Clinical trials: SARS-CoV-2 Infection Covid19
Coronavirus Infections
Compassionate Use of Opaganib in Patients With Coronavirus Disease 2019 (COVID-19)
Shaare-Zedek Medical Center is a tertiary academic hospital in Jerusalem, Israel. On March 2020, a dramatic increase in the number of COVID-19 cases were diagnosed in Jerusalem. RedHill Biopharma, Ltd.
- Trial name
- NCT04435106
- Testing
- Opaganib, Standard of Care
- Where
- Israel
- Volunteers
- 23 people
- Sponsor
- Shaare Zedek Medical Center
Covid-19
Exploratory Study to Evaluate the Efficacy of RUTI® Against SARS-COV-2 Infection (COVID-19) in Healthcare Workers
The aim of this study is to explore potential for reduction of incidence and/or morbidity of SARS-CoV-2 infection in healthcare personnel. The study will include a comparison between placebo and RUTI® vaccine in a 2:1 design.
- Trial name
- NCT04903184
- Testing
- RUTI® vaccine
- Where
- 6 sites in Argentina
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- RUTI Immunotherapeutics S.L.
Heparin Overdose of Undetermined Intent, COVID-19
Unfractionated Heparin in COVID-19 and Non-COVID-19 Patients
The majority of ICU patients with COVID-19 show profound activation of coagulation, potentially resulting in thromboembolic events.
- Trial name
- NCT05509647
- Testing
- Unfractionated heparin
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Leiden University Medical Center
Coronavirus
Telephony Or Videophony for Isolated elDerly in Maine-Et-Loire 49 During COVID-19
The current health crisis at COVID-19 is forcing us to profoundly rethink our social organizations, especially towards our most fragile seniors.
- Trial name
- TOVID-49 (NCT04333849)
- Where
- France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Angers
Cystic Fibrosis
Psychosocial Factors and Quality of Life in the Effect of Fear of COVID-19 With Cystic Fibrosis
The purpose of this study; The COVID-19 pandemic is to investigate the effects of COVID-19 fear levels of patients with cystic fibrosis on the psychosocial and quality of life levels of individuals.
- Trial name
- NCT05195216
- Testing
- Survey Form, The Hospital Anxiety and Depression Scale, The Fear of COVID-19 Scale,World Health Organization Quality of Life Scale- Bref Form
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Elif Kabasakal
COVID-19 Pandemic
Elevated Liver Enzymes as a Predictor of Acute Kidney Injury in Hospitalized Patients With COVID-19
In critically ill patients, AKI is a common complication of COVID-19 infection, occurring in 23% to 43% of cases, and was correlated with poor clinical outcomes.
- Trial name
- COVID-19 (NCT05157152)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Thrombosis, Nadroparin
Nadroparin Pharmacokinetics in Different Stages of COVID-19
Objective: The risk of thrombotic complications in critical COVID-19 patients remains extremely high, and multicenter trials failed to prove the survival benefit of escalated doses of low molecular weight heparins (LMWH) in this…
- Conditions
- Thrombosis, Nadroparin, COVID-19, Mechanical Ventilation
- Trial name
- NCT05621915
- Testing
- Nadroparin
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Medical University of Lublin
Covid19
Phase 3 Inhaled Novaferon Study in Hospitalized Patients With Moderate to Severe COVID-19
This study is a randomized, double-blind, multicenter, placebo-controlled trial to evaluate the safety and efficacy of a novel therapeutic agent, Novaferon, in hospitalized adult patients diagnosed with COVID-19.
- Trial name
- NOVATION-1 (NCT04669015)
- Testing
- Novaferon
- Where
- 88 sites in Argentina, Brazil and 10 more
- Volunteers
- 914 people
- Sponsor
- Genova Inc.
Colorectal Neoplasms Malignant
Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread…
- Trial name
- COVID-CRC (NCT04712292)
- Testing
- Surgical procedure for confirmed or suspected colorectal cancer
- Where
- 45 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- University of Bologna
COVID-19 Pneumonia, Non-invasive Ventilation
The Difference Between Non-invasive High-frequency Oscillatory Ventilation and Non-invasive Continuous Airway Pressure Ventilation in COVID-19 With Acute Hypoxemia
High frequency oscillatory ventilation (HFOV), as an ideal lung protection ventilation method, has been gradually applied to neonatal intensive care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05706467
- Testing
- Non-invasive high-frequency oscillatory ventilation, Non-invasive continuous positive airway pressure ventilation
- Volunteers
- 20 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
SARS-CoV-2, Covid19
Tomographic Findings in COVID-19 and Influenza
The investigators decided to conduct a longitudinal study that compares the pulmonary tomographic patterns found in patients with viral pneumonia (i.e. influenza H1N1 and SARS-CoV-2) at a regional hospital.
