Clinical trials: SARS-CoV-2 Virus
Covid-19
Prevention and Treatment for COVID -19 (Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2) Associated Severe Pneumonia in the Gambia
The trial aims to assess the impact of cheap, licenced and widely available investigational products on the natural history of SARS-CoV-2 infection in 2 groups of patients - those with mild or moderate pneumonia (Cohort 1) and…
- Trial name
- PaTS-COVID (NCT04703608)
- Testing
- Ivermectin, ASP
- Where
- The Gambia
- Volunteers
- 1,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Immunogenicity, Safety
A Phase II/III Study to Evaluate the Immunogenicity and Safety and Efficacy of SWIM816 Vaccines for SARS-CoV-2
Primary Immunogenicity Objective：Cohort 1: GMTs of SARS-CoV-2 Omicron and related strain neutralizing antibody levels for SWIM816.Cohort 2: To demonstrate the non- inferiority of neutralizing antibody response in terms of…
- Trial name
- NCT05911087
- Testing
- Phase II:SWIM816;SARS-Cov-2;, Phase II:SW-BIC-213;SARS-Cov-2;, PhaseIII:SWIM816;SARS-Cov-2;
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Stemirna Therapeutics
SARS-Cov2
SARS-CoV2 Antibodies in Pediatric Patients (COVID-19)
Since the beginning of the year, the entire world has been concerned with the novel SARS-CoV2 virus. After the first case descriptions in Wuhan, there has been a rapid increase in the number of cases in Germany as well.
- Trial name
- SARS-CoV2_KIDS (NCT04581148)
- Testing
- Blood test antibodies against SARS-CoV-2
- Where
- Germany
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
COVID-19, SARS-CoV-2
PEP Flute-selfcare in COVID-19
Most research on the coronavirus SARS-CoV-2 and COVID-19 disease relate to screening measures, development of vaccines and optimising treatment of hospitalised patients.
- Trial name
- PEP-CoV (NCT04530435)
- Testing
- PEP flute
- Where
- Denmark
- Volunteers
- 378 people
- Sponsor
- Bispebjerg Hospital
COVID, Neurologic Manifestations
Neurologic Manifestations of COVID 19 in Children
The purpose of this study is to perform a secondary analysis of pre-existing de-identified limited datasets obtained from sites participating in Tier 1 (STUDY20040154: Neurologic Manifestations of COVID 19 in Children) and Tier 2…
- Trial name
- NCT04379089
- Testing
- Observational study only
- Where
- United States
- Volunteers
- 3,568 people
- Sponsor
- University of Pittsburgh
Covid19
Efficacy of BACMUNE (MV130) in the Prevention of Disease Due to COVID-19 Infection in Healthcare Personnel
The purpose of this trial is to assess the effect of immunotherapy with the bacterial preparation MV130 on the spread and course of SARS-CoV-2 infection in highly exposed subjets, as is the case with healthcare personnel.
- Trial name
- Bacmune (NCT04452643)
- Testing
- BACMUNE (MV130)
- Where
- 3 sites in Mexico
- Sponsor
- Inmunotek S.L.
Mesenchymal Stromal Cells, Remestemcel-L
MSCs in COVID-19 ARDS
The mortality rate in SARS-CoV-2-related severe ARDS is high despite treatment with antivirals, glucocorticoids, immunoglobulins, and ventilation.
- Conditions
- Mesenchymal Stromal Cells, Remestemcel-L, Acute Respiratory Distress Syndrome, COVID
- Trial name
- NCT04371393
- Testing
- Remestemcel-L
- Where
- 21 sites in United States
- Volunteers
- 223 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Tracheal Stenosis
Observational Study for the Evaluation of Tracheal Stenosis in COVID-19 Patients
Define the actual incidence of tracheal stenosis in patients who underwent either prolonged intubation or tracheostomy and to compare incidence, clinical course and outcome between COVID-19 and non-COVID-19 patients.
- Trial name
- TS1 (NCT04686721)
- Testing
- Chest CT scan + baseline spirometry
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
COVID-19
The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial
This COVID-19 pandemic warrants urgent strategies to protect people at high risk of infection, particularly the healthcare workers.
- Trial name
- NCT04364815
- Testing
- Hydroxychloroquine plus standard preventive measures
- Where
- Philippines
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of the Philippines
Sars-CoV2, Severe Neurologic Injury
COVID-19 Brain Injury
A prospective cohort minimal risk study to determine the impact of the COVID-19 crisis on outcomes of neurologically injured ICU patients.
- Conditions
- Sars-CoV2, Severe Neurologic Injury, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT04496076
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pittsburgh
Subacute Thyroiditis, SARS CoV 2 Infection
Subacute Thyroiditis in the SARS-CoV-2 Era
Many cases of subacute thyroiditis (SAT) have been described related to SARS-CoV-2 infection, but no prospective data about follow-up is known.
- Conditions
- Subacute Thyroiditis, SARS CoV 2 Infection, Thyrotoxicosis
- Trial name
- SAT-COVID-19 (NCT06391515)
- Testing
- Blood sample, CRF, thyroid ultrasound
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- University of Modena and Reggio Emilia
COVID-19, SARS-CoV-2 Infection
PERC Health Canada COVID-19
Although there are several licensed vaccines for SAR-CoV-2 (COVID-19) in Canada, none of them are approved for use in children under the age of 12, leaving five million children under 12 years unvaccinated.
- Trial name
- NCT05040763
- Testing
- Buccal Swabc- Copan flocked swab, Standard of Care COVID-19 swab
- Where
- 13 sites in Canada
- Volunteers
- 7,263 people
- Sponsor
- University of Calgary
Post-Acute COVID-19, Post COVID-19 Condition
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
- Conditions
- Post-Acute COVID-19, Post COVID-19 Condition, Post Viral Fatigue, Dyspnea
- Trial name
- PASC VQ (NCT05866952)
- Testing
- Computed Tomography of the Chest
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
COVID-19
Favipiravir in Hospitalized COVID-19 Patients
The present study is a randomized, double-blind, controlled, clinical trial, with the approval of the ethics committee will be conducted on patients who have a positive test confirming COVID-19 in Shahid Modarres Medical…
- Trial name
- FIC (NCT04359615)
- Testing
- Favipiravir, Hydroxychloroquine
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Covid19
Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes
The aim of this study is to analyze the efficacy of oral disinfection with 0.075% Cetylpyridinium Chloride alone and 0.075% Cetylpyridinium Chloride associated with 0.28% zinc lactate in reduction of the viral load of SARS-CoV-2…
- Trial name
- NCT04902976
- Testing
- CPC+ZN, CPC, Negative Control
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Hospital Israelita Albert Einstein
Covid-19, Endothelial Dysfunction
Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection
The outbreak at covid-19 is caused by the SARS-CoV-2 virus. This virus can be responsible for severe respiratory failure but also for extra-respiratory organ dysfunctions associated with severe inflammatory stress.
- Conditions
- Covid-19, Endothelial Dysfunction, Thrombosis, Critically Ill
- Trial name
- Covid-Thelium (NCT04357847)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
COVID-19, Children With Medical Complexity (CMC)
ReSET Aim 1a: Restarting Safe Education and Testing for Children With Medical Complexity - Feasibility of In-home Cohort COVID-19 Testing Strategies, and Associations With CMC Parent Perceptions About In-person School Attendance
The purpose of this research study is to learn about the factors parents consider when deciding whether their child will go to school in-person or attend from home.
- Trial name
- NCT04895085
- Testing
- BinaxNOW Rapid Antigen System
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
SARS-CoV Infection, Covid19
International Registry of Healthcare Workers Exposed to COVID-19 Patients (UNITY Global)
The International Registry of Healthcare Workers Exposed to COVID-19 Patients (UNITY Global), is an international registry of approximately 10,000 healthcare workers in low- and middle-income countries experiencing increasing…
- Trial name
- NCT04626076
- Testing
- Comparative Observational Cohort Study
- Where
- Pakistan
- Volunteers
- 6,808 people, healthy volunteers welcome
- Sponsor
- Certara
COVID, SARS-CoV 2
Transfusion of Convalescent Plasma for the Early Treatment of Patients With COVID-19
No specific therapeutic agents or vaccines for COVID-19 are available. Several therapies, are under investigation, but the antiviral efficacy of these drugs is not yet known.
- Trial name
- TSUNAMI (NCT04393727)
- Testing
- CONVALESCENT PLASMA
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
COVID-19, Post-COVID-19 Syndrome
The COVID HOME Study: Prospective Cohort Study of Non-hospitalised COVID-19 Patients
Background. Guidelines on COVID-19 management are developed as we learn from this pandemic. However, most research has been done on hospitalised patients and the impact of the disease on non-hospitalised and their role in…
- Trial name
- COVID-HOME (NCT06282627)
- Testing
- Observational study
- Where
- Netherlands
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen