Clinical trials: SARS-CoV-2 Infection Covid19
COVID 19, SARS-CoV 2
Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation
The purpose of this prospective, Phase 2, multicenter, blinded, randomized placebo controlled study is to demonstrate that early treatment with mavrilimumab prevents progression of respiratory failure in patients with severe…
- Conditions
- COVID 19, SARS-CoV 2, Pneumonia
- Trial name
- NCT04492514
- Testing
- Mavrilimumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Kristin Hudock
Disease, Infectious, Respiratory Disease
Effectiveness and Safety of Respiratory Training in the Prevention and Severity of COVID-19
A randomized controlled clinical trial will be carried out using inspiratory and expiratory training devices on healthy subjects recruited in social networks and university environments.
- Conditions
- Disease, Infectious, Respiratory Disease, Safety Issues, Effectiveness
- Trial name
- NCT04326114
- Testing
- Inspiratory training device, Expiratory training device
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
The Effect of Listening to Music During CPAP on the Agitation Levels and Compliance.
Aim: This study was conducted to determine the effect of listening to music during CPAP on the agitation levels of intensive care patients who underwent CPAP due to COVID-19 and their compliance with the treatment.
- Trial name
- NCT05102084
- Testing
- Listening to music with a bluetooth headset to patients receiving CPAP support
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- SÜMEYYE BİLGİLİ
COVID-19
The COVID-19 Mobile Health Study (CMHS)
This study evaluates a brand-new cell phone-based auto-diagnosis system, which is based on the clinical guidelines, clinical experience, and statistic training model.
- Trial name
- CMHS (NCT04275947)
- Testing
- nCapp, a cell phone-based auto-diagnosis system
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Chinese Alliance Against Lung Cancer
COVID 19 Disease
Tafenoquine in Patients With Mild to Moderate COVID-19
A clinical study to assess the efficacy and safety of oral tafenoquine compared to placebo in patients with mild to moderate COVID 19 disease.
- Trial name
- NCT04533347
- Testing
- Tafenoquine Oral Tablet
- Where
- 10 sites in United States
- Volunteers
- 86 people
- Sponsor
- 60 Degrees Pharmaceuticals LLC
Headache, Migraine
New-onset Severe Headache After Covid-19 Vaccine
Hypotheses: 1. Severe new-onset headache after Covid-19 vaccine occur in a minor subset of vaccinated individuals. 2. Immunological reactivity with activation of trigeminal nociceptors can be among the mechanisms in severe…
- Conditions
- Headache, Migraine, COVID-19
- Trial name
- CovaxHEAD (NCT05235776)
- Testing
- observation
- Where
- 10 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Oslo University Hospital
Telehealth
A Comparison of 3D and 2D Telemedicine During Covid 19
It is critical to establish an effective form of telemedicine during the Covid 19 pandemic, that will allow safe social distancing of clinicians and patients.
- Trial name
- NCT04359225
- Testing
- 3D Telemedicine, 2D Telemedicine
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- NHS Greater Glasgow and Clyde
Psychological Burnout
Effects of Mindfulness Practice on Healthcare Workers
This study aims to examine the effects of mindfulness practice administered using a mobile app on psychological health among health care workers in Singapore.
- Trial name
- NCT04936893
- Testing
- Mindfulness Practice, Cognitive training
- Where
- Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Gender Relations, Partner Communication
Impact of COVID-19 on Family Dynamics on Bandebereho Study Participants
This proposed study will assess how COVID-19 and the associated 'stay at home' orders are affecting low-income Rwandan couples' relationships and family dynamics.
- Conditions
- Gender Relations, Partner Communication, Division of Carework, Couple Conflict
- Trial name
- NCT04442152
- Testing
- MenCare+/Bandebereho fathers'/couples' group education
- Where
- Rwanda
- Volunteers
- 998 people, healthy volunteers welcome
- Sponsor
- Promundo, United States
Respiratory Failure
HFNC and NIV for COVID-19 Complicated by Respiratory Failure
Background: Patients with COVID-19 have a range of clinical spectrum from asymptomatic infection, mild illness, moderate infection requiring supplemental oxygen and severe infection requiring intensive care support.
