Clinical trials: SBP - Spontaneous Bacterial Peritonitis
Spontaneous Bacterial Peritonitis
Cefotaxime Resistance in Treatment of Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is a serious complication in cirrhotic patients, and the changes in the microbiological characteristics reported in the last years are impacting the choice of antibiotic used in the…
- Trial name
- NCT02388035
- Testing
- Cefotaxime
- Where
- Egypt
- Volunteers
- 254 people
- Sponsor
- Dr Ahmed Ali Elbaz
Advanced Chronic Liver Disease, Urinary Infection
The INFECIR-2 Albumin Prevention Study
The aim of this study is to evaluate whether albumin administration improves short-term survival in patients with advanced cirrhosis and bacterial infections other than Spontaneous Bacterial Peritonitis (SBP).
- Conditions
- Advanced Chronic Liver Disease, Urinary Infection, Pneumonia, Cholangitis
- Trial name
- INFECIR2 (NCT02034279)
- Testing
- Albumin
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- EASL - CLIF Consortium
SBP - Spontaneous Bacterial Peritonitis
Nitazoxanide in Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of liver cirrhosis characterized by infection of ascitic fluid in the absence of an evident intra-abdominal source.
- Trial name
- NCT07808450
- Testing
- Nitazoxanide (NTZ)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis
MPV and NLR as Predictors of SBP Diagnosis
The aim of the study is to investigate the clinical utility of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as diagnostic markers for spontaneous bacterial peritonitis (SBP).
- Trial name
- NCT04775420
- Testing
- Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)
- Where
- Egypt
- Volunteers
- 332 people
- Sponsor
- Sohag University
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Spontaneous Bacterial Peritonitis
To Compare the Efficacy of Carbepenem Versus Carbepenem Plus GM-CSF in Difficult To Treat Spontaneous Bacterial Peritonitis
A Minimum of 150 consecutive patients of decompensated cirrhosis of any etiology, presenting to the Institute of Liver and Biliary Sciences hospital with a diagnosis of difficult to treat SBP will be included and randomized into…
- Trial name
- NCT02468089
- Testing
- Carbepenem, Albumin, GMCSF (of Granulocyte-Monocyte Colony-Stimulating Factor) .
- Where
- India
- Volunteers
- 146 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Spontaneous Bacterial Peritonitis
Oral Gemifloxacin Versus Intravenous Cefotaxime in Treatment of Spontaneous Bacterial Peritonitis
oral Gemifloxacin versus intravenous Cefotaxime in treatment of spontaneous bacterial peritonitis
- Trial name
- NCT04168099
- Testing
- Cefotaxime, Gemifloxacin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis, Hepatorenal Syndrome
Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis
Advanced liver disease and low ascitic fluid protein concentration have been identified as risk factors for spontaneous bacterial peritonitis in cirrhosis.
- Conditions
- Spontaneous Bacterial Peritonitis, Hepatorenal Syndrome, Cirrhosis
- Trial name
- NCT00359853
- Testing
- Oral norfloxacin
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Clinic of Barcelona
Spontaneous Bacterial Peritonitis
Efficacy of Rifaximin vs Norfloxacin for Secondary Prophylaxis of SBP (NORRIF Trial)
SBP is a common complication of cirrhotics with associated increased mortality. After first episode of SBP there is increased risk of again developing SBP, with increased chance of developing resistant organism.
- Trial name
- NCT06199843
- Testing
- Rifaximin, Norfloxacin
- Where
- India
- Volunteers
- 280 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Spontaneous Bacterial Peritonitis
Laboratory Diagnosis of Spontaneous Bacterial Peritonitis
This study aims at evaluating the diagnostic accuracy of serum procalcitonin, PEC index, modified Wehmeyer, and Mansoura scoring systems for SBP in cirrhotic patients with ascites
- Trial name
- SBP (NCT05696054)
- Volunteers
- 80 people
- Sponsor
- Sohag University
Decompensated Cirrhosis, Ascites
VSL#3 and Spontaneous Bacterial Peritonitis
Research question: Do oral probiotics in patients with cirrhosis and ascites reduce intestinal bacterial concentrations, ascitic bacterial DNA, SBP and bacteraemia compared to antibiotics or placebo? This study is designed to…
- Trial name
- NCT01701297
- Testing
- cotrimoxazole, VSL#3 active
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Ascites Infection
Rifaximin Prophylaxis for Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome in Cirrhotic Patients
Norfloxacin is the most commonly used drug for the prophylaxis against spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis.
