Clinical trials: SCI, open to volunteers
Spinal Cord Injuries and Disorders (SCI/D)
Using Non-invasive Brain and Spinal Cord Stimulation to Improve Arm and Hand Function After Spinal Cord Injury
Cervical spinal cord injury (SCI) disrupts communication between the brain and spinal circuits, affecting voluntary movement control and contributing to arm and hand impairments, the top recovery priority for people with…
- Trial name
- NCT07423949
- Testing
- Cerebellar theta burst stimulation, Cervical transcutaneous spinal cord stimulation, Functional task practice
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of British Columbia
Spinal Cord Injury, Chronic Pain
VR Mindfulness Training for Veterans With SCI
This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA…
- Trial name
- NCT06587607
- Testing
- VA Compassionate Awareness Learning Module (VA CALM) a mindfulness curriculum.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
tSCS + UL Robotics Training in SCI Patients
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment upper limb robotic training (ULRT) to improve functional mobility in participants with chronic spinal cord injuries.
- Trial name
- NCT07432321
- Testing
- ULRT + tSCS + conventional occupational therapy, ULRT + conventional occupational therapy
- Where
- Singapore
- Volunteers
- 6 people
- Sponsor
- National University Hospital, Singapore
SCI - Spinal Cord Injury
Effect of tSCS on Ankle Movement Training in Individuals With SCI
This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI).
- Trial name
- NCT06596174
- Testing
- Transcutaneous spinal cord stimulation (tSCS), Short-term Machine-Assisted Ankle Movement Training with tSCS, Long-term Effects of Machine-Assisted Ankle Movement Training with tSCS
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Spinal Cord Injuries, Neurogenic Detrusor Overactivity
TTNS in SCI Patients With Neurogenic Detrusor Overactivity
This is a prospective, single-arm, pilot study to assess effectiveness and tolerability of transcutaneous tibial nerve stimulation (TTNS) in managing neurogenic detrusor overactivity in spinal cord injury patients.
- Trial name
- NCT07785258
- Testing
- TTNS
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- National University Hospital, Singapore
SCI - Spinal Cord Injury, SCI
NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI
The purpose of this study is to assess the safety and tolerability of intrathecal administration of CE-1 at a weight-based dose (cells/kg BW), capped at a maximum total dose of 1×10⁸ cells in 10 mL, with administered volume…
- Conditions
- SCI - Spinal Cord Injury, SCI, Spinal Cord Injury
- Trial name
- NeuroRise (NCT07739043)
- Testing
- Human allogeneic, culture expanded, UC-MSC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Cell Therapy LLC
SCI - Spinal Cord Injury
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
- Trial name
- NCT06853015
- Testing
- Dalfampridine, STDP stimulation, Exercise training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury, Paraplegia, Spinal
tSCS Combined With Rehabilitation Training in Treating Paraplegic Patients After SCI
This clinical trial aims to evaluate the safety and efficacy of transcutaneous spinal cord stimulation (tSCS) combined with rehabilitation training for treating paraplegia after spinal cord injury (SCI).
- Trial name
- tSCScwRT (NCT07907952)
- Testing
- Transcutaneous Spinal Cord Stimulation Combined with Rehabilitation Training
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Spinal Cord Injuries (SCI), Spinal Cord Injury
Guttmann NeuroRecovery - Viability, Safety, and Efficacy of Intrathecal Wharton's Jelly Mesenchymal Stem Cells and Transcutaneous Spinal Cord Stimulation in Chronic Spinal Cord Injury Rehabilitation
This clinical trial primarily aims to evaluate the safety and feasibility of a combined therapeutic approach for chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Traumatic Spinal Cord Injuries, Spinal Cord Disease
- Trial name
- GNR-SCI-01 (NCT06981338)
- Testing
- Allogeneic Wharton's jelly mesenchymal stem cells (WJ-MSCs)
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Institut Guttmann
Spinal Cord Injuries, Depression
Dosing rTMS for Depression Post-SCI
Depression is a leading cause of disability worldwide and is more commonly seen in individual's post-spinal cord injury (SCI) than in the general population.
- Conditions
- Spinal Cord Injuries, Depression, Depressive Disorder, Major
- Trial name
- NCT05553353
- Testing
- repetitive transcranial magnetic stimulation--Active
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries (SCI)
High-intensity Walking Rehabilitation in Outpatient Subacute Spinal Cord Injury
People with incomplete spinal cord injury (SCI) often have some preserved movement and may regain walking ability, but recovery can be limited, and more effective rehabilitation approaches are needed.The goal of this clinical…
- Trial name
- NCT07553923
- Testing
- High-intensity Rehabilitation, Usual Care
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta
Spinal Cord Injuries (SCI)
Exploring the Feasibility and Benefits of Implementing Pelvic Floor Muscle Training During Inpatient Rehabilitation for People With Spinal Cord Injury
The goal of this clinical study is to determine the feasibility and explore the potential benefits of pelvic floor muscle training during inpatient SCI rehabilitation on urinary, bowel, and sexual function and quality of life in…
- Trial name
- NCT07519928
- Testing
- Pelvic Floor Muscle Physiotherapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Spinal Cord Injury
Effect of Blood Flow-restricted Exercise Frequency on Strength Recovery Following Incomplete SCI
The goal of this clinical trial is to determine the effect of treatment frequency on the physical recovery of adults with incomplete spinal cord injury.
- Trial name
- NCT07678437
- Testing
- Blood flow-restricted exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Quality Living, Inc.
Spinal Cord Injuries (SCI)
Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury
This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI).
- Trial name
- DOSA-SCI (NCT07739992)
- Testing
- Acute Intermittent Hypoxia (AIH) 15, Acute Intermittent Hypoxia (AIH) 23
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milap Sandhu
Spinal Cord Injuries, Cardiovascular Diseases
Role of Endothelial Function in SCI CVD Risk
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT06443151
- Testing
- Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid), venous occlusion plethysmography, Acetylcholine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Neurogenic Bladder
Device for Bladder Control for Men With SCI
Urinary incontinence, bladder frequency, and bladder urgency are significant medical problems for people with overactive bladder (OAB) or neurogenic bladder overactivity (NDO).
- Trial name
- NCT07668063
- Testing
- Noninvasive electrical stimulation device to improve bladder control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for SCI
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Spinal Cord Injury.
- Trial name
- NCT05152290
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Spinal Cord Injury
Neuromodulation to Improve Grasping Function After SCI
The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI.
- Trial name
- NCT07433959
- Testing
- iTBS, PCMS, Exercise
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spinal Cord Injuries
BioFLO for Respiratory Recovery in SCI
Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing low oxygen air to stimulate spinal neuroplasticity.
- Trial name
- NCT06011876
- Testing
- Acute Intermittent Hypoxia (AIH), Acute Intermittent Hypercapnic-Hypoxia (AIHH)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Florida