- Trial name
- NCT04452708
- Testing
- HFNC
- Where
- Hong Kong
- Volunteers
- 26 people
- Sponsor
- Chinese University of Hong Kong
COVID-19
A Drug-drug Interaction Study of S-892216 Coadministered With Carbamazepime to Healthy Adult Participants
The primary objective of this study is to investigate the effect of multiple-dose administration of carbamazepine on the pharmacokinetics of S-892216 in healthy adults.
- Trial name
- NCT06751017
- Testing
- S-892216, Carbamazepine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shionogi
SARS CoV-2 Post-Acute Sequelae
Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical Trial
The DEFEND trial will be the world's first clinical trial to study the effectiveness of Paxlovid or Veklury in the prevention of cardiovascular post-acute sequelae of SARS-CoV-2 among hospitalized adults.
- Trial name
- DEFEND (NCT06792214)
- Testing
- Nirmatrelvir/ritonavir, Remdesivir
- Where
- 4 sites in Canada
- Volunteers
- 118 people
- Sponsor
- Mount Sinai Hospital, Canada
Abdominal Cancer
Characterizing Postoperative T and B Cell Dysfunction in Cancer Surgery Patients, Using COVID-19 as a Model Antigen
The Auer Lab research program studies how surgery affects the immune system and how this can lead to suppression in cancer patients which can lead to cancer reoccurrence.
- Trial name
- NCT06925906
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
COVID-19
COVID-19 and Brain: Cognition and Mental Health
The main goal of DIANA is to investigate the potential discriminative power of multimodal biomarkers in COVID adverse outcomes. The study of the neuropathological underlying mechanisms in COVID from a translational approach at…
- Trial name
- DIANA (NCT05307549)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Hip Fractures, COVID-19
Anesthesia Technique in COVID-19 Positive Hip Fracture Patients
Patients with COVID undergoing hip fracture repair have high mortality rates. If spinal anesthesia is associated with decreased rates of mortality, this study could provide hypothesis generating data for prospective studies.
- Conditions
- Hip Fractures, COVID-19, General Anesthesia, Spinal Anesthesia
- Trial name
- NCT05133648
- Testing
- Hip Fracture Surgery, COVID-19 infection
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Covid19
Lipid Emulsion Infusion and COVID-19 Patients
Investigators suggest that early administration of intravenous lipid emulsion (ILE) affect the inflammatory response and improve outcome in COVID-19.
- Trial name
- NCT04957940
- Testing
- SMOFlipid, 0.9% saline
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Assiut University
Post Viral Fatigue, Viral Myocarditis
Post-COVID-19 Outpatient Care and Biomarkers
The aims of this case-control, non-randomized study including patients with post-COVID-19 persisting symptoms are 1) to establish the large blood biobank, 2) to examine levels of circulating inflammatory biomarkers and different…
- Conditions
- Post Viral Fatigue, Viral Myocarditis, POTS
- Trial name
- POSTCOV (NCT05398952)
- Testing
- Laboratory investigations
- Where
- Austria
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
COVID-19
Efficacy and Safety Study of Allogeneic HB-adMSCs for the Treatment of COVID-19
Hope Biosciences is conducting a research study of an investigational product called allogeneic adipose-derived mesenchymal stem cells (abbreviated as HB-adMSCs) as treatment for patients suspected to have COVID-19.
- Trial name
- NCT04362189
- Testing
- HB-adMSC
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Hope Biosciences Research Foundation
Covid19, Hypoxic Respiratory Failure
SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival
Patients suffering lung failure, possibly from COVID-19 or hypoxic lung failure, will need life-saving support from a breathing machine.
- Trial name
- SAVE-ICU (NCT04415060)
- Testing
- Isoflurane Inhalant Product, Sevoflurane inhalant product
- Where
- 13 sites in Canada
- Volunteers
- 800 people
- Sponsor
- Sunnybrook Health Sciences Centre
COVID-19
Communities Fighting COVID Return to School
San Diego State University (SDSU), a designated Hispanic-serving institution, is partnering with Sweetwater Union High School District, an independent public school district serving 90% ethnic minority and a high proportion of…
- Trial name
- NCT05150860
- Testing
- At-home COVID-19 testing, Onsite COVID-19 testing
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- San Diego State University
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