoids in Long COVID-19 Patients (FLALOC)
The study use a triple blind, placebo-controlled design enrolling male and female subjects between 30-70 yo to evaluate the effect of daily consumption of a cacao supplement on inflammation, endothelial damage, handgrip strength…
- Trial name
- FLALOC (NCT06064838)
- Testing
- Flavonoids
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Guillermo Ceballos Reyes
Myocarditis and Cardiomyopathy
Myocarditis After SARS-CoV2-Vaccination
Background The novel coronavirus disease 2019 (COVID-19) caused by an infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic with more than 190.000.000 infections and…
- Trial name
- MYOVACC (NCT05268458)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Theresien Hospital Mannheim
SARS CoV 2 Infection, Hypoxemic Respiratory Failure
Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient
Introduction: The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure…
- Trial name
- NCT04995289
- Testing
- Prone position on ECMO patient
- Where
- Morocco
- Volunteers
- 23 people
- Sponsor
- Mohammed VI University Hospital
SARS-CoV-2 Infection, Lung Fibrosis
Study to Assess Efficacy and Safety of Treamid for Patients With Reduced Exercise Tolerance After COVID-19
The innovative drug Treamid is planned for use in the treatment of patients with persistent lung damage and reduced exercise tolerance exertion after COVID-19 pneumonia in a multicenter, randomized, double-blind…
- Trial name
- NCT05516550
- Testing
- Treamid, Treamid twice a day, Treamid once a day
- Volunteers
- 412 people
- Sponsor
- PHARMENTERPRISES LLC
Corticosteroids, Covid19
Short Term Corticosteroids in SARS-CoV2 Patients
The investigators reviewed the charts of SARS-CoV-2 patients with pneumonia and moderate to severely elevated CRP and worsening hypoxemia who were treated with early, short-term dexamethasone.
- Conditions
- Corticosteroids, Covid19, SARS-CoV 2, Steroids
- Trial name
- NCT04445506
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
COVID-19
The Safety and Immunogenicity Following a Heterologous Booster Dose of Recombinant SARS-CoV-2 Vaccine LYB002
To evaluate the safety, humoral immunogenicity, cellular immunogenicity and immune persistence following a heterologous booster dose of recombinant SARS-CoV-2 trivalent vaccine (CHO Cell) LYB002 in Chinese adults 18 years and…
- Trial name
- NCT05928468
- Testing
- LYB002V14, LYB002V14A, LYB002CA
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Guangzhou Patronus Biotech Co., Ltd.
Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection, COVID-19
A Phase 2 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Patients With Multi-Site Pain Associated With Post-Acute Sequelae of SARS-CoV-2 Infection
This is a Phase 2, randomized, parallel-group, double-blind, placebo-controlled, 14-week study designed to evaluate the efficacy and safety of TNX-102 SL 5.6 mg (2 x 2.8 mg tablets) taken once daily at bedtime for the management…
- Conditions
- Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection, COVID-19, Long COVID, Long Haul COVID
- Trial name
- PREVAIL (NCT05472090)
- Testing
- TNX-102 SL
- Where
- 29 sites in United States
- Volunteers
- 63 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
COVID-19
Sleep Quality and Quality of Life in Coronavirus 19 Disease ( COVID 19) Patients
To study the impact of COVID 19 infection on sleep habit as regards quality of sleep, emergence of insomnia. To assess quality of life in patients after COVID 19 infection.
- Trial name
- NCT05148858
- Volunteers
- 100 people
- Sponsor
- Assiut University
Long COVID
Effects of Sodium Pyruvate Nasal Spray in COVID-19 Long Haulers.
There are approximately 12 million Americans with COVID-19 Long Hauler Symptoms, including athletes. The symptoms include hypoxemia (low SaO2), fatigue, coughing/sneezing, dyspnea, trouble breathing, body aches, headaches.
- Trial name
- NCT04871815
- Testing
- sodium pyruvate nasal spray
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Cellular Sciences, inc.
Vaccination Refusal, COVID-19
Digital Applications to Monitor Novel Coronavirus Disease and Response in Colombia - Syndromic and Vaccination Surveillance
Brief Summary: The main objective of this activity is to assess the effectiveness of different messaging strategies (factual, narrative, mixed and a control) to promote COVID-19 adult vaccination.
- Trial name
- DIAMOND-R (NCT05764174)
- Testing
- Factual messages, Narrative message, Mixed message
- Where
- United States
- Volunteers
- 2,409 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
COVID-19 Pneumonia
Evaluation of Immunogenicity, Safety and Antibody Persistence of COVID-19 Booster Vaccine (Produced in Beijing) in Patients With Hypertension and/or Diabetes
To evaluate the post-marketing immunogenicity, safety and antibody persistence of the third dose (booster) of Covid-19 vaccine in patients aged 60 years or older with hypertension and/or diabetes.
- Trial name
- NCT05104333
- Testing
- Covid-19 vaccine (0-1-4 schedule), Covid-19 vaccine (0-1-6 schedule)
- Where
- 5 sites in China
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
Post-COVID Conditions
Cardiovascular and Psychological Consequences of COVID-19
The study will assess cardiac and psychological profile at 2-3 months after recovery from COVID-19 infection.
- Trial name
- NCT05758649
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA