Clinical trials: SARS-COV2 Virus
COVID-19
Phase I/II Clinical Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in Canada
This study is a phase I /II adaptive clinical trial to evaluate the safety, tolerability and the Immunogenicity of Ad5-nCoV in healthy adults from 18 to <55 and 65 to <85 years of age，with the randomized, observer-blind…
- Trial name
- NCT04398147
- Testing
- Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
- Where
- Canada
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Long COVID
Inspiratory Muscle Training in People With Long COVID-19- A Pilot Investigation.
This pilot investigation will recruit people with Long COVID to participate in a 4 week individualized inspiratory muscle training intervention with pre and post spirometry testing and additional functional outcomes to assess the…
- Trial name
- NCT06091358
- Testing
- PrO2
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Bath
Tinnitus
DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury
The goal of this clinical trial is to test a compounded dimethyl sulfoxide (DMSO)-based dual-route therapy for adults with refractory subjective tinnitus linked to long-COVID (post-acute sequelae of SARS-CoV-2) or post-COVID-19…
- Trial name
- DART-TINN (NCT07567274)
- Testing
- DMSO-based otic solution with betahistine, dexamethasone, and lidocaine, DMSO-based transdermal cream with levocarnitine and N-acetylcysteine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Leading Edge Clinic
SARS-CoV-2
Evaluation of the Safety of CD24-Exosomes in Patients With COVID-19 Infection
This is an open-label Phase I study, four dose escalation groups, to evaluate the safety of CD24-exosomes in patients with moderate/severe COVID-19 disease.
- Trial name
- NCT04747574
- Testing
- EXO-CD24
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Covid19, Dexamethasone
Early Treatment Strategy With High-dose Dexamethasone in Patients With SARS-CoV-2
Early identification and treatment of this inflammatory cascade using existing therapeutic strategies with proven safety profiles could change the course and prognosis of COVID-19 infection, reducing mortality rates.
- Trial name
- NCT05293210
- Testing
- Dexamethasone
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario Infanta Leonor
COVID-19
Adaptive COVID-19 Treatment Trial 2 (ACTT-2)
ACTT-2 will evaluate the combination of baricitinib and remdesivir compared to remdesivir alone. Subjects will be assessed daily while hospitalized.
- Trial name
- NCT04401579
- Testing
- Remdesivir, Baricitinib
- Where
- 71 sites in United States, Denmark and 6 more
- Volunteers
- 1,033 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid19
A Study to Evaluate Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long COVID)
This is a phase I study to evaluate the safety and efficacy of inhaled Ampion on patients with prolonged respiratory symptoms due to COVID-19 (Long COVID).
- Trial name
- NCT04880161
- Testing
- Ampion
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
COVID-19
Immuno-bridging and Broadening Study of a Whole, Inactivated COVID-19 Vaccine BBV152 in Healthy Adults
A randomized, observer-blind, placebo-controlled immuno-bridging, and broadening study to demonstrate the equivalence of the immune response between participants enrolled in Phase 3 efficacy trial in India and demographically…
- Trial name
- NCT05258669
- Testing
- BBV152
- Where
- 10 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ocugen
SARS-CoV-2 Infection
To Evaluate the Safety, Tolerability and Pharmacokinetics of CT-P59 in Healthy Subjects
This is a Phase I study that randomized, double-blind, Placebo-controlled, Parallel Group, Single Ascending Dose Study to evaluate Safety, Tolerability and Pharmacokinetics of CT-P59 in Healthy Subjects.
- Trial name
- NCT04525079
- Testing
- CT-P59
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Celltrion
Covid19
Convalescent Plasma for Treatment of COVID-19
Convalescent plasma has been shown to be safe and effective for treatment of several diseases. Preliminary data indicate that it is safe for treatment of COVID-19.
- Trial name
- NCT04649879
- Testing
- SARS-CoV-2 convalescent plasma, Standard of care
- Where
- 3 sites in Sweden
- Volunteers
- 59 people
- Sponsor
- Joakim Dillner
COVID-19
Telerehabilitation in People With Long COVID
The aim of our study is to investigate the effectiveness of telerehabilitation in Post-COVID patients.
- Trial name
- NCT05205460
- Testing
- Home-based telerehabilitation, Education and self-exercise
- Where
- Taiwan
- Volunteers
- 182 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Covid19, SARS-CoV Infection
COVID-19 in Polish Ice Swimmers.
Ice swimming is an increasingly common phenomenon in Poland. It has been confirmed that it has a beneficial effect on health by increasing the natural non-specific immunity to infections.