- Conditions
- SARS-CoV-2, Covid19, H1N1 Influenza, Computed Tomography
- Trial name
- TOMOCOVIDMX (NCT04497311)
- Testing
- Thoraxic computed tomography
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Universidad de Guanajuato
SARS-CoV2, COVID-19
Are SARS-CoV-2 Specific Antibodies a Correlate for Protection?
The objectives of this study are (1) to determine the ex vivo neutralizing capacity and the longevity of SARS-CoV-2-specific Ab responses and (2) to measure the memory B-cell responses in a cohort of health care workers (HCW)…
- Trial name
- ImmCoV (NCT04469634)
- Testing
- Assessing antibody responses, neutralizing capacity and memory B-cell function
- Where
- 2 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Adult Patients With Lesions on Fingers or Toes
Clinical and Mechanistic Study of Patients (With COVID-19 or Not) With a Recent Acrosyndrome
The recent and unexpected occurrence of patients with the development of skin lesions on the hands and/ or feet has been described recently.
- Trial name
- ACROCOVID (NCT04590209)
- Testing
- Blood sampling, Skin biopsy
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid-19 Vaccine
Oxidative Stress Parameters, Trace Element and Quality of Life in Women Before and After Covid-19 Vaccines
There is no effective treatment method for COVID-19 yet. With vaccination being the most effective approach to control the COVID-19 pandemic, vaccines have been developed with many different methods.
- Trial name
- NCT04751721
- Testing
- CoronoVac Vaccine
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
COVID-19 Vaccines
The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01)
This is a Phase 1/2/3, randomized, placebo-controlled, observer-blind study designed to evaluate the safety, immunogenicity and efficacy of ARCT-154 in adult participants to be enrolled in Vietnam.
- Trial name
- ARCT-154-01 (NCT05012943)
- Testing
- ARCT-154 Self-Amplifying RNA SARS-CoV-2 Vaccine, Astra Zeneca COVID-19 vaccine
- Where
- 3 sites in Vietnam
- Volunteers
- 19,474 people, healthy volunteers welcome
- Sponsor
- Vinbiocare Biotechnology Joint Stock Company
COVID-19
Dietary Intake and Eating Habits During the COVID-19 Pandemic
The COVID-19 pandemic affects eating habits, diet quality and physical activity differently among individuals; it is unclear how these behaviours will evolve as the pandemic continues.
- Trial name
- COVIDiet (NCT04407533)
- Testing
- Diet tracking and survey
- Where
- Canada
- Volunteers
- 2,020 people, healthy volunteers welcome
- Sponsor
- McGill University
Stress, Burnout, Professional
Aromatherapy for Stress and Burnout Among Healthcare Providers
The purpose of this study is to evaluate the potential for inhalation of plant-based aromas to reduce stress and burnout among healthcare professionals and staff in hospitals and urgent care centers.
- Conditions
- Stress, Burnout, Professional, Stress, Job
- Trial name
- NCT05114655
- Testing
- Herbaceous Essential Oil Blend, Citrus Essential Oil Blend, Inert Oil
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Diabetes Mellitus, Type One, Diabetes Mellitus, Type I
Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes
This Phase II RCT using multi-dose Bacillus Calmette-Guérin (BCG) in adults with juvenile or childhood onset diabetes is based on prior clinical trials showing that even with advanced disease and little of no remaining pancreas…
- Conditions
- Diabetes Mellitus, Type One, Diabetes Mellitus, Type I, Autoimmune Diabetes, Covid19
- Trial name
- NCT02081326
- Testing
- Bacillus Calmette-Guérin, Saline injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
COVID-19, Fibrosis
Covid-19 Respiratory Sequelae French Cohort
As the investigators need data on long term outcome of Covid-19, especially respiratory sequelae, a national cohort is required.
- Conditions
- COVID-19, Fibrosis, Cohort, Follow-up
- Trial name
- PNEUMOCOVID (NCT05075785)
- Where
- France
- Volunteers
- 2,933 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
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