Clinical trials: SARS-CoV-2 Infection Covid19
COVID-19, Influenza
Immunogenicity of Concomitant Administration of COVID-19 Vaccines With Influenza Vaccines
The goal is to evaluate the in-depth immunogenicity analysis (including B-cell and T-cell response) of coadministration of a omicron-containing COVID-19 vaccine and influenza vaccine among healthy adults during 2023-24 season.
- Conditions
- COVID-19, Influenza, Vaccine Reaction, Contaminant Injected
- Trial name
- NCT06091410
- Testing
- Omicron-containing COVID-19 vaccine, influenza vaccine
- Where
- 2 sites in South Korea
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Catholic Kwandong University
SARS-CoV-2
A Study to Evaluate Safety, Reactogenicity, and Immunogenicity of mRNA-1283 and mRNA-1273 Vaccines in Healthy Adults Between 18 Years and 55 Years of Age to Prevent COVID-19
The primary goal for this study is to evaluate the safety and reactogenicity of 3 dose levels of mRNA-1283 and 1 dose level of mRNA-1273 vaccine given to healthy adults in 2 doses, 28 days apart, and 1 dose level of mRNA-1283…
- Trial name
- NCT04813796
- Testing
- mRNA-1283, mRNA-1273
- Where
- 5 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
SARS-CoV-2, Oncology
Oncological Surgery in Times of COVID-19: Effectiveness of Preoperative Screening for Sars-Cov-2
To evaluate the incidence of patients with a positive test for SARS-CoV-2, performed in the preoperative screening for patients treated at the institution
- Conditions
- SARS-CoV-2, Oncology, Surgery
- Trial name
- ASTANA (NCT04434261)
- Testing
- PT-PCR test for SARS-CoV-2
- Where
- Brazil
- Volunteers
- 1,500 people
- Sponsor
- Instituto Brasileiro de Controle do Cancer
Coronavirus, COVID
Prevalence of Covid-19 in Children Admitted to Paediatric Emergency Departments During the Pandemic Period in France
Arriving in December 2019, Coronavirus COVID-19 infection is causing a global pandemic with high morbidity and mortality among adults and especially seniors. The child appears little or no affected by this infection.
- Conditions
- Coronavirus, COVID, Infection Viral
- Trial name
- INCOVPED (NCT04336761)
- Testing
- nasopharyngeal swab
- Where
- 6 sites in France
- Volunteers
- 901 people
- Sponsor
- University Hospital, Lille
Ocular Infection, Viral
Can COVID-19 Persist in Intraocular Fluid?
Several common viruses thrive and persist in intraocular fluid due to ocular immune privilege. Immune privilege is maintained by lack of lymphatic tissue, a strong blood ocular barrier, and regulation of the systemic immune…
- Trial name
- NCT04945850
- Testing
- routine care intraocular sx
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Covid19
COVID-19 Vaccine Effectiveness in Albanian Health Workers
The purpose of this study is to evaluate the effectiveness of the COVID-19 vaccine in hospital based HWs in Albania. This will answer critical questions about the real-world performance of COVID-19 vaccines in one of the key…
- Trial name
- COVEAL (NCT04811391)
- Testing
- COVID-19 vaccine
- Where
- 3 sites in Albania
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Institute of Public Health, Albania
Coronavirus Infections
A Study of Opaganib in Coronavirus Disease 2019 Pneumonia
This proof of concept study will take place in the US and other countries in approximately 15 clinical sites and will enroll about 40 hospitalized patients diagnosed with COVID-19 infection who have developed pneumonia and…
- Trial name
- COVID-19 (NCT04414618)
- Testing
- Opaganib
- Where
- 9 sites in United States, Israel
- Volunteers
- 42 people
- Sponsor
- RedHill Biopharma Limited
Depression, Anxiety, Cognitive Impairment
Telehealth Intervention Program for Older Adults
COVID-19 is having profound effects on older adults' due to social isolation measures which may negatively impact individuals' mental and physical health.
- Conditions
- Depression, Anxiety, Cognitive Impairment, Stress
- Trial name
- TIP-OA (NCT04523610)
- Testing
- Telehealth phone calls, Volunteer of TIP-OA Program, Stakeholder of TIP-OA Program
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
COVID-19
Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting
This is a randomized, open-label trial to assess the safety and efficacy of hydroxychloroquine, and zinc in combination with either azithromycin or doxycycline in a higher risk COVID-19 positive outpatient population.
- Trial name
- NCT04370782
- Testing
- Hydroxychloroquine, Azithromycin, Zinc Sulfate
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- St. Francis Hospital, New York
COVID-19
Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)
The Austrian Coronavirus Adaptive Clinical Trial (ACOVACT) is a randomized, controlled, multicenter, open-label basket trial that aims to compare various antiviral treatments for COVID-19.
- Trial name
- ACOVACT (NCT04351724)
- Testing
- Chloroquine or Hydroxychloroquine, Lopinavir/Ritonavir, Best standard of care
- Where
- 9 sites in Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Anosmia, Asymptomatic COVID-19
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
The purpose of this study is to learn more about how to better track smell recovery in people who have been infected with the SARS-CoV-2 virus (which causes COVID-19).
- Conditions
- Anosmia, Asymptomatic COVID-19, COVID-19 Respiratory Infection, Influenza
- Trial name
- NCT05040659
- Testing
- AROMHA Longitudinal Smell Test
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
COVID-19
A Bridging Study of FB2001 in Healthy Subjects
In the first human clinical trial conducted in the United States, single and multiple dosing of FB2001 in multiple dose groups were partially completed，and FB2001 demonstrated good safety and tolerability.
- Trial name
- NCT05197179
- Testing
- FB2001
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Frontier Biotechnologies Inc.
SARS-CoV2 Infection
Expanded Access Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection (COVID-19)
The primary objective of this study is to provide expanded access of remdesivir (RDV) for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.
- Trial name
- NCT04323761
- Testing
- Remdesivir
- Where
- 272 sites in United States, Australia and 25 more
- Sponsor
- Gilead Sciences
COVID-19
Study of SHEN26 Capsule in Patients With Mild to Moderate COVID-19
This is a multicenter, randomized, double-blind, placebo-parallel-controlled phase II clinical trial. It is designed to evaluate the efficacy, safety, tolerability, and pharmacokinetic (PK) profile of SHEN26 capsules in Chinese…
- Trial name
- NCT05676073
- Testing
- SHEN26 dose 1, SHEN26 dose 2
- Where
- 4 sites in China
- Volunteers
- 91 people
- Sponsor
- Shenzhen Kexing Pharmaceutical Co., Ltd.
SARS-CoV2 Infection, COVID-19
Viral Dynamics of Omicron in Children
SARS-CoV-2 transmission is dependent on multiple factors, which may be related to either host-virus interaction or the environment.
- Trial name
- NCT05240183
- Testing
- Daily SARS-CoV-2 PCR Testing for 10 days
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- The Hospital for Sick Children
Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-Cov-2
Paediatric Inflammatory Multisystem Syndrome During COVID-19 Pandemic
During the COVID-19 pandemic, a small minority of children have been presenting to acute paediatric services with a new syndrome, Paediatric Inflammatory Multisystem Syndrome temporally associated with SARS-Cov-2 (PIMS-TS).
- Trial name
- NCT04761913
- Where
- 6 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Anglia Ruskin University
COVID-19, Surgical Outcomes
Impact of COVID-19 on Surgical Outcomes
Following the introduction of the COVID-19 vaccination, elective surgeries have resumed, allowing for greater insight into the postoperative period and outcomes aims on-going COVID-19 infections.
- Conditions
- COVID-19, Surgical Outcomes, Postoperative Complications
- Trial name
- NCT06197282
- Testing
- Major surgery involving general anesthesia
- Where
- United States
- Volunteers
- 7,696 people
- Sponsor
- Kern Medical Center
SARS-CoV-2 Infection
Ad26.COV2.S as a Heterologous Booster in Adults After Single- or Two-Dose of Inactivated COVID-19 Vaccine
This study aims to address evidence gaps regarding the safety, reactogenicity and immune responses of a heterologous boost of a single dose of Ad26.COV2.S (half or full dose) at pre-specified time intervals in recipients who are…
- Trial name
- NCT05109559
- Testing
- Full dose of Ad26.COV2. 5x10^10vp, Half dose of Ad26.COV2. 2.5x10^10vp
- Where
- Thailand
- Volunteers
- 690 people, healthy volunteers welcome
- Sponsor
- Mahidol University
COVID-19
Allocetra-OTS in COVID-19
This is a multi-center, open-label study evaluating the safety of Allocetra-OTS, in 5 subjects with severe COVID-19 and respiratory dysfunction. Subjects, who will be identified as suffering from COVID-19, will be recruited.
- Trial name
- NCT04513470
- Testing
- Allocetra-OTS
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Gastroenteritis, Rota Virus Gastroenteritis
Admission Pattern Among Children With Gastro-intestinal Infections Before and During the Covid-19 Pandemic
During the Covid-19 pandemic, admission patterns for infections other than Covid-19 have changed dramatically among children worldwide.
- Conditions
- Gastroenteritis, Rota Virus Gastroenteritis, Dehydration in Children, Infectious Disease
- Trial name
- NCT06211621
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Region Zealand
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