- Conditions
- Covid19, SARS-CoV Infection, Resistance, Disease, Hypothermia
- Trial name
- ICE (NCT04817280)
- Testing
- Ice Swimming
- Where
- 3 sites in Poland
- Volunteers
- 2,534 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Long COVID
Consequences of COVID-19 Infection for Child Health and Wellbeing: Protocol for a Prospective, Observational, Longitudinal Study in Children
Prospective follow-up of children with SARS-CoV-2
- Trial name
- NCT05799508
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID-19, Cardiovascular Diseases
The COVID-RASi Trial (COVID-19)
The COVID-RASi study is an international randomized clinical trial that will evaluate the potential benefit of angiotensin modulators on clinical outcomes, in COVID-19 patients.
- Trial name
- NCT04591210
- Testing
- Angiotensin converting enzyme inhibitor, Angiotensin II Receptor Blockers
- Where
- 31 sites in Brazil, Canada and 1 more
- Volunteers
- 372 people
- Sponsor
- Ottawa Heart Institute Research Corporation
SARS COV-2 IgG Levels on Health Workers
SARS Cov_2 Incidence of Healthy Health Workers
Since the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China, on 12 December 2019, it has spread rapidly across the world and developed into a pandemic.
- Trial name
- NCT04845880
- Testing
- Spike protein (S) or the nucleocapsid (N) of SARS-CoV-2
- Where
- Turkey (Türkiye)
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Baskent University
Coronavirus Disease 2019, Coronavirus Disease 2019 (COVID-19)
A Study of How Ibuzatrelvir is Taken up Into the Blood of Healthy Adults After Taking Different Tablets of Ibuzatrelvir
Healthy adults will be enrolled into this open-label, Phase 1 research study. Participants will spend about 9 nights and 10 days in the clinical research unit (CRU) and the total time in the study will be about 11 weeks.
- Conditions
- Coronavirus Disease 2019, Coronavirus Disease 2019 (COVID-19), COVID-19 (Coronavirus Disease 2019), Upper Respiratory Tract Infections
- Trial name
- NCT07552779
- Testing
- Ibuzatrelvir co-process API film coated tablet, Ibuzatrelvir filmcoated tablet
- Where
- Belgium
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
SARS-CoV 2, Viral Infection
Anti-SARS Cov-2 T Cell Infusions for COVID 19
This is a dose-finding safety trial followed by a randomized pilot trial comparing administration of SARS-CoV2-specific T cells (SARS-CoVSTs) to standard of care treatment in hospitalized patients with COVID19 who are at high…
- Conditions
- SARS-CoV 2, Viral Infection, COVID 19
- Trial name
- BATIT (NCT04401410)
- Testing
- Dose Finding Phase (MTD), Partially HLA-matched SARS-CoVSTs, Routine care (no SARS-CoVSTs)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor College of Medicine
SARS-CoV 2, COVID-19
Favipiravir vs Hydroxychloroquine vs Control in COVID -19
Hydroxychloroquine is widely used to treat autoimmune diseases. Clinical investigation has found that a high concentration of cytokines were detected in the plasma of critically ill patients infected with SARS-CoV-2, therefore…
- Trial name
- NCT04387760
- Testing
- Hydroxychloroquine, Favipiravir, Routine care for COVID-19 patients
- Where
- Bahrain
- Volunteers
- 150 people
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
SARS-CoV-2
A Study to Evaluate Safety, Reactogenicity, and Immunogenicity of mRNA-1283 and mRNA-1273 Vaccines in Healthy Adults Between 18 Years and 55 Years of Age to Prevent COVID-19
The primary goal for this study is to evaluate the safety and reactogenicity of 3 dose levels of mRNA-1283 and 1 dose level of mRNA-1273 vaccine given to healthy adults in 2 doses, 28 days apart, and 1 dose level of mRNA-1283…
- Trial name
- NCT04813796
- Testing
- mRNA-1283, mRNA-1273
- Where
- 5 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
SARS-CoV-2, Oncology
Oncological Surgery in Times of COVID-19: Effectiveness of Preoperative Screening for Sars-Cov-2
To evaluate the incidence of patients with a positive test for SARS-CoV-2, performed in the preoperative screening for patients treated at the institution
- Conditions
- SARS-CoV-2, Oncology, Surgery
- Trial name
- ASTANA (NCT04434261)
- Testing
- PT-PCR test for SARS-CoV-2
- Where
- Brazil
- Volunteers
- 1,500 people
- Sponsor
- Instituto Brasileiro de Controle do Cancer
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