Clinical trials: SBRT
Carcinoma, Hepatocellular
TACE vs TACE+SBRT for Unresectable Hepatocellular Cancer
Vast majority of patients with hepatocellular carcinoma (HCC) present with unresectable disease. In the last decade results of randomized trials and a subsequent metaanalyses established transarterial chemoembolization (TACE) or…
- Trial name
- TACE-SBRT (NCT02794337)
- Testing
- SBRT, TACE, Sorafenib
- Where
- 2 sites in India
- Volunteers
- 67 people
- Sponsor
- Tata Memorial Hospital
Hepatocellular Carcinoma
TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients
This trial is designed to be the initial prospective pilot investigation of the effectiveness of combined SBRT and TACE as bridging therapy for HCC patients awaiting liver transplanation.
- Trial name
- NCT01918683
- Testing
- TACE transarterial chemoembolization, stereotatic body radiotherapy (SBRT)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Metastatic Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Cancer
The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation
The purpose of this study is to assess if radiation therapy (which uses high-energy radiation to damage or destroy cancer cells) combined with immune checkpoint inhibitors (medications that helps the body recognize and attack…
- Trial name
- EMPIRE (NCT06843551)
- Testing
- Stereotactic Body Radiation Therapy, Botensilimab, Balstilimab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Benjamin Spieler
Adenocarcinoma of the Pancreas, Stage III Pancreatic Cancer
Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer
This phase I trial is studying the side effects and best dose of stereotactic radiation therapy and nelfinavir mesylate when given together with gemcitabine hydrochloride, leucovorin calcium, and fluorouracil in treating patients…
- Trial name
- NCT01068327
- Testing
- gemcitabine hydrochloride, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Nebraska
BTC
Chidamide Combined With Benmelstobart, Nab-paclitaxel, and SBRT as Second-Line Treatment for Advanced BTC
This study is a prospective, single-arm, multicenter, exploratory clinical trial. It aims to evaluate the efficacy and safety of chidamide combined with benmelstobart, nab-paclitaxel, and immunogenic radiotherapy (SBRT) as…
- Trial name
- NCT07890506
- Testing
- chidamide+benmelstobart+nab-paclitaxel+SBRT
- Where
- China
- Volunteers
- 41 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Breast Cancer, Ductal Carcinoma in Situ
Preoperative Partial Breast Irradiation in Early-Stage Breast Cancer
In the management of early breast cancer patients, postoperative radiotherapy following breast-conserving surgery has been established as the standard treatment.
- Conditions
- Breast Cancer, Ductal Carcinoma in Situ, Invasive Breast Cancer
- Trial name
- NCT06677944
- Testing
- Preoperative PBI
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Yonsei University
Biliary Tract Cancer
Liposomal Irinotecan Plus 5-FU/LV and Sintilimab With Sequential SBRT for Locally Advanced Biliary Tract Cancer
This is a prospective, single-arm, exploratory interventional study designed to evaluate the efficacy and safety of liposomal irinotecan (II) plus fluorouracil/leucovorin (5-FU/LV) and sintilimab with sequential stereotactic body…
- Trial name
- NCT07797816
- Testing
- Irinotecan Hydrochloride Liposome Injection (II), Fluorouracil, Leucovorin
- Where
- China
- Volunteers
- 31 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Breast Cancer, Prostate Cancer
Stereotactic Body Radiation Therapy for Spinal Metastases in Favorite Tumors
Stereotactic Body Radiation Therapy(SBRT) for spinal metastases has been proved a good results in pain relieve and local control, However,the longterm of efficacy and safety of this regimen is unclear.The purpose of the study is…
- Conditions
- Breast Cancer, Prostate Cancer, Non Small Cell Lung Cancer
- Trial name
- NCT03392233
- Testing
- Stereotactic Body Radiation Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Pancreatic Cancer
Stereotactic Body Radiation Therapy Followed by NALIRIFOX vs NALIRIFOX for Borderline Resectable Pancreatic Cancer
This multicentric open-label trial will compare the efficacy and safety of stereotactic body radiation therapy (SBRT) followed by NALIRIFOX (5-fluorouracil, leucovorin, irinotecan liposome injection and oxaliplatin) vs NALIRIFOX…
- Trial name
- NCT06259058
- Testing
- Irinotecan liposome injection, Oxaliplatin, 5-Fluorouracil
- Volunteers
- 96 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Neovascular (Wet) Age-related Macular Degeneration (AMD)
Stereotactic Radiotherapy for Wet AMD (STAR)
This study investigates the use of radiation to treat wet age-related macular degeneration (AMD). The radiation is delivered using a robotically controlled device that projects overlapping beams of radiation onto the macula, the…
- Trial name
- STAR (NCT02243878)
- Testing
- 0.5 mg ranibizumab
- Where
- 30 sites in United Kingdom
- Volunteers
- 411 people
- Sponsor
- King's College Hospital NHS Trust
Metastatic Malignant Neoplasm
Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer
This phase II trial studies how well single-fraction stereotactic body radiation therapy (SBRT) works when compared to standard radiation therapy in treating patients with cancer that has spread to other places in the body…
- Trial name
- NCT04068649
- Testing
- Palliative Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Roswell Park Cancer Institute
Early-stage Glottic Larynx Cancer
CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Study for Early-stage Glottic Larynx Cancer
The feasibility of reducing fractions in early-stage laryngeal cancer has not previously been prospectively studied, and we will therefore conduct a careful phase I bio-equivalent dose fraction reduction study.
- Trial name
- NCT01984502
- Testing
- CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Liver Neoplasms, Carcinoma, Hepatocellular
Novel Abdominal Compression Positioning Technique for Respiratory Motion Management in Liver Tumors
1. Research Background The background of this study centers on stereotactic body radiation therapy (SBRT), an advanced form of radiotherapy that is short in duration, highly effective, and easy for patients to comply with.
- Trial name
- NCT07745153
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Southern Medical University, China
Early Stage Non-small Cell Lung Cancer, Non-small Cell Lung Cancer
Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer
This study will evaluate the impact of CT-guided adaptive stereotactic radiotherapy (CT-STAR) to central and ultra-central early-stage non-small cell lung cancers on grade 3 or greater toxicity.
- Trial name
- NCT05785845
- Testing
- Computed tomography-guided stereotactic adaptive radiotherapy, ETHOS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Child-Pugh Class A, Child-Pugh Class B
Transarterial Chemoembolization Compared With Stereotactic Body Radiation Therapy or Stereotactic Ablative Radiation Therapy in Treating Patients With Residual or Recurrent Liver Cancer Undergone Initial Transarterial Chemoembolization
This randomized phase III trial studies how well transarterial chemoembolization (TACE) works compared to stereotactic body radiation therapy (SBRT) or stereotactic ablative radiation therapy (SABR) in patients with liver cancer…
- Conditions
- Child-Pugh Class A, Child-Pugh Class B, Recurrent Hepatocellular Carcinoma
- Trial name
- NCT02762266
- Testing
- Stereotactic Body Radiation Therapy, Transarterial Chemoembolization, embolic agent
- Where
- 2 sites in United States, Japan
- Volunteers
- 13 people
- Sponsor
- Stanford University
Non-small Cell Lung Cancer
Efficacy and Safety of Almonertinib Combined With Stereotactic Body Radiotherapy (SBRT) in the Treatment of Non-small Cell Lung Cancer With EGFR Sensitive Mutation: a Single-arm, Open-label Clinical Trial
The goal of this clinical trial is to learn if first-line Almonertinib plus upfront stereotactic ablative body radiotherapy (SABR) works to treat EGFR-mutated advanced non-small cell lung cancer.
- Trial name
- NCT06481566
- Testing
- stereotactic ablative body radiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chongqing University Cancer Hospital
Hepatocellular Carcinoma
SBRT With Atezo/Bev for HCC
A phase I dose escalation and pharmacodynamic study of repeated dose stereotactic body radiotherapy (SBRT) administered with concurrent atezolizumab and bevacizumab for patients with advanced hepatocellular carcinoma (HCC)
- Trial name
- NCT05488522
- Testing
- SBRT + atezolizumab and bevacizumab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Brain Metastases
Perfexion Brain Metastasis
Brain metastases occur in 20% to 40% of all patients with cancer , with an incidence 10 times higher than that of primary malignant brain tumors.
- Trial name
- HF-SRT (NCT00805103)
- Testing
- Hypofractionated stereotactic radiotherapy
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University Health Network, Toronto
Locally Advanced Pancreatic Cancer
Combined Chemotherapy And Ablative Radiotherapy (SBRT) As First-Line Treatment In Locally Advanced Inoperable Pancreatic Cancer (SBRT-PANC)
This prospective interventional clinical study evaluates the efficacy and safety of combining systemic chemotherapy followed by ablative stereotactic body radiotherapy (SBRT) as first-line treatment in adult patients with locally…
- Trial name
- NCT07407231
- Testing
- Ablative Stereotactic Body Radiotherapy (SBRT), Standard First-Line Chemotherapy
- Where
- Slovenia
- Volunteers
- 18 people
- Sponsor
- Institute of Oncology Ljubljana
TNBC - Triple-Negative Breast Cancer, Triple Negative Breast Cancer
Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and Lung
The purpose of this study is determine if receiving stereotactic body radiation(SBRT) when participants' metastatic tumors have just begun to grow increase the length of time before disease gets worse
- Conditions
- TNBC - Triple-Negative Breast Cancer, Triple Negative Breast Cancer, NSCLC, NSCLC Stage IV
- Trial name
- NCT03808662
- Testing
- Sterotactic Body Radiotherapy/SBRT, Standard of care
- Where
- 10 sites in United States, Canada
- Volunteers
- 107 people
- Sponsor
- Memorial Sloan Kettering Cancer Center