- Trial name
- NCT05621005
- Testing
- Rifaximin 550 milligram Oral Tablet [XIFAXAN]
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Samar Atef Sebaweh Mohammed
Cirrhosis, Hepatic Encephalopathy
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis
The study aims to compare the potential benefit of allopurinol versus atorvastatin in reducing the risk of developing cirrhosis-related complications, delaying the onset of hepatocellular carcinoma, and improving survival.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Ascites, Varices
- Trial name
- NCT05511766
- Testing
- Allopurinol 300 MG, Atorvastatin 20mg
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis
Diagnostic of Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP), an infection of ascitic fluid in the absence of localized intra-abdominal infection, is one of the main potentially fatal complications of cirrhosis.
- Trial name
- NCT01193426
- Testing
- Ascite liquid puncture
- Where
- 5 sites in France
- Volunteers
- 316 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Portal Hypertension Gastropathy, Esophageal Varices
Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal
This is a multicenter, randomized, double-blind, placebo-controlled study on the effectiveness of treatment with beta-blockers to prevent decompensation of cirrhosis with portal hypertension.
- Conditions
- Portal Hypertension Gastropathy, Esophageal Varices, Spontaneous Bacterial Peritonitis, Hepatic Encephalopathy
- Trial name
- PREDESCI (NCT01059396)
- Testing
- propranolol, carvedilol
- Where
- 8 sites in Spain
- Volunteers
- 201 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Spontaneous Bacterial Peritonitis, Primary Peritonitis
Spontaneous Bacterial Peritonitis: Incidence, Risk Factors and Outcome
Spontaneous bacterial peritonitis (SBP) is a severe complication of ascites in cirrhotic patients. Under clinical experience, this condition seems to be more uncommon in Finland.
- Conditions
- Spontaneous Bacterial Peritonitis, Primary Peritonitis, Ascites
- Trial name
- NCT00490217
- Where
- Finland
- Volunteers
- 240 people
- Sponsor
- Tampere University
Adverse Reaction to Other Drugs and Medicines
Norfloxacin Versus Ciprofloxacin for Spontaneous Bacterial Peritonitis (SBP) Prevention
For the prevention of spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis, norfloxacin 400mg per day is a standard regimen. Ciprofloxacin 750 mg per week is also known to be effective for prevention of SBP.
- Trial name
- NCT01542801
- Testing
- Norfloxacin, ciprofloxacin
- Where
- 7 sites in South Korea
- Volunteers
- 124 people
- Sponsor
- Korea University
Spontaneous Bacterial Peritonitis
Clinical, Inflammatory, and Economic Impact of Dextran 70 in Treating Spontaneous Bacterial Peritonitis
The core of the proposal is a prospective, randomized, double-blinded, controlled study which will compare the efficacy of dextran 70 versus human albumin in the treatment of cirrhotic patients with spontaneous bacterial…
- Trial name
- NCT00570960
- Testing
- Dextran 70, human albumin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia
Spontaneous Bacterial Peritonitis
Comparison of the Efficacy of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Norfloxacin in Secondary Prophylaxis for Spontaneous Bacterial Peritonitis
-Consecutive patients of decompensated cirrhosis of any etiology, presenting to the Institute of Liver and Biliary Sciences hospital with spontaneous bacterial peritonitis will be evaluated
- Trial name
- NCT03702426
- Testing
- GMCSF, Norfloxacin
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
SBP - Spontaneous Bacterial Peritonitis
N-Acetylcysteine in the Management of Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is one of the most serious infectious complications of liver cirrhosis and ascites. It affects approximately 10-30% of hospitalized patients with decompensated cirrhosis and carries an…
- Trial name
- NCT07803952
- Testing
- NAC